Cheng Kui Qu

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder
    Dan Xu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 8:e63152. 2013
  2. pmc Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells
    Dan Xu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, and Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    J Exp Med 208:1977-88. 2011
  3. pmc Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies
    Bing Yu
    Corresponding Author Cheng Kui Qu, Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave, Wolstein Bldg, Rm 2 126, Cleveland, OH 44106
    Mol Cancer Ther 12:1738-48. 2013
  4. pmc Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft
    Olgun Guvench
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, HSF II 629, Baltimore, MD 21201, USA
    BMC Struct Biol 7:14. 2007
  5. pmc A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells
    Dan Xu
    Department of Medicine, Division of Hematology Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 116:3611-21. 2010
  6. pmc Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation
    Wen Mei Yu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Stem Cell 12:62-74. 2013
  7. ncbi request reprint SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively
    Liangping Yuan
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:42701-6. 2005
  8. pmc A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells
    Jinhua Shen
    Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 31:4902-16. 2011
  9. ncbi request reprint Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling
    Wen Mei Yu
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 281:5426-34. 2006
  10. pmc Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence
    Hong Zheng
    Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 288:25727-38. 2013

Collaborators

Detail Information

Publications26

  1. pmc Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder
    Dan Xu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 8:e63152. 2013
    ..This study provides new insights into the pathogenic effects of GOF mutations of Ptpn11 and implies that antioxidants may have a therapeutic benefit for the leukemic patients with these mutations...
  2. pmc Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells
    Dan Xu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, and Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    J Exp Med 208:1977-88. 2011
    ..Thus, Ptpn11(E76K) mutation has non-lineage-specific effects on malignant transformation of hematopoietic cells and initiates acute leukemias at various stages of hematopoiesis...
  3. pmc Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies
    Bing Yu
    Corresponding Author Cheng Kui Qu, Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave, Wolstein Bldg, Rm 2 126, Cleveland, OH 44106
    Mol Cancer Ther 12:1738-48. 2013
    ..As the small-molecule SHP2 inhibitor identified has a simple chemical structure, it represents an ideal lead compound for the development of novel anti-SHP2 drugs. Mol Cancer Ther; 12(9); 1738-48. ©2013 AACR. ..
  4. pmc Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft
    Olgun Guvench
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, HSF II 629, Baltimore, MD 21201, USA
    BMC Struct Biol 7:14. 2007
    ..To better characterize the molecular process involved in N-SH2 pY-dependent binding, we have applied explicit-solvent molecular dynamics simulations to study the closed-to-open transition of the N-SH2 pY-peptide binding cleft...
  5. pmc A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells
    Dan Xu
    Department of Medicine, Division of Hematology Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 116:3611-21. 2010
    ..Collectively, our data suggest that oncogenic Ptpn11 induces MPD by aberrant activation of HSCs. This study also identifies Gab2 as an important mediator for the pathogenic effects of Ptpn11 mutations...
  6. pmc Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation
    Wen Mei Yu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Stem Cell 12:62-74. 2013
    ..This study establishes a crucial role of PTPMT1 in the metabolic regulation of HSC function...
  7. ncbi request reprint SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively
    Liangping Yuan
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:42701-6. 2005
    ..Collectively, these studies have further defined the mechanisms by which SHP-2 phosphatase regulates DNA damage responses...
  8. pmc A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells
    Jinhua Shen
    Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 31:4902-16. 2011
    ..These studies, while establishing a crucial role for Ptpmt1 phosphatase in embryogenesis, reveal a mitochondrial metabolic stress-activated checkpoint in the control of ES cell differentiation...
  9. ncbi request reprint Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling
    Wen Mei Yu
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 281:5426-34. 2006
    ....
  10. pmc Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence
    Hong Zheng
    Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 288:25727-38. 2013
    ..This study provides novel insights into the initial effects of tumor-associated Ptpn11 mutations. ..
  11. pmc Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability
    Xia Liu
    Division of Hematology Oncology, Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cancer Res 72:5296-306. 2012
    ..Together, our findings show a previously unrecognized role for Shp2 in the maintenance of chromosome stability and suggest a new mechanism by which dysregulation of Shp2 signaling contributes to malignancy development...
  12. doi request reprint Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11)
    Wei Liu
    Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States
    J Med Chem 56:7212-21. 2013
    ..Since cryptotanshinone is used to treat cardiovascular diseases in Asian countries, this drug has a potential to be used directly or to be further developed to treat PTPN11-associated malignancies. ..
  13. pmc Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay
    Wen Mei Yu
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Med Chem 51:7396-404. 2008
    ..Because of their simple chemical structures, these small organic compounds have the potential to act as lead compounds for the development of novel anti-SHP-2 drugs...
  14. pmc SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl
    Jing Chen
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Blood 109:778-85. 2007
    ..These studies identified a novel function of SHP-2 and suggest that SHP-2 might be a useful target for controlling Bcr-Abl-positive leukemias...
  15. pmc Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis
    Siying Wang
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 284:913-20. 2009
    ..Collectively, these studies reaffirm the positive role of SHP-2 phosphatase in cell motility and suggest a new mechanism by which SHP-2 GOF mutations contribute to diseases...
  16. pmc SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG
    A R M Ruhul Amin
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:5419-24. 2007
    ..Our results have identified SHP-2 as a negative regulator of EGCG-induced-apoptosis and have identified a subset of p53 target genes whose expression is paradoxically not mediated by p53 but by one of its family members, p73...
  17. doi request reprint In vitro hematopoietic differentiation of murine embryonic stem cells
    Jinhua Shen
    Department of Medicine, Division of Hematology Oncology, Center for Stem Cell and Regenerative Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 430:103-18. 2008
    ....
  18. pmc Metabolic plasticity and hematopoietic stem cell biology
    Peter Hsu
    Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Opin Hematol 20:289-94. 2013
    ..Emerging evidence has revealed that metabolism and bioenergetics play important roles in determining stem cell fate in concert with other regulatory networks. In this review, we will discuss recent advances in this field...
  19. pmc SHP-2 tyrosine phosphatase in human diseases
    Hong Zheng
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University Cleveland, OH 44106, USA
    Int J Clin Exp Med 2:17-25. 2009
    ..In light of this hint given by nature, new cell and animal models now provide the opportunity to uncover how this molecule functions in multiple cellular processes, and more importantly, how its known mutations induce human diseases...
  20. pmc Abnormal hematopoiesis in Gab2 mutant mice
    Yi Zhang
    Department of Medicine, Division of Hematology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 7284, USA
    Blood 110:116-24. 2007
    ..Therefore, we demonstrate that Gab2 adapter function is intrinsically required for hematopoietic cell response to early-acting cytokines, resulting in defective hematopoiesis in Gab2-deficient mice...
  21. pmc Protein tyrosine phosphatases in the JAK/STAT pathway
    Dan Xu
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Front Biosci 13:4925-32. 2008
    ..Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway...
  22. pmc Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis
    Jinhua Shen
    Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Nat Cell Biol 11:769-76. 2009
    ..These studies provide the first evidence that finely controlled PtdInsP levels in muscle cells are essential for maintaining Ca(2+) homeostasis and muscle performance...
  23. pmc Chromosomal instability in in vitro cultured mouse hematopoietic cells associated with oxidative stress
    Alice M Liu
    Department of Medicine, Division of Hematology Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University Cleveland, OH, USA
    Am J Blood Res 2:71-6. 2012
    ..Because hematopoietic cells are commonly processed in laboratory settings before transplantation for patient treatment, our findings also raise a concern on the therapeutic use of cultured hematopoietic cells...
  24. pmc Molecular targets for the treatment of juvenile myelomonocytic leukemia
    Xiaoling Liu
    Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Adv Hematol 2012:308252. 2012
    ..However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field...
  25. pmc Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis
    Xia Liu
    Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Signal Transduct 2011:195239. 2011
    ....
  26. pmc Complex systems biology approach to understanding coordination of JAK-STAT signaling
    Radina P Soebiyanto
    Case Complex Systems Biology Center, Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA
    Biosystems 90:830-42. 2007
    ..The coordinator identified is also being investigated to determine its relationship to pathological conditions...

