Research Topics
| Qin WangSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligationQin Wang
Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
Am J Physiol Lung Cell Mol Physiol 288:L359-69. 2005....- Lung microvascular and arterial endothelial cells differ in their responses to intercellular adhesion molecule-1 ligationQin Wang
Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio 44106, USA
Am J Respir Crit Care Med 166:872-7. 2002..Thus, neutrophil adhesion through ICAM-1 induced signaling events leading to cytoskeletal changes only in PMECs, the site of neutrophil emigration and edema formation, and not in PAECs... - Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cellsQin Wang
Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 278:47731-43. 2003.... - SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1Qin Wang
Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E8
J Biol Chem 280:8397-406. 2005..Focal adhesions co-localizing with the endoplasmic reticulum may provide molecular staging sites required for ERK activation... - Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cellsMcKenzie Koss
Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 176:1218-27. 2006..Phosphorylation of ERM likely plays important roles in EC responses to TNF-alpha by modulating the F-actin cytoskeleton, adhesion molecules, and signaling events... - Neutrophil cytoskeletal rearrangements during capillary sequestration in bacterial pneumonia in ratsKazuo Yoshida
Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
Am J Respir Crit Care Med 174:689-98. 2006.... - Effect of neutrophil adhesion on the mechanical properties of lung microvascular endothelial cellsInkyung Kang
Department of Biomedical Engineering, and Division of Integrative Biology, Case Western Reserve University, Cleveland, Ohio, USA
Am J Respir Cell Mol Biol 43:591-8. 2010..Our results demonstrate that neutrophil adhesion induces regional changes in the stiffness of ECs... - CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in miceQin Wang
Department of Pediatrics, Division of Integrative Biology, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Am J Pathol 161:2219-28. 2002..These data demonstrate that CD44 deficiency results in enhanced inflammation in E. coli but not S. pneumoniae-induced pneumonia, suggesting a previously unrecognized role for CD44 in limiting the inflammatory response to E. coli... - Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitrilesNeelu Kaila
Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
Bioorg Med Chem 15:6425-42. 2007..Lead compound 4-cycloheptylamino-6-[(pyridin-3-ylmethyl)-amino]-[1,7]naphthyridine-3-carbonitrile (30) was efficacious in a rat model of LPS-induced TNF-alpha production... - Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesionsMaria Teresa Herrera Abreu
Department of Medicine, University of Toronto, Toronto General Hospital Research Institute of the University Health Network, Ontario, Canada
J Cell Physiol 207:132-43. 2006..We conclude that IL-1beta mediated maturation of focal adhesions is dependent on tyrosine phosphorylation of SHP-2 at Y542, leading to recruitment of Gab1, a process that may influence the downstream activation of ERK... - The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblastsMairi MacGillivray
Division of Respirology, The Department of Medicine, The Toronto General Hospital Research Institute of the University Health Network, Toronto, Ontario M5S 1A8, Canada
J Biol Chem 278:27190-8. 2003..In summary, our data indicate that SHP-2, a focal adhesion-associated protein, participates in IL-1-induced ERK activation likely via an adaptor function... - The signaling pathways induced by neutrophil-endothelial cell adhesionQin Wang
Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
Antioxid Redox Signal 4:39-47. 2002..Finally, the potential physiological roles of these signaling events induced by EC adhesion molecules in mediating neutrophil migration will be addressed... - Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptorsQin Wang
Department of Pharmacology and Center of Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Science 304:1940-4. 2004..The reciprocal interactions of GPCRs with spinophilin and arrestin represent a regulatory mechanism for fine-tuning complex receptor-orchestrated cell signaling and responses... - Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cellsPhyllus Y Mong
Tumor Immunology Laboratory, Division of Surgical Oncology, Department of Surgery, Columbia University, New York, NY 10032, USA
J Immunol 180:550-8. 2008..Therefore, Rho kinase plays important roles in EC responses to TNF-alpha by regulating permeability increases and JNK-dependent IL-6 production during pulmonary inflammation... - All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cellsQin Wang
Department of Medicine, Division of Oncology/Hematology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, MSB I-596, 185 South Orange Avenue, Newark, NJ 07103, USA
