John D Porter

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Exp Biol 206:3101-12. 2003
  2. ncbi request reprint The development of extraocular muscle calcium homeostasis parallels visuomotor system maturation
    J D Porter
    Departments of Ophthalmology, Neurology, and Neuroscience, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106 5068, USA
    Biochem Biophys Res Commun 257:678-83. 1999
  3. ncbi request reprint Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Mol Genet 12:1813-21. 2003
  4. ncbi request reprint Extraocular muscle is spared despite the absence of an intact sarcoglycan complex in gamma- or delta-sarcoglycan-deficient mice
    J D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5068, USA
    Neuromuscul Disord 11:197-207. 2001
  5. ncbi request reprint Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, Ohio 44106 5068, USA
    FASEB J 17:893-5. 2003
  6. pmc Extraocular muscle is defined by a fundamentally distinct gene expression profile
    J D Porter
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 98:12062-7. 2001
  7. ncbi request reprint A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
    Hum Mol Genet 11:263-72. 2002
  8. ncbi request reprint Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscle
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
    Neuromuscul Disord 13:223-35. 2003
  9. ncbi request reprint Extraocular muscle: cellular adaptations for a diverse functional repertoire
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106 5068, USA
    Ann N Y Acad Sci 956:7-16. 2002
  10. ncbi request reprint Conserved and muscle-group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotype
    Georgiana Cheng
    Department of Neurology, Cleveland, Ohio 44106, USA
    Physiol Genomics 18:184-95. 2004

