Qin Wang

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Lung Cell Mol Physiol 288:L359-69. 2005
  2. ncbi request reprint Lung microvascular and arterial endothelial cells differ in their responses to intercellular adhesion molecule-1 ligation
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 166:872-7. 2002
  3. ncbi request reprint Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:47731-43. 2003
  4. ncbi request reprint SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E8
    J Biol Chem 280:8397-406. 2005
  5. ncbi request reprint Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells
    McKenzie Koss
    Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 176:1218-27. 2006
  6. pmc Neutrophil cytoskeletal rearrangements during capillary sequestration in bacterial pneumonia in rats
    Kazuo Yoshida
    Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 174:689-98. 2006
  7. pmc Effect of neutrophil adhesion on the mechanical properties of lung microvascular endothelial cells
    Inkyung Kang
    Department of Biomedical Engineering, and Division of Integrative Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Respir Cell Mol Biol 43:591-8. 2010
  8. pmc CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice
    Qin Wang
    Department of Pediatrics, Division of Integrative Biology, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Am J Pathol 161:2219-28. 2002
  9. ncbi request reprint Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles
    Neelu Kaila
    Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem 15:6425-42. 2007
  10. ncbi request reprint Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions
    Maria Teresa Herrera Abreu
    Department of Medicine, University of Toronto, Toronto General Hospital Research Institute of the University Health Network, Ontario, Canada
    J Cell Physiol 207:132-43. 2006

Collaborators

Detail Information

Publications58

  1. ncbi request reprint MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Lung Cell Mol Physiol 288:L359-69. 2005
    ....
  2. ncbi request reprint Lung microvascular and arterial endothelial cells differ in their responses to intercellular adhesion molecule-1 ligation
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Respir Crit Care Med 166:872-7. 2002
    ..Thus, neutrophil adhesion through ICAM-1 induced signaling events leading to cytoskeletal changes only in PMECs, the site of neutrophil emigration and edema formation, and not in PAECs...
  3. ncbi request reprint Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:47731-43. 2003
    ....
  4. ncbi request reprint SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E8
    J Biol Chem 280:8397-406. 2005
    ..Focal adhesions co-localizing with the endoplasmic reticulum may provide molecular staging sites required for ERK activation...
  5. ncbi request reprint Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells
    McKenzie Koss
    Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 176:1218-27. 2006
    ..Phosphorylation of ERM likely plays important roles in EC responses to TNF-alpha by modulating the F-actin cytoskeleton, adhesion molecules, and signaling events...
  6. pmc Neutrophil cytoskeletal rearrangements during capillary sequestration in bacterial pneumonia in rats
    Kazuo Yoshida
    Division of Integrative Biology, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 174:689-98. 2006
    ..Cytoskeletal rearrangements, as assessed by submembrane F-actin rims, result in poorly deformable neutrophils that may not pass through capillaries...
  7. pmc Effect of neutrophil adhesion on the mechanical properties of lung microvascular endothelial cells
    Inkyung Kang
    Department of Biomedical Engineering, and Division of Integrative Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Respir Cell Mol Biol 43:591-8. 2010
    ..Our results demonstrate that neutrophil adhesion induces regional changes in the stiffness of ECs...
  8. pmc CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice
    Qin Wang
    Department of Pediatrics, Division of Integrative Biology, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Am J Pathol 161:2219-28. 2002
    ..These data demonstrate that CD44 deficiency results in enhanced inflammation in E. coli but not S. pneumoniae-induced pneumonia, suggesting a previously unrecognized role for CD44 in limiting the inflammatory response to E. coli...
  9. ncbi request reprint Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles
    Neelu Kaila
    Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
    Bioorg Med Chem 15:6425-42. 2007
    ..Lead compound 4-cycloheptylamino-6-[(pyridin-3-ylmethyl)-amino]-[1,7]naphthyridine-3-carbonitrile (30) was efficacious in a rat model of LPS-induced TNF-alpha production...