Oncogene 23:426-33. 2004..These data demonstrate the potentiation of Taxotere-induced cell death by ATRA pretreatment in breast and prostate cancer cells, and support a mechanism through accentuated and sustained JNK activation... - IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activationQin Wang
CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
FASEB J 17:1898-900. 2003..Thus interactions with the extracellular matrix and focal adhesion formation regulate IL-1-induced generation of intracellular Ca2+ signals that in turn are required for ERK activation... - Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activationQin Wang
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 281:25948-55. 2006.... - Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signalingQin Wang
Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
J Biol Chem 281:31093-105. 2006..We conclude that Tyr-542 of SHP-2 modulates IL-1-induced Ca2+ signals and association of the ER with focal adhesions... - Iron loading inhibits ferroportin1 expression in PC12 cellsYanming Chen
Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology and National Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, PR China
Neurochem Int 47:507-13. 2005.... - Mitochondrial function is a critical determinant of IL-1-induced ERK activationQin Wang
CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
FASEB J 19:837-9. 2005..Consequently, mitochondria regulate key downstream effectors of IL-1, including MAP kinases... - Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cellsQin Wang
Department of Pharmacology, The University of Michigan, Ann Arbor 48109 0632, USA
J Biol Chem 277:24949-58. 2002.... - Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitrilesNeal Green
Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
J Med Chem 50:4728-45. 2007.... - Nickel-induced histone hypoacetylation: the role of reactive oxygen speciesJiuhong Kang
School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China
Toxicol Sci 74:279-86. 2003.... - Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitroGuang Bo Zhang
Institute of Biotechnology, Soochow University, Key Laboratory of Clinical Immunology of Jiangsu Province, Suzhou 215007, China
Acta Biochim Biophys Sin (Shanghai) 36:430-6. 2004..The results showed that the GST/hB7-H3 protein produced in bacteria had modest biological activities to proliferate the T lymphocyte and enhance IFN-gamma as well as IL-10 secretion... - Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitorsXiuxin Liu
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520-8082, USA
Nat Neurosci 8:1179-87. 2005..Thus, as GFAP-expressing cells generate neuroblasts, GABA released from neuroblasts provides a feedback mechanism to control the proliferation of GFAP-expressing progenitors by activating GABA(A) receptors... - Inhibitory effects of fluorobenzaldehydes on the activity of mushroom tyrosinaseXiao-Hong Huang
Key Laboratory of Biopesticide and Chemical Biology, Fujian Agriculture and Forestry University, Ministry of Education, Fuzhou 350002, PR China
J Enzyme Inhib Med Chem 21:413-8. 2006..The inhibition constants for these three fluorobenzaldehydes on the diphenolase were determined and compared... - Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus bisporus) tyrosinaseQin Wang
Department of Biochemistry and Biotechnology, Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Bioorg Med Chem 15:1568-71. 2007..There were almost no changes in the lag period and the steady-state rate, while the plateaus in the inhibitory curve lowered with increasing the concentration of phloridzin when using tyrosine as a substrate... - A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha productionQin Wang
Department of Discovery Pharmacokinetics, Wyeth Research, 1 Burtt Road, Andover, MA 01810, USA
J Pharmacol Toxicol Methods 56:67-71. 2007..The purpose of this study was to validate a rat pharmacokinetic/pharmacodynamic (PK/PD) model for rapid assessment of drug candidates that intended to interrupt TNFalpha synthesis or release... - In vitro-in vivo correlation on delivery of drug candidates to articular cartilageQin Wang
Discovery Pharmacokinetics, Wyeth Research, One Burtt Rd, Andover, Massachusetts 01810, USA
Pharm Res 25:1641-6. 2008..The purpose of this study was to investigate the correlation in cartilage compound levels between in vitro experiments and in vivo animal studies... - Regulation of alpha2AR trafficking and signaling by interacting proteinsQin Wang
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biochem Pharmacol 73:1135-45. 2007..Dr. Hancock's love of life, of family, and of commitment to making the world a better place are a model of the life well lived, and truly missed by those who were privileged to know, and thus love, him... - Reduction of drosopterin content caused by a 45-nt insertion in Henna pre-mRNA of Drosophila melanogasterQin Wang
