ROBERT GERD SALOMON

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo
    Eugenia Poliakov
    Department of Chemistry, Case Western Reserve University, Ohio, USA
    FASEB J 17:2209-20. 2003
  2. ncbi request reprint Isolevuglandins, oxidatively truncated phospholipids, and atherosclerosis
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    Ann N Y Acad Sci 1043:327-42. 2005
  3. pmc Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE
    Suresh P Annangudi
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 21:1384-95. 2008
  4. pmc Structural identification and cardiovascular activities of oxidized phospholipids
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Circ Res 111:930-46. 2012
  5. pmc Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 24:1803-16. 2011
  6. pmc Critical insights into cardiovascular disease from basic research on the oxidation of phospholipids: the γ-hydroxyalkenal phospholipid hypothesis
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 24:1791-802. 2011
  7. ncbi request reprint Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, 2074, Adelbert Road, Cleveland, OH 44106 7078, USA
    Chem Phys Lipids 134:1-20. 2005
  8. ncbi request reprint Iso[7]LGD2-protein adducts are abundant in vivo and free radical-induced oxidation of an arachidonyl phospholipid generates this D series isolevuglandin in vitro
    Eugenia Poliakov
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 17:613-22. 2004
  9. ncbi request reprint Levuglandins and isolevuglandins: stealthy toxins of oxidative injury
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    Antioxid Redox Signal 7:185-201. 2005
  10. ncbi request reprint A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38517-23. 2002

Research Grants

  1. PREPROSTAGLANDIN ENDOPEROXIDES
    ROBERT GERD SALOMON; Fiscal Year: 2010
  2. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2006
  3. Reactive Intermediates of Oxidative Lipid Fragmentation
    Robert Salomon; Fiscal Year: 2006
  4. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2005
  5. Preprostaglandin Endoperoxides (supplement)
    Robert Salomon; Fiscal Year: 2004
  6. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2004
  7. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2003
  8. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2002
  9. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2001
  10. Reactive Intermediates of Oxidative Lipid Fragmentation
    Robert Salomon; Fiscal Year: 2007

Collaborators

  • G Subbanagounder
  • John Crabb
  • Stanley Hazen
  • JOE GILBERT HOLLYFIELD
  • Henry F Hoff
  • W Li
  • Zhongzhou Shen
  • Shadi Moghaddas
  • Seon Hwa Lee
  • Masaru Miyagi
  • Sanjoy Bhattacharya
  • J R Sparrow
  • Lian Shan
  • G Hoppe
  • Mohammad Z Ashraf
  • JUDITH ANNE BERLINER
  • Mingjiang Sun
  • Xiaorong Gu
  • Eugene A Podrez
  • Wujuan Zhang
  • Bogdan G Gugiu
  • Eugenia Poliakov
  • James Laird
  • Xi Chen
  • Yijun Deng
  • Renliang Zhang
  • Clementina Mesaros
  • Xiaodong Gu
  • Suresh P Annangudi
  • Maria Febbraio
  • Roy L Silverstein
  • Bogdan Gugiu
  • Paula J Finton
  • Xiaoxia Z West
  • Sanjoy Roychowdhury
  • Rui Chen
  • Jiayin Gu
  • Tatiana V Byzova
  • Bharathi Govindarajan
  • Kwok Peng Ng
  • Michael E Greenberg
  • Bela Anand-Apte
  • Kutralanathan Renganathan
  • Quteba Ebrahem
  • Kimberly A Walton
  • Mary E Rayborn
  • Yuvaraju N Balamraju
  • Susan Gillette Meer
  • Wei Sha
  • Jaewoo Choi
  • Mira Tischenko
  • Bethany A Kerr
  • Ernest C Borden
  • Rong Zhou
  • Ian A Blair
  • Alona A Merkulova
  • Nikolay L Malinin
  • Ronald R Krueger
  • Nadia Waheed
  • Andrew P Schachat
  • Sonya Bamba
  • David Barnhart
  • Bennie H Jeng
  • James Bena
  • Jonathan E Sears
  • Umadevi Narendra
  • Sue Crowe
  • Gayle J T Pauer
  • Richard E Gans
  • William J Dupps
  • Stephanie A Hagstrom
  • Michele T Pritchard
  • Scott D Smith
  • Ann Laurenzi
  • Tiffany Ruez
  • Steven E Wilson
  • Elias I Traboulsi
  • Hilel Lewis
  • Megan R McMullen
  • Patrice Nerone
  • Gwen M Sturgill
  • Thomas M McIntyre
  • Elisa Bala
  • William E Sax
  • Roger H S Langston
  • Ellen Simpson
  • Rishi Singh
  • Gregory S Kosmorsky
  • Neal S Peachey
  • Laura E Nagy

