Alvin Schmaier

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc The elusive physiologic role of Factor XII
    Alvin H Schmaier
    Division of Hematology and Oncology, Case Western Reserve University, Cleveland, Ohio 44106 7284, USA
    J Clin Invest 118:3006-9. 2008
  2. ncbi request reprint The physiologic basis of assembly and activation of the plasma kallikrein/kinin system
    Alvin H Schmaier
    Thromb Haemost 91:1-3. 2004
  3. ncbi request reprint Mapping the interaction between high molecular mass kininogen and the urokinase plasminogen activator receptor
    Fakhri Mahdi
    Departments of Internal Medicine and Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:16621-8. 2004
  4. ncbi request reprint The plasma kallikrein/kinin and renin angiotensin systems in blood pressure regulation in sepsis
    Zia Shariat-Madar
    Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109 0640, USA
    J Endotoxin Res 10:3-13. 2004
  5. ncbi request reprint Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4
    Marvin T Nieman
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0640, USA
    FEBS Lett 579:25-9. 2005
  6. pmc Are maternal antiplatelet antibodies a prothrombotic condition leading to miscarriage?
    Alvin H Schmaier
    Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Invest 121:4241-3. 2011
  7. ncbi request reprint The plasma kallikrein-kinin system: its evolution from contact activation
    A H Schmaier
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Thromb Haemost 5:2323-9. 2007
  8. pmc Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system
    Alvin H Schmaier
    Department of Medicine, Case Western Reserve University, University Hospital Case Medical Center, Division of Hematology and Oncology, Cleveland, OH 44106 7284, United States
    Int Immunopharmacol 8:161-5. 2008
  9. doi request reprint Factor XII: new life for an old protein
    A H Schmaier
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106 7284, USA
    Thromb Haemost 104:915-8. 2010
  10. pmc Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
    Marvin T Nieman
    Division of Hematology Oncology, Case Western Reserve University, Cleveland, Ohio 44106 7284, USA
    Biochemistry 46:8603-10. 2007

Research Grants

  1. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin H Schmaier; Fiscal Year: 2010
  2. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin Schmaier; Fiscal Year: 2007
  3. Thrombostatin-A Thrombin Receptor Inhibitor
    Alvin Schmaier; Fiscal Year: 2006
  4. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin Schmaier; Fiscal Year: 2004
  5. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003
  6. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin Schmaier; Fiscal Year: 2000

Collaborators

  • Marvin T Nieman
  • Anton A Komar
  • Francis J Castellino
  • AYAD JAFFA
  • William Van Nostrand
  • ROBERT GARY SITRIN
  • NANCY JOAN BROWN
  • Keith R McCrae
  • HENRY MOSBERG
  • Laine J Murphey
  • Joshua M Astern
  • Peter Ward
  • D T Lackland
  • Zia Shariat-Madar
  • Fakhri Mahdi
  • Xiaoyun Chen
  • Mark Warnock
  • Jie Wang
  • Yelena Krijanovski
  • Gretchen A LaRusch
  • Evi Stavrou
  • Wan Ming Zhang
  • Ahmed A K Hasan
  • Cecilia M Choi
  • Feng Xu
  • Sergei Merkulov
  • Willem J van Heeckeren
  • Fernanda M Burke
  • Zhan Chen
  • Lan Zhou
  • Sujata Srikanth
  • Andrew C Parker
  • Werner Muller-Esterl
  • Ana Paula C A Lima
  • Christopher H Chay
  • Alejandro R Prieto
  • Ines J Laudes
  • Claudia R Moreira
  • Gregory Adams
  • Michael R Snell
  • Judianne Davis
  • Hillard M Lazarus
  • Mary Lou Previti
  • Ellen Barnes
  • Guangbin Luo
  • Xincheng Lu
  • Takayuki Iwaki
  • Yihua Zhou
  • Zoltan Paszti
  • Sharon L Sanborn
  • Volodymyr V Tarabara
  • Scot C Remick
  • Matthew M Cooney
  • Joel N Schrauben
  • Ajita Narayan
  • Fulin Wang
  • Jonathon W Homeister
  • Douglas B Cines
  • Lakshmi V Mundada
  • Alice Kuo
  • Maria Carinato
  • William P Fay
  • Mark A Even
  • Marie Dreyfus
  • Valerie Proulle
  • J Herbert Waite
  • Raman Krishnan
  • Alexander Tulinsky
  • Markus Huber-Lang
  • Julio Scharfstein
  • Kenneth J Pienta
  • Jair R Chagas
  • Carlos D Figueroa
  • J Vidya Sarma
  • Ren Feng Guo
  • Sujata Sikranth
  • Arul M Chinnaiyan
  • Jeffrey C Chu
  • Ivarne L S Tersariol
  • Paulo C Almeida
  • Isaura Y Hirata
  • Veronica Schmitz
  • Elie E Hage-Korban
  • Gauhar Khan
  • Zia Shariat Madar
  • Hongbao Ma
  • James D Gendernalik
  • Helena B Nader
  • Luiz Juliano
  • Carlton R Cooper