  10. ncbi request reprint Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions
    Maria Teresa Herrera Abreu
    Department of Medicine, University of Toronto, Toronto General Hospital Research Institute of the University Health Network, Ontario, Canada
    J Cell Physiol 207:132-43. 2006
    ..We conclude that IL-1beta mediated maturation of focal adhesions is dependent on tyrosine phosphorylation of SHP-2 at Y542, leading to recruitment of Gab1, a process that may influence the downstream activation of ERK...
  11. ncbi request reprint The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts
    Mairi MacGillivray
    Division of Respirology, The Department of Medicine, The Toronto General Hospital Research Institute of the University Health Network, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:27190-8. 2003
    ..In summary, our data indicate that SHP-2, a focal adhesion-associated protein, participates in IL-1-induced ERK activation likely via an adaptor function...
  12. ncbi request reprint The signaling pathways induced by neutrophil-endothelial cell adhesion
    Qin Wang
    Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    Antioxid Redox Signal 4:39-47. 2002
    ..Finally, the potential physiological roles of these signaling events induced by EC adhesion molecules in mediating neutrophil migration will be addressed...
  13. ncbi request reprint Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors
    Qin Wang
    Department of Pharmacology and Center of Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 304:1940-4. 2004
    ..The reciprocal interactions of GPCRs with spinophilin and arrestin represent a regulatory mechanism for fine-tuning complex receptor-orchestrated cell signaling and responses...
  14. ncbi request reprint Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells
    Phyllus Y Mong
    Tumor Immunology Laboratory, Division of Surgical Oncology, Department of Surgery, Columbia University, New York, NY 10032, USA
    J Immunol 180:550-8. 2008
    ..Therefore, Rho kinase plays important roles in EC responses to TNF-alpha by regulating permeability increases and JNK-dependent IL-6 production during pulmonary inflammation...
  15. ncbi request reprint All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells
    Qin Wang
    Department of Medicine, Division of Oncology Hematology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, MSB I 596, 185 South Orange Avenue, Newark, NJ 07103, USA
    Oncogene 23:426-33. 2004
    ..These data demonstrate the potentiation of Taxotere-induced cell death by ATRA pretreatment in breast and prostate cancer cells, and support a mechanism through accentuated and sustained JNK activation...
  16. ncbi request reprint IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation
    Qin Wang
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    FASEB J 17:1898-900. 2003
    ..Thus interactions with the extracellular matrix and focal adhesion formation regulate IL-1-induced generation of intracellular Ca2+ signals that in turn are required for ERK activation...
  17. ncbi request reprint Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation
    Qin Wang
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 281:25948-55. 2006
    ....
  18. ncbi request reprint Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 281:31093-105. 2006
    ..We conclude that Tyr-542 of SHP-2 modulates IL-1-induced Ca2+ signals and association of the ER with focal adhesions...
  19. ncbi request reprint Iron loading inhibits ferroportin1 expression in PC12 cells
    Yanmin Chen
    Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology and National Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, PR China
    Neurochem Int 47:507-13. 2005
    ....
  20. ncbi request reprint Mitochondrial function is a critical determinant of IL-1-induced ERK activation
    Qin Wang
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    FASEB J 19:837-9. 2005
    ..Consequently, mitochondria regulate key downstream effectors of IL-1, including MAP kinases...
  21. ncbi request reprint Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells
    Qin Wang
    Department of Pharmacology, The University of Michigan, Ann Arbor 48109 0632, USA
    J Biol Chem 277:24949-58. 2002
    ....
  22. ncbi request reprint Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles
    Neal Green
    Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    J Med Chem 50:4728-45. 2007
    ....
  23. ncbi request reprint Nickel-induced histone hypoacetylation: the role of reactive oxygen species
    Jiuhong Kang
    School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China
    Toxicol Sci 74:279-86. 2003
    ....
  24. ncbi request reprint Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro
    Guang Bo Zhang
    Institute of Biotechnology, Soochow University, Key Laboratory of Clinical Immunology of Jiangsu Province, Suzhou 215007, China
    Acta Biochim Biophys Sin (Shanghai) 36:430-6. 2004
    ..The results showed that the GST/hB7-H3 protein produced in bacteria had modest biological activities to proliferate the T lymphocyte and enhance IFN-gamma as well as IL-10 secretion...
