William C Stanley

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
  2. ncbi request reprint Rationale for a metabolic approach in diabetic coronary patients
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Coron Artery Dis 16:S11-5. 2005
  3. ncbi request reprint Myocardial energy metabolism during ischemia and the mechanisms of metabolic therapies
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Cardiovasc Pharmacol Ther 9:S31-45. 2004
  4. ncbi request reprint Ranolazine: new approach for the treatment of stable angina pectoris
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Expert Rev Cardiovasc Ther 3:821-9. 2005
  5. ncbi request reprint Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44122, USA
    Heart Fail Rev 10:275-9. 2005
  6. ncbi request reprint Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia
    William C Stanley
    Dept of Physiology and Biophysics, School of Medicine, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 289:H2304-9. 2005
  7. pmc Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Physiol 579:811-21. 2007
  8. pmc Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation
    Naveen Sharma
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    J Physiol 562:593-603. 2005
  9. ncbi request reprint Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Heart Circ Physiol 294:H954-60. 2008
  10. ncbi request reprint Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power
    Kristen L King
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 289:H1033-7. 2005

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
    ....
  2. ncbi request reprint Rationale for a metabolic approach in diabetic coronary patients
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Coron Artery Dis 16:S11-5. 2005
    ....
  3. ncbi request reprint Myocardial energy metabolism during ischemia and the mechanisms of metabolic therapies
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Cardiovasc Pharmacol Ther 9:S31-45. 2004
    ..Moreover, because these agents do not suppress heart rate, blood pressure, or contractility, they are effective as add-on therapy to Ca(2+)-channel and beta-adrenergic receptor antagonists...
  4. ncbi request reprint Ranolazine: new approach for the treatment of stable angina pectoris
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Expert Rev Cardiovasc Ther 3:821-9. 2005
    ..At present, ranolazine is under review for US Food and Drug Administration approval and, if approved, it will represent the first drug of its class in the USA...
  5. ncbi request reprint Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44122, USA
    Heart Fail Rev 10:275-9. 2005
  6. ncbi request reprint Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia
    William C Stanley
    Dept of Physiology and Biophysics, School of Medicine, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 289:H2304-9. 2005
    ..Thus modulation of MCD activity is an effective means of regulating myocardial fatty acid oxidation under normal and ischemic conditions and reducing lactate production during demand-induced ischemia...
  7. pmc Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Physiol 579:811-21. 2007
    ..In conclusion, in the transition to a high cardiac workload there is rapid parallel activation of substrate oxidation that results in an increase in the NADH/NAD+ ratio...
  8. pmc Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation
    Naveen Sharma
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    J Physiol 562:593-603. 2005
    ....
  9. ncbi request reprint Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Heart Circ Physiol 294:H954-60. 2008
    ....
  10. ncbi request reprint Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power
    Kristen L King
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 289:H1033-7. 2005
    ....
  11. ncbi request reprint Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet
    Isidore C Okere
    Department of Physiology, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Clin Exp Pharmacol Physiol 34:113-9. 2007
    ..5. Taken together, the data suggest that consuming a high-fat diet or inhibiting CPT-I do not result in cardiac hypertrophy or cardiac dysfunction in normal rats...
  12. ncbi request reprint High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet
    Naveen Sharma
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Am J Hypertens 20:403-9. 2007
    ..We investigated the effects of consuming either a high complex carbohydrate diet, a high simple sugar diet, or a high fat diet on cardiac hypertrophy and mortality in hypertensive Dahl salt-sensitive (DSS) rats...
  13. ncbi request reprint Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation
    Margaret P Chandler
    Dept of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 287:H1538-43. 2004
    ....
  14. pmc High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets
    Naveen Sharma
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    J Hypertens 26:1402-10. 2008
    ..We investigated the effects of high-fructose or sucrose diets on ventricular function and mortality in hypertensive Dahl salt-sensitive rats...
  15. pmc Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Heart Circ Physiol 295:H939-H945. 2008
    ....
