Benigno Rodriguez

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
  2. ncbi request reprint Statins Blunt HAART-Induced CD4 T-Cell Gains but Have No Long-Term Effect on Virologic Response to HAART
    Benigno Rodriguez
    University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, OH
    J Int Assoc Physicians AIDS Care (Chic) 6:198-202. 2007
  3. pmc In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infection
    Benigno Rodriguez
    Case Western Reserve University Center for AIDS Research, Cleveland, OH 44106 5083, USA
    Clin Immunol 136:400-8. 2010
  4. ncbi request reprint Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection
    Benigno Rodriguez
    Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio, USA
    JAMA 296:1498-506. 2006
  5. pmc Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function
    Sara J Conry
    Department of Medicine, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland, OH, USA
    J Virol 83:11175-87. 2009
  6. ncbi request reprint TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    Nicole L Yonkers
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Veterans Affairs Medical Center, University Hospitals of Cleveland and Cleveland Clinic Foundation, Cleveland, OH 44106, USA
    J Immunol 178:4436-44. 2007
  7. ncbi request reprint Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection
    Nicole L Yonkers
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland and VA Medical Center, Cleveland, OH, USA
    Clin Immunol 131:288-97. 2009
  8. pmc Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS ONE 8:e56527. 2013
  9. ncbi request reprint New entrants to HIV care are presenting only at marginally earlier stages of disease but may increasingly represent groups perceived at lower risk
    Chariclia V Loupa
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Int Assoc Physicians AIDS Care (Chic) 4:47-51. 2005
  10. pmc Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    Wei Jiang
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 199:1177-85. 2009

Detail Information

Publications50

  1. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
    ..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed...
  2. ncbi request reprint Statins Blunt HAART-Induced CD4 T-Cell Gains but Have No Long-Term Effect on Virologic Response to HAART
    Benigno Rodriguez
    University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, OH
    J Int Assoc Physicians AIDS Care (Chic) 6:198-202. 2007
    ..Background: Statins are increasingly used in HIV-infected patients, but the effect of their immunomodulatory properties on antiretroviral-induced immune reconstitution is unknown...
  3. pmc In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infection
    Benigno Rodriguez
    Case Western Reserve University Center for AIDS Research, Cleveland, OH 44106 5083, USA
    Clin Immunol 136:400-8. 2010
    ..Our results indicate that naïve T cell proliferation predicts response to neo-, but not recall antigens, and suggest that it may be a meaningful reflection of in vivo immune competence in HIV-infected persons...
  4. ncbi request reprint Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection
    Benigno Rodriguez
    Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio, USA
    JAMA 296:1498-506. 2006
    ..Plasma human immunodeficiency virus (HIV) RNA level predicts HIV disease progression, but the extent to which it explains the variability in rate of CD4 cell depletion is poorly characterized...
  5. pmc Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function
    Sara J Conry
    Department of Medicine, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland, OH, USA
    J Virol 83:11175-87. 2009
    ....
  6. ncbi request reprint TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    Nicole L Yonkers
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Veterans Affairs Medical Center, University Hospitals of Cleveland and Cleveland Clinic Foundation, Cleveland, OH 44106, USA
    J Immunol 178:4436-44. 2007
    ....
  7. ncbi request reprint Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection
    Nicole L Yonkers
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland and VA Medical Center, Cleveland, OH, USA
    Clin Immunol 131:288-97. 2009
    ..These data indicate that during viral infection with HIV, accessory cell dependent NK function in the periphery is impaired. This impairment may be related to the identified MDC numerical defect...
  8. pmc Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS ONE 8:e56527. 2013
    ..003). These studies identify IFNα derived from lymph nodes, rather than blood leukocytes, as a possible source of the IFN-I signature that contributes to immune activation in HIV-1 infection...
  9. ncbi request reprint New entrants to HIV care are presenting only at marginally earlier stages of disease but may increasingly represent groups perceived at lower risk
    Chariclia V Loupa
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Int Assoc Physicians AIDS Care (Chic) 4:47-51. 2005
    ..Treatment has improved HIV infection prognosis, but whether risk and health care seeking behavior have improved is unclear...
  10. pmc Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    Wei Jiang
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 199:1177-85. 2009
    ..These findings are consistent with the importance of microbial translocation in immunodeficiency and T cell homeostasis in chronic HIV infection...