Detail Information

Publications41

  1. ncbi request reprint Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo
    Eugenia Poliakov
    Department of Chemistry, Case Western Reserve University, Ohio, USA
    FASEB J 17:2209-20. 2003
    ..The present studies thus identify MPO as one pathway for generation of isoLGs in vivo. They also suggest that long-lived protein isoLG adducts may serve as an alternative integrated sensor of oxidant stress in vivo...
  2. ncbi request reprint Isolevuglandins, oxidatively truncated phospholipids, and atherosclerosis
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    Ann N Y Acad Sci 1043:327-42. 2005
    ....
  3. pmc Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE
    Suresh P Annangudi
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 21:1384-95. 2008
    ..A domino-like reaction of initial 1:1 HNE Michael adducts of histidyl or lysyl nucleophiles with multiple additional HNE molecules forms 2:1 and 3:1 adducts that were structurally characterized by tandem mass spectrometry...
  4. pmc Structural identification and cardiovascular activities of oxidized phospholipids
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Circ Res 111:930-46. 2012
    ..Those pure samples are critical for determining the biological activities attributable to specific molecular species of oxPLs in the complex mixtures generated in vivo as a consequence of oxidative stress...
  5. pmc Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 24:1803-16. 2011
    ..This investigational approach, from the chemistry of biomolecules to disease phenotype, is proving to be remarkably productive...
  6. pmc Critical insights into cardiovascular disease from basic research on the oxidation of phospholipids: the γ-hydroxyalkenal phospholipid hypothesis
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 24:1791-802. 2011
    ..This investigational approach, from the chemistry of biomolecules to disease phenotype, that complements the more common opposite paradigm, is proving remarkably productive...
  7. ncbi request reprint Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, 2074, Adelbert Road, Cleveland, OH 44106 7078, USA
    Chem Phys Lipids 134:1-20. 2005
    ..Immunoassays that selectively recognize iso[n]LGE(2)-protein adducts are the only tools available to unambiguously detect and quantify the production of isolevuglandins in vivo through free radical-induced oxidation of arachidonates...
  8. ncbi request reprint Iso[7]LGD2-protein adducts are abundant in vivo and free radical-induced oxidation of an arachidonyl phospholipid generates this D series isolevuglandin in vitro
    Eugenia Poliakov
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Chem Res Toxicol 17:613-22. 2004
    ..933) and isoLGE(2)-protein adducts (r = 0.877). This supports the hypothesis that isoLGs are generated in vivo by parallel competing radical-induced pathways...
  9. ncbi request reprint Levuglandins and isolevuglandins: stealthy toxins of oxidative injury
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    Antioxid Redox Signal 7:185-201. 2005
    ..Because they can accumulate over the lifetimes of proteins, iso[n]LG-protein adducts represent a convenient dosimeter of oxidative stress...
  10. ncbi request reprint A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38517-23. 2002
    ..Collectively, our data suggest that formation of this novel family of oxidized phospholipids participates in CD36-mediated recognition of oxidized lipoproteins and foam cell formation in vivo...
  11. ncbi request reprint Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry
    Xiaorong Gu
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    J Org Chem 68:3749-61. 2003
    ....
  12. ncbi request reprint Oxidized phospholipids, isolevuglandins, and atherosclerosis
    Wujuan Zhang
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    Mol Nutr Food Res 49:1050-62. 2005
    ..They are also ligands for unregulated receptor-mediated uptake of oxLDL by monocyte macrophages leading to foam cell formation...
  13. pmc Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids
    Xi Chen
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    J Lipid Res 49:832-46. 2008
    ..Remarkably, these reactions do not occur readily with MPO in SUVs composed entirely of saturated diacyl-PCs. A mechanistic rationale is presented that can account for this dichotomy...
  14. ncbi request reprint Gamma-hydroxyalkenals are oxidatively cleaved through Michael addition of acylperoxy radicals and fragmentation of intermediate beta-hydroxyperesters
    Yuvaraju N Balamraju
    Contribution from the Department of Chemistry, Case Western Reserve University, Cleveland, OH 44107 7078, USA
