Research Topics
Genomes and Genes
| David C SchultzSummaryAffiliation: Case Western Reserve University Country: USA Publications
| Collaborators
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Detail Information
Publications
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteinsDavid C Schultz
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:919-32. 2002..Thus, KAP-1 is a molecular scaffold that is targeted by KRAB-ZFPs to specific loci and coordinates both histone methylation and the deposition of HP1 proteins to silence gene expression...
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathwayYael Ziv
The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Nat Cell Biol 8:870-6. 2006..These results suggest that chromatin relaxation is a fundamental pathway in the DNA-damage response and identify its primary mediators...- Assessment of sera for chromatin-immunoprecipitationJuliette Nguyen
Centre National de la Recherche Scientifique, Paris, France
Biotechniques 44:66, 68. 2008..This approach is useful as a first step toward ChIP-on-chip or ChIP-sequencing, especially in the case of recently identified proteins for which no binding sites are yet known... - PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencingAlexey V Ivanov
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Mol Cell 28:823-37. 2007..These data provide a mechanistic explanation for the cooperation of PHD and bromodomains in gene regulation and describe a function of the PHD domain as an intramolecular E3 SUMO ligase... - Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegationKasirajan Ayyanathan
The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
Genes Dev 17:1855-69. 2003..Thus, like variegation in Drosophila, recruitment of mammalian HP1 to a euchromatic promoter can establish a silenced state that is epigenetically heritable... - The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domainMark S Lechner
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Biochem Biophys Res Commun 331:929-37. 2005..Thus, this spectrum of direct binding partners suggests an expanded role for HP1 as factor participating in promoter-enhancer communication, chromatin remodeling/assembly, and sub-nuclear compartmentalization... - Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiaeKristin Ingvarsdottir
Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 27:7856-64. 2007..Thus, analysis of lysine demethylation in yeast provides new insight into the physiological roles of jumonji demethylase enzymes... - Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complexYong Tang
The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
Biochemistry 51:2366-77. 2012..Together, these studies implicate the NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex... - Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteinsDaniela Fera
Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA 19104, USA
Chem Biol 19:518-28. 2012..These inhibitors provide a promising scaffold for the development of therapies to treat HPV-mediated pathologies... - Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1Scott Thompson
The Wistar Institute, Philadelphia, PA 19104, USA
J Biomol Screen 15:1107-15. 2010..Further screening in conjunction with medicinal chemistry optimization may provide a selective inhibitor of EBNA1 and EBV latent infection... - Deacetylation of the DNA-binding domain regulates p53-mediated apoptosisHestia S Mellert
Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 286:4264-70. 2011..This knowledge may impact the rational application of deacetylase inhibitors in the treatment of human cancer... - The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repressionSmitha P Sripathy
Case Western Reserve University, Department of Pharmacology and Case Comprehensive Cancer Center, Cleveland, Ohio 44106 4965, USA
Mol Cell Biol 26:8623-38. 2006.... - Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repressionXu Li
Department of Molecular and Clinical Pharmacology, City of Hope, Duarte, California 91010, USA
J Biol Chem 282:36177-89. 2007.... - Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signalingMeghan E Pennini
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 176:4323-30. 2006..Chromatin remodeling at MHC2TA is a novel target of inhibition by Mtb. These mechanisms may diminish class II MHC expression by infected macrophages, contributing to immune evasion by Mtb...