  11. pmc Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation
    Nicholas T Funderburg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, OH, USA
    Blood 115:161-7. 2010
    ..Thus, drivers of immune activation in HIV disease, such as HIV replication, and potentially, microbial translocation, may activate clotting cascades and contribute to thrombus formation and cardiovascular morbidities in HIV infection...
  12. pmc Baseline levels of soluble CD14 and CD16+56- natural killer cells are negatively associated with response to interferon/ribavirin therapy during HCV-HIV-1 coinfection
    Donald D Anthony
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Case Western Reserve University, Center for AIDS Research, University Hospitals of Cleveland and VA Medical Center, Cleveland, OH 44106, USA
    J Infect Dis 206:969-73. 2012
    ..IL28B genotype was associated with therapy response but not sCD14 or CD16(+)56(-) NK frequency. Markers of innate immune activation predict poor host response to IFN-α-based HCV therapy during HCV-HIV coinfection...
  13. pmc Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7288, USA
    Blood 113:5497-505. 2009
    ..Defective monocyte responses to IFNalpha/beta may play an important role in the pathogenesis of HIV-1 infection, and decreased IFNalpha/betaR expression may serve as a novel marker of disease progression...
  14. pmc Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells
    Hua Liang
    Department of Medicine, Division of Infectious and Rheumatic Diseases, Case Western Reserve University, Center for AIDS Research and VA Medical Center, Cleveland Ohio 44106, USA
    J Virol 83:5693-707. 2009
    ....
  15. pmc Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease
    Benigno Rodriguez
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    J Leukoc Biol 90:621-8. 2011
    ..These observations suggest that alterations in naïve T cell subset frequencies could contribute to naïve T cell dysfunction in HIV disease, but these alterations are not necessarily the result of chronic immune activation...
  16. pmc Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    Michael M Lederman
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 204:1217-26. 2011
    ..Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection...
  17. ncbi request reprint Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection
    Benigno Rodriguez
    Division of Infectious Diseases, Case Western Reserve University, Center foe AIDS Research, University Hospitals of Cleveland, Cleveland, Ohio, USA
    AIDS 20:1379-89. 2006
    ..To examine the effects of interferon-alpha (IFN-alpha) on T cell survival and activation in HIV infection...
  18. pmc Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
    Nicholas Funderburg
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 3:e1915. 2008
    ..Recently, heightened systemic translocation of microbial products was found in persons with chronic HIV infection and this was linked to immune activation and CD4(+) T cell homeostasis...
  19. ncbi request reprint Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement
    Scott F Sieg
    Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, Ohio 44106 4984, USA
    J Infect Dis 192:62-70. 2005
    ..Thus, in HIV infection, central memory T cells may be highly susceptible to bystander mechanisms of immune activation, leading to S-phase entry...
  20. pmc Plasma proteome analysis reveals overlapping, yet distinct mechanisms of immune activation in chronic HCV and HIV infections
    Daniela M Schlatzer
    Center for Proteomics and Bioinformatics Divisions of Infectious and Rheumatic Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH and Veterans Administration Medical Center, Center for AIDS Research, University Hospitals of Cleveland, Cleveland, OH
    J Acquir Immune Defic Syndr 63:563-71. 2013
    ..Although mechanisms underlying these interactions are not well known, soluble and cellular markers of immune activation associate with disease progression during both infections...
  21. pmc Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    J Virol 82:7837-45. 2008
    ..Impaired responsiveness to TLR9 agonists may contribute to defects in humoral immunity in HIV infection...
  22. pmc Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome
    Nicholas T Funderburg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Blood 120:4599-608. 2012
    ..Therefore, drivers of immune activation and inflammation in HIV-1 disease may alter monocyte subpopulations and activation phenotype, contributing to a pro-atherothrombotic state that may drive cardiovascular risk in HIV-1 infection...
  23. pmc Bacterial colonization and beta defensins in the female genital tract in HIV infection
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, 2109 Adelbert Rd, CWRU BRB1048B, 4984, Cleveland, OH 44106, USA
    Curr HIV Res 10:504-12. 2012
    ..These results suggest that HIV infection is associated with impaired regulation of innate defenses at mucosal sites...
  24. pmc HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease
    Carey L Shive
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 61:145-52. 2012
    ..This study was designed to explore the relationship between HIV-1 replication and IL-6 induction...
  25. pmc Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
    Maura Manion
    Division of Infectious Diseases, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 7:e30306. 2012
    ..In HIV infection, type I interferons may delay disease progression by inhibiting viral replication while at the same time accelerating disease progression by contributing to chronic immune activation...
