A D Seftel

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles
    Allen D Seftel
    Dept of Urology and Reproductive Biology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    Clin Cardiol 27:I14-19. 2004
  2. ncbi Erectile dysfunction: etiology, evaluation, and treatment options
    Allen D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5046, USA
    Med Clin North Am 88:387-416, xi. 2004
  3. ncbi Restorative increases in serum testosterone levels are significantly correlated to improvements in sexual functioning
    Allen D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland VA Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    J Androl 25:963-72. 2004
  4. ncbi Peyronie disease in younger men
    Allen D Seftel
    Case Western Reserve University School of Medicine Cleveland, OH 44106 5046, USA
    J Androl 24:33-4. 2003
  5. ncbi A three-part study to investigate the incidence and potential etiologies of tadalafil-associated back pain or myalgia
    A D Seftel
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 17:455-61. 2005
  6. ncbi Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases
    Allen D Seftel
    Professor of Urology and Reproductive Biology, Department of Urology, Case Western Reserve University, School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    Curr Pharm Des 11:4047-58. 2005
  7. ncbi The impact of formulary replacement of sildenafil by vardenafil at a local VA hospital
    M Singh
    Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH 44112, USA
    Int J Impot Res 20:188-91. 2008
  8. ncbi Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospital of Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:584-90. 2007
  9. doi Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily
    A D Seftel
    Department of Urology, Case Medical Center University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Int J Impot Res 21:240-8. 2009
  10. ncbi Male hypogonadism. Part I: Epidemiology of hypogonadism
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 18:115-20. 2006

