M F Romero

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi The electrogenic Na+/HCO3- cotransporter, NBC
    M F Romero
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4970, USA
    JOP 2:182-91. 2001
  2. ncbi Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter
    M F Romero
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 275:24552-9. 2000
  3. ncbi Cloning and immunolocalization of a rat pancreatic Na(+) bicarbonate cotransporter
    F Thevenod
    Department of Physiology, University of Saarland, Homburg, 66421, Federal Republic of Germany
    Biochem Biophys Res Commun 264:291-8. 1999
  4. ncbi Electrogenic Na+/HCO3- cotransporters: cloning and physiology
    M F Romero
    Department of Physiology and Biophysics and Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4790, USA
    Annu Rev Physiol 61:699-723. 1999
  5. ncbi Localization of endogenous and recombinant Na(+)-driven anion exchanger protein NDAE1 from Drosophila melanogaster
    C M Sciortino
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    Am J Physiol Cell Physiol 281:C449-63. 2001
  6. ncbi Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding
    J Marcelino
    Department of Genetics and Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 98:11353-8. 2001
  7. ncbi The electrogenic Na/HCO3 cotransporter
    W F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Wien Klin Wochenschr 109:445-56. 1997
  8. ncbi The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: inhibition by tenidap and benzamil and effect of temperature on transport rate and stoichiometry
    O Ducoudret
    , , Parc Valrose, Nice, France
    Pflugers Arch 442:709-17. 2001
  9. ncbi Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1
    A Steel
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Physiol 498:563-9. 1997
  10. ncbi Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1
    S Nussberger
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:7777-85. 1997

Collaborators

  • W F Boron
  • Matthias Hediger
  • Vadivel Ganapathy
  • A Bril
  • D Trotti
  • I Choi
  • C M Sciortino
  • S Nussberger
  • B M Schmitt
  • J Marcelino
  • O Ducoudret
  • A Steel
  • F Thevenod
  • M Heyer
  • H Gunshin
  • L M Ulatowski
  • B R Fletcher
  • P J Harte
  • P M Eimon
  • L D Shrode
  • M L Warman
  • R M Harland
  • R T Ballock
  • A N Economides
  • A Diakov
  • E Roussa
  • D Biemesderfer
  • E L Boulpaep
  • Y J Fei
  • U V Berger
  • C A Boyd
  • Y Gunshin
  • B Mackenzie
  • J L Gollan
  • Y Kanai
  • S K Singh
  • F H Leibach

Detail Information

Publications16

  1. ncbi The electrogenic Na+/HCO3- cotransporter, NBC
    M F Romero
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4970, USA
    JOP 2:182-91. 2001
    ..Functionally, NBC appears HCO(3)(-) and Na(+) selective. NBC stoichiometry in Xenopus oocytes is 1 Na(+) : 2 HCO(3)(-), implicating a possible accessory protein interaction...
  2. ncbi Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter
    M F Romero
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 275:24552-9. 2000
    ..NDAE1 may be generally important for fly development, because disruption of this gene is apparently lethal to the Drosophila larva...
  3. ncbi Cloning and immunolocalization of a rat pancreatic Na(+) bicarbonate cotransporter
    F Thevenod
    Department of Physiology, University of Saarland, Homburg, 66421, Federal Republic of Germany
    Biochem Biophys Res Commun 264:291-8. 1999
    ..The data suggest that rpNBC likely plays a more important role in the transport of HCO(-)(3) by rat pancreatic acinar and duct cells than previously believed...
  4. ncbi Electrogenic Na+/HCO3- cotransporters: cloning and physiology
    M F Romero
    Department of Physiology and Biophysics and Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4790, USA
    Annu Rev Physiol 61:699-723. 1999
    ..For example, NBC occurs in pancreas, prostate, brain, heart, small and large intestine, stomach, and epididymis. Finally, there are at least two genes that encode NBC proteins. Possible future directions of research are discussed...
  5. ncbi Localization of endogenous and recombinant Na(+)-driven anion exchanger protein NDAE1 from Drosophila melanogaster
    C M Sciortino
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    Am J Physiol Cell Physiol 281:C449-63. 2001
    ..These results suggest that NDAE1 may be a key pH(i) regulatory protein and may contribute to basolateral ion transport in epithelia and nervous system of Drosophila...
  6. ncbi Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding
    J Marcelino
    Department of Genetics and Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 98:11353-8. 2001
    ..This finding indicates that there also exist species-specific differences in the ability to process mutant noggin polypeptides...
  7. ncbi The electrogenic Na/HCO3 cotransporter
    W F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Wien Klin Wochenschr 109:445-56. 1997
    ..Using aNBC to screen a rat-kidney cDNA library, we identified a full-length cDNA clone (rNBC), rNBC encodes a protein of 1035 amino acids, is 86% identical to aNBC, and can be functionally expressed in oocytes...
  8. ncbi The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: inhibition by tenidap and benzamil and effect of temperature on transport rate and stoichiometry
    O Ducoudret
    , , Parc Valrose, Nice, France
    Pflugers Arch 442:709-17. 2001
    ..Pflügers Arch (2001) DOI 10.1007/s004240100592] show that these ratios are integer numbers i.e. either 2:1 or 3:1...
  9. ncbi Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1
    A Steel
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Physiol 498:563-9. 1997
    ..g. protonation of a histidine group). These considerations have led us to propose a model for coupled transport of neutral, acidic and basic dipeptides...
  10. ncbi Symmetry of H+ binding to the intra- and extracellular side of the H+-coupled oligopeptide cotransporter PepT1
    S Nussberger
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:7777-85. 1997
    ..This concept constitutes an important extension of previous kinetic models of ion-coupled solute transporters by including a more detailed description of intracellular events...
  11. ncbi Stoichiometry of the rat kidney Na+-HCO3- cotransporter expressed in Xenopus laevis oocytes
    M Heyer
    Zentrum der Physiologie, , D 60590 Frankfurt Main, Germany
    Pflugers Arch 438:322-9. 1999
    ....
  12. ncbi Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    H Gunshin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 388:482-8. 1997
    ..DCT1 is a member of the 'natural-resistance-associated macrophage protein' (Nramp) family and thus its properties provide insight into how these proteins confer resistance to pathogens...
  13. ncbi Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)
    I Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:C576-84. 1999
    ..We conclude that hhNBC is an electrogenic Na+-HCO-3 cotransporter and that hkNBC is also electrogenic...
  14. ncbi Immunolocalization of the electrogenic Na+-HCO-3 cotransporter in mammalian and amphibian kidney
    B M Schmitt
    Department of Cellular and Molecular Physiology, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:F27-38. 1999
    ....
  15. ncbi Cloning and functional expression of rNBC, an electrogenic Na(+)-HCO3- cotransporter from rat kidney
    M F Romero
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 274:F425-32. 1998
    ..Subsequent removal of Na+ in the presence of CO2/HCO3- causes a depolarization of > 50 mV and a concomitant decrease of pHi. Thus rNBC is in the same newly identified family of Na(+)-linked HCO3- transporters as is aNBC...
  16. ncbi Expression cloning of a mammalian proton-coupled oligopeptide transporter
    Y J Fei
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 368:563-6. 1994
    ....