- Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loopMichael S Simonson
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 286:11003-8. 2011..Taken together, these results demonstrate that an autocrine signaling loop involving MCP-1 and IL-6 contributes to ET-1-induced collagen accumulation...
- The renal transcriptome of db/db mice identifies putative urinary biomarker proteins in patients with type 2 diabetes: a pilot studyMichael S Simonson
Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
Am J Physiol Renal Physiol 302:F820-9. 2012..These results suggest that gene expression profiling in diabetic mouse kidney can complement existing proteomic-based approaches for renal biomarker discovery in humans...
- MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDESMichael Simonson; Fiscal Year: 1993..Because ET-1 has been implicated the vascular response to injury and in renal failure, the ability to block the mitogenic actions of ET might be relevant in clinical settings...
- MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDESMichael Simonson; Fiscal Year: 2002..Finally, whether rho is in the Src pathway or not, will be examined by cotransfection with constitutively active v-Src/dominant negative RhoA and vice versa and evaluation of c-fos induction/ DNA synthesis. ..