Research Grants11

  1. Tyrosine Phosphatases and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2002
    ..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
  2. Protein Tyrosine Phosphatase and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2010
    ..The information gathered will provide a molecular basis for a future rational design of new therapeutics that specifically target SHP-2 for treatment of related leukemias. ..
  3. Protein Tyrosine Phosphatase and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2009
    ..The information gathered will provide a molecular basis for a future rational design of new therapeutics that specifically target SHP-2 for treatment of related leukemias. ..
  4. Tyrosine Phosphatases and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2007
    ..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
  5. SHP-2 Inhibitors as Potential Therapeutic Agents for JMML and Noonan Syndrome
    Cheng Kui Qu; Fiscal Year: 2007
    ..It is anticipated that this study will identify selective and effective SHP-2 inhibitors that can be used as lead compounds for the development of novel therapeutic agents for SHP-2-associated diseases, such as JMML and Noonan syndrome. ..
  6. Tyrosine Phosphatases and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2005
    ..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
  7. Tyrosine Phosphatases and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2004
    ..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
  8. Tyrosine Phosphatases and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2003
    ..The results of these experiments should yield new insights into the intracellular signaling regulation of hematopoiesis, which may lead to novel therapeutic approaches for certain blood disorders. ..
  9. Protein Tyrosine Phosphatase and Hematopoietic Cell Regulation
    Cheng Kui Qu; Fiscal Year: 2011
    ..The information gathered will provide a molecular basis for a future rational design of new therapeutics that specifically target SHP-2 for treatment of related leukemias. ..