Research Topics
| John D PorterSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Detail Information
Publications
Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscleJohn D Porter
Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
J Exp Biol 206:3101-12. 2003....- The development of extraocular muscle calcium homeostasis parallels visuomotor system maturationJ D Porter
Departments of Ophthalmology, Neurology, and Neuroscience, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106 5068, USA
Biochem Biophys Res Commun 257:678-83. 1999..Findings suggest that cation homeostasis in extraocular muscle may be susceptible to perturbations of the developing visual sensory system, as we have previously shown for myosin... - Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) miceJohn D Porter
Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Hum Mol Genet 12:1813-21. 2003.... - Extraocular muscle is spared despite the absence of an intact sarcoglycan complex in gamma- or delta-sarcoglycan-deficient miceJ D Porter
Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5068, USA
Neuromuscul Disord 11:197-207. 2001.... - Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx miceJohn D Porter
Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, Ohio 44106 5068, USA
FASEB J 17:893-5. 2003.... 
Extraocular muscle is defined by a fundamentally distinct gene expression profileJ D Porter
Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 98:12062-7. 2001..These patterned differences in gene expression define EOM as a distinct muscle class and may explain the unique response of these muscles in neuromuscular diseases...- A chronic inflammatory response dominates the skeletal muscle molecular signature in dystrophin-deficient mdx miceJohn D Porter
Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
Hum Mol Genet 11:263-72. 2002..Taken together, these data identify a relatively neglected aspect of DMD, suggest new treatment avenues, and highlight the value of genome-wide profiling in study of complex disease processes... - Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscleJohn D Porter
Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
Neuromuscul Disord 13:223-35. 2003..The chemokine pro-inflammatory pathways described here in mdx may represent new targets for treatment of Duchenne muscular dystrophy... - Extraocular muscle: cellular adaptations for a diverse functional repertoireJohn D Porter
Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106 5068, USA
Ann N Y Acad Sci 956:7-16. 2002..This novel eye muscle phenotype represents an adaptation that exploits the full range of variability in skeletal muscle to meet the needs of visuomotor systems... - Conserved and muscle-group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotypeGeorgiana Cheng
Department of Neurology, Cleveland, Ohio 44106, USA
Physiol Genomics 18:184-95. 2004..This represents an important first step in dissecting allotype-specific regulatory mechanisms that may, in turn, explain differential muscle group sensitivity to a variety of metabolic and neuromuscular diseases... - Temporal gene expression profiling of dystrophin-deficient (mdx) mouse diaphragm identifies conserved and muscle group-specific mechanisms in the pathogenesis of muscular dystrophyJohn D Porter
Department of Neurology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Hum Mol Genet 13:257-69. 2004..We further suggest that muscle group-specific transcriptional profiles contribute toward the muscle targeting and sparing patterns observed for a variety of metabolic and neuromuscular diseases... - Distinctive morphological and gene/protein expression signatures during myogenesis in novel cell lines from extraocular and hindlimb muscleJohn D Porter
Department of Neurology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
Physiol Genomics 24:264-75. 2006..Taken together, these data show that myoblast lineage plays a significant role in the divergence of the distinctive muscle groups or allotypes... - Temporal and spatial mRNA expression patterns of TGF-beta1, 2, 3 and TbetaRI, II, III in skeletal muscles of mdx miceLan Zhou
Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue S90, Cleveland, OH 44195, USA
Neuromuscul Disord 16:32-8. 2006..Our data support a regulatory role for TGF-beta1 in muscle inflammation in mdx mice. It also suggests different susceptibility of quadriceps and diaphragm muscles to fibrosis induced by TGF-beta1 signaling pathway... - Paradoxical absence of M lines and downregulation of creatine kinase in mouse extraocular muscleFrancisco H Andrade
Department of Neurology, Case Western Reserve University, Cleveland, OH 44106 5040, USA
