Research Topics
| Daniel W WessonSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Detail Information
Publications
Sniffing behavior communicates social hierarchyDaniel W Wesson
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA Electronic address
Curr Biol 23:575-80. 2013..Together, these findings demonstrate that rodents utilize sniffing behaviors communicatively, not only to collect [6, 10-14] but also to convey information...
Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis modelDaniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
Behav Brain Res 237:96-102. 2013..Further, these results provide mechanistic insights into olfactory dysfunction as a biomarker for AD by yielding evidence that focal reductions of Aβ may be sufficient to preserve olfaction...
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse modelDaniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Neurosci 31:15962-71. 2011....
Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse modelJose Morales-Corraliza
Center for Dementia Research, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neurobiol Aging 34:137-45. 2013....
Respiratory and sniffing behaviors throughout adulthood and aging in miceDaniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Behav Brain Res 223:99-106. 2011..These results show that odor-orienting responses are minimally impacted throughout aging in mice, and suggest that the olfactomotor network is mostly spared of insults due to aging...
Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse modelDaniel W Wesson
Emotional Brain Institute and Center for Dementia Research, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Neurosci 30:505-14. 2010..Furthermore, these results present the odor cross-habituation test as a powerful behavioral assay, which reflects Abeta deposition and thus may serve to monitor the efficacy of therapies aimed at reducing Abeta...
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse modelsPaige E Cramer
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Science 335:1503-6. 2012..Thus, RXR activation stimulates physiological Aβ clearance mechanisms, resulting in the rapid reversal of a broad range of Aβ-induced deficits...
Mechanisms of neural and behavioral dysfunction in Alzheimer's diseaseDaniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USA
Mol Neurobiol 43:163-79. 2011....
Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) miceDaniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
Behav Brain Res 216:408-13. 2011..These results suggest that the APP gene plays a role in affiliative behaviors and are discussed in relation to disorders characteristic of mutations in the APP gene and in affective dysfunction, including Alzheimer's disease...
Sniffing out the contributions of the olfactory tubercle to the sense of smell: hedonics, sensory integration, and more?Daniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neurosci Biobehav Rev 35:655-68. 2011..Together, the information within this review highlights an understudied yet potentially critical component in central odor processing...
Smelling sounds: olfactory-auditory sensory convergence in the olfactory tubercleDaniel W Wesson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Neurosci 30:3013-21. 2010..Thus, the tubercle presents itself as a source for direct multimodal convergence within an early stage of odor processing and may serve as a seat for psychophysical interactions between smells and sounds...
Parallel odor processing by two anatomically distinct olfactory bulb target structuresColleen A Payton
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
PLoS ONE 7:e34926. 2012..We predict that the olfactory code follows a distributed processing stream in transmitting behaviorally and perceptually-relevant information from low-level stations...
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysisDun Sheng Yang
Nathan Kline Institute, Orangeburg, NY, USA
Autophagy 7:788-9. 2011..Our findings underscore the pathogenic significance of autophagic-lysosomal dysfunction in AD and demonstrate the value of reversing this dysfunction as an innovative therapeautic strategy for AD...