    J Am Chem Soc 126:11522-8. 2004
    ..This unprecedented transformation is shown to involve Michael addition of an acylperoxy radical and fragmentation of the resulting beta-hydroxyperester...
  15. ncbi request reprint Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1)
    Mingjiang Sun
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    J Org Chem 67:3575-84. 2002
    ....
  16. ncbi request reprint Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38503-16. 2002
    ..The present results offer structural insights into the molecular patterns recognized by the scavenger receptor CD36 and provide a platform for the development of potential therapeutic inhibitory agents...
  17. ncbi request reprint Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria
    Shadi Moghaddas
    Department of Medicine, Divisions of Cardiology, Case Western Reserve University, Cleveland, Ohio, USA
    J Gerontol A Biol Sci Med Sci 57:B22-8. 2002
    ..Thus, alterations in cardiolipin are not the mechanism for the aging defect in IFM in Fischer 344 rats...
  18. ncbi request reprint Oxidative fragmentation of hydroxy octadecadienoates generates biologically active gamma-hydroxyalkenals
    Mingjiang Sun
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44107 7078, USA
    J Am Chem Soc 126:5699-708. 2004
    ..Our findings also show that the formation of dioxetane intermediates through peroxyradical cyclization is not required to achieve oxidative fragmentation of PUFAs...
  19. pmc Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters
    Mohammad Z Ashraf
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 283:10408-14. 2008
    ..Thus, oxidative stress and accumulation of specific oxidized phospholipids in plasma may have an inhibitory effect on reverse cholesterol transport...
  20. pmc Retinal pigment epithelium lipofuscin proteomics
    Kwok Peng Ng
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, Case Western Reserve University, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 7:1397-405. 2008
    ....
  21. pmc Platelet activation by low concentrations of intact oxidized LDL particles involves the PAF receptor
    Rui Chen
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 29:363-71. 2009
    ..Oxidized LDL (oxLDL) contains the medium length oxidatively truncated phospholipid hexadecyl azelaoyl-lysoPAF (HAz-LPAF) that disrupts mitochondrial function in nucleated cells, so oxLDL may augment platelet activation...
  22. pmc Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers
    Jiayin Gu
    Cole Eye Institute, Lerner Research Inst, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Mol Cell Proteomics 8:1338-49. 2009
    ..We conclude that CEP plasma biomarkers, particularly in combination with genomic markers, offer a potential early warning system for assessing susceptibility to this blinding, multifactorial disease...
  23. pmc Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice
    Sanjoy Roychowdhury
    Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Free Radic Biol Med 47:1526-38. 2009
    ..In summary, ethanol feeding enhanced gamma-ketoaldehyde-protein adduct production via a TNFR1/CYP2E1-dependent, but cyclooxygenase-independent, mechanism in mouse liver...
  24. pmc Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts
    Wei Li
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 47:1539-52. 2009
    ..4+/-0.1 ng/ml, n=15). Just as LG/isoLG-protein adducts provide a dosimeter of oxidative injury, this study suggests that LG/isoLG-PE-hydroxylactams are potential biomarkers for assessing risk for oxidative stress-stimulated diseases...
  25. pmc A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration
    Joe G Hollyfield
    Cole Eye Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    Mol Neurobiol 41:290-8. 2010
    ..Such a model will allow for the efficient preclinical testing of the much-needed therapeutics quickly and inexpensively...
  26. pmc Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
    Xiaoxia Z West
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nature 467:972-6. 2010
    ..Taken together, these findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis...
  27. ncbi request reprint Total syntheses of bioactive oxidized ethanolamine phospholipids
    Bogdan G Gugiu
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    Org Lett 5:2797-9. 2003
    ..g. OVPC, total syntheses were developed. An efficient general strategy was used that features selective N-protection of 2-lysophosphatidylethanolamine, and generation of the target compounds by mild deprotection of stable precursors...
  28. pmc Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork
    Bharathi Govindarajan
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 47:817-25. 2008