  25. pmc Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
    Xiuxin Liu
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    Nat Neurosci 8:1179-87. 2005
    ..Thus, as GFAP-expressing cells generate neuroblasts, GABA released from neuroblasts provides a feedback mechanism to control the proliferation of GFAP-expressing progenitors by activating GABA(A) receptors...
  26. ncbi request reprint Inhibitory effects of fluorobenzaldehydes on the activity of mushroom tyrosinase
    Xiao hong Huang
    Key Laboratory of Biopesticide and Chemical Biology, Fujian Agriculture and Forestry University, Ministry of Education, Fuzhou 350002, PR China
    J Enzyme Inhib Med Chem 21:413-8. 2006
    ..The inhibition constants for these three fluorobenzaldehydes on the diphenolase were determined and compared...
  27. ncbi request reprint Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus bisporus) tyrosinase
    Qin Wang
    Department of Biochemistry and Biotechnology, Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Bioorg Med Chem 15:1568-71. 2007
    ..There were almost no changes in the lag period and the steady-state rate, while the plateaus in the inhibitory curve lowered with increasing the concentration of phloridzin when using tyrosine as a substrate...
  28. ncbi request reprint A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production
    Qin Wang
    Department of Discovery Pharmacokinetics, Wyeth Research, 1 Burtt Road, Andover, MA 01810, USA
    J Pharmacol Toxicol Methods 56:67-71. 2007
    ..The purpose of this study was to validate a rat pharmacokinetic/pharmacodynamic (PK/PD) model for rapid assessment of drug candidates that intended to interrupt TNFalpha synthesis or release...
  29. doi request reprint In vitro-in vivo correlation on delivery of drug candidates to articular cartilage
    Qin Wang
    Discovery Pharmacokinetics, Wyeth Research, One Burtt Rd, Andover, Massachusetts 01810, USA
    Pharm Res 25:1641-6. 2008
    ..The purpose of this study was to investigate the correlation in cartilage compound levels between in vitro experiments and in vivo animal studies...
  30. pmc Regulation of alpha2AR trafficking and signaling by interacting proteins
    Qin Wang
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem Pharmacol 73:1135-45. 2007
    ..Dr. Hancock's love of life, of family, and of commitment to making the world a better place are a model of the life well lived, and truly missed by those who were privileged to know, and thus love, him...
  31. doi request reprint Reduction of drosopterin content caused by a 45-nt insertion in Henna pre-mRNA of Drosophila melanogaster
    Qin Wang
    State Key Laboratory of Agrobiotechnology and Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
    Sci China C Life Sci 51:702-10. 2008
    ....
  32. doi request reprint Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II
    Jing Shi
    State Key Laboratory of Pathogens and Biosecurity, Institute of Microbiology and Epidemiology, No 20 Dongdajie, Fengtai District, Beijing 100071, PR China
    Biochem Biophys Res Commun 374:331-5. 2008
    ..Both were derived from the uninterrupted segments of the amino acid residues H(1241-1277) of BoNTb. Kinetic data of the antigen-receptor interaction were depicted in real-time and calculated as affinity constant of 2.99x10(-7)M...
  33. doi request reprint Drug release behavior from in situ gelatinized thermosensitive nanogel aqueous dispersions
    Qin Wang
    Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Int J Pharm 361:189-93. 2008
    ..These results imply potential application of prepared thermosensitive nanogel dispersions as embolizing and tissue engineering materials...
  34. doi request reprint Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis
    Hongqiang Fei
    School of Life Science and Biotechnology, Key Laboratory of Microbial Metabolism, Ministry of Education, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, People s Republic of China
    Mol Cell Biochem 315:75-84. 2008
    ..Together, these data suggest that glucose- and IL-1beta-induced beta-cell secretory dysfunction and apoptosis are Ca(2+) influx and ERK dependent in rat islets...
  35. doi request reprint Vanadyl bisacetylacetonate induced G1/S cell cycle arrest via high-intensity ERK phosphorylation in HepG2 cells
    Ying Fu
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, People s Republic of China
    J Biol Inorg Chem 13:1001-9. 2008
    ..The results presented here provided new insight into the development of vanadium compounds as potential anticancer agents...