Detail Information

Publications39

  1. pmc The elusive physiologic role of Factor XII
    Alvin H Schmaier
    Division of Hematology and Oncology, Case Western Reserve University, Cleveland, Ohio 44106 7284, USA
    J Clin Invest 118:3006-9. 2008
    ..This study describes a novel biologic surface for FXII activation and activity, which initiates inflammatory events independent of hemostasis...
  2. ncbi request reprint The physiologic basis of assembly and activation of the plasma kallikrein/kinin system
    Alvin H Schmaier
    Thromb Haemost 91:1-3. 2004
  3. ncbi request reprint Mapping the interaction between high molecular mass kininogen and the urokinase plasminogen activator receptor
    Fakhri Mahdi
    Departments of Internal Medicine and Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:16621-8. 2004
    ..Therefore, HK interacts with suPAR at several sites. HK binds to uPAR as part of its interaction with its multiprotein receptor complex on HUVEC, and the biological functions that depend upon this binding are modulated by urokinase...
  4. ncbi request reprint The plasma kallikrein/kinin and renin angiotensin systems in blood pressure regulation in sepsis
    Zia Shariat-Madar
    Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109 0640, USA
    J Endotoxin Res 10:3-13. 2004
    ..Understanding the interactions between these two systems may lead to development of better pharmacological treatments for endotoxin-induced shock...
  5. ncbi request reprint Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4
    Marvin T Nieman
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0640, USA
    FEBS Lett 579:25-9. 2005
    ..The N-terminal arginine on RPPGF binds to the P2 position or proline46 on PAR4 to block thrombin cleavage. These data indicate that RPPGF influences thrombin activity by binding to the thrombin cleavage site on both PAR4 and PAR1...
  6. pmc Are maternal antiplatelet antibodies a prothrombotic condition leading to miscarriage?
    Alvin H Schmaier
    Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Invest 121:4241-3. 2011
    ..have identified a potential reason for this - they find that in the majority of pregnant mice, anti-GPIb╬▒ antibodies enhance platelet activation and accelerate thrombus formation in the placenta and that this leads to miscarriage...
  7. ncbi request reprint The plasma kallikrein-kinin system: its evolution from contact activation
    A H Schmaier
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Thromb Haemost 5:2323-9. 2007
    ..The present characterizations of this system, which incorrectly had been thought to initiate coagulation, represent an evolution of understanding in this field...
  8. pmc Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system
    Alvin H Schmaier
    Department of Medicine, Case Western Reserve University, University Hospital Case Medical Center, Division of Hematology and Oncology, Cleveland, OH 44106 7284, United States
    Int Immunopharmacol 8:161-5. 2008
    ..Better understanding of this system may lead to insight into mechanisms for arterial thrombosis, independent of hemostasis...
  9. doi request reprint Factor XII: new life for an old protein
    A H Schmaier
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106 7284, USA
    Thromb Haemost 104:915-8. 2010
    ..These studies indicate that XII stimulates angiogenesis, a physiologic function independent of contact activation...
  10. pmc Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
    Marvin T Nieman
    Division of Hematology Oncology, Case Western Reserve University, Cleveland, Ohio 44106 7284, USA
    Biochemistry 46:8603-10. 2007
    ..It also implies that factors other than the hirudin-like binding region on PAR1 exodomain predominate in influencing PAR1 cleavage on cells...
  11. pmc Factor XII: what does it contribute to our understanding of the physiology and pathophysiology of hemostasis & thrombosis
    Evi Stavrou
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7284, USA
    Thromb Res 125:210-5. 2010
    ..These combined studies suggest that FXII may become a pharmacologic target to reduce arterial thrombosis risk and promote cell repair after injury, without influencing hemostasis...
  12. ncbi request reprint Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes
    Ayad A Jaffa
    Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, PO Box 250776, Charleston, SC 29425, USA
    Diabetes 52:1215-21. 2003
    ....
  13. ncbi request reprint Assembly and activation of the plasma kallikrein/kinin system: a new interpretation
    Zia Shariat-Madar
    Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0640, USA
    Int Immunopharmacol 2:1841-9. 2002
    ..Insights into the integrated role of these two systems may afford the development of novel therapeutic drugs to manage hypertension and thrombosis...
  14. pmc Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis
    Gretchen A LaRusch
    Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 115:5111-20. 2010
    ..In sum, FXII initiates signaling mediated by uPAR, beta(1) integrin, and the EGFR to induce human umbilical vein endothelial cell proliferation, growth, and angiogenesis...
