T Radivoyevitch

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Sex differences in the incidence of chronic myeloid leukemia
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA
    Radiat Environ Biophys 53:55-63. 2014
  2. pmc Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Transl Med 10:79. 2012
  3. pmc On model ensemble analyses of nonmonotonic data
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nucleosides Nucleotides Nucleic Acids 31:147-56. 2012
  4. pmc A mathematical model of human thymidine kinase 2 activity
    T Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nucleosides Nucleotides Nucleic Acids 30:203-9. 2011
  5. pmc How to use the computing environment R to analyze ATP-induced ribonucleotide reductase R1 hexamerization data
    T Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nucleosides Nucleotides Nucleic Acids 29:427-32. 2010
  6. pmc Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: an analysis of ATP-induced ribonucleotide reductase R1 hexamerization data
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biol Direct 4:50. 2009
  7. pmc Mass action models versus the Hill model: an analysis of tetrameric human thymidine kinase 1 positive cooperativity
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biol Direct 4:49. 2009
  8. pmc Equilibrium model selection: dTTP induced R1 dimerization
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    BMC Syst Biol 2:15. 2008
  9. ncbi request reprint Novel Phase I dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416
    Afshin Dowlati
    Developmental Therapeutics Program, Case Comprehensive Cancer Center, Department of Pathology and Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Clin Cancer Res 11:7938-44. 2005
  10. pmc Rational polynomial representation of ribonucleotide reductase activity
    Tomas Radivoyevitch
    Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Biochem 6:8. 2005

Collaborators

Detail Information

Publications16

  1. pmc Sex differences in the incidence of chronic myeloid leukemia
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA
    Radiat Environ Biophys 53:55-63. 2014
    ..Comprehensive mathematical models of CML could lead to a better understanding of the role of HSCs in CML and other preleukemias that can progress to acute leukemia...
  2. pmc Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Transl Med 10:79. 2012
    ..The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer...
  3. pmc On model ensemble analyses of nonmonotonic data
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nucleosides Nucleotides Nucleic Acids 31:147-56. 2012
    ..We use this approach to show that troughs in RNR activity versus ATP can be fitted similarly well by models that do or do not demand a third ATP binding site...
  4. pmc A mathematical model of human thymidine kinase 2 activity
    T Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nucleosides Nucleotides Nucleic Acids 30:203-9. 2011
    ..TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium...
  5. pmc How to use the computing environment R to analyze ATP-induced ribonucleotide reductase R1 hexamerization data
    T Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nucleosides Nucleotides Nucleic Acids 29:427-32. 2010
    ..This example involves ATP-induced R1 hexamerization dynamic light scattering data that suggests that R1 hexamers have two types of a-sites, one that binds ATP and another that does not (here, R1 is the large subunit of RNR)...
  6. pmc Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: an analysis of ATP-induced ribonucleotide reductase R1 hexamerization data
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biol Direct 4:50. 2009
    ..Trillions of RNR complexes are possible as a result. The problem is to determine which are needed in models to explain available data. This problem is intractable for 10 reactants, but it can be solved for 2 and is here for R1 and ATP...
  7. pmc Mass action models versus the Hill model: an analysis of tetrameric human thymidine kinase 1 positive cooperativity
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biol Direct 4:49. 2009
    ..In contrast, models based on the equilibrium concept of mass action can suggest mechanisms of cooperativity, but there are often many such models and often many with too many parameters...
  8. pmc Equilibrium model selection: dTTP induced R1 dimerization
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    BMC Syst Biol 2:15. 2008
    ..An alternative is to first generate a comprehensive standardized list of plausible models, and to then fit them exhaustively, or semi-exhaustively...
  9. ncbi request reprint Novel Phase I dose de-escalation design trial to determine the biological modulatory dose of the antiangiogenic agent SU5416
    Afshin Dowlati
    Developmental Therapeutics Program, Case Comprehensive Cancer Center, Department of Pathology and Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Clin Cancer Res 11:7938-44. 2005
    ..If such an effect was shown, dose de-escalation to a predefined dose level would occur to determine if the lower dose exhibited the same amount of pharmacodynamic effect as the higher dose...
  10. pmc Rational polynomial representation of ribonucleotide reductase activity
    Tomas Radivoyevitch
    Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Biochem 6:8. 2005
    ....
  11. pmc On systems and control approaches to therapeutic gain
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Cancer 6:104. 2006
    ..Mathematical models of cancer relevant processes are being developed at an increasing rate. Conceptual frameworks are needed to support new treatment designs based on such models...
  12. pmc Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
    Charles A Kunos
    Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Radiat Res 174:574-81. 2010
    ..We conclude that blockage of RNR activity by 3-AP impairs DNA damage responses that rely on deoxyribonucleotide production and thereby may substantially increase chemoradiosensitivity of human cervical cancers...
  13. pmc Folate system correlations in DNA microarray data
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Cancer 5:95. 2005
    ..Pathway specific analyses of gene-gene correlations across these datasets remain relatively unexplored, though they could be informative...
  14. pmc A two-way interface between limited Systems Biology Markup Language and R
    Tomas Radivoyevitch
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Bioinformatics 5:190. 2004
    ..An interface between SBML and R does not exist, though one might be useful to R users interested in SBML, and SBML users interested in R...
  15. ncbi request reprint A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia
    Brenda W Cooper
    Department of Medicine, University Hospitals of Cleveland, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Clin Cancer Res 10:6830-9. 2004
    ..A novel regimen designed to maximize antileukemia activity of carboplatin through inhibiting repair of platinum-DNA adducts was conducted in poor prognosis, acute leukemia patients...
  16. ncbi request reprint Inflammatory breast cancer as a model disease to study tumor angiogenesis: results of a phase IB trial of combination SU5416 and doxorubicin
    Beth Overmoyer
    Connecticut Oncology and Hematology Associates US Oncology, Torrington, Connecticut 06790, USA
    Clin Cancer Res 13:5862-8. 2007
    ..We used inflammatory breast cancer (IBC) as a model disease to investigate biological changes associated with an antiangiogenesis agent, SU5416, combined with doxorubicin...