  36. doi request reprint Significance of the C-terminal globular domain and the extra tail of the calmodulin-like protein (Pinctada fucata) in subcellular localization and protein-protein interaction
    Zi Fang
    Institute of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Haidian, Beijing 100084, PR China
    Cell Biol Int 32:920-7. 2008
    ..Fluorescence confocal microscopy and co-immunoprecipitation on different mutants of CaLP with p21Cip1 indicated that the C-terminal globular domain of CaLP is responsible for the trafficking of CaLP from cytoplasm to nucleus...
  37. doi request reprint Protein kinase A phosphorylation of spinophilin modulates its interaction with the alpha 2A-adrenergic receptor (AR) and alters temporal properties of alpha 2AAR internalization
    Jianmin Xu
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 283:14516-23. 2008
    ..Therefore, modulation of spinophilin-receptor interaction through phosphorylation of spinophilin may represent a novel mechanism whereby PKA regulates G protein-coupled receptor trafficking...
  38. doi request reprint Topography and biocompatibility of patterned hydrophobic/hydrophilic zein layers
    Qin Wang
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 382 D AESB, Urbana, IL 61801, USA
    Acta Biomater 4:844-51. 2008
    ..This property may be useful in controlling the spatial distribution of cells on patterned protein layers...
  39. ncbi request reprint Effect of von Willebrand factor on the pharmacokinetics of recombinant human platelet glycoprotein Ibalpha-immunoglobulin G1 chimeric proteins
    Qin Wang
    Wyeth Research, 1 Burtt Road, Andover, Massachusetts 01810, USA
    Pharm Res 23:1743-9. 2006
    ....
  40. ncbi request reprint Inhibitory kinetics of mercuric ion on the activity of beta-N-acetyl-D-glucosaminidase from green crab (Scylla serrata)
    Jin Jin Xie
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Department of Biochemistry and Biotechnology, School of Life Sciences, Xiamen University, Xiamen, China
    Int J Biol Macromol 39:159-64. 2006
    ..The above results suggest that the cysteine residue is essential for activity and is situated at the active site of the enzyme...
  41. ncbi request reprint Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report
    Dao Pei Lu
    Peking University Institute of Hematology and People s Hospital, Beijing, China
    Blood 99:3136-43. 2002
    ..Our results show, for the first time, that As(4)S(4) treatment alone is highly effective and safe in both remission induction and maintenance therapy in patients with APL, regardless of disease stage...
  42. ncbi request reprint Serum xanthine oxidase: origin, regulation, and contribution to control of trypanosome parasitemia
    Jun Wang
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Antioxid Redox Signal 4:161-78. 2002
    ....
  43. ncbi request reprint Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3
    Qin Wang
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 277:50589-96. 2002
    ..These data are consistent with a model where sequential or competitive interactions among spinophilin, arrestin, and/or 14-3-3zeta play a role in alpha(2A)-AR functions...
  44. ncbi request reprint Current study of APL treatment in China
    Dao Pei Lu
    Peking University Institute of Hematology, Peking University People s Hospital, China
    Int J Hematol 76:316-8. 2002
    ..According to the data and principles above, most of the t(15;17) APL patients can be cured...
  45. ncbi request reprint Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene
    Qin Wang
    Department of Cancer Cell Biology, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, W12 ONN, London, UK
    Cancer Lett 175:63-9. 2002
    ..These observations of PTPCAAX2 overexpression in prostate tumour cells and tissue suggest that PTPCAAX2 may potentially function as an oncogene in prostate cancer...
  46. ncbi request reprint Inhibitory effects on mushroom tyrosinase by some alkylbenzaldehydes
    Qing Xi Chen
    The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, People s Republic of China
    J Enzyme Inhib Med Chem 18:491-6. 2003
    ....
  47. ncbi request reprint Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells
    Qin Wang
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:28831-4. 2004
    ..Suppression of p115rhoGEF had no effect. Thus different rhoGEFs (LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and LPA receptors...