  26. ncbi request reprint TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 4984, USA
    Eur J Immunol 37:2205-13. 2007
    ..We propose that the activation and expansion of naïve B cells induced by TLR9 agonists could enhance the potential of these cells to interact with cognate antigens and facilitate cell-mediated immune responses...
  27. pmc African ancestry influences CCR5 -2459G>A genotype-associated virologic success of highly active antiretroviral therapy
    Vinay K Cheruvu
    Department of Biostatistics, Environmental Health Sciences, and Epidemiology, College of Public Health, Kent State University, Kent, OH Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH Department of Biological Sciences, Case Western Reserve University School of Dental Medicine, Cleveland, OH Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, OH and Department of Medicine, Division of Infectious Diseases and HIV Medicine, Case Western Reserve University School of Medicine, Cleveland, OH Dr Richard J Jurevic, DDS, PhD, is now with the Department of Oral Diagnostics, School of Dentistry, West Virginia University, Morgantown, WV
    J Acquir Immune Defic Syndr 66:102-7. 2014
    ....
  28. pmc Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine care
    Robert C Kalayjian
    Metro Health Medical Center, Cleveland, Ohio, USA
    AIDS 26:1907-15. 2012
    ....
  29. pmc Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression
    Elizabeth Mayne
    National Health Laboratory Services and University of Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 59:340-6. 2012
    ..In this study, we explore the activation state of platelets in HIV disease...
  30. pmc Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success
    Rajeev K Mehlotra
    Center for Global Health and Diseases and Diseases, Wolstein Research Bldg, Room 4204, 2103 Cornell Rd, Cleveland, OH 44106 7286, USA
    J Infect Dis 204:291-8. 2011
    ..In patients receiving highly active antiretroviral therapy (HAART), antiretroviral drug-metabolizing enzyme and transporter gene polymorphisms, as well as chemokine receptor gene polymorphisms, may influence response to treatment...
  31. ncbi request reprint Plasma levels of B-lymphocyte stimulator increase with HIV disease progression
    Benigno Rodriguez
    University Hospitals of Cleveland, Cleveland, OH, USA
    AIDS 17:1983-5. 2003
    ..Moreover, BLyS levels increased exponentially below 100 CD4 cells/microl. BLyS and globulin levels increase as HIV dis ease progresses, suggesting a role for BLyS in the hypergammaglobulinemia of HIV infection...
  32. pmc Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and production
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Virol 79:4109-19. 2005
    ..Application of CpG ODNs in HIV disease for adjuvant or immunoregulatory purposes may be particularly useful for HIV+ donors without high-level viremia...
  33. pmc Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection
    Julia M Sugalski
    Department of Medicine, Case Western Reserve University Center for AIDS Research and VA Medical Center, Cleveland, OH 44106, USA
    J Immunol 185:3019-27. 2010
    ....
  34. ncbi request reprint Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138
    Michael M Lederman
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Infect Dis 194:1677-85. 2006
    ..Although the determinants of immune deficiency and immune restoration in chronic human immunodeficiency virus (HIV)-1 infection are not well understood, immune activation has been proposed as being central to the pathogenesis of HIV...
  35. pmc Effect of Nadir CD4+ T cell count on clinical measures of periodontal disease in HIV+ adults before and during immune reconstitution on HAART
    LANCE T VERNON
    Department of Biological Sciences, Case Western Reserve University School of Dental Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 8:e76986. 2013
    ..The contribution of HIV-infection to periodontal disease (PD) is poorly understood. We proposed that immunological markers would be associated with improved clinical measures of PD...
  36. ncbi request reprint Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients
    Benigno Rodriguez
    University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, Ohio 44106, USA
    J Infect Dis 187:504-7. 2003
    ..This association was found to be independent of baseline CD4 cell count and plasma HIV RNA, which indicates that an association exists between GBV-C infection and response to HAART...
  37. pmc Genetically associated CD16(+)56(-) natural killer cell interferon (IFN)-αR expression regulates signaling and is implicated in IFN-α-induced hepatitis C virus decline
    Sara J Conry
    Department of Medicine, Division of Infectious Diseases, University Hospital Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 205:1131-41. 2012
    ..We previously observed IFN-αR and NKp30 expression associated with IFN-α-dependent NK cell activity...