J Appl Physiol 95:692-9. 2003.... - Comprehensive evaluation of the extraocular muscle critical period by expression profiling in the dark-reared rat and monocularly deprived monkeyGeorgiana Cheng
Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Invest Ophthalmol Vis Sci 44:3842-55. 2003..The data extend the concept of an EOM-critical period and establish that activity patterns in developing eye movement systems play vital determinant roles in the novel EOM phenotype... - Genome-wide transcriptional profiles are consistent with functional specialization of the extraocular muscle layersSangeeta Khanna
Department of Neurology, Case Western Reserve University, University Hospistals of Cleveland, Ohio 44106 5040, USA
Invest Ophthalmol Vis Sci 45:3055-66. 2004..Microarray technology was used to identify muscle-layer-specific transcriptional profiles and, thereby, extend understanding of the structure-function characteristics of extraocular muscle layers... - Comprehensive expression profiling by muscle tissue class and identification of the molecular niche of extraocular muscleSangeeta Khanna
Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106 5068, USA
FASEB J 17:1370-2. 2003..These, and additional proteomic data, establish that extraocular muscle does not constitute a distinctive muscle class but that it does occupy a novel niche within the skeletal muscle class... - Molecular organization of the extraocular muscle neuromuscular junction: partial conservation of and divergence from the skeletal muscle prototypeSangeeta Khanna
Department of Ophthalmology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106 5068, USA
Invest Ophthalmol Vis Sci 44:1918-26. 2003.... - The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophinJ D Porter
Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106 5068, USA
J Cell Sci 111:1801-11. 1998..Moreover, data lend support to the hypothesis that interventions designed to increase utrophin levels may ameliorate the pathology in other skeletal muscles in Duchenne muscular dystrophy... - FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cellsLuis A Solchaga
Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
J Cell Physiol 203:398-409. 2005..With the generation of gene expression profiles of FGF-treated and control cells we have taken the first steps in the elucidation of the molecular mechanism(s) behind these phenomena... - Transcriptional profile of rat extraocular muscle by serial analysis of gene expressionGeorgiana Cheng
Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106-5068, USA
Invest Ophthalmol Vis Sci 43:1048-58. 2002.... - Evidence for rectus extraocular muscle pulleys in rodentsS Khanna
Department of Ophthalmology, The Research Institute of University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106 5068, USA
Invest Ophthalmol Vis Sci 42:1986-92. 2001.... - Eye muscle sparing by the muscular dystrophies: lessons to be learned?F H Andrade
Departments of Neurology, Case Western Reserve University, University Hospitals of Cleveland, and Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Microsc Res Tech 48:192-203. 2000.... - Extraocular muscle gene expression and function after dark rearingFrancisco H Andrade
Departments of Neurology and Ophthalmology, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
Ann N Y Acad Sci 956:391-3. 2002 - Conservation of synapse-signaling pathways at the extraocular muscle neuromuscular junctionSangeeta Khanna
Department of Ophthalmology, Case Western Reserve University, and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
Ann N Y Acad Sci 956:394-6. 2002 - The development of longitudinal variation of Myosin isoforms in the orbital fibers of extraocular muscles of ratsNeal A Rubinstein
Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
Invest Ophthalmol Vis Sci 45:3067-72. 2004..To examine the appearance of longitudinal variation of extraocular and embryonic myosin heavy chain (MyHC) isoforms during the development of orbital singly innervated fibers of rat extraocular muscles (EOMs)... - Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb musclesPatrick E Baker
Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH, USA
Neurogenetics 7:81-91. 2006..This data suggests that at least part of the fiber-type abnormality is due directly to the combined absence of utrophin and dystrophin and is not an indirect effect of the postsynaptic membrane abnormalities... - Challenges in drug development for muscle disease: a stakeholders' meetingJerry R Mendell
Columbus Children s Research Institute, and Ohio State University, 700 Children s Drive, Columbus, OH 43235, USA
Muscle Nerve 35:8-16. 2007..The meeting provided a format for communication for diverse disciplines that usually have no common meeting ground, helping to lay the foundation for bringing products to market in a timely fashion...