Research Topics
| Sanjay R PatelSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Detail Information
Publications
Correlates of long sleep durationSanjay R Patel
Division of Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Sleep 29:881-9. 2006..Future causal research on the effects of long sleep should include a detailed assessment of psychiatric disease and socioeconomic status...- Association between reduced sleep and weight gain in womenSanjay R Patel
Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
Am J Epidemiol 164:947-54. 2006..These data suggest that short sleep duration is associated with a modest increase in future weight gain and incident obesity. Further research is needed to understand the mechanisms by which sleep duration may affect weight... - Social and demographic factors related to sleep durationSanjay R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
Sleep 30:1077-8. 2007 - Shared genetic basis for obstructive sleep apnea and adiposity measuresS R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
Int J Obes (Lond) 32:795-800. 2008..Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified... - Short sleep duration and weight gain: a systematic reviewSanjay R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
Obesity (Silver Spring) 16:643-53. 2008..This work reviews the literature regarding short sleep duration as an independent risk factor for obesity and weight gain... - Heritability of upper airway dimensions derived using acoustic pharyngometryS R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
Eur Respir J 32:1304-8. 2008..These findings demonstrate the potential utility of acoustic pharyngometry in dissecting the genetic basis of sleep apnoea... 
The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertensionSanjay R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital and Case Western Reserve University, Cleveland, OH, USA
Sleep 30:531-3. 2007..To identify the role of polymorphisms in the angiotensin-converting enzyme (ACE) gene in modulating susceptibility to hypertension in sleep apnea...- The association between sleep duration and obesity in older adultsS R Patel
Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
Int J Obes (Lond) 32:1825-34. 2008..In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults... - Sleep duration and biomarkers of inflammationSanjay R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
Sleep 32:200-4. 2009..Extremes of sleep duration have been associated with adverse health outcomes. The mechanism is unclear but may be related to increased inflammation. We sought to assess the association between sleep duration and inflammatory biomarkers... 
Invited Commentary: understanding the role of sleepSanjay R Patel
Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
Am J Epidemiol 170:814-6; discussion 817-8. 2009..Further research into the relation between sleep quantity and quality relative to obesity by use of more refined measures of sleep is needed to identify which, if any, aspects of sleep are important in weight homeostasis...- Reduced sleep as an obesity risk factorS R Patel
Division of Pulmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, OH, USA
Obes Rev 10:61-8. 2009..Thus, reduced sleep appears to represent a novel, independent risk factor for increased weight gain. Further research is needed to determine whether interventions aimed at increasing sleep may be useful in combating obesity... - Relationship between obstructive sleep apnea and diurnal leptin rhythmsSanjay R Patel
Rainbow Babies and Children s Hospital, Cleveland, OH, USA
Sleep 27:235-9. 2004..Several studies have reported an association between obstructive sleep apnea and leptin, a hormone that influences satiety and body weight. We evaluated the relationship of leptin levels and the overnight change in levels with sleep apnea... - Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peakEmma K Larkin
Department of Epidemiology and Biostatistics, Case Western Reserve University, 11400 Euclid Avenue, Ste 260, Cleveland, OH 44106 6083, USA
Genet Epidemiol 30:101-10. 2006..Overall, the evidence suggests that there is a disease susceptibility locus for obstructive sleep apnea in the region of ApoE, but ApoE itself is unlikely to be the causative locus... - Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based techniqueLamia H Ibrahim
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 6003, USA
Sleep 33:643-6. 2010..We evaluated the familial aggregation of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency cardiopulmonary coupling (e-LFC), to assess their utility in genetic studies... - A measure of ventilatory variability at wake-sleep transition predicts sleep apnea severityLamia H Ibrahim
Department of Medicine, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 6003, USA
Chest 134:73-8. 2008..We assessed the association of a measure of ventilatory variability measured at the wake-sleep transition with OSA and associated covariates... - Entropy-based measures of EEG arousals as biomarkers for sleep dynamics: applications to hypertensionReza Jamasebi
Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA
Sleep 31:935-43. 2008..We also investigate the influence of age on these entropy-based measures as compared to traditional indices... - Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family StudyReena Mehra
Department of Medicine, Case Comprehensive Cancer Center, Case School of Medicine, Cleveland, Ohio, USA
Am J Respir Crit Care Med 182:826-33. 2010..Individuals with sleep-disordered breathing (SDB) are at increased cardiovascular risk, possibly due to SDB-related stresses contributing to atherosclerosis... - Sleep duration and circulating adipokine levelsAmanda L Hayes
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
Sleep 34:147-52. 2011..One possibility is sleep may impact secretion of adipocyte derived hormones that regulate inflammation and insulin resistance. In this study we assessed the association between sleep duration and 3 adipokine levels... - A whole-genome scan for obstructive sleep apnea and obesityLyle J Palmer
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 72:340-50. 2003.... - Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measuresNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7281, USA
Sleep 32:615-22. 2009.... - A prospective study of sleep duration and mortality risk in womenSanjay R Patel