State Key Laboratory of Agrobiotechnology and Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Sci China C Life Sci 51:702-10. 2008.... - Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin IIJing Shi
State Key Laboratory of Pathogens and Biosecurity, Institute of Microbiology and Epidemiology, No 20 Dongdajie, Fengtai District, Beijing 100071, PR China
Biochem Biophys Res Commun 374:331-5. 2008..Both were derived from the uninterrupted segments of the amino acid residues H(1241-1277) of BoNTb. Kinetic data of the antigen-receptor interaction were depicted in real-time and calculated as affinity constant of 2.99x10(-7)M... - Drug release behavior from in situ gelatinized thermosensitive nanogel aqueous dispersionsQin Wang
Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Int J Pharm 361:189-93. 2008..These results imply potential application of prepared thermosensitive nanogel dispersions as embolizing and tissue engineering materials... - Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosisHongqiang Fei
School of Life Science and Biotechnology, Key Laboratory of Microbial Metabolism, Ministry of Education, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, People s Republic of China
Mol Cell Biochem 315:75-84. 2008..Together, these data suggest that glucose- and IL-1beta-induced beta-cell secretory dysfunction and apoptosis are Ca(2+) influx and ERK dependent in rat islets... - Vanadyl bisacetylacetonate induced G1/S cell cycle arrest via high-intensity ERK phosphorylation in HepG2 cellsYing Fu
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, People s Republic of China
J Biol Inorg Chem 13:1001-9. 2008..The results presented here provided new insight into the development of vanadium compounds as potential anticancer agents... - Significance of the C-terminal globular domain and the extra tail of the calmodulin-like protein (Pinctada fucata) in subcellular localization and protein-protein interactionZi Fang
Institute of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Haidian, Beijing 100084, PR China
Cell Biol Int 32:920-7. 2008..Fluorescence confocal microscopy and co-immunoprecipitation on different mutants of CaLP with p21Cip1 indicated that the C-terminal globular domain of CaLP is responsible for the trafficking of CaLP from cytoplasm to nucleus... - Protein kinase A phosphorylation of spinophilin modulates its interaction with the alpha 2A-adrenergic receptor (AR) and alters temporal properties of alpha 2AAR internalizationJianmin Xu
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Biol Chem 283:14516-23. 2008..Therefore, modulation of spinophilin-receptor interaction through phosphorylation of spinophilin may represent a novel mechanism whereby PKA regulates G protein-coupled receptor trafficking... - Topography and biocompatibility of patterned hydrophobic/hydrophilic zein layersQin Wang
Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 382 D AESB, Urbana, IL 61801, USA
Acta Biomater 4:844-51. 2008..This property may be useful in controlling the spatial distribution of cells on patterned protein layers... - Effect of von Willebrand factor on the pharmacokinetics of recombinant human platelet glycoprotein Ibalpha-immunoglobulin G1 chimeric proteinsQin Wang
Wyeth Research, 1 Burtt Road, Andover, Massachusetts 01810, USA
Pharm Res 23:1743-9. 2006.... - Inhibitory kinetics of mercuric ion on the activity of beta-N-acetyl-D-glucosaminidase from green crab (Scylla serrata)Jin-Jin Xie
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Department of Biochemistry and Biotechnology, School of Life Sciences, Xiamen University, Xiamen, China
Int J Biol Macromol 39:159-64. 2006..The above results suggest that the cysteine residue is essential for activity and is situated at the active site of the enzyme... - Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot reportDao-pei Lu
Peking University Institute of Hematology and People's Hospital, Beijing, China
Blood 99:3136-43. 2002..Our results show, for the first time, that As(4)S(4) treatment alone is highly effective and safe in both remission induction and maintenance therapy in patients with APL, regardless of disease stage... - Serum xanthine oxidase: origin, regulation, and contribution to control of trypanosome parasitemiaJun Wang
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
Antioxid Redox Signal 4:161-78. 2002.... - Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3Qin Wang
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6600, USA
J Biol Chem 277:50589-96. 2002..These data are consistent with a model where sequential or competitive interactions among spinophilin, arrestin, and/or 14-3-3zeta play a role in alpha(2A)-AR functions... - Current study of APL treatment in ChinaDao-pei Lu
Peking University Institute of Hematology, Peking University People's Hospital, China
Int J Hematol 76:316-8. 2002..According to the data and principles above, most of the t(15;17) APL patients can be cured... - Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogeneQin Wang