Detail Information

Publications28

  1. ncbi request reprint Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Exp Biol 206:3101-12. 2003
    ....
  2. ncbi request reprint The development of extraocular muscle calcium homeostasis parallels visuomotor system maturation
    J D Porter
    Departments of Ophthalmology, Neurology, and Neuroscience, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106 5068, USA
    Biochem Biophys Res Commun 257:678-83. 1999
    ..Findings suggest that cation homeostasis in extraocular muscle may be susceptible to perturbations of the developing visual sensory system, as we have previously shown for myosin...
  3. ncbi request reprint Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Mol Genet 12:1813-21. 2003
    ....
  4. ncbi request reprint Extraocular muscle is spared despite the absence of an intact sarcoglycan complex in gamma- or delta-sarcoglycan-deficient mice
    J D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5068, USA
    Neuromuscul Disord 11:197-207. 2001
    ....
  5. ncbi request reprint Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, Ohio 44106 5068, USA
    FASEB J 17:893-5. 2003
    ....
  6. pmc Extraocular muscle is defined by a fundamentally distinct gene expression profile
    J D Porter
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 98:12062-7. 2001
    ..These patterned differences in gene expression define EOM as a distinct muscle class and may explain the unique response of these muscles in neuromuscular diseases...
  7. ncbi request reprint A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx mice
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
    Hum Mol Genet 11:263-72. 2002
    ..Taken together, these data identify a relatively neglected aspect of DMD, suggest new treatment avenues, and highlight the value of genome-wide profiling in study of complex disease processes...
  8. ncbi request reprint Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscle
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
    Neuromuscul Disord 13:223-35. 2003
    ..The chemokine pro-inflammatory pathways described here in mdx may represent new targets for treatment of Duchenne muscular dystrophy...
  9. ncbi request reprint Extraocular muscle: cellular adaptations for a diverse functional repertoire
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106 5068, USA
    Ann N Y Acad Sci 956:7-16. 2002
    ..This novel eye muscle phenotype represents an adaptation that exploits the full range of variability in skeletal muscle to meet the needs of visuomotor systems...
  10. ncbi request reprint Conserved and muscle-group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotype
    Georgiana Cheng
    Department of Neurology, Cleveland, Ohio 44106, USA
    Physiol Genomics 18:184-95. 2004
    ..This represents an important first step in dissecting allotype-specific regulatory mechanisms that may, in turn, explain differential muscle group sensitivity to a variety of metabolic and neuromuscular diseases...
  11. ncbi request reprint Temporal gene expression profiling of dystrophin-deficient (mdx) mouse diaphragm identifies conserved and muscle group-specific mechanisms in the pathogenesis of muscular dystrophy
    John D Porter
    Department of Neurology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Mol Genet 13:257-69. 2004
    ..We further suggest that muscle group-specific transcriptional profiles contribute toward the muscle targeting and sparing patterns observed for a variety of metabolic and neuromuscular diseases...
  12. ncbi request reprint Distinctive morphological and gene/protein expression signatures during myogenesis in novel cell lines from extraocular and hindlimb muscle
    John D Porter
    Department of Neurology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Physiol Genomics 24:264-75. 2006
    ..Taken together, these data show that myoblast lineage plays a significant role in the divergence of the distinctive muscle groups or allotypes...
  13. ncbi request reprint Temporal and spatial mRNA expression patterns of TGF-beta1, 2, 3 and TbetaRI, II, III in skeletal muscles of mdx mice
    Lan Zhou
    Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue S90, Cleveland, OH 44195, USA
    Neuromuscul Disord 16:32-8. 2006
    ..Our data support a regulatory role for TGF-beta1 in muscle inflammation in mdx mice. It also suggests different susceptibility of quadriceps and diaphragm muscles to fibrosis induced by TGF-beta1 signaling pathway...
  14. ncbi request reprint Paradoxical absence of M lines and downregulation of creatine kinase in mouse extraocular muscle
    Francisco H Andrade
    Department of Neurology, Case Western Reserve University, Cleveland, OH 44106 5040, USA
    J Appl Physiol 95:692-9. 2003
    ....
  15. ncbi request reprint Comprehensive evaluation of the extraocular muscle critical period by expression profiling in the dark-reared rat and monocularly deprived monkey
    Georgiana Cheng
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Invest Ophthalmol Vis Sci 44:3842-55. 2003
    ..To address the consequences of visual deprivation paradigms in rat (dark rearing) and monkey (monocular deprivation) on extraocular muscle (EOM) development using genome-wide expression profiling...
  16. ncbi request reprint Genome-wide transcriptional profiles are consistent with functional specialization of the extraocular muscle layers
    Sangeeta Khanna
    Department of Neurology, Case Western Reserve University, University Hospistals of Cleveland, Ohio 44106 5040, USA
    Invest Ophthalmol Vis Sci 45:3055-66. 2004
    ..Microarray technology was used to identify muscle-layer-specific transcriptional profiles and, thereby, extend understanding of the structure-function characteristics of extraocular muscle layers...
  17. ncbi request reprint Comprehensive expression profiling by muscle tissue class and identification of the molecular niche of extraocular muscle
    Sangeeta Khanna
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
    FASEB J 17:1370-2. 2003
    ..These, and additional proteomic data, establish that extraocular muscle does not constitute a distinctive muscle class but that it does occupy a novel niche within the skeletal muscle class...
  18. ncbi request reprint Molecular organization of the extraocular muscle neuromuscular junction: partial conservation of and divergence from the skeletal muscle prototype
    Sangeeta Khanna
    Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106 5068, USA
    Invest Ophthalmol Vis Sci 44:1918-26. 2003
    ....
  19. ncbi request reprint The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin
    J D Porter
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106 5068, USA
    J Cell Sci 111:1801-11. 1998
    ..Moreover, data lend support to the hypothesis that interventions designed to increase utrophin levels may ameliorate the pathology in other skeletal muscles in Duchenne muscular dystrophy...
  20. ncbi request reprint FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells
    Luis A Solchaga
    Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Cell Physiol 203:398-409. 2005
    ..With the generation of gene expression profiles of FGF-treated and control cells we have taken the first steps in the elucidation of the molecular mechanism(s) behind these phenomena...
  21. ncbi request reprint Transcriptional profile of rat extraocular muscle by serial analysis of gene expression
    Georgiana Cheng
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106 5068, USA
    Invest Ophthalmol Vis Sci 43:1048-58. 2002
    ..Although extraocular muscle (EOM) is skeletal muscle, aspects of its biology are unlike other striated muscle. In this study, the broad molecular genetics profile underlying the novel EOM phenotype was examined...
  22. ncbi request reprint Evidence for rectus extraocular muscle pulleys in rodents
    S Khanna
    Department of Ophthalmology, The Research Institute of University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106 5068, USA
    Invest Ophthalmol Vis Sci 42:1986-92. 2001
    ....
  23. ncbi request reprint Eye muscle sparing by the muscular dystrophies: lessons to be learned?
    F H Andrade
    Departments of Neurology, Case Western Reserve University, University Hospitals of Cleveland, and Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Microsc Res Tech 48:192-203. 2000
    ....
  24. ncbi request reprint Extraocular muscle gene expression and function after dark rearing
    Francisco H Andrade
    Departments of Neurology and Ophthalmology, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    Ann N Y Acad Sci 956:391-3. 2002
  25. ncbi request reprint Conservation of synapse-signaling pathways at the extraocular muscle neuromuscular junction
    Sangeeta Khanna
    Department of Ophthalmology, Case Western Reserve University, and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    Ann N Y Acad Sci 956:394-6. 2002
  26. ncbi request reprint The development of longitudinal variation of Myosin isoforms in the orbital fibers of extraocular muscles of rats
    Neal A Rubinstein
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
    Invest Ophthalmol Vis Sci 45:3067-72. 2004
    ..To examine the appearance of longitudinal variation of extraocular and embryonic myosin heavy chain (MyHC) isoforms during the development of orbital singly innervated fibers of rat extraocular muscles (EOMs)...
  27. ncbi request reprint Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb muscles
    Patrick E Baker
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA
    Neurogenetics 7:81-91. 2006
    ..This data suggests that at least part of the fiber-type abnormality is due directly to the combined absence of utrophin and dystrophin and is not an indirect effect of the postsynaptic membrane abnormalities...
  28. ncbi request reprint Challenges in drug development for muscle disease: a stakeholders' meeting
    Jerry R Mendell
    Columbus Children s Research Institute, and Ohio State University, 700 Children s Drive, Columbus, OH 43235, USA
    Muscle Nerve 35:8-16. 2007
    ..The meeting provided a format for communication for diverse disciplines that usually have no common meeting ground, helping to lay the foundation for bringing products to market in a timely fashion...