    ..These data suggest that interference with proteasomal activity, owing to protein modification by isoLGs, could contribute to glaucoma pathophysiology by decreasing the ability of the TM to modulate outflow resistance...
  29. ncbi request reprint Proteomic approaches to understanding age-related macular degeneration
    Joe G Hollyfield
    Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Adv Exp Med Biol 533:83-9. 2003
    ..Lipid oxidation products and oxidative protein modifications may be causally involved in drusen formation and Bruch's membrane thickening...
  30. pmc Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions
    Mingjiang Sun
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol Chem 281:4222-30. 2006
    ....
  31. ncbi request reprint Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration
    Xiaorong Gu
    Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Biol Chem 278:42027-35. 2003
    ..These results suggest that together CEP immunoreactivity and autoantibody titer may have diagnostic utility in predicting AMD susceptibility...
  32. ncbi request reprint Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo
    Wujuan Zhang
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 7078, USA
    J Org Chem 71:5607-15. 2006
    ..Each of these was subsequently converted into a different, regioisomerically pure, diHPODE through further singlet oxygenation...
  33. pmc Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration
    Quteba Ebrahem
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, and Department of Chemistry, Case Western Reserve University, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 103:13480-4. 2006
    ..Overall, these results suggest that CEP-induced angiogenesis utilizes VEGF-independent pathways and that anti-CEP therapeutic modalities might be of value in limiting CNV in AMD...
  34. ncbi request reprint Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals
    Xiaodong Gu
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA
    J Am Chem Soc 129:6088-9. 2007
  35. pmc Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
    Eugene A Podrez
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Med 13:1086-95. 2007
    ..Thus, interactions of platelet CD36 with specific endogenous oxidized lipids play a crucial role in the well-known clinical associations between dyslipidemia, oxidant stress and a prothrombotic phenotype...
  36. pmc A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA
    Clementina Mesaros
    Department of Chemistry, Case Western Reserve University, 2074 Adelbert Road, Millis 212, Cleveland, Ohio 44106, USA
    Chem Res Toxicol 23:516-27. 2010
    ..As predicted by analogy with 4,5-EDE, OETA-PC reacts with dAdo and dGuo, as well as with DNA, to form mutagenic etheno adducts...
  37. ncbi request reprint Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells
    Ganesamoorthy Subbanagounder
    Department of Medicine Cardiology, Center for the Health Sciences, Room 47 123, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Vascul Pharmacol 38:201-9. 2002
    ..These studies demonstrate the importance of HOOA-PC as a new potential proinflammatory molecule that regulates leukocyte-endothelial interactions...
  38. ncbi request reprint A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products
    Kimberly A Walton
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:1967-74. 2006
    ..Furthermore, we identify specific oxidized phospholipids responsible for this inhibition...
  39. ncbi request reprint Identification of oxidatively truncated ethanolamine phospholipids in retina and their generation from polyunsaturated phosphatidylethanolamines
    Bogdan G Gugiu
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44106, USA
    Chem Res Toxicol 19:262-71. 2006
    ..The resistance of omega-oxononanoyl-PE, as compared with omega-oxobutyryl-PE and omega-oxovaleryl-PE, to further oxidation may contribute to the greater amount of this oxPE relative to its precursor, linoleyl-PE, in retina...
  40. ncbi request reprint Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse
    Sanjoy K Bhattacharya
    Exp Eye Res 80:741-4. 2005
    ..Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma...
  41. ncbi request reprint The lipid whisker model of the structure of oxidized cell membranes
    Michael E Greenberg
    Department of Cell Biology, Cleveland Clinic, Ohio 44195, USA
    J Biol Chem 283:2385-96. 2008
    ..This enables physical contact between pattern recognition receptor and molecular pattern ligand. Cell membranes thus "grow whiskers" as phospholipids undergo peroxidation, and many of their oxidized fatty acids protrude at the surface...

