Nanduri R Prabhakar

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
    Anita Pawar
    Center for Systems Biology, Department of Medicine, The University of Chicago, 5841 S Maryland MC, Chicago, IL 60637, USA
    J Appl Physiol (1985) 104:1287-94. 2008
  2. ncbi request reprint Endogenous carbon monoxide in control of respiration
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Respir Physiol 114:57-64. 1998
  3. ncbi request reprint Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Exp Pharmacol Physiol 32:447-9. 2005
  4. ncbi request reprint Peripheral chemoreceptors in health and disease
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol (1985) 96:359-66. 2004
  5. ncbi request reprint Ventilatory changes during intermittent hypoxia: importance of pattern and duration
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, OH, 44106, USA
    High Alt Med Biol 3:195-204. 2002
  6. ncbi request reprint Oxidative stress in the systemic and cellular responses to intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    Biol Chem 385:217-21. 2004
  7. ncbi request reprint Intermittent hypoxia: cell to system
    N R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol Lung Cell Mol Physiol 281:L524-8. 2001
  8. ncbi request reprint Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol (1985) 90:1986-94. 2001
  9. ncbi request reprint Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Respir Physiol 122:209-21. 2000
  10. ncbi request reprint Oxygen sensing by the carotid body chemoreceptors
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol (1985) 88:2287-95. 2000

