Saba Valadkhan

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint Role of small nuclear RNAs in eukaryotic gene expression
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Essays Biochem 54:79-90. 2013
  2. pmc Reprogramming of the non-coding transcriptome during brain development
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol 9:5. 2010
  3. pmc The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44113, USA
    Proteomics 10:4128-41. 2010
  4. ncbi request reprint Role of the snRNAs in spliceosomal active site
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA
    RNA Biol 7:345-53. 2010
  5. pmc Protein-free small nuclear RNAs catalyze a two-step splicing reaction
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 106:11901-6. 2009
  6. pmc A snRNP's ordered path to maturity
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genes Dev 25:1563-7. 2011
  7. pmc Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    RNA 13:2300-11. 2007
  8. ncbi request reprint The spliceosome: caught in a web of shifting interactions
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, 10900 Euclid Avenue, Wood RT 100 8, Cleveland, OH 44106, USA
    Curr Opin Struct Biol 17:310-5. 2007
  9. ncbi request reprint The spliceosome: a ribozyme at heart?
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Biol Chem 388:693-7. 2007
  10. ncbi request reprint snRNAs as the catalysts of pre-mRNA splicing
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Curr Opin Chem Biol 9:603-8. 2005

Collaborators

Detail Information

Publications18

  1. doi request reprint Role of small nuclear RNAs in eukaryotic gene expression
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Essays Biochem 54:79-90. 2013
    ..These snRNP-mediated regulatory roles probably serve to ensure the co-ordination of the different processes involved in biogenesis of RNAs and point to the central importance of snRNAs in eukaryotic gene expression. ..
  2. pmc Reprogramming of the non-coding transcriptome during brain development
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol 9:5. 2010
    ....
  3. pmc The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44113, USA
    Proteomics 10:4128-41. 2010
    ....
  4. ncbi request reprint Role of the snRNAs in spliceosomal active site
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA
    RNA Biol 7:345-53. 2010
    ..Thus, whether the spliceosome is an RNA or RNA-protein catalyst remains uncertain...
  5. pmc Protein-free small nuclear RNAs catalyze a two-step splicing reaction
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 106:11901-6. 2009
    ..These results prove that the complex formed by U6 and U2 RNAs is a ribozyme and can potentially carry out RNA-based catalysis in the spliceosome...
  6. pmc A snRNP's ordered path to maturity
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genes Dev 25:1563-7. 2011
    ..1601-1612) shed light on the dynamic assembly of this critical spliceosomal component and elucidate the molecular interactions underlying the ordered addition of Brr2, a pivotal spliceosomal helicase, to the U5 snRNP...
  7. pmc Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    RNA 13:2300-11. 2007
    ..Our results demonstrate the ability of protein-free snRNAs to recognize the sequences involved in the first splicing step and to perform splicing-related catalysis between these two pre-mRNA-like substrates...
  8. ncbi request reprint The spliceosome: caught in a web of shifting interactions
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, 10900 Euclid Avenue, Wood RT 100 8, Cleveland, OH 44106, USA
    Curr Opin Struct Biol 17:310-5. 2007
    ..Overall, the past two years have seen a convergence of data from different lines of research into what promises to become a holistic picture of spliceosome function...
  9. ncbi request reprint The spliceosome: a ribozyme at heart?
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Biol Chem 388:693-7. 2007
    ..Of the five spliceosomal RNAs, U2 and U6 are the only ones that are absolutely required for both steps of splicing. These two snRNAs form an elaborate base-paired complex that might in fact constitute the active site of the spliceosome...
  10. ncbi request reprint snRNAs as the catalysts of pre-mRNA splicing
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Curr Opin Chem Biol 9:603-8. 2005
    ..An emerging model for the active site of group II introns, a closely related class of natural ribozymes, is likely to provide a wealth of insights on structure and function of the active site of the spliceosome...
  11. ncbi request reprint Young Scientist Award essay winner. Construction of a minimal, protein-free spliceosome
    Saba Valadkhan
    Case Western University, 2109 Adelbert Road, Wood RT 100 8, Cleveland, OH 44106, USA
    Science 307:863-4. 2005
  12. pmc Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs
    Caroline Lee
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    RNA 16:2226-38. 2010
    ....
  13. pmc Splicing of an intervening sequence by protein-free human snRNAs
    Yasaman Jaladat
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA
    RNA Biol 8:372-7. 2011
    ..These results prove that the protein-free snRNAs are competent to perform splicing on pre-mRNAs and further strengthen the possibility of an evolutionary relationship to group II introns...
  14. pmc The use of simple model systems to study spliceosomal catalysis
    Saba Valadkhan
    Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    RNA 15:4-7. 2009
    ..Furthermore, they strongly suggest that with further optimization, these RNAs might indeed be able to recapitulate the function of the spliceosomal catalytic core, thus opening the door to several lines of study not previously possible...
  15. doi request reprint The role of snRNAs in spliceosomal catalysis
    Saba Valadkhan
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
    Prog Mol Biol Transl Sci 120:195-228. 2013
    ..Whether they also contribute functional groups to the spliceosomal active site, and thus whether the spliceosomes are RNA or RNP enzymes remain uncertain. ..
  16. ncbi request reprint A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA
    Bing Zhang
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 34:2318-29. 2014
    ..Further, the presence of this motif in other cellular RNAs showed a direct correlation with nuclear localization, suggesting that the motif may act as a general nuclear localization signal for cellular RNAs. ..
  17. pmc Characterization of the catalytic activity of U2 and U6 snRNAs
    Saba Valadkhan
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    RNA 9:892-904. 2003
    ..Our data suggest that the ability to form RNA X might be an intrinsic property of spliceosomal snRNAs...
  18. ncbi request reprint Intrinsic metal binding by a spliceosomal RNA
    Saba Valadkhan
    Nat Struct Biol 9:498-9. 2002