Department of Cancer Cell Biology, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, W12 ONN, London, UK
Cancer Lett 175:63-9. 2002..These observations of PTPCAAX2 overexpression in prostate tumour cells and tissue suggest that PTPCAAX2 may potentially function as an oncogene in prostate cancer... - Inhibitory effects on mushroom tyrosinase by some alkylbenzaldehydesQing Xi Chen
The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, People s Republic of China
J Enzyme Inhib Med Chem 18:491-6. 2003.... - Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cellsQin Wang
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 279:28831-4. 2004..Suppression of p115rhoGEF had no effect. Thus different rhoGEFs (LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and LPA receptors... - Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteinsQin Wang
Department of Pharmacology, University of Michigan, Ann Arbor 48109, USA
Methods Enzymol 389:244-65. 2004..Also, the three siRNAs targeting LARG, PDZ-RhoGEF, and p115-RhoGEF are able to discriminate the closely related sequences within this RGS-RhoGEF gene family... - Inhibitory effects of 4-halobenzoic acids on the diphenolase and monophenolase activity of mushroom tyrosinaseQin Wang
The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Protein J 23:303-8. 2004..The lag time of the monophenolase was obviously lengthened by these three 4-halobenzoic acids. When the concentration of inhibitors reached 1.4 mM, the lag time was lengthened from 30 s to 120, 125, and 150 s, respectively... - Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding proteinQin Wang
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
FASEB J 19:869-71. 2005.... - Inhibitory effects of 4-vinylbenzaldehyde and 4-vinylbenzoic acid on the activity of mushroom tyrosinaseKang-Kang Song
The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, P R China
J Enzyme Inhib Med Chem 20:239-43. 2005..33 mM, respectively. Kinetic analyses showed that inhibition by both compounds was reversible and their mechanisms were mixed-II type; their inhibition constants were also determined and compared... - Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritisYonghan Hu
Department of Chemical and Screening Sciences, Wyeth Research, Cambridge, MA 02140, USA
Bioorg Med Chem 13:6629-44. 2005..Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL... - Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adultsMark A Fishel
Department of Neurology, University of Washington, Seattle, WA 98108, USA
Arch Neurol 62:1539-44. 2005..05). CONCLUSION: Moderate hyperinsulinemia can elevate inflammatory markers and Abeta42 in the periphery and the brain, thereby potentially increasing the risk of Alzheimer disease... - Inactivation kinetics of guanidinium chloride on Penaeus vannamei beta-N-acetyl-D-glucosaminidase and the relationship of enzyme activity and its conformationXiao-Lan Xie
Department of Biochemistry and Biotechnology, School of Life Sciences, Xiamen University, Xiamen, 361005, China
Protein J 24:267-73. 2005..The rate constants of inactivation have been determined. The value of k(+0) is larger than that of k'(+0) which suggests that the enzyme is protected by substrate to a certain extent during guanidine denaturation... - Increased divalent metal transporter 1 expression might be associated with the neurotoxicity of L-DOPAYan-Zhong Chang
Department of Applied Biology and Chemistry Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong
Mol Pharmacol 69:968-74. 2006..The findings suggested that the increased DMT1(-IRE) expression might be partly associated with the neurotoxicity of L-DOPA. Clinical relevance of the findings needs to be investigated further... - [Construction of human breast carcinoma cell line transfected with OX40L and its costimulatory effect on T cells]Qin Shi
Medical Biotechnology Institute, Soochow University, Suzhou, Jiangsu 215007, P. R. China
Ai Zheng 25:148-52. 2006..3+/-5.6)%, P<0.05]. CONCLUSION: OX40L-MDA-MB-435 cells could activate T cells in vitro, promote T cell proliferation and cytokine secretion, and suppress T cell activation-induced cell death... - Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzymeYuhua Zhang
Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
Int Immunopharmacol 4:1845-57. 2004..TMI-2 represents a novel class of TACE inhibitors that may be effective and beneficial in the treatment of rheumatoid arthritis as well as other TNF-mediated inflammatory autoimmune diseases... - [Effect of sodium chloride treatment on remineralization of human root dentine caries in vitro]Xiaoling Wang
Caries Research Laboratory, Peking University School of Stomatology, Beijing 100081, China
Zhonghua Kou Qiang Yi Xue Za Zhi 37:30-2. 2002..CONCLUSION: 0.5 mol/L NaCl solution has no damage on the root caries surface. The in vitro results suggested that removal of soluble phosphoprotein from dentin lesions is an interesting approach to enhance remineralization...