  16. ncbi request reprint Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension
    Isidore C Okere
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Hypertension 48:1116-23. 2006
    ..In conclusion, increased dietary lipid intake can reduce cardiac growth, left ventricular remodeling, contractile dysfunction, and alterations in gene expression in response to hypertension...
  17. ncbi request reprint Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure
    Eric E Morgan
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA
    Fundam Clin Pharmacol 20:503-5. 2006
    ..On the other hand, TMZ significantly reduced atrial natriuretic peptide mRNA levels compared with untreated rats...
  18. pmc Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload
    David J Chess
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    J Card Fail 14:82-8. 2008
    ..This study investigated the effects of a high-fat diet on the development of cardiac hypertrophy...
  19. ncbi request reprint Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies
    Lufang Zhou
    Department of Biomedical Engineering, Center for Modeling Integrated Metabolic Systems, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 291:H1036-46. 2006
    ....
  20. pmc The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet
    David J Chess
    Department of Physiology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Am J Physiol Heart Circ Physiol 295:H2223-30. 2008
    ..In conclusion, tempol significantly blunted markers of cardiac hypertrophy, LV remodeling, contractile dysfunction, and oxidative stress in fructose-fed TAC mice...
  21. ncbi request reprint Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion
    Isidore C Okere
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    J Appl Physiol 100:76-82. 2006
    ..This suggests that reduced anaplerosis and CAC dysfunction do not play a major role in contractile and metabolic derangements observed with a 60% decrease in coronary flow followed by reperfusion...
  22. ncbi request reprint Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia
    Pedro N Chavez
    Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Am J Physiol Heart Circ Physiol 284:H1521-7. 2003
    ....
  23. pmc Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism
    Jennifer E Salem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    Biomed Eng Online 3:15. 2004
    ..The goal was to examine to what extent glycolysis and lactate formation are controlled by the supply of glycolytic substrate and/or the cellular redox (NADH/NAD+) and phosphorylation (ATP/ADP) states...
  24. pmc Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia
    Ming Lu
    Department of Biomedical Engineering, Case Western Reserve University, Wickenden 427, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Theor Biol 254:466-75. 2008
    ....
  25. ncbi request reprint Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure
    Eric E Morgan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Eur J Heart Fail 8:687-93. 2006
    ..In conclusion, reduced mRNA expression of PPAR/RXR regulated genes is not dependent on reduced PPAR/RXR protein expression...
  26. ncbi request reprint Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia
    Margaret P Chandler
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Cardiovasc Res 59:143-51. 2003
    ..We tested the hypothesis that partial inhibition of fatty acid oxidation with oxfenicine (a carnitine palmitoyl transferase-I inhibitor) reduces lactate production and increases regional myocardial power during demand-induced ischemia...
  27. ncbi request reprint Regulation of malonyl-CoA concentration and turnover in the normal heart
    Aneta E Reszko
    Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 279:34298-301. 2004
    ..Our data show that, in the absence of enzyme inhibitors, the rate of acetyl-CoA carboxylation is the main determinant of the malonyl-CoA concentration in the heart...
  28. ncbi request reprint Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart
    Kristen L King
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Lipid Res 48:1511-7. 2007
    ..Both diabetes and specific PPAR alpha activation increased MTE-I protein, activity, and palmitate export in the heart, with little effect on UCP3 protein expression...
  29. ncbi request reprint Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin
    Isidore C Okere
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 291:H38-44. 2006
    ..In conclusion, dietary fatty acid composition affects cardiac ceramide accumulation, cardiomyocyte apoptosis, and expression of PPAR-regulated genes independent of cardiac mass or function...
  30. ncbi request reprint Mechanistic model of myocardial energy metabolism under normal and ischemic conditions
    Jennifer E Salem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    Ann Biomed Eng 30:202-16. 2002
    ..These findings are consistent with the concept that pyruvate oxidation is inhibited during ischemia partially by the rise in NADH/NAD+...