Research Grants41

  1. PREPROSTAGLANDIN ENDOPEROXIDES
    ROBERT GERD SALOMON; Fiscal Year: 2010
    ..The understanding gleaned through these studies will provide new approaches to the prevention, early diagnosis, and treatment of eye diseases associated with oxidative injury. ..
  2. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2006
    ..The understanding gleaned through these studies will provide new approaches to the prevention, early diagnosis, and treatment of eye diseases associated with oxidative injury. ..
  3. Reactive Intermediates of Oxidative Lipid Fragmentation
    Robert Salomon; Fiscal Year: 2006
    ....
  4. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2005
    ....
  5. Preprostaglandin Endoperoxides (supplement)
    Robert Salomon; Fiscal Year: 2004
    ....
  6. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2004
    ....
  7. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2003
    ....
  8. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2002
    ....
  9. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2001
    ....
  10. Reactive Intermediates of Oxidative Lipid Fragmentation
    Robert Salomon; Fiscal Year: 2007
    ....
  11. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2007
    ..The understanding gleaned through these studies will provide new approaches to the prevention, early diagnosis, and treatment of eye diseases associated with oxidative injury. ..
  12. MOLECULAR BASIS OF OXIDATIVE MODIFICATION OF LDL
    ROBERT GERD SALOMON; Fiscal Year: 2010
    ..Our research is aimed at understanding why there is an accumulation of cholesterol in these cells because of their inability to efficiently break down the oxLDL and clear the released cholesterol. ..
  13. Reactive Intermediates of Oxidative Lipid Fragmentation
    ROBERT GERD SALOMON; Fiscal Year: 2010
    ....
  14. Reactive Intermediates of Oxidative Lipid Fragmentation
    Robert Salomon; Fiscal Year: 2009
    ....
  15. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2009
    ..The understanding gleaned through these studies will provide new approaches to the prevention, early diagnosis, and treatment of eye diseases associated with oxidative injury. ..
  16. MOLECULAR BASIS OF OXIDATIVE MODIFICATION OF LDL
    Robert Salomon; Fiscal Year: 2009
    ..Our research is aimed at understanding why there is an accumulation of cholesterol in these cells because of their inability to efficiently break down the oxLDL and clear the released cholesterol. ..
  17. MOLECULAR BASIS OF OXIDATIVE MODIFICATION OF LDL
    Robert Salomon; Fiscal Year: 1999
    ....
  18. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 1999
    ....
  19. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 1992
    ..Furthermore, LGE2 forms a stable bis methoxime (LGM2) which is amenable to immunoassay, GC, and GC-MS analyses...
  20. PREPROSTAGLANDIN EXDOPEROXIDES
    Robert Salomon; Fiscal Year: 1980
    ..Our studies on the chemistry of simple models will guide parallel studies of the natural products and eventually provide a basis for understanding prostaglandin endoperoxide and thromboxane biochemistry. ..
  21. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 1990
    ..We will explore the molecular mechanisms of these biological actions inter alia, testing the possibility that dihydroxpyrrolidines are intermediates in the covalent binding and cross-linking of proteins by levuglandins...
  22. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 1993
    ..Furthermore, LGE2 forms a stable bis methoxime (LGM2) which is amenable to immunoassay, GC, and GC-MS analyses...
  23. PREPROSTAGLANDIN ENDOPEROXIDES
    Robert Salomon; Fiscal Year: 2000
    ....