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
Sleep 27:440-4. 2004..However, recent studies suggest the risk of death is lower in those sleeping 7 hours. We prospectively examined the association between sleep duration and mortality in women to better understand the effect of sleep duration on health... - Rapid eye movement-related sleep-disordered breathing: influence of age and genderBrian B Koo
Department of Pulmonary, Case Western Reserve University, Cleveland, OH, USA
Chest 134:1156-61. 2008..We sought to characterize REM SDB prevalence by gender and age to identify factors that could account for this discrepancy... - Clinical presentation of shift workers to a sleep clinicHarneet K Walia
Department of Sleep Medicine, University Hospitals Case Medical Center, 11000 Euclid Avenue, Cleveland, OH, USA
Sleep Breath 16:543-7. 2012..The purpose of this study was to assess the relationship between shift work (SW) history and symptom severity in a sleep clinic population... - The Epworth score in African American populationsAmanda L Hayes
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
J Clin Sleep Med 5:344-8. 2009..African Americans have elevated scores on the Epworth Sleepiness Scale (ESS) compared to whites. The reason for this difference is not clear... - A pathway-based analysis on the effects of obstructive sleep apnea in modulating visceral fat transcriptomeSina A Gharib
Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA 98109, USA
Sleep 36:23-30. 2013..This may be due to pathophysiologic effects of OSA on visceral adipose tissue. We sought to assess the transcriptional consequences of OSA on adipocytes by utilizing pathway-focused analyses... - Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndromeMichael H Cho
Division of Pulmonary, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Ann Thorac Surg 82:261-6. 2006..Persistent air leak is the most common postoperative complication. Risk factors in this setting are not known... - Right-to-left anatomic shunt associated with a persistent left superior vena cava: the importance of injection site in demonstrating the shuntNandhitha N Thaiyananthan
Pulmonary, Critical Care and Sleep Medicine Division, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
Chest 136:617-20. 2009..This case reminds pulmonary clinicians, who are frequently called on to assess the cause of hypoxemia, that specifying a contrast injection into the left arm is required in the pursuit of this specific shunt-producing anomaly... - Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetesCatherine J Williams
Department of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02115, USA
Diabetes Care 30:1233-40. 2007..We aim to determine whether sleep duration and/or snoring are associated with biomarkers of CVD in women with type 2 diabetes... - Is siesta more beneficial than nocturnal sleep?Sanjay R Patel
Arch Intern Med 167:2143-4; author reply 2144. 2007 - Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs samplingLyle J Palmer
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
BMC Genet 4:S12. 2003..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data... - Lack of reproducibility of linkage results in serially measured blood pressure dataSanjay R Patel
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
BMC Genet 4:S37. 2003.... - Whole genome scan for obstructive sleep apnea and obesity in African-American familiesLyle J Palmer
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, Australia
Am J Respir Crit Care Med 169:1314-21. 2004..Our results suggest that there are both shared and unshared genetic factors underlying susceptibility to OSA and obesity, and that the genetic determinants of obesity in this population may be modulated by apnea severity... - Shared genetic risk factors for obstructive sleep apnea and obesitySanjay R Patel
Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Appl Physiol 99:1600-6. 2005..Conversely, environmental stressors such as intermittent hypoxia and sleep fragmentation produced by OSA may interact with obesity susceptibility genes to modulate the importance that these loci have on defining obesity-related traits... - Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysisNajib T Ayas
Department of Medicine, University of British Colombia
Sleep 27:249-53. 2004.... - Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apneaAmy S Jordan
Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Research Program, Boston, MA 02115, USA
J Appl Physiol 99:2020-7. 2005..38 +/- 0.02 vs. 0.33 +/- 0.03; P = 0.14). These results suggest that women may be protected from developing OSA by having a less collapsible upper airway for any given degree of obesity... - Two epidemics: are we getting fatter as we sleep less?Sanjay R Patel
Sleep 27:602-3. 2004 - Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysisSanjay R Patel
Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, Mass, USA
Arch Intern Med 163:565-71. 2003..Patients with more severe apnea and sleepiness seem to benefit the most... - Lung volume and continuous positive airway pressure requirements in obstructive sleep apneaRaphael C Heinzer
Division of Sleep Medicine, Sleep Disorders Program BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 172:114-7. 2005..These results demonstrate that relatively small changes in lung volume have an important effect on the upper airway in subjects with sleep apnea during non-REM sleep... - Postural effects on pharyngeal protective reflex mechanismsAtul Malhotra
Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Sleep 27:1105-12. 2004..We hypothesized that tongue protruder muscles are maximally responsive to negative pressure pulses during supine sleep, when posterior tongue displacement yields pharyngeal occlusion...
Research Grants
- The Genetics of Metabolic Dysfunction in Sleep ApneaSanjay Patel; Fiscal Year: 2007..These association studies will be repeated in an independent OSA population recruited from a clinical trial to ensure generalizability of findings. ..
- Sleep Patterns as a risk factor for disease in the Hispanic Community Health StudSanjay R Patel; Fiscal Year: 2010....
- A randomized trial of bariatric surgery for the treatment of sleep apneaSanjay R Patel; Fiscal Year: 2010..In this study, we will conduct a trial comparing the ability of CPAP and bariatric surgery to treat sleep apnea in patients who have severe sleep apnea and morbid obesity. ..