  31. ncbi request reprint Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia
    Lufang Zhou
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 6011, USA
    Am J Physiol Heart Circ Physiol 288:H2400-11. 2005
    ....
  32. pmc Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart
    Takhar Kasumov
    Department Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Cardiovasc Drugs Ther 23:459-69. 2009
    ....
  33. pmc Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria
    Takhar Kasumov
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 304:H1201-14. 2013
    ....
  34. ncbi request reprint Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia
    Margaret P Chandler
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Am J Physiol Heart Circ Physiol 282:H1871-8. 2002
    ..Thus demand-induced ischemia stimulated nonoxidative glycolysis and lactate production, but did not effect fatty acid uptake despite a fall in exogenous fatty acid oxidation...
  35. ncbi request reprint Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure
    Eric E Morgan
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 290:H1899-904. 2006
    ..In conclusion, LV dysfunction and dilation are not worsened despite upregulation of the fatty acid metabolic pathway and LV hypertrophy or accumulation of myocardial triglyceride in the rat infarct model of HF...
  36. ncbi request reprint Partial fatty acid oxidation inhibitors for stable angina
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Expert Opin Investig Drugs 11:615-29. 2002
    ..Clinical trials with ranolazine or trimetazidine, either alone or in combination with a Ca2+ channel antagonist or a beta-adrenergic receptor antagonist, have demonstrated reduced symptoms of exercise-induced angina...
  37. pmc Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition
    Karen M O'Shea
    Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA
    J Mol Cell Cardiol 47:819-27. 2009
    ..In conclusion, dietary supplementation with EPA + DHA altered mitochondrial membrane phospholipid fatty acid composition in normal and infarcted hearts, but delayed MPTP opening only in normal hearts...
  38. pmc Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle
    Celvie L Yuan
    Department of Nutrition, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Am J Physiol Endocrinol Metab 295:E216-22. 2008
    ..We conclude that cardiac protein synthesis is maintained in cases of nutritional perturbations, in strong contrast to liver and gastrocnemius muscle, where protein synthesis is decreased by acute fasting or chronic food restriction...
  39. ncbi request reprint High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat
    Isidore C Okere
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    Clin Exp Pharmacol Physiol 32:825-31. 2005
    ..It remains to be determined whether preventing cardiac hypertrophic adaptations would be deleterious to the heart if the hypertensive stress is maintained long term...
  40. ncbi request reprint Mouse strain-specific differences in cardiac metabolic enzyme activities observed in a model of isoproterenol-induced cardiac hypertrophy
    Michael D Faulx
    Department of Medicine, Division of Cardiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5038, USA
    Clin Exp Pharmacol Physiol 34:77-80. 2007
    ..The metabolic adaptations associated with ISO-induced hypertrophy differ from those reported with pressure overload hypertrophy...
  41. ncbi request reprint Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload
    David J Chess
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Heart Circ Physiol 293:H1853-60. 2007
    ....
  42. pmc Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
    Naveen Sharma
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Cardiovasc Res 73:257-68. 2007
    ..This review discusses potential mechanisms by which dietary carbohydrates and fats ca affect cardiac growth, metabolism, and function, mainly in the context of pressure overload-induced LVH...
  43. ncbi request reprint Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Fundam Clin Pharmacol 17:133-45. 2003
    ....
  44. ncbi request reprint Regulation of cardiac energetics: role of redox state and cellular compartmentation during ischemia
    Marco E Cabrera
    Department of Pediatrics, Case Western Reserve University, 11100 Euclid Avenue, RBC 389, Cleveland, OH 44106 6011, USA
    Ann N Y Acad Sci 1047:259-70. 2005
    ....
  45. ncbi request reprint [Potential impact of carbohydrate and fat intake on cardiac hypertrophy]
    Monika Duda
    Department of Physiology, School of Medicine, Case Western Reserve University, Cleveland 44106 4970, USA
    Kardiol Pol 64:S572-7. 2006
    ..This review discusses potential mechanisms by which dietary carbohydrates and fats can affect cardiac growth, metabolism and function, particularly in the context of pressure overload LVH...
