Michael Simonson

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop
    Michael S Simonson
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:11003-8. 2011
  2. pmc The renal transcriptome of db/db mice identifies putative urinary biomarker proteins in patients with type 2 diabetes: a pilot study
    Michael S Simonson
    Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Am J Physiol Renal Physiol 302:F820-9. 2012

Research Grants

  1. MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDES
    Michael Simonson; Fiscal Year: 1993
  2. MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDES
    Michael Simonson; Fiscal Year: 2002

Detail Information

Publications2

  1. pmc Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop
    Michael S Simonson
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:11003-8. 2011
    ..Taken together, these results demonstrate that an autocrine signaling loop involving MCP-1 and IL-6 contributes to ET-1-induced collagen accumulation...
  2. pmc The renal transcriptome of db/db mice identifies putative urinary biomarker proteins in patients with type 2 diabetes: a pilot study
    Michael S Simonson
    Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Am J Physiol Renal Physiol 302:F820-9. 2012
    ..These results suggest that gene expression profiling in diabetic mouse kidney can complement existing proteomic-based approaches for renal biomarker discovery in humans...

Research Grants9

  1. MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDES
    Michael Simonson; Fiscal Year: 1993
    ..Because ET-1 has been implicated the vascular response to injury and in renal failure, the ability to block the mitogenic actions of ET might be relevant in clinical settings...
  2. MITOGENIC SIGNALING BY ENDOTHELIN PEPTIDES
    Michael Simonson; Fiscal Year: 2002
    ..Finally, whether rho is in the Src pathway or not, will be examined by cotransfection with constitutively active v-Src/dominant negative RhoA and vice versa and evaluation of c-fos induction/ DNA synthesis. ..