  15. ncbi request reprint Recombinant prolylcarboxypeptidase activates plasma prekallikrein
    Zia Shariat-Madar
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, 5301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0649, USA
    Blood 103:4554-61. 2004
    ..These investigations indicate that rPRCP is functionally identical to isolated HUVEC PRCP and is a major HUVEC membrane-expressed, PK-activating enzyme detected in the intravascular compartment...
  16. pmc AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis
    Feng Xu
    Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8153, USA
    J Neurosci 29:5666-70. 2009
    ..Together, these results indicate that AbetaPP and APLP2 share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury...
  17. ncbi request reprint Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator
    Zia Shariat-Madar
    Division of Hematology and Oncology, Departments of Internal Medicine and Pathology, University of Michigan, Ann Arbor, Michigan 48109 0640, USA
    J Biol Chem 277:17962-9. 2002
    ..The K(m) of PK activation by PRCP is 6.7 nm. PRCP antigen is present on the membrane of fixed but not permeabilized HUVEC. PRCP appears to be a HUVEC-associated PK activator...
  18. ncbi request reprint Complications from vascular disrupting agents and angiogenesis inhibitors: aberrant control of hemostasis and thrombosis
    Willem J van Heeckeren
    Case Comprehensive Cancer Center, Case School of Medicine, Division of Hematology Oncology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Curr Opin Hematol 14:468-80. 2007
    ..To discuss thrombotic and hemorrhagic complications from angiogenesis inhibitors and vascular disrupting agents, pathogenesis, and recommendations for prophylaxis and management of those complications...
  19. doi request reprint Thrombotic microangiopathy in haematopoietic stem cell transplantation: diagnosis and treatment
    Cecilia M Choi
    Department of Medicine, Division of Hematology Oncology, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Drugs 69:183-98. 2009
    ..One candidate may be daclizumab, especially in those with mild to moderate TMA. Rituximab therapy or the addition of defibrotide may also be beneficial. In general, plasma exchange is not recommended...
  20. pmc Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis
    Sergei Merkulov
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Blood 111:1274-81. 2008
    ..These results suggest that a single gene, mKng1, is responsible for production of plasma kininogen, and that plasma HK contributes to induced arterial thrombosis in mice...
  21. pmc Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system
    Joshua M Astern
    Burnett Womack, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
    Am J Pathol 171:349-60. 2007
    ..This study identifies CK1 as a facilitator of MPO-mediated vascular responses and thus provides a new paradigm by which MPO affects vasoregulatory systems...
  22. ncbi request reprint Synthesis of novel peptide inhibitors of thrombin-induced platelet activation
    Fernanda M Burke
    Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 1065, USA
    Chem Biol Drug Des 68:235-8. 2006
    ....
  23. ncbi request reprint The preparation and characterization of novel peptide antagonists to thrombin and factor VIIa and activation of protease-activated receptor 1
    Marvin T Nieman
    Thromgen Inc, Ann Arbor, MI 48109 0640, USA
    J Pharmacol Exp Ther 311:492-501. 2004
    ..TH146 and MAP4-TH146 inhibit human and mouse platelet aggregation and mouse thrombosis. Analogs of RPPGF are model compounds to develop PAR1 activation antagonists as well as direct inhibitors to thrombin and factor VIIa...
  24. ncbi request reprint A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines
    Christopher H Chay
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0946, USA
    Urology 60:760-5. 2002
    ..To identify genes important in prostate cancer metastatic to bone. Bone-specific metastasis is a common feature of prostate cancer and a significant cause of morbidity...
  25. ncbi request reprint Characterization of molecular defects of Fitzgerald trait and another novel high-molecular-weight kininogen-deficient patient: insights into structural requirements for kininogen expression
    Yelena Krijanovski
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0640, USA
    Blood 101:4430-6. 2003
    ..Fitzgerald DNA has a normal exon 10, but a 17-bp mutation in intron 9. These combined results indicate that mutations in the kininogen gene may differentially affect biosynthesis, processing, and/or secretion of HK...
  26. ncbi request reprint Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin
    Ahmed A K Hasan
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0640, USA
    Am J Physiol Heart Circ Physiol 285:H183-93. 2003
    ..These studies indicate that RPPGF is a bifunctional inhibitor of thrombin: it binds to PAR1 to prevent thrombin cleavage at Arg41 and interacts with the active site of alpha-thrombin...
  27. ncbi request reprint The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells
    Fakhri Mahdi
    Department of Internal Medicine, Hematology and Oncology Division, The University of Michigan, Ann Arbor, Michigan 48109 0640, USA
    J Biol Chem 278:43983-90. 2003
    ..PK preferential binding to endothelial cells contributes to their anticoagulant nature...
  28. ncbi request reprint Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes
    Fakhri Mahdi
    Department of Internal Medicine and Pathology, University of Michigan, Ann Arbor, MI 48109 0640, USA
    Blood 99:3585-96. 2002
    ..Thus, physiologic FXII expression on HUVECs is secondary to HK binding and highly restricted in its ability to initiate prekallikrein or FXI activation...
  29. pmc The plasma kallikrein-kinin system counterbalances the renin-angiotensin system
    Alvin H Schmaier
    University of Michigan, Departments of Internal Medicine and Pathology, 5301 Medical Science Research Building III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0640, USA
    J Clin Invest 109:1007-9. 2002
  30. pmc Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis
    Ines J Laudes
    Departments of Pathology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
    Am J Pathol 160:1867-75. 2002
    ..Most of these parameters were reversed in CLP rats that had been treated with anti-C5a. Production of C5a during sepsis may directly or indirectly cause hemostatic defects that can be reduced by blockade of C5a...
  31. ncbi request reprint Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator
    Claudia R Moreira
    Departmento de Bioquimica, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    FEBS Lett 523:167-70. 2002
    ..On immunoblot, prolylcarboxypeptidase antigen is associated with HUVEC matrix. These studies indicate that prolylcarboxypeptidase is the matrix PK activator...
  32. ncbi request reprint Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injury
    Alejandro R Prieto
    Department of Internal Medicine, Division of Cardiology, Michigan State University, East Lansing, MI 48824, USA
    Cardiovasc Res 53:984-92. 2002
    ..We hypothesized that thrombostatin prevents platelet aggregation and adhesion after balloon angioplasty (BA)...
  33. ncbi request reprint Factor VLeiden inhibits fibrinolysis in vivo
    Andrew C Parker
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0644, USA
    Circulation 110:3594-8. 2004
    ..Factor V(Leiden) (fV(Leiden)) predisposes to thrombosis by enhancing thrombin formation. This study tested the hypothesis that fV(Leiden) inhibits fibrinolysis in vivo...
  34. ncbi request reprint The kallikrein-kinin and the renin-angiotensin systems have a multilayered interaction
    Alvin H Schmaier
    The Univ of Michigan, 5301 MSRB III, 1150 West Medical Center Dr, Ann Arbor, MI 48109 0640, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1-13. 2003
    ..This analysis suggests that there is a multilayered interaction between these two systems that are important for a wide array of physiological functions...
  35. ncbi request reprint Detection of amide I signals of interfacial proteins in situ using SFG
    Jie Wang
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    J Am Chem Soc 125:9914-5. 2003
    ..Our studies indicate that different proteins generate different SFG amide signals at the polystyrene/protein solution interface, showing that they have different interfacial coverage, secondary structure, or orientation...
  36. ncbi request reprint Ordered adsorption of coagulation factor XII on negatively charged polymer surfaces probed by sum frequency generation vibrational spectroscopy
    Xiaoyun Chen
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Anal Bioanal Chem 388:65-72. 2007
    ..These investigations indicate that negatively charged surfaces facilitate or induce FXII autoactivation on the molecular level by imposing specific orientation and ordering on the adsorbed protein molecules...
  37. pmc Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin
    Zia Shariat-Madar
    Hematology Oncology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Blood 108:192-9. 2006
    ..These investigations indicate a pathway for thrombosis risk reduction via the plasma kallikrein/kinin and renin angiotensin systems...
  38. ncbi request reprint Platelet aggregation testing in platelet-rich plasma: description of procedures with the aim to develop standards in the field
    Lan Zhou
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0640, USA
    Am J Clin Pathol 123:172-83. 2005
    ..Our intent is to stimulate interest in the development of professional guidelines for platelet function testing in the clinical laboratory...
  39. ncbi request reprint Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain
    Ana Paula C A Lima
    Instituto de Biofisica Carlos Chagas Filho, Universidade do Brasil, CCS, Bloco G, Cidade Universitaria, CEP 21944 900, Rio de Janeiro, Brazil
    J Biol Chem 277:5875-81. 2002
    ..These studies suggest that the efficiency of T. cruzi to initiate kinin release is potently enhanced by the mutual interactions between cruzipain, HK, and heparan sulfate proteoglycans...

