Sanjay R Patel

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Correlates of long sleep duration
    Sanjay R Patel
    Division of Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Sleep 29:881-9. 2006
  2. pmc Association between reduced sleep and weight gain in women
    Sanjay R Patel
    Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Epidemiol 164:947-54. 2006
  3. ncbi request reprint The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital and Case Western Reserve University, Cleveland, OH, USA
    Sleep 30:531-3. 2007
  4. pmc Shared genetic basis for obstructive sleep apnea and adiposity measures
    S R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:795-800. 2008
  5. pmc Heritability of upper airway dimensions derived using acoustic pharyngometry
    S R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Eur Respir J 32:1304-8. 2008
  6. pmc The association between sleep duration and obesity in older adults
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:1825-34. 2008
  7. pmc Social and demographic factors related to sleep duration
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Sleep 30:1077-8. 2007
  8. pmc Sleep duration and biomarkers of inflammation
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Sleep 32:200-4. 2009
  9. doi request reprint Invited Commentary: understanding the role of sleep
    Sanjay R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Epidemiol 170:814-6; discussion 817-8. 2009
  10. doi request reprint Reduced sleep as an obesity risk factor
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, OH, USA
    Obes Rev 10:61-8. 2009

Detail Information

Publications41

  1. pmc Correlates of long sleep duration
    Sanjay R Patel
    Division of Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Sleep 29:881-9. 2006
    ..Whether this association is causal and what pathways explain this association are unknown. We sought to identify factors that could potentially explain the association between long sleep and mortality...
  2. pmc Association between reduced sleep and weight gain in women
    Sanjay R Patel
    Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Epidemiol 164:947-54. 2006
    ..These data suggest that short sleep duration is associated with a modest increase in future weight gain and incident obesity. Further research is needed to understand the mechanisms by which sleep duration may affect weight...
  3. ncbi request reprint The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital and Case Western Reserve University, Cleveland, OH, USA
    Sleep 30:531-3. 2007
    ..To identify the role of polymorphisms in the angiotensin-converting enzyme (ACE) gene in modulating susceptibility to hypertension in sleep apnea...
  4. pmc Shared genetic basis for obstructive sleep apnea and adiposity measures
    S R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:795-800. 2008
    ..Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified...
  5. pmc Heritability of upper airway dimensions derived using acoustic pharyngometry
    S R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Eur Respir J 32:1304-8. 2008
    ..These findings demonstrate the potential utility of acoustic pharyngometry in dissecting the genetic basis of sleep apnoea...
  6. pmc The association between sleep duration and obesity in older adults
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:1825-34. 2008
    ..In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults...
  7. pmc Social and demographic factors related to sleep duration
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Sleep 30:1077-8. 2007
  8. pmc Sleep duration and biomarkers of inflammation
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Sleep 32:200-4. 2009
    ..Extremes of sleep duration have been associated with adverse health outcomes. The mechanism is unclear but may be related to increased inflammation. We sought to assess the association between sleep duration and inflammatory biomarkers...
  9. doi request reprint Invited Commentary: understanding the role of sleep
    Sanjay R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Epidemiol 170:814-6; discussion 817-8. 2009
    ..Further research into the relation between sleep quantity and quality relative to obesity by use of more refined measures of sleep is needed to identify which, if any, aspects of sleep are important in weight homeostasis...
  10. doi request reprint Reduced sleep as an obesity risk factor
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, OH, USA
    Obes Rev 10:61-8. 2009
    ..Thus, reduced sleep appears to represent a novel, independent risk factor for increased weight gain. Further research is needed to determine whether interventions aimed at increasing sleep may be useful in combating obesity...
  11. pmc Short sleep duration and weight gain: a systematic review
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Obesity (Silver Spring) 16:643-53. 2008
    ..This work reviews the literature regarding short sleep duration as an independent risk factor for obesity and weight gain...
  12. ncbi request reprint Relationship between obstructive sleep apnea and diurnal leptin rhythms
    Sanjay R Patel
    Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Sleep 27:235-9. 2004
    ..Several studies have reported an association between obstructive sleep apnea and leptin, a hormone that influences satiety and body weight. We evaluated the relationship of leptin levels and the overnight change in levels with sleep apnea...
  13. ncbi request reprint Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak
    Emma K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 11400 Euclid Avenue, Ste 260, Cleveland, OH 44106 6083, USA
    Genet Epidemiol 30:101-10. 2006