  48. ncbi request reprint Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins
    Qin Wang
    Department of Pharmacology, University of Michigan, Ann Arbor 48109, USA
    Methods Enzymol 389:244-65. 2004
    ..Also, the three siRNAs targeting LARG, PDZ-RhoGEF, and p115-RhoGEF are able to discriminate the closely related sequences within this RGS-RhoGEF gene family...
  49. ncbi request reprint Inhibitory effects of 4-halobenzoic acids on the diphenolase and monophenolase activity of mushroom tyrosinase
    Qin Wang
    The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Protein J 23:303-8. 2004
    ..The lag time of the monophenolase was obviously lengthened by these three 4-halobenzoic acids. When the concentration of inhibitors reached 1.4 mM, the lag time was lengthened from 30 s to 120, 125, and 150 s, respectively...
  50. ncbi request reprint Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
    Qin Wang
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
    FASEB J 19:869-71. 2005
    ....
  51. ncbi request reprint Inhibitory effects of 4-vinylbenzaldehyde and 4-vinylbenzoic acid on the activity of mushroom tyrosinase
    Kang Kang Song
    The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, P R China
    J Enzyme Inhib Med Chem 20:239-43. 2005
    ..33 mM, respectively. Kinetic analyses showed that inhibition by both compounds was reversible and their mechanisms were mixed-II type; their inhibition constants were also determined and compared...
  52. ncbi request reprint Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
    Yonghan Hu
    Department of Chemical and Screening Sciences, Wyeth Research, Cambridge, MA 02140, USA
    Bioorg Med Chem 13:6629-44. 2005
    ..Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL...
  53. ncbi request reprint Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    Mark A Fishel
    Department of Neurology, University of Washington, Seattle, WA 98108, USA
    Arch Neurol 62:1539-44. 2005
    ..Hyperinsulinemia induces inflammation and is a risk factor for Alzheimer disease. Thus, insulin abnormalities may contribute to Alzheimer disease pathophysiology through effects on the inflammatory network...
  54. ncbi request reprint Inactivation kinetics of guanidinium chloride on Penaeus vannamei beta-N-acetyl-D-glucosaminidase and the relationship of enzyme activity and its conformation
    Xiao Lan Xie
    Department of Biochemistry and Biotechnology, School of Life Sciences, Xiamen University, Xiamen, 361005, China
    Protein J 24:267-73. 2005
    ..The rate constants of inactivation have been determined. The value of k(+0) is larger than that of k'(+0) which suggests that the enzyme is protected by substrate to a certain extent during guanidine denaturation...
  55. ncbi request reprint Increased divalent metal transporter 1 expression might be associated with the neurotoxicity of L-DOPA
    Yan Zhong Chang
    Department of Applied Biology and Chemistry Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    Mol Pharmacol 69:968-74. 2006
    ..The findings suggested that the increased DMT1(-IRE) expression might be partly associated with the neurotoxicity of L-DOPA. Clinical relevance of the findings needs to be investigated further...
  56. ncbi request reprint [Construction of human breast carcinoma cell line transfected with OX40L and its costimulatory effect on T cells]
    Qin Shi
    Medical Biotechnology Institute, Soochow University, Suzhou, Jiangsu 215007, P R China
    Ai Zheng 25:148-52. 2006
    ..This research was to transfect OX40L into human breast cancer cell line MDA-MB-435 to construct OX40L-MDA-MB-435 cells, and to investigate the costimulatory effect of OX40-OX40L signal on biological activity of T cells in vitro...
  57. ncbi request reprint Characterization of (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide, a potent and selective inhibitor of TNF-alpha converting enzyme
    Yuhua Zhang
    Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Int Immunopharmacol 4:1845-57. 2004
    ..TMI-2 represents a novel class of TACE inhibitors that may be effective and beneficial in the treatment of rheumatoid arthritis as well as other TNF-mediated inflammatory autoimmune diseases...
  58. ncbi request reprint [Effect of sodium chloride treatment on remineralization of human root dentine caries in vitro]
    Xiaoling Wang
    Caries Research Laboratory, Peking University School of Stomatology, Beijing 100081, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 37:30-2. 2002
    ..To investigate the influence of soluble phosphoprotein removal from artificial dentin caries lesions by pretreatment of NaCl on subsequent remineralization...