Anna M van Heeckeren

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Murine models of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Lab Anim 36:291-312. 2002
  2. ncbi Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice
    Anna M van Heeckeren
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 287:L944-52. 2004
  3. ncbi Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice
    Anna M van Heeckeren
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Am J Respir Crit Care Med 173:288-96. 2006
  4. ncbi Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Case Western Reserve Univ School of Medicine, Biomedical Research Bldg 827, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 286:L717-26. 2004
  5. ncbi Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice
    Anna M van Heeckeren
    Case Western Reserve University School of Medicine, Cleveland, Ohio Hospital San Rafael, La Coruna, Spain
    Infect Immun 72:1479-86. 2004
  6. ncbi Peroxisome proliferator-activated receptor-gamma in cystic fibrosis lung epithelium
    Aura Perez
    Deptartment of Pediatrics, School of Medicine, Case Western Reserve University, BRB Bldg R829, 10900 Euclid Ave, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 295:L303-13. 2008
  7. ncbi Monitoring infection and inflammation in murine models of cystic fibrosis with magnetic resonance imaging
    Vipul R Sheth
    Case Center for Imaging Research and Department of Biomedical Engineering, Case Western Reserve University Cystic Fibrosis Core Center Animal Core, Cleveland, Ohio 44106 7207, USA
    J Magn Reson Imaging 28:527-32. 2008
  8. ncbi SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis
    Barbara R Grubb
    Cystic Fibrosis Pulmonary Research and Treatment Center, 7011 Thurston Bowles Bldg, CB 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Am J Respir Cell Mol Biol 34:355-63. 2006
  9. ncbi Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
    Volker Teichgräber
    Department of Molecular Biology, Hufelandstrasse 55, University of Duisburg Essen, 45122 Essen, Germany
    Nat Med 14:382-91. 2008
  10. ncbi Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection
    Brian J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Infect Immun 72:2045-51. 2004

Research Grants

  1. P. aeruginosa lung disease in CF
    Anna Van Heeckeren; Fiscal Year: 2006

Collaborators

Detail Information

Publications11

  1. ncbi Murine models of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Lab Anim 36:291-312. 2002
    ..aeruginosa-laden agarose beads, since the histopathological features were similar, though further characterization is needed to evaluate its utility as an adequate model of cystic fibrosis...
  2. ncbi Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice
    Anna M van Heeckeren
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 287:L944-52. 2004
    ..Therefore, it appears that any functional defect in CFTR produces comparable inflammatory responses to lung infections with P. aeruginosa...
  3. ncbi Response to acute lung infection with mucoid Pseudomonas aeruginosa in cystic fibrosis mice
    Anna M van Heeckeren
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Am J Respir Crit Care Med 173:288-96. 2006
    ....
  4. ncbi Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection
    Anna M van Heeckeren
    Case Western Reserve Univ School of Medicine, Biomedical Research Bldg 827, 2109 Adelbert Road, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 286:L717-26. 2004
    ..In conclusion, the observed survival advantage of adenoviral delivery of CFTR to the CF lung may be due either to CFTR expression or possibly to proinflammatory effects of the adenoviral vector, or both...
  5. ncbi Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice
    Anna M van Heeckeren
    Case Western Reserve University School of Medicine, Cleveland, Ohio Hospital San Rafael, La Coruna, Spain
    Infect Immun 72:1479-86. 2004
    ..In conclusion, diet and docosahexaenoic acid imbalances alone are unlikely to explain the differences in the host response to lung infections with mucoid P. aeruginosa between mice with cystic fibrosis and their wild-type counterparts...
  6. ncbi Peroxisome proliferator-activated receptor-gamma in cystic fibrosis lung epithelium
    Aura Perez
    Deptartment of Pediatrics, School of Medicine, Case Western Reserve University, BRB Bldg R829, 10900 Euclid Ave, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 295:L303-13. 2008
    ..aeruginosa in CF, but not wild-type, mice. In summary, PPARgamma inhibits the inflammatory response in CF, at least in part by interaction with NF-kappaB in airway epithelial cells. PPARgamma agonists may be therapeutic in CF...
  7. ncbi Monitoring infection and inflammation in murine models of cystic fibrosis with magnetic resonance imaging
    Vipul R Sheth
    Case Center for Imaging Research and Department of Biomedical Engineering, Case Western Reserve University Cystic Fibrosis Core Center Animal Core, Cleveland, Ohio 44106 7207, USA
    J Magn Reson Imaging 28:527-32. 2008
    ..To evaluate magnetic resonance imaging (MRI) in assessing lung inflammation longitudinally in genetic mouse models of cystic fibrosis (CF). MRI is used to view soft tissues noninvasively, but the lung is challenging to image...
  8. ncbi SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis
    Barbara R Grubb
    Cystic Fibrosis Pulmonary Research and Treatment Center, 7011 Thurston Bowles Bldg, CB 7248, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Am J Respir Cell Mol Biol 34:355-63. 2006
    ....
  9. ncbi Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
    Volker Teichgräber
    Department of Molecular Biology, Hufelandstrasse 55, University of Duisburg Essen, 45122 Essen, Germany
    Nat Med 14:382-91. 2008
    ..These data suggest inhibition of Asm as a new treatment strategy for cystic fibrosis...
  10. ncbi Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection
    Brian J Day
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Infect Immun 72:2045-51. 2004
    ..Individuals with lung diseases associated with altered antioxidant transport, such as cystic fibrosis, might lack the ability to adapt to the infection and present with a more severe inflammatory response...
  11. ncbi Tissue inhibitor of metalloproteinase 1 regulates resistance to infection
    Marie Mei Lee
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Infect Immun 73:661-5. 2005
    ..Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance...

Research Grants1

  1. P. aeruginosa lung disease in CF
    Anna Van Heeckeren; Fiscal Year: 2006
    ..These studies will direct future studies to more fully understand the pathophysiology of CF so novel treatments can be evaluated for use in CF patients. ..