  46. ncbi request reprint Post-ischemic treatment with dipyruvyl-acetyl-glycerol decreases myocardial infarct size in the pig
    William C Stanley
    Departments of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cardiovasc Drugs Ther 17:209-16. 2003
    ..05)), with no difference in blood pressure or heart rate between groups. In conclusion, an intravenous infusion of DPAG safely increases arterial pyruvate concentration and reduces myocardial infarct size following myocardial ischemia...
  47. ncbi request reprint beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 285:H1626-31. 2003
    ..In conclusion, fatty acid uptake and oxidation is blocked by an infusion of beta-hydroxybutyrate; this effect was not due to elevated myocardial malonyl-CoA content...
  48. ncbi request reprint Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction
    Eric E Morgan
    Department of Physiology and Biophysics, Case Western University, Univ Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106 5038, USA
    Am J Physiol Heart Circ Physiol 287:H2049-53. 2004
    ..These findings support the use of WMSI and MPI as indexes of global LV function in the rat infarction model of heart failure...
  49. pmc Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36
    Kristen L King
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, USA
    Arch Biochem Biophys 467:234-8. 2007
    ..Palmitate export was not different between wild type and CD36 knock-out mice. Taken together, CD36 does not appear to play an essential role in mitochondrial uptake of fatty acids or export of fatty acid anions...
  50. ncbi request reprint Assessing the reversibility of the anaplerotic reactions of the propionyl-CoA pathway in heart and liver
    Aneta E Reszko
    Department of Biochemistry, Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:34959-65. 2003
    ..The thermodynamic dis-equilibrium of the combined reactions of the propionyl-CoA pathway explains the effectiveness of anaplerosis from propionyl-CoA precursors such as heptanoate...
  51. pmc Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction
    Hong Wang
    Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    J Lipid Res 54:953-65. 2013
    ..Perilipin 5 regulates the formation and stabilization of cardiac LDs, and it promotes cardiac steatosis without major heart function impairment...
  52. ncbi request reprint Energy metabolism in the normal and failing heart: potential for therapeutic interventions
    William C Stanley
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Heart Fail Rev 7:115-30. 2002
    ..At present, this intriguing hypothesis requires further evaluation...
  53. ncbi request reprint Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry
    Xiao Wang
    Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    Anal Biochem 363:169-74. 2007
    ..80+/-0.41, 2.59+/-0.37 (P<0.05), and 3.07+/-0.70 (P<0.05), respectively. We report a practical, nonradioactive, sensitive assay of MCD in crude tissue extract...
  54. doi request reprint Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure
    Mariana G Rosca
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4981, USA
    J Mol Cell Cardiol 46:927-35. 2009
    ..In conclusion, pacing-induced HF causes a decrease in the oxidative phosphorylation of skeletal muscle mitochondria due to defects in the ETC and phosphorylation apparatus...
  55. pmc Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion
    Theodore A Kung
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Mol Cell Cardiol 43:744-53. 2007
    ..In conclusion, these data show that in a rodent model of myocardial I/R, circadian clocks within the ischemic region become rapidly impaired, through a mechanism that appears to be independent of hypoxia...
  56. ncbi request reprint Quantitative assessment of anaplerosis from propionate in pig heart in vivo
    Wenjun Z Martini
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 7139, USA
    Am J Physiol Endocrinol Metab 284:E351-6. 2003
    ..033 +/- 0.002% of propionate uptake. Methylcitrate did not accumulate. Thus administration of a low concentration of propionate appears to be a convenient and safe way to boost anaplerosis in the heart...
  57. pmc Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland, Ohio 441195, USA
    Am J Physiol Endocrinol Metab 297:E552-9. 2009
    ..7 +/- 7.8%, P < 0.05). We conclude that the exercise-induced improvement in FFA-induced insulin resistance is independent of the magnitude of weight loss and FFA turnover, yet it is linked to increased intracellular FFA utilization...