  38. pmc Factors Associated With Delayed Hepatitis B Viral Suppression on Tenofovir Among Patients Coinfected With HBV-HIV in the CNICS Cohort
    H Nina Kim
    Department of Medicine, University of Washington, Seattle, WA Departments of Medicine, Epidemiology, University of North Carolina, Chapel Hill, NC Department of Medicine, Johns Hopkins University, Baltimore, MD Department of Medicine, University of Alabama, Birmingham, AL University of California, San Francisco, San Francisco, CA Department of Medicine, Case Western Reserve University, Cleveland, OH Department of Medicine, University of California, San Diego, La Jolla, CA and Department of Medicine, Harvard University and Fenway Community Health, Boston, MA
    J Acquir Immune Defic Syndr 66:96-101. 2014
    ..We examined the effect of prior lamivudine (3TC) treatment and other factors on HBV DNA suppression with TDF in a multisite clinical cohort of coinfected patients...
  39. pmc Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes
    Joseph C Mudd
    Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University UniversityHospitals Case Medical Center, Cleveland, OH 44106, USA
    Blood 121:2914-22. 2013
    ..Impairment in T-cell egress from lymph nodes through decreased S1P responsiveness may contribute to HIV-1-associated LN enlargement and to immune dysregulation in a key organ of immune homeostasis...
  40. pmc Determinants of protection among HIV‐exposed seronegative persons: an overview
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Infect Dis 202:S333-8. 2010
    ....
  41. pmc Persistent replication of human immunodeficiency virus type 1 despite treatment of pulmonary tuberculosis in dually infected subjects
    Harriet Mayanja Kizza
    Case Western Reserve University, Department of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44106 4984, USA
    Clin Diagn Lab Immunol 12:1298-304. 2005
    ..Concurrent institution of highly active antiretroviral treatment needs to be evaluated in patients dually infected with pulmonary TB and HIV-1...
  42. pmc A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults
    LANCE T VERNON
    Case Western Reserve University School of Dental Medicine, Department of Biological Sciences, Cleveland, Ohio 44106 4905, USA
    AIDS Res Hum Retroviruses 27:1157-66. 2011
    ..In the context of HIV infection, PD may contribute to CVD risk. Intervention studies treating PD may help clarify this association...
  43. pmc Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229
    Grace A McComsey
    Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    AIDS 24:2507-15. 2010
    ..Lipoatrophy is prevalent on thymidine nucleoside reverse transcriptase inhibitors (tNRTIs). A pilot trial showed that uridine (NucleomaxX) increased limb fat...
  44. ncbi request reprint HIV coinfection impairs CD28-mediated costimulation of hepatitis C virus-specific CD8 cells
    Nicole L Yonkers
    Department of Medicine, Cleveland Veterans Administration Medical Center, Center for AIDS Research and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    J Infect Dis 194:391-400. 2006
    ..However, it is unclear whether reduced CD28 expression affects immune responses to non-HIV antigens, potentially contributing to susceptibility to opportunistic infection...
  45. ncbi request reprint Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    Michael M Lederman
    Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA
    Science 306:485-7. 2004
    ..These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention...
  46. pmc Dynamics of Immune Reconstitution and Activation Markers in HIV+ Treatment-Naïve Patients Treated with Raltegravir, Tenofovir Disoproxil Fumarate and Emtricitabine
    Nicholas T Funderburg
    Case Western Reserve University, Division of Infectious Diseases and HIV Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 8:e83514. 2013
    ..The dynamics of CD4+ T cell reconstitution and changes in immune activation and inflammation in HIV-1 disease following initiation of antiretroviral therapy (ART) are incompletely defined and their underlying mechanisms poorly understood...
  47. pmc Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection
    Nicole L Yonkers
    Department of Pathology, Division of Infectious and Rheumatic Diseases, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Infect Dis 203:635-45. 2011
    ..In addition, chronically HCV-infected individuals have reduced response to vaccine. Alterations in naive CD4 T cell phenotype or function may contribute to these immune impairments...
  48. ncbi request reprint Monitoring clinical trials of therapeutic vaccines in HIV infection: role of treatment interruption
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    Curr Opin HIV AIDS 2:56-61. 2007
    ....
  49. doi request reprint Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations
    Rebekah L Benish
    Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Infect Genet Evol 10:60-7. 2010
    ....
  50. pmc Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of antiretro
    Jan Weber
    Diagnostic Hybrids, Inc, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:3729-42. 2011
    ....