Detail Information

Publications39

  1. ncbi Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles
    Allen D Seftel
    Dept of Urology and Reproductive Biology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    Clin Cardiol 27:I14-19. 2004
    ..In addition, in the presence of high-fat food, absorption of sildenafil and vardenafil may be delayed; however, the rate and extent of tadalafil absorption are unaffected by high-fat food...
  2. ncbi Erectile dysfunction: etiology, evaluation, and treatment options
    Allen D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5046, USA
    Med Clin North Am 88:387-416, xi. 2004
    ..Inclusion of the partner in the evaluation and management scheme will provide added benefit and may produce a better outcome...
  3. ncbi Restorative increases in serum testosterone levels are significantly correlated to improvements in sexual functioning
    Allen D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland VA Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    J Androl 25:963-72. 2004
    ..We propose that threshold T levels are needed in order to significantly affect improvements in sexual functioning...
  4. ncbi Peyronie disease in younger men
    Allen D Seftel
    Case Western Reserve University School of Medicine Cleveland, OH 44106 5046, USA
    J Androl 24:33-4. 2003
  5. ncbi A three-part study to investigate the incidence and potential etiologies of tadalafil-associated back pain or myalgia
    A D Seftel
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 17:455-61. 2005
    ..Although the mechanism of back pain and/or myalgia remains unknown, these events appear to be self-limiting and a general effect of phosphodiesterase 5 inhibition...
  6. ncbi Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases
    Allen D Seftel
    Professor of Urology and Reproductive Biology, Department of Urology, Case Western Reserve University, School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    Curr Pharm Des 11:4047-58. 2005
    ....
  7. ncbi The impact of formulary replacement of sildenafil by vardenafil at a local VA hospital
    M Singh
    Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH 44112, USA
    Int J Impot Res 20:188-91. 2008
    ..The substantial cost savings to the VA seem to be justified by the minimal adverse effects on men treated for erectile dysfunction...
  8. ncbi Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospital of Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:584-90. 2007
    ..The change in EF domain score correlated positively with the change in total transformed EDS score (0.43, P<0.0001). Successful treatment of ED with sildenafil may reduce the bother associated with ED...
  9. doi Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily
    A D Seftel
    Department of Urology, Case Medical Center University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Int J Impot Res 21:240-8. 2009
    ..001) correlated with erectile function (EF) improvement (assessed by change from baseline in IIEF-EF score). Tadalafil significantly improved treatment and sexual satisfaction, while improving multiple outcomes measured by SEAR...
  10. ncbi Male hypogonadism. Part I: Epidemiology of hypogonadism
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 18:115-20. 2006
    ....
  11. doi Coexisting lower urinary tract symptoms and erectile dysfunction: a systematic review of epidemiological data
    A D Seftel
    Department of Urology, Cooper University Hospitals, Camden, NJ 081003, USA
    Int J Clin Pract 67:32-45. 2013
    ..Assess and categorise the available prevalence data on coexistent LUTS and ED in the general population and among individuals consulting a healthcare provider for any reason or when seeking treatment for LUTS and/or ED...
  12. ncbi Nocturnal penile tumescence activity unchanged after long-term intracavernous injection therapy
    P Maniam
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    J Urol 165:830-2; discussion 832-3. 2001
    ..However, as measured by nocturnal penile tumescence testing, no objective improvement in spontaneous erectile function occurs...
  13. ncbi Rapid ejaculation
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 1611 S Green Road, Cleveland, OH 44121, USA
    Curr Urol Rep 1:302-6. 2000
    ..This article provides a basic review of the pathophysiology of ejaculatory dysfunction and discusses the current treatment options for rapid ejaculation...
  14. ncbi Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction
    Ridwan Shabsigh
    Department of Urology, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Urology 68:689-96. 2006
  15. ncbi Medical solutions to sexual problems continue to make sexological care and science essential to the successful treatment of male ED
    Allen D Seftel
    Case Medical Center, Cleveland, Ohio 44106 4920, USA
    J Sex Marital Ther 33:467-8. 2007
  16. ncbi Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens
    Allen D Seftel
    J Urol 174:1043. 2005
  17. ncbi Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
    Allen D Seftel
    J Urol 174:1043-4. 2005
  18. ncbi Prostate-specific antigen changes in hypogonadal men treated with testosterone replacement
    Robert E Gerstenbluth
    Department of Urology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Ohio 44124, USA
    J Androl 23:922-6. 2002
    ....
  19. ncbi Challenges in oral therapy for erectile dysfunction
    Allen D Seftel
    Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland VA Medical Center, Ohio 44106, USA
    J Androl 23:729-36. 2002
  20. ncbi Efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and spinal cord injury: a review
    Fadel Derry
    National Spinal Injuries Center, Stoke Mandeville Hospital, Buckinghamshire, United Kingdom
    Urology 60:49-57. 2002
    ..Symptoms of autonomic dysreflexia were not reported in any study. Existing evidence suggests that oral sildenafil is a highly effective and well-tolerated treatment for ED associated with SCI...
  21. ncbi From aspiration to achievement: assessment and noninvasive treatment of erectile dysfunction in aging men
    Allen D Seftel
    Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Am Geriatr Soc 53:119-30. 2005
    ..These treatment alternatives include the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil, as well as other oral medications, such as alpha-adrenoceptor antagonists and topical vasoactive or testosterone therapy...
  22. ncbi Computational models for detection of erectile dysfunction
    Moshe Wald
    Department of Urology, University of Illinois at Chicago, 200 Hawkins Drive, Chicago, Illinois 52242, USA
    J Urol 173:167-70. 2005
    ..Using several linear and nonlinear mathematical models we investigated the correlation of age, hypogonadism and depression with ED using the Sexual Health Inventory for Men (SHIM) as a surrogate marker for ED...
  23. ncbi Centrally acting mechanisms for the treatment of male sexual dysfunction
    Martin M Miner
    Division of Biology and Medicine, Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA
    Urol Clin North Am 34:483-96, v. 2007
    ..Drugs available in Europe include apomorphine. This article focuses on the mechanism of centrally acting agents and reviews clinical data on potential new centrally acting drugs for men who have ED...
  24. ncbi Editorial commentary on Rochiro, et al
    Allen D Seftel
    J Androl 23:481; discussion 481-2. 2002
  25. ncbi The efficacy and safety of tadalafil in United States and Puerto Rican men with erectile dysfunction
    Allen D Seftel
    University Hospitals, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    J Urol 172:652-7. 2004
    ..We evaluate the efficacy and safety of tadalafil, taken as needed, in men with mild to severe erectile dysfunction (ED) and assess sexual intercourse attempt patterns...
  26. ncbi Office evaluation of male sexual dysfunction
    Allen D Seftel
    Department of Urology, Case Medical Center, Cleveland, OH, USA
    Urol Clin North Am 34:463-82, v. 2007
    ..This article provides the rationale for this global assessment paradigm...
  27. ncbi Erectile dysfunction and symptoms of sleep disorders
    Allen D Seftel
    Department of Urology, Cleveland VA Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Sleep 25:643-7. 2002
    ..Sleep apnea often is associated with impotence and/or erectile dysfunction (ED). The purpose of this study was to test whether a presentation for ED confers a pretest probability for obstructive sleep apnea hypopnea syndrome (OSAHS)...
  28. ncbi Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction
    Raymond C Rosen
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    Urology 69:805-9. 2007
    ..An abridged version of the 25-item Male Sexual Health Questionnaire (MSHQ) was developed and validated (MSHQ-EjD Short Form) for assessing ejaculatory dysfunction (EjD)...
  29. ncbi The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction
    Allen D Seftel
    School of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    J Urol 171:2341-5. 2004
    ..We quantified the prevalence of diagnosed hypertension, hyperlipidemia, diabetes mellitus and depression in male health plan members with erectile dysfunction (ED)...
  30. ncbi Erectile dysfunction. Diagnosis and treatment in older men
    Dominick J Carbone
    Department of Urology, Wake Forest University, Winston Salem, North Carolina, USA
    Geriatrics 57:18-24. 2002
    ..Treatments include medical management of multi-drug regimens, oral therapy, intracavernosal injection, testosterone replacement therapy, vacuum erection devices, and penile prostheses...
  31. ncbi The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
    Allen D Seftel
    J Urol 174:1045. 2005
  32. ncbi Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    Allen D Seftel
    J Urol 174:1045-6. 2005
  33. ncbi 3',5'-Cyclic nucleotide phosphodiesterase 11A: localization in human tissues
    Allen D Seftel
    J Urol 174:1044. 2005
  34. ncbi Cavernosal dysfunction in a rabbit model of hyperhomocysteinaemia
    Allen D Seftel
    J Urol 174:1044-5. 2005
  35. ncbi Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation
    Allen D Seftel
    J Urol 173:2077. 2005
  36. ncbi Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction
    Allen D Seftel
    J Urol 173:2076-7. 2005
  37. ncbi Male Sexual Health Questionnaire (MSHQ): scale development and psychometric validation
    Raymond C Rosen
    Department of Psychiatry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Urology 64:777-82. 2004
    ..To validate a new, self-administered questionnaire for assessing key domains of sexual function and satisfaction in aging men with urogenital health concerns...
  38. ncbi Erectile dysfunction in the elderly: epidemiology, etiology and approaches to treatment
    Allen D Seftel
    Case Western Reserve University, Department of Urology, University Hospital of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio, USA
    J Urol 169:1999-2007. 2003
    ..The prevalence of erectile dysfunction is high in men of all ages and increases greatly in the elderly...
  39. ncbi Erectile dysfunction in smokers: a penile dynamic and vascular study
    Allen D Seftel
    J Urol 173:2076. 2005