- Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNADerek J Taylor
Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA
J Mol Biol 410:10-7. 2011..The results revealed that POT1-N and POT1-TPP1 can completely coat long telomeric ssDNA substrates. Furthermore, we show that ssDNA coated with human POT1-TPP1 heterodimers forms compact, potentially ordered structures...
- Multiple facets of TPP1 in telomere maintenanceMalligarjunan Rajavel
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland OH 44106, USA
Biochim Biophys Acta 1844:1550-9. 2014..In this review, we summarize the current knowledge regarding the role of TPP1 in telomere maintenance. ..
- Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNAMark Corriveau
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
J Biol Chem 288:16361-70. 2013..Together, these data suggest that POT1-TPP1 binds telomeric DNA in a coordinated manner to facilitate assembly of the nucleoprotein complexes into a state that is more accessible to enzymatic activity...