Research Topics
| Michele C WalshSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Benchmarking techniques to improve neonatal care: uses and abusesMichele C Walsh
Department of Pediatrics, Case Western Reserve University, USA
Clin Perinatol 30:343-50, x. 2003..The technique of benchmarking is one tool that can accelerate improvements. This article describes the uses of benchmarking and steps in implementation...
Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxideMichele C Walsh
Case Western Reserve University, Cleveland, OH, USA
J Pediatr 156:556-61.e1. 2010..Because some preventative BPD treatments are associated with neurodevelopmental impairment, we designed a follow-up study to assess the safety of nitric oxide...
Meconium stained fluid: approach to the mother and the babyMichele C Walsh
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
Clin Perinatol 34:653-65, viii. 2007..Optimal care for an infant born through MSAF involves cooperation between the obstetrician and pediatrician, each with separate but imperative roles...
Impact of a physiologic definition on bronchopulmonary dysplasia ratesMichele C Walsh
Rainbow Babies and Childrens Hospital, Department of Pediatrics, CASE Case Western Reserve University, 11100 Euclid Ave, Mailstop 6010, Cleveland, OH 44106, USA
Pediatrics 114:1305-11. 2004..Safety (apnea, bradycardia, increased oxygen use) and outcomes of the physiologic definition versus the clinical definition were assessed...
Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomesMichele C Walsh
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
J Pediatr 146:798-804. 2005..To compare duration of ventilation to mortality and adverse neurodevelopmental outcomes among extremely low birth weight (ELBW; 501-1000 g) infants...
Oxygen delivery through nasal cannulae to preterm infants: can practice be improved?Michele Walsh
Case Western Reserve University, Cleveland, OH 44106 6010, USA
Pediatrics 116:857-61. 2005..We hypothesized that some infants treated with oxygen through nasal cannulae were receiving oxygen levels equivalent to those of room air...
Neurodevelopmental outcomes in the early CPAP and pulse oximetry trialYvonne E Vaucher
Department of Pediatrics, University of California at San Diego, San Diego, California 92013, USA
N Engl J Med 367:2495-504. 2012..A lower (vs. higher) target range of oxygen saturation was associated with a lower rate of severe retinopathy but higher mortality. We now report longer-term results from our prespecified hypotheses...
Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathyAbbot R Laptook
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02906, USA
Pediatrics 124:1619-26. 2009..The objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy...
Outcome trajectories in extremely preterm infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Pediatrics 130:e115-25. 2012..Our objective was to develop serial predictions of outcome by using prognostic factors available over the course of NICU hospitalization...
Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestationWaldemar A Carlo
Department of Pediatrics, University of Alabama, 9380 Women and Infants Center, 1700 Sixth Ave S, Birmingham, AL 35249, USA
JAMA 306:2348-58. 2011..However, many infants born before 24 weeks' gestation are provided intensive care...
Predicting time to hospital discharge for extremely preterm infantsSusan R Hintz
Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine and Lucile Packard Children s Hospital, Palo Alto, CA 94304, USA
Pediatrics 125:e146-54. 2010..Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives...
Accounting for multiple births in neonatal and perinatal trials: systematic review and case studyAnna Maria Hibbs
Department of Pediatrics, Case Western Reserve University and Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Suite 3100, Cleveland, OH 44106
J Pediatr 156:202-8. 2010..To determine the prevalence in the neonatal literature of statistical approaches accounting for the unique clustering patterns of multiple births and to explore the sensitivity of an actual trial to several analytic approaches to multiples...
Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definitionGirija Natarajan
Department of Pediatrics, Wayne State University, Detroit, MI, USA
Early Hum Dev 88:509-15. 2012..We compared neurodevelopmental outcomes of extremely low birth weight (ELBW) infants with and without bronchopulmonary dysplasia (BPD), using the physiologic definition...
Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathySeetha Shankaran
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
J Pediatr 160:567-572.e3. 2012..To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia...
Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollmentWade D Rich
Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
Pediatrics 126:e215-21. 2010....
Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infantsAndi L Shane
Department of Pediatrics, Emory University School of Medicine, Children s Healthcare of Atlanta, Atlanta, GA 30322, USA
Pediatrics 129:e914-22. 2012..Data are limited on the impact of methicillin-resistant Staphylococcus aureus (MRSA) on morbidity and mortality among very low birth weight (VLBW) infants with S aureus (SA) bacteremia and/or meningitis (B/M)...
Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infantsP Brian Smith
Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
Pediatrics 129:e1508-16. 2012..We sought to determine if a center's approach to care of premature infants at the youngest gestational ages (22-24 weeks' gestation) is associated with clinical outcomes among infants of older gestational ages (25-27 weeks' gestation)...
Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infantsEdward F Bell
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Pediatrics 126:222-31. 2010....
Early nutrition mediates the influence of severity of illness on extremely LBW infantsRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Pediatr Res 69:522-9. 2011....
Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infantsMatthew M Laughon
Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7596, USA
Am J Respir Crit Care Med 183:1715-22. 2011....
Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infantsLilia C De Jesus
Department of Pediatrics, Wayne State University, Detroit, MI, USA
J Pediatr 161:70-4.e1-2. 2012..The study goal was to evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among extremely low birth weight (ELBW) infants...
Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational ageSusan R Hintz
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
Pediatrics 127:62-70. 2011..We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999-2001 (epoch 1) and 2002-2004 (epoch 2)...
Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathySeetha Shankaran
Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
Pediatrics 122:e791-8. 2008..Whole-body hypothermia reduced the frequency of death or moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a randomized, controlled multicenter trial...
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infantsDeanne Wilson-Costello
Rainbow Babies and Children s Hospital, Division of Neonatology, 11100 Euclid Ave, Cleveland, OH 44106, USA
Pediatrics 123:e430-7. 2009....
One-year respiratory outcomes of preterm infants enrolled in the Nitric Oxide (to prevent) Chronic Lung Disease trialAnna Maria Hibbs
Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106 6010, USA
J Pediatr 153:525-9. 2008..To identify whether inhaled nitric oxide treatment decreased indicators of long-term pulmonary morbidities after discharge from the neonatal intensive care unit...
Outcome of Extremely Preterm Infants (<1,000 g) With Congenital Heart Defects From the National Institute of Child Health and Human Development Neonatal Research NetworkAthina Pappas
Department of Pediatrics, Children s Hospital of Michigan and Hutzel Women s Hospital, Wayne State University, 3901 Beaubien, Detroit, MI, 48201, USA
Pediatr Cardiol 33:1415-26. 2012..38 %, p = 0.004). Risk of death or NDI was greater for ELBW infants with CHD, although 20 % of infants survived without NDI...
Empiric antifungal therapy and outcomes in extremely low birth weight infants with invasive candidiasisRachel G Greenberg
Department of Pediatrics, Duke University, Durham, NC, USA
J Pediatr 161:264-9.e2. 2012..To assess the impact of empiric antifungal therapy for invasive candidiasis on subsequent outcomes in premature infants...
Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathyAthina Pappas
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Pediatr 158:752-758.e1. 2011..To evaluate the association between early hypocarbia and 18- to 22-month outcome among neonates with hypoxic-ischemic encephalopathy...
Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 123:1132-41. 2009..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days...
Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continuesBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, and Children s Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA, USA
Pediatrics 127:817-26. 2011..Guidelines for prevention of group B streptococcal (GBS) infection have successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia coli is an important EO pathogen...
Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasiaRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Pediatrics 116:1353-60. 2005..The objective of this study was to determine the predictive validity of the severity-based, consensus definition of BPD...
Feasibility study of early blood pressure management in extremely preterm infantsBeau J Batton
Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH, USA
J Pediatr 161:65-9.e1. 2012..To assess the feasibility of a randomized placebo controlled trial (RCT) of blood pressure (BP) management for extremely preterm infants...
Population pharmacokinetics of piperacillin using scavenged samples from preterm infantsMichael Cohen-Wolkowiez
Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
Ther Drug Monit 34:312-9. 2012..We evaluated the population pharmacokinetics (PK) of piperacillin using targeted sparse sampling and scavenged samples obtained from preterm infants ≤ 32 weeks of gestational age at birth and <120 postnatal days...
Outcomes following candiduria in extremely low birth weight infantsJames L Wynn
Department of Pediatrics, Duke University, Durham, NC 27715, USA
Clin Infect Dis 54:331-9. 2012..Candidiasis carries a significant risk of death or neurodevelopmental impairment (NDI) in extremely low birth weight infants (ELBW; <1000 g). We sought to determine the impact of candiduria in ELBW preterm infants...
Bloodstream infections in very low birth weight infants with intestinal failureConrad R Cole
Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Pediatr 160:54-9.e2. 2012..To examine pathogens and other characteristics associated with late-onset bloodstream infections (BSIs) in infants with intestinal failure (IF) as a consequence of necrotizing enterocolitis (NEC)...
Controversies in the treatment of meconium aspiration syndromeSteven L Gelfand
Division of Neonatology, Department of Pediatrics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-6010, USA
Clin Perinatol 31:445-52. 2004..Surfactant lavage or replacement may be beneficial. When hypoxic respiratory failure progresses, iNO may improve oxygenation and avoid ECMO...
Maternal age, multiple birth, and extremely low birth weight infantsBetty R Vohr
Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
J Pediatr 154:498-503.e2. 2009..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers...
Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research NetworkBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine and Children s Healthcare of Atlanta, 2015 Uppergate Dr, Atlanta, GA 30322, USA
Pediatrics 126:443-56. 2010....
Survival and morbidity outcomes for very low birth weight infants with Down syndromeNansi S Boghossian
University of Iowa Health Care, Department of Pediatrics, 200 Hawkins Dr, Iowa City, IA 52242, USA
Pediatrics 126:1132-40. 2010....
Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhoodSusan R Hintz
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
Arch Pediatr Adolesc Med 162:748-55. 2008..To determine special outpatient services (SOS) use, need, associated factors, and neurodevelopmental and functional outcomes among extremely preterm infants at 18 to 22 months' corrected age...
Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomesVineet Bhandari
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
Pediatrics 124:517-26. 2009..Limited information is available on the outcomes of infants managed with SNIPPV...
Neonatal candidiasis: epidemiology, risk factors, and clinical judgmentDaniel K Benjamin
Department of Pediatrics, Duke University, Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
Pediatrics 126:e865-73. 2010..We quantified risk factors that predict infection in premature infants at high risk and compared clinical judgment with a prediction model of invasive candidiasis...
Perinatal systemic inflammatory response syndrome and retinopathy of prematurityBeena G Sood
Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
Pediatr Res 67:394-400. 2010..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP...
T cell cytokines and the risk of blood stream infection in extremely low birth weight infantsRobert L Schelonka
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Cytokine 53:249-55. 2011..Altered maturation of regulatory and inflammatory cytokines may increase the risk of serious infection in this population...
Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infantsMichael Cohen-Wolkowiez
Department of Pediatrics, Duke University, Durham, North Carolina, USA
Antimicrob Agents Chemother 56:1828-37. 2012..Minimal-risk methods such as scavenged PK sampling provided meaningful information related to development of metronidazole PK models and dosing recommendations...
The NICHD neonatal research network: changes in practice and outcomes during the first 15 yearsAvroy A Fanaroff
Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Semin Perinatol 27:281-7. 2003..Advances in perinatal care within NICHD Network centers have resulted in marked improvements in survival. Further advances are required to increase survival free of neonatal morbidity or neurodevelopmental impairment...
Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomesAbbot Laptook
Department of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley St, Providence, RI 02906, USA
Pediatrics 122:491-9. 2008....
Summary proceedings from the bronchopulmonary dysplasia groupMichele C Walsh
Division of Neonatology, Rainbow Babies and Children s Hospital, Department of Pediatrics, Case Western Reserve University, 11100 Euclid Ave, Mailstop 6010, Cleveland, Ohio 44106 6010, USA
Pediatrics 117:S52-6. 2006..Finally, we discuss trial-design issues that are common to all neonatal studies...
Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasiaMichele C Walsh
Rainbow Babies and Children's Hospital, Case Western Reserve University, Mailstop 6010, 11100 Euclid Avenue, Cleveland, OH 44106, USA
J Perinatol 23:451-6. 2003..CONCLUSIONS: The physiologic definition of BPD is safe, feasible, reliable, and valid and improves the precision of the diagnosis of BPD. This may be of benefit in future multicenter clinical trials...
Effects of delayed cord clamping in very-low-birth-weight infantsW Oh
Department of Pediatrics, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
J Perinatol 31:S68-71. 2011..Delayed cord clamping (DCC) may be beneficial in very-preterm and very-low-birth-weight infants...
Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathyNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 118:2084-93. 2006..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy...
Total parenteral nutrition-associated hyperglycemia correlates with prolonged mechanical ventilation and hospital stay in septic infantsDiya I Alaedeen
Division of Pediatric Surgery, Department of Surgery, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
J Pediatr Surg 41:239-44; discussion 239-44. 2006..Avoidance of excessive nutrient delivery and tight glycemic control during periods of acute metabolic stress may improve outcome in this patient population...
Meconium stained fluid: approach to the mother and the babySteven L Gelfand
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
Pediatr Clin North Am 51:655-67, ix. 2004..As always, effective communication and advanced preparation and anticipation of potential problems form the cornerstone of this partnership. Together the health of infants may be improved...
Inhaled nitric oxide in preterm infants undergoing mechanical ventilationRoberta A Ballard
Children s Hospital of Philadelphia, Philadelphia 19104, USA
N Engl J Med 355:343-53. 2006..In animal models, inhaled nitric oxide improves both gas exchange and lung structural development, but the use of this therapy in infants at risk for bronchopulmonary dysplasia is controversial...
Long-term outcomes: what should the focus be?Judy L Aschner
Department of Pediatrics and The Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232 9544, USA
Clin Perinatol 34:205-17, ix. 2007..Future trials must be designed and powered to address the potential for harm as well as the prospect of benefit...
Pre- and postnatal factors in chronic lung disease: implications for managementRichard J Martin
Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, Case Western Reserve University School of Medicinem 44106-6010, USA
Paediatr Respir Rev 5:S235-40. 2004
Inhaled nitric oxide for preterm infants--who benefits?Richard J Martin
N Engl J Med 353:82-4. 2005
Changes in the use of postnatal steroids for bronchopulmonary dysplasia in 3 large neonatal networksMichele C Walsh
Neonatal Research Network, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Pediatrics 118:e1328-35. 2006..In early 2002, a joint statement of the American Academy of Pediatrics and Canadian Paediatric Society called for limitation in the use of postnatal corticosteroids. The impact of this statement is not known...
Reevaluating neonatal resuscitation with 100% oxygenRichard J Martin
Am J Respir Crit Care Med 172:1360-1. 2005
Research Grants
- NICHD Cooperative Multicenter Neonatal Research NetworkMichele Walsh; Fiscal Year: 2007....