Research Grants19

  1. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin H Schmaier; Fiscal Year: 2010
    ..The proposal aims to characterize the first recognized prothrombotic mouse due to increased reactive oxygen therapy. Studies will also examine if the prothrombotic and hypertensive mechanisms are linked. ..
  2. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin Schmaier; Fiscal Year: 2007
    ..These investigations will lead to the recognition of new targets for drug development that could be used to treat hypertension and decrease thrombosis risk. ..
  3. Thrombostatin-A Thrombin Receptor Inhibitor
    Alvin Schmaier; Fiscal Year: 2006
    ..Second, the preparation of an IND application for its human use for one indication will be achieved. Thrombostatin(tm) has the opportunity to be a first-in-its-class thrombin receptor activation antagonist. ..
  4. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin Schmaier; Fiscal Year: 2004
    ..These studies are intended to characterize this system's contribution to vascular biology and to develop new strategies to modulate intravascular thrombosis. ..
  5. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003
    ..These studies could serve as a basis for the development of a global assay(s) to predict the prothrombotic state in man. (End of Abstract.) ..
  6. REGULATION OF KININ DELIVERY ON HUVEC
    Alvin Schmaier; Fiscal Year: 2000
    ..Modulation of bradykinin liberation is important in the regulation of local blood pressure in coronary, renal, pulmonary, and cerebral circulations. ..