Canaday D, Sridaran S, Van Epps P, Aung H, Burant C, Nsereko M, et al. CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection. Tuberculosis (Edinb). 2015;95:470-5 pubmed publisher
..This may be a contributory mechanism to the significantly increased risk of progression to PTB in this population. ..
Meng Q, Canaday D, MCDONALD D, Mayanja Kizza H, Baseke J, Toossi Z. Productive HIV-1 infection is enriched in CD4(-)CD8(-) double negative (DN) T cells at pleural sites of dual infection with HIV and Mycobacterium tuberculosis. Arch Virol. 2016;161:181-7 pubmed publisher
..These data indicate that productively HIV-1-infected DN T cells, generated through down-modulation of surface CD4, likely by HIV-1 Nef and Vpu, are the predominant source of HIV-1 at pleural sites of HIV/MTB coinfection. ..
Toossi Z, Funderburg N, Sirdeshmuk S, Whalen C, Nanteza M, Johnson D, et al. Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects. J Infect Dis. 2013;207:1841-9 pubmed publisher
..During HIV/tuberculosis, systemic immune activation is dissociated from microbial translocation. Changes in circulating sCD14 and LPS are dependent on CD4 T-cell count. ..