Catherine M Stein

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda
    Ningning Ma
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Rd, Wolstein Research Building room 1316, Cleveland, OH 44106, USA
    BMC Infect Dis 14:352. 2014
  2. pmc Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data
    Allison R Baker
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e47597. 2012
  3. pmc The household contact study design for genetic epidemiological studies of infectious diseases
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA Uganda Case Western Reserve University Research Collaboration Kampala, Uganda
    Front Genet 4:61. 2013
  4. doi request reprint Structural equation modeling
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 850:495-512. 2012
  5. pmc Tuberculosis as a complex trait: impact of genetic epidemiological study design
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Room 1316, 2103 Cornell Rd, Cleveland, OH, 44106, USA
    Mamm Genome 22:91-9. 2011
  6. pmc Genetic epidemiology of tuberculosis susceptibility: impact of study design
    Catherine M Stein
    Department of Epidemiology and Biostatistics, and Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 7:e1001189. 2011
  7. pmc Literacy outcomes of children with early childhood speech sound disorders: impact of endophenotypes
    Barbara A Lewis
    Case Western Reserve University, Cleveland, OH, USA
    J Speech Lang Hear Res 54:1628-43. 2011
  8. ncbi request reprint Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building Room 1303, 2103 Cornell Rd, Cleveland, OH 44106, USA
    Hum Genet 121:663-73. 2007
  9. pmc Genome scan of M. tuberculosis infection and disease in Ugandans
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    PLoS ONE 3:e4094. 2008
  10. pmc Heritability estimation for speech-sound traits with developmental trajectories
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Behav Genet 41:184-91. 2011