Collaborators

Detail Information

Publications48

  1. pmc Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
    Anita Pawar
    Center for Systems Biology, Department of Medicine, The University of Chicago, 5841 S Maryland MC, Chicago, IL 60637, USA
    J Appl Physiol (1985) 104:1287-94. 2008
    ....
  2. ncbi request reprint Endogenous carbon monoxide in control of respiration
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Respir Physiol 114:57-64. 1998
    ..Many of the neuronal structures that express HO also contain NOS, the enzyme that generates NO. Much remains to be studied on regulatory interactions between CO and NO and their impact on breathing...
  3. ncbi request reprint Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Exp Pharmacol Physiol 32:447-9. 2005
    ..Bilateral sectioning of the sinus nerves abolished these responses, suggesting chronic IH-induced alterations in carotid body sensitivity contribute to LTF in SNA and the subsequent cardiovascular alterations...
  4. ncbi request reprint Peripheral chemoreceptors in health and disease
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol (1985) 96:359-66. 2004
    ..Experimental models of recurrent apneas, congestive heart failure, and hypertension offer excellent opportunities to unravel the cellular mechanisms associated with altered chemoreceptor function...
  5. ncbi request reprint Ventilatory changes during intermittent hypoxia: importance of pattern and duration
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, OH, 44106, USA
    High Alt Med Biol 3:195-204. 2002
    ..Future studies are needed to identify the molecular and cellular signaling pathways associated with intermittent hypoxia and their impact on ventilatory control during hypoxia and hypercapnia...
  6. ncbi request reprint Oxidative stress in the systemic and cellular responses to intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    Biol Chem 385:217-21. 2004
    ....
  7. ncbi request reprint Intermittent hypoxia: cell to system
    N R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol Lung Cell Mol Physiol 281:L524-8. 2001
    ..Chronic intermittent hypoxia leads to sustained elevation in arterial blood pressure and is associated with upregulation of catecholaminergic and renin-angiotensin systems and downregulation of nitric oxide synthases...
  8. ncbi request reprint Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol (1985) 90:1986-94. 2001
    ....
  9. ncbi request reprint Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4970, USA
    Respir Physiol 122:209-21. 2000
    ..Most importantly, it is possible that the carotid body response to oxygen requires multiple sensors, and they work together to shape the overall sensory response of the carotid body over a wide range of arterial oxygen tensions...
  10. ncbi request reprint Oxygen sensing by the carotid body chemoreceptors
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol (1985) 88:2287-95. 2000
    ..Further studies are necessary to identify whether a single sensor or multiple oxygen sensors are needed for the transduction process...
  11. ncbi request reprint NO and CO as second messengers in oxygen sensing in the carotid body
    N R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Respir Physiol 115:161-8. 1999
    ..Under normoxia, basal levels of NO and CO act as amplifiers of molecular oxygen and keep the sensory discharge low. During hypoxia, decreased synthesis of NO and CO may contribute in part to the augmentation of sensory discharge...
  12. ncbi request reprint Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    High Alt Med Biol 6:112-20. 2005
    ....
  13. pmc Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    Ying Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44109, USA
    J Physiol 577:705-16. 2006
    ....
  14. ncbi request reprint Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration
    David D Kline
    Rammelkamp Center for Education and Research, MetroHealth Medical System, Cleveland, Ohio 44109 1998, USA
    J Neurosci 25:3389-99. 2005
    ..These results demonstrate the important role of Kv1.1 in afferent chemosensory activity and suggest that mutations in the human Kv1.1 gene have functional consequences during stress responses that involve respiratory reflexes...
  15. pmc Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells
    Guoxiang Yuan
    Department of Physiology, Case Western Reserve, University, Cleveland, OH 44106, USA
    J Physiol 557:773-83. 2004
    ..These results suggest IH-induced c-fos-mediated transcriptional activation involves oxidative stress...
  16. ncbi request reprint Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    Guoxiang Yuan
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:4321-8. 2005
    ..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase...
  17. pmc 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase
    Ying Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44019, USA
    J Physiol 576:289-95. 2006
    ....
  18. ncbi request reprint Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling
    Hong Wang
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Neurochem 96:694-705. 2006
    ..These data indicate that oxidative stress can stimulate BDNF release through an autocrine or paracrine loop that requires dopamine receptor activation...
  19. ncbi request reprint Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B
    Mohammad T Malik
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 145:23-31. 2005
    ..These results suggest that the fos B, an immediate early gene, plays an important role in ventilatory acclimatization to hypoxia in mice...
  20. ncbi request reprint Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction
    Yingjie Peng
    School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Adv Exp Med Biol 536:559-64. 2003
  21. ncbi request reprint Detection of oxygen sensing during intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Methods Enzymol 381:107-20. 2004
  22. ncbi request reprint Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44109, USA
    Exp Physiol 92:39-44. 2007
    ....
  23. ncbi request reprint Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia
    Ying Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol 94:2342-9. 2003
    ....
  24. ncbi request reprint Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species
    Dong Kyu Kim
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol 96:1206-15; discussion 1196. 2004
    ..Our findings also suggest that oxidative stress plays a central role in IH-induced augmentation of transmitter release from PC12 cells during acute hypoxia...