  58. ncbi request reprint Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models
    Lufang Zhou
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Ann N Y Acad Sci 1080:120-39. 2006
    ....
  59. ncbi request reprint A radiochemical pyruvate dehydrogenase assay: activity in heart
    Joseph P Sterk
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    Anal Biochem 313:179-82. 2003
  60. pmc Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labeling
    Ling Li
    Department of Research Core Services, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 11:M111.014209. 2012
    ..We conclude that this technique can effectively measure the synthesis of plasma proteins and can be used to study the regulation of protein homeostasis under physiological and pathological conditions...
  61. pmc Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
    Hong Wang
    The Geriatric Research, Education and Clinical Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Lipid Res 52:2159-68. 2011
    ..These results suggest that Plin5 regulates oxidative LD hydrolysis and controls local FA flux to protect mitochondria against excessive exposure to FA during physiological stress...
  62. doi request reprint Role of diet and fuel overabundance in the development and progression of heart failure
    David J Chess
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Cardiovasc Res 79:269-78. 2008
    ....
  63. ncbi request reprint Introduction to special issue on myocardial energy metabolism in heart failure
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 4970, USA
    Heart Fail Rev 7:113. 2002
  64. ncbi request reprint Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs
    Fabio A Recchia
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Endocrinol Metab 282:E197-206. 2002
    ..In conclusion, the acute inhibition of NO synthesis causes marked metabolic alterations that do not involve key rate-controlling enzymes of fatty acid oxidation nor glyceraldehyde-3-phosphate dehydrogenase...
  65. ncbi request reprint Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs
    Chiara d'Agostino
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 290:H1721-6. 2006
    ..This phenomenon may constitute an adaptive mechanism to counterbalance cardiac mechanical inefficiency...
  66. ncbi request reprint Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure
    Hani H Sabbah
    Eur J Heart Fail 4:3-6. 2002
  67. ncbi request reprint Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid
    Francois Labarthe
    Department of Nutrition, University of Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 288:H1425-36. 2005
    ....
  68. pmc Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies
    Lufang Zhou
    Pediatric Cardiology, Rainbow Babies and Children s Hospital 11100 Euclid Avenue, RBC 389 Cleveland, OH 44106 6011, USA
    J Physiol 569:925-37. 2005
    ....
  69. ncbi request reprint Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation
    Jason R B Dyck
    Cardiovascular Research Group, Department of Pediatrics, Faculty of Medicine, 474 Heritage Medical Research Centre, The University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
    Circ Res 94:e78-84. 2004
    ..This switch in energy substrate preference improves cardiac function during and after ischemia, suggesting that pharmacological inhibition of MCD may be a novel approach to treating ischemic heart disease...
  70. ncbi request reprint Metabolic therapy for heart disease: impact of trimetazidine
    Hani N Sabbah
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan 48202, USA
    Heart Fail Rev 10:281-8. 2005
  71. ncbi request reprint Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
    Danilo Neglia
    Institute of Clinical Physiology, National Council for Research, Pisa 56124, Italy
    Am J Physiol Heart Circ Physiol 293:H3270-8. 2007
    ..These metabolic abnormalities might contribute to progressive cardiac deterioration and represent a target for therapeutic strategies aimed at modulating cardiac substrate utilization...
  72. ncbi request reprint Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure
    Hani N Sabbah
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan 48202, USA
    J Card Fail 8:416-22. 2002
    ..The present study tested the hypothesis that partial inhibition of fatty acids will ameliorate the hemodynamic abnormalities associated with HF...
  73. ncbi request reprint Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease
    Gary D Lopaschuk
    Cardiovascular Research Group, 423 Heritage Medical Research Building, The University of Alberta, Edmonton, AL, T6G 2S2, Canada
    Cardiovasc Drugs Ther 20:433-9. 2006
    ....