    ..Overall, the evidence suggests that there is a disease susceptibility locus for obstructive sleep apnea in the region of ApoE, but ApoE itself is unlikely to be the causative locus...
  14. pmc Entropy-based measures of EEG arousals as biomarkers for sleep dynamics: applications to hypertension
    Reza Jamasebi
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA
    Sleep 31:935-43. 2008
    ..We also investigate the influence of age on these entropy-based measures as compared to traditional indices...
  15. pmc Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique
    Lamia H Ibrahim
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 6003, USA
    Sleep 33:643-6. 2010
    ..We evaluated the familial aggregation of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency cardiopulmonary coupling (e-LFC), to assess their utility in genetic studies...
  16. pmc A measure of ventilatory variability at wake-sleep transition predicts sleep apnea severity
    Lamia H Ibrahim
    Department of Medicine, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 6003, USA
    Chest 134:73-8. 2008
    ..We assessed the association of a measure of ventilatory variability measured at the wake-sleep transition with OSA and associated covariates...
  17. pmc Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family Study
    Reena Mehra
    Department of Medicine, Case Comprehensive Cancer Center, Case School of Medicine, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 182:826-33. 2010
    ..Individuals with sleep-disordered breathing (SDB) are at increased cardiovascular risk, possibly due to SDB-related stresses contributing to atherosclerosis...
  18. doi request reprint Obstructive sleep apnea and diurnal nondipping hemodynamic indices in patients at increased cardiovascular risk
    Fadi Seif
    aDepartment of Medicine, Case School of Medicine, Cleveland, Ohio bBrigham and Women s Hospital cBeth Israel Deaconess Medical Center dVA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts eJohns Hopkins University, Baltimore, Maryland fDepartment of Epidemiology and Biostatistics, Case Western Reserve University gCleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA
    J Hypertens 32:267-75. 2014
    ..We hypothesized increasing obstructive sleep apnea (OSA) severity would be associated with nondipping blood pressure (BP) in increased cardiovascular disease (CVD) risk...
  19. pmc Sleep duration and circulating adipokine levels
    Amanda L Hayes
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Sleep 34:147-52. 2011
    ..One possibility is sleep may impact secretion of adipocyte derived hormones that regulate inflammation and insulin resistance. In this study we assessed the association between sleep duration and 3 adipokine levels...
  20. pmc A whole-genome scan for obstructive sleep apnea and obesity
    Lyle J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 72:340-50. 2003
    ....
  21. pmc Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7281, USA
    Sleep 32:615-22. 2009
    ....
  22. doi request reprint Association between obstructive sleep apnea severity and endothelial dysfunction in an increased background of cardiovascular burden
    Fadi Seif
    Department of Medicine, Case School of Medicine, Cleveland, OH, USA
    J Sleep Res 22:443-51. 2013
    ..No relation was noted with total sleep time <90 and F-RHI. There was evidence of a graded decline in endothelial function in association with higher levels of intermittent hypoxaemia. ..
  23. doi request reprint Rapid eye movement-related sleep-disordered breathing: influence of age and gender
    Brian B Koo
    Department of Pulmonary, Case Western Reserve University, Cleveland, OH, USA
    Chest 134:1156-61. 2008
    ..We sought to characterize REM SDB prevalence by gender and age to identify factors that could account for this discrepancy...
  24. ncbi request reprint A prospective study of sleep duration and mortality risk in women
    Sanjay R Patel
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Sleep 27:440-4. 2004
    ..However, recent studies suggest the risk of death is lower in those sleeping 7 hours. We prospectively examined the association between sleep duration and mortality in women to better understand the effect of sleep duration on health...
  25. pmc Clinical presentation of shift workers to a sleep clinic
    Harneet K Walia
    Department of Sleep Medicine, University Hospitals Case Medical Center, 11000 Euclid Avenue, Cleveland, OH, USA
    Sleep Breath 16:543-7. 2012
    ..The purpose of this study was to assess the relationship between shift work (SW) history and symptom severity in a sleep clinic population...
  26. pmc The Epworth score in African American populations
    Amanda L Hayes
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    J Clin Sleep Med 5:344-8. 2009
    ..African Americans have elevated scores on the Epworth Sleepiness Scale (ESS) compared to whites. The reason for this difference is not clear...
  27. pmc A pathway-based analysis on the effects of obstructive sleep apnea in modulating visceral fat transcriptome
    Sina A Gharib
    Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Sleep 36:23-30. 2013
    ..This may be due to pathophysiologic effects of OSA on visceral adipose tissue. We sought to assess the transcriptional consequences of OSA on adipocytes by utilizing pathway-focused analyses...
  28. pmc Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome
    Michael H Cho
    Division of Pulmonary, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Ann Thorac Surg 82:261-6. 2006
    ..Persistent air leak is the most common postoperative complication. Risk factors in this setting are not known...
  29. doi request reprint Right-to-left anatomic shunt associated with a persistent left superior vena cava: the importance of injection site in demonstrating the shunt
    Nandhitha N Thaiyananthan