Collaborators

Detail Information

Publications32

  1. pmc Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda
    Ningning Ma
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Rd, Wolstein Research Building room 1316, Cleveland, OH 44106, USA
    BMC Infect Dis 14:352. 2014
    ..Our objective was to characterize these persistently negative TST (PTST-) individuals and compare them to TST converters (TSTC) and individuals who are TST positive at study enrollment...
  2. pmc Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data
    Allison R Baker
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e47597. 2012
    ..We also discovered three novel polymorphisms that appear to be population-specific and would only be detected by sequencing efforts...
  3. pmc The household contact study design for genetic epidemiological studies of infectious diseases
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA Uganda Case Western Reserve University Research Collaboration Kampala, Uganda
    Front Genet 4:61. 2013
    ..These study design characteristics are particularly appealing for current sequencing studies...
  4. doi request reprint Structural equation modeling
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 850:495-512. 2012
    ..Here, we review the theory of SEM for both unrelated and family data, the available software for SEM, and provide an example of SEM analysis...
  5. pmc Tuberculosis as a complex trait: impact of genetic epidemiological study design
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Room 1316, 2103 Cornell Rd, Cleveland, OH, 44106, USA
    Mamm Genome 22:91-9. 2011
    ..Finally, we provide suggestions for the design of future genetic epidemiological studies of TB...
  6. pmc Genetic epidemiology of tuberculosis susceptibility: impact of study design
    Catherine M Stein
    Department of Epidemiology and Biostatistics, and Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 7:e1001189. 2011
    ..tuberculosis strain. These considerable differences between studies should be accounted for when examining the current literature. Recommendations are made for future studies to further clarify the host genetics of TB...
  7. pmc Literacy outcomes of children with early childhood speech sound disorders: impact of endophenotypes
    Barbara A Lewis
    Case Western Reserve University, Cleveland, OH, USA
    J Speech Lang Hear Res 54:1628-43. 2011
    ..To demonstrate that early childhood speech sound disorders (SSD) and later school-age reading, written expression, and spelling skills are influenced by shared endophenotypes that may be in part genetic...
  8. ncbi request reprint Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building Room 1303, 2103 Cornell Rd, Cleveland, OH 44106, USA
    Hum Genet 121:663-73. 2007
    ..This study further illustrates the utility of such a model for disentangling complex traits...
  9. pmc Genome scan of M. tuberculosis infection and disease in Ugandans
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    PLoS ONE 3:e4094. 2008
    ..Many of the genetic factors for each of these stages are part of the innate immune system...
  10. pmc Heritability estimation for speech-sound traits with developmental trajectories
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Behav Genet 41:184-91. 2011
    ..We conclude that differences in measurement scales across the age span can be reconciled through non-linear modeling of the developmental process...
  11. pmc Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study
    Allison R Baker
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Immunol 72:426-30. 2011
    ..05). Haplotype analyses identified a significant risk haplotype in cathepsin X (CTSZ; p = 0.0281, odds ratio = 1.5493, 95% confidence interval [1.039, 2.320])...
  12. ncbi request reprint The genetic bases of speech sound disorders: evidence from spoken and written language
    Barbara A Lewis
    Behavioral Pediatrics and Psychology 6038, Rainbow Babies and Children s Hospital, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 6038, USA
    J Speech Lang Hear Res 49:1294-312. 2006
    ..Finally, they discuss challenges for identifying genetic influence on SSD and propose a conceptual framework for study of the genetic basis of SSD...
  13. ncbi request reprint Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Hered 60:109-18. 2005
    ..Furthermore, these studies have not accounted for the influence of shared environment within households on TB risk, which may spuriously inflate estimates of heritability...
  14. pmc Narrative ability of children with speech sound disorders and the prediction of later literacy skills
    Rachel L Wellman
    Cleveland Hearing and Speech Center, Cleveland, OH, USA
    Lang Speech Hear Serv Sch 42:561-79. 2011
    ..The second purpose was to determine if early narrative ability predicts school-age (8-12 years) literacy skills...
  15. pmc Tuberculin skin test reversion following isoniazid preventive therapy reflects diversity of immune response to primary Mycobacterium tuberculosis infection
    Denise F Johnson
    Tuberculosis Research Unit TBRU, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 9:e96613. 2014
    ..The immunologic, clinical, and public health implications of TST reversions that occur following Isoniazid preventive therapy (IPT) remain controversial...
  16. pmc Genetic and shared environmental influences on interferon-γ production in response to Mycobacterium tuberculosis antigens in a Ugandan population
    Li Tao
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Am J Trop Med Hyg 89:169-73. 2013
    ..These estimates are remarkably close to those reported for components of the innate immune response. These findings have implications for the interpretation of IFN-γ response assays and vaccine studies...
  17. pmc Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda
    C Scott Mahan
    Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    Am J Trop Med Hyg 86:690-7. 2012
    ..Thus, no differences in innate responses were found among the three household contact groups. However, adaptive T cell responses to MTB antigens did differ before and during MTB infection among PTST-, TSTC, and TST+ contacts...
  18. ncbi request reprint Speech sound disorder influenced by a locus in 15q14 region
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, and Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106, USA
    Behav Genet 36:858-68. 2006
    ..97 to 2.17, P=0.0633). These results suggest shared genetic determinants in this chromosomal region for SSD, autism, and PWS/AS...
  19. doi request reprint Model-free linkage analysis of a quantitative trait
    Nathan J Morris
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 850:301-16. 2012
    ..A.G.E.) software suite...
  20. pmc Structural equation model-based genome scan for the metabolic syndrome
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University 2500 MetroHealth Dr, R258 Rammelkamp Building, Cleveland, Ohio, USA
    BMC Genet 4:S99. 2003
    ..Because these traits cluster, there are likely common genetic factors involved...
  21. pmc A framework for structural equation models in general pedigrees
    Nathan J Morris
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Hered 70:278-86. 2010
    ..It also allows for a nearly endless array of genetic association and/or linkage tests. A preliminary Matlab program is available, and we are currently implementing a more complete and user-friendly R package...
  22. pmc Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106 USA
    BMC Proc 3:S50. 2009
    ....
  23. pmc Comparison of affected sibling-pair linkage methods to identify gene x gene interaction in GAW15 simulated data
    Emma K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Triangle Building, Suite 260, 11400 Euclid Avenue, Cleveland, Ohio 44106 USA
    BMC Proc 1:S66. 2007
    ..Additionally, the lack of data on discordant sibships may have decreased the power to identify gene x gene interactions...
  24. ncbi request reprint Dimensions of early speech sound disorders: A factor analytic study
    Barbara A Lewis
    Department of Pediatrics, Rainbow Babies and Childrens Hospital, Behavioral Pediatrics and Psychology 6038, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 6038
    J Commun Disord 39:139-57. 2006
    ..The findings suggest that articulation/phonology and language abilities are at least partially independent in children with SSD and that these constructs have distinct clinical and biological correlates...
  25. pmc Comparison of univariate and multivariate linkage analysis of traits related to hypertension
    Courtney Gray-McGuire
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA
    BMC Proc 3:S99. 2009
    ..We conclude that multivariate analysis is appropriate for the analysis of multiple correlated phenotypes, and our findings suggest that it may yield new linkage signals undetected by univariate analysis...
  26. pmc Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort
    Sangeeta R Kashyap
    Endocrinology Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 17:1696-701. 2009
    ..061). In summary, both TG and ALT levels assist in identification of NASH in an obesity surgery cohort. These findings underscore the importance of fatty acid delivery mechanisms to NASH development in severely obese individuals...
  27. pmc Calculating asymptotic significance levels of the constrained likelihood ratio test with application to multivariate genetic linkage analysis
    Nathan J Morris
    Case Western Reserve University, USA
    Stat Appl Genet Mol Biol 8:Article 39. 2009
    ..We illustrate how the approach can be applied to multivariate linkage analysis in a simulation study. Some more philosophical issues relating to one-sided tests in variance components linkage analysis are discussed...
  28. pmc Modeling the complex gene x environment interplay in the simulated rheumatoid arthritis GAW15 data using latent variable structural equation modeling
    Nora L Nock
    Division of Genetic and Molecular Epidemiology, Case Western Reserve University, Cleveland, OH 44106 7281, USA
    BMC Proc 1:S118. 2007
    ..Moreover, because some a priori biological information is needed to form an initial substantive model, our approach may be most appropriate for candidate gene SNP panel applications...
  29. pmc Mendelian randomization in family data
    Nathan J Morris
    Department of Epidemiology and Biostatistics, MS 72818, Wolstein Building, 2103 Cornell Road, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Proc 3:S45. 2009
    ..We use the Framingham Heart Study data as distributed to participants in the Genetics Analysis Workshop 16...
  30. ncbi request reprint The fa leptin receptor mutation and the heritability of respiratory frequency in a Brown Norway and Zucker intercross
    Sudha K Iyengar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol 97:811-20. 2004
    ..We conclude that, unlike its major effect on weight, the effect of the fa allele is not a major gene involved in the regulation of breathing frequency...
  31. pmc Heritability analysis of cytokines as intermediate phenotypes of tuberculosis
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 187:1679-85. 2003
    ..This analysis illustrates the value of such intermediate phenotypes in mapping susceptibility loci for TB and demonstrates that this area deserves further research...
  32. pmc Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Rammelkamp Center for Research, Case Western Reserve University, Cleveland, OH 44109, USA
    Am J Hum Genet 74:283-97. 2004
    ..9 cM and is bounded by markers D3S3049 and D3S3045. Our results suggest that domains common to SSD and dyslexia are pleiotropically influenced by a putative quantitative trait locus on chromosome 3...