  74. ncbi request reprint Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure
    Margaret P Chandler
    Department of Medicine, Henry Ford Heart and Vascular Institute, Detroit, Mich 48202, USA
    Circ Res 91:278-80. 2002
    ..Thus, short-term treatment with ranolazine improved LV function without an increase in MO2, resulting in an increased myocardial mechanical efficiency in dogs with HF...
  75. ncbi request reprint Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure
    Juan Carlos Osorio
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 106:606-12. 2002
    ..We tested the hypothesis that the altered metabolic phenotype of the failing heart involves changes in the protein expression of PPARalpha and RXRalpha...
  76. ncbi request reprint CVT-4325 inhibits myocardial fatty acid uptake and improves left ventricular systolic function without increasing myocardial oxygen consumption in dogs with chronic heart failure
    Makoto Imai
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, MI, USA
    Cardiovasc Drugs Ther 21:9-15. 2007
    ..In the present study, we tested the hemodynamic and metabolic effects of acute intravenous CVT-4325 in dogs with HF...
  77. ncbi request reprint Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure
    Vincenzo Lionetti
    Department of Physiology, BSB 622, New York Medical College, Valhalla, 10595, USA
    Cardiovasc Res 66:454-61. 2005
    ..We tested whether the inhibition of carnitine palmitoyl transferase-I (CPT-I), the enzyme regulating mitochondrial fatty acid oxidation, slows left ventricular remodeling and deterioration of function in pacing-induced HF...
  78. ncbi request reprint Chronic activation of peroxisome proliferator-activated receptor-alpha with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failure
    Volodymyr Labinskyy
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 321:165-71. 2007
    ..S. versus control). Thus, preventing changes in myocardial substrate metabolism in the failing heart causes a modest improvement of cardiac function during the progression of the disease, with no effects on the onset of decompensation...
  79. ncbi request reprint Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure
    Biao Lei
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    J Mol Cell Cardiol 36:567-76. 2004
    ....
  80. pmc Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo
    Biao Lei
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:6966-71. 2005
    ....
  81. ncbi request reprint Diabetes and ischaemic heart disease: essential role for metabolic therapies
    William C Stanley
    Coron Artery Dis 16:S1. 2005
  82. ncbi request reprint Metabolic therapies for heart disease: fish for prevention and treatment of cardiac failure?
    William C Stanley
    Cardiovasc Res 68:175-7. 2005
  83. doi request reprint The role of Ca2+ in coupling cardiac metabolism with regulation of contraction: in silico modeling
    Yael Yaniv
    Faculty of Biomedical Engineering, Technion, Isreal Institute of Technology, Haifa 32000 Israel
    Ann N Y Acad Sci 1123:69-78. 2008
    ..Quantitative investigations of the mechanisms underlying the cardiac control of biochemical to mechanical energy conversion may lead to novel therapeutic modalities for the ischemic and failing myocardium...
  84. ncbi request reprint Metabolic approaches to the treatment of ischemic heart disease: the clinicians' perspective
    Andrew A Wolff
    CV Therapeutics, Palo Alto, California 94304, USA
    Heart Fail Rev 7:187-203. 2002
    ..These metabolic therapies are free of direct hemodynamic or chronotropic effects, and thus are well positioned for use alongside traditional agents such as beta-adrenergic receptor antagonists or calcium channel antagonists...
  85. ncbi request reprint Cardiac energy metabolism in obesity
    Gary D Lopaschuk
    Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada
    Circ Res 101:335-47. 2007
    ..The clinical implications of obesity and energy metabolism on cardiac disease are also discussed...
  86. ncbi request reprint Extracellular matrix maturation in the left ventricle of normal and diabetic swine
    Daniel A Martinez
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research Building II, Houston, TX 77204 5001, USA
    Diabetes Res Clin Pract 59:1-9. 2003
    ..05), but not in other layers. In summary, the accumulation and/or increase in HP cross-link content in the Diabetic-Swine subendocardial layer suggests that myocardial fibrosis may be greater in this specific region...