  25. ncbi request reprint Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body
    Dong Kyu Kim
    School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Adv Exp Med Biol 536:291-6. 2003
  26. ncbi request reprint O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 1090 Euclid Avenue, Cleveland, OH 44019, USA
    Exp Physiol 91:17-23. 2006
    ..Further studies are needed to test the interactions between putative O2 sensors and excitatory and inhibitory transmitters in the carotid body...
  27. pmc Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    J Physiol 575:229-39. 2006
    ....
  28. pmc Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing
    David D Kline
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Physiol 539:309-15. 2002
    ..These results suggest endogenous NO is an important physiological modulator of ventilatory STP and LTF...
  29. pmc Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha
    David D Kline
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:821-6. 2002
    ..Thus partial HIF-1 alpha deficiency has a dramatic effect on carotid body neural activity and ventilatory adaptation to chronic hypoxia...
  30. ncbi request reprint Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors
    Dong Kyu Kim
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol (1985) 96:376-83. 2004
    ..These results demonstrate that glomus cells of the rabbit carotid body express ACh and that hypoxia overall inhibits ACh release via activation of muscarinic and dopaminergic autoinhibitory receptors in the carotid body...
  31. ncbi request reprint Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups
    Ying Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Appl Physiol 97:2020-5. 2004
    ..These results demonstrate that neonatal IH facilitates carotid body sensory response to hypoxia and augments hypoxic ventilatory chemoreflex...
  32. ncbi request reprint Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 157:148-53. 2007
    ....
  33. ncbi request reprint Reactive oxygen species facilitate oxygen sensing
    Nanduri R Prabhakar
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Novartis Found Symp 272:95-9; discussion 100-5, 131-40. 2006
    ..These observations suggest that chronic IH facilitates O2 sensing in the CB by mechanisms involving increased generation of ROS in the chemoreceptor tissue...
  34. pmc Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C
    Barbara A Kuri
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    J Physiol 584:313-9. 2007
    ....
  35. pmc Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas
    Ying Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 100:10073-8. 2003
    ..The sensory LTF may contribute to persistent reflex activation of sympathetic nerve activity and blood pressure in recurrent apnea patients experiencing CIH...
  36. ncbi request reprint CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells
    Beth A Summers
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurophysiol 88:604-12. 2002
    ..The effect of CO(2) is not secondary to changes in pH and seems to be mediated by a protein kinase A-dependent mechanism. Furthermore, hypercapnia and hypoxia act additively in stimulating Ca(2+) current in glomus cells...
  37. ncbi request reprint Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era
    Ganesh K Kumar
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 135:145-54. 2003
    ..The combined observations from the pre- and post-genomic era strongly support the involvement of SP and also other tachykinins in the control of respiration during hypoxia...
  38. pmc Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide
    Yu Long Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Physiol 555:219-29. 2004
    ..This effect is due mainly to the suppression of KCa channel activity caused by decreased availability of NO. In addition, intracellular cGMP is necessary for the KCa channel modulation by NO...
  39. ncbi request reprint Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation
    Ganesh K Kumar
    Department of Biochemistry, Western Reserve University, Cleveland, OH 44106 4935, USA
    J Appl Physiol (1985) 95:536-44. 2003
    ..Our results also suggest that IH-induced phosphorylation of TH facilitates the removal of endogenous inhibition of TH, leading to increased synthesis of dopamine...
  40. ncbi request reprint Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity
    Ying Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol 96:1236-42; discussion 1196. 2004
    ..These results demonstrate that SDIH but not LDIH results in selective augmentation of the hypoxic response of the carotid body and O(2)(-)* radicals play an important role in SDIH-induced sensitization of the carotid body...
  41. ncbi request reprint Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation
    Shingi Akada
    Department of Anesthesiology and Intensive Care Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Respir Physiol Neurobiol 160:284-8. 2008
    ....
  42. pmc Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
    Guoxiang Yuan
    The Center for Systems Biology, Department of Medicine, University of Chicago, Illinois 60637, USA
    J Cell Physiol 217:674-85. 2008
    ..Rapamycin or cycloheximide, blocked increased HIF-1alpha levels during re-oxygenation indicating that mTOR-dependent protein synthesis is required for the persistent elevation of HIF-1alpha levels during re-oxygenation...
  43. ncbi request reprint ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 9:1397-403. 2007
    ....
  44. ncbi request reprint Novel role for reactive oxygen species as amplifiers of intermittent hypoxia. Focus on "Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia"
    Nanduri R Prabhakar
    J Neurophysiol 97:1877. 2007
  45. ncbi request reprint Sleep apneas: an oxidative stress?
    Nanduri R Prabhakar
    Am J Respir Crit Care Med 165:859-60. 2002
  46. ncbi request reprint Regulation of breathing by tissue oxygen: evidence from mutant mice with Presbyterian hemoglobinopathy
    Nanduri R Prabhakar
    Am J Physiol Regul Integr Comp Physiol 285:R724. 2003
  47. doi request reprint Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein
    Jayasri Nanduri
    Center for Systems Biology, Department of Medicine, University of Chicago, 5841S Maryland Avenue, N603, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 373:309-14. 2008
    ..These results demonstrate that hypoxia enhances the production of ROS in the mitochondria, resulting in down-regulation of hERG translation and decreased hERG-mediated K+ conductance...
  48. ncbi request reprint HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:1391-6. 2007
    ....