Zahra Toossi


Affiliation: Case Western Reserve University
Country: USA


  1. Canaday D, Sridaran S, Van Epps P, Aung H, Burant C, Nsereko M, et al. CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection. Tuberculosis (Edinb). 2015;95:470-5 pubmed publisher
    ..This may be a contributory mechanism to the significantly increased risk of progression to PTB in this population. ..
  2. Meng Q, Canaday D, MCDONALD D, Mayanja Kizza H, Baseke J, Toossi Z. Productive HIV-1 infection is enriched in CD4(-)CD8(-) double negative (DN) T cells at pleural sites of dual infection with HIV and Mycobacterium tuberculosis. Arch Virol. 2016;161:181-7 pubmed publisher
    ..These data indicate that productively HIV-1-infected DN T cells, generated through down-modulation of surface CD4, likely by HIV-1 Nef and Vpu, are the predominant source of HIV-1 at pleural sites of HIV/MTB coinfection. ..
  3. Toossi Z, Funderburg N, Sirdeshmuk S, Whalen C, Nanteza M, Johnson D, et al. Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects. J Infect Dis. 2013;207:1841-9 pubmed publisher
    ..During HIV/tuberculosis, systemic immune activation is dissociated from microbial translocation. Changes in circulating sCD14 and LPS are dependent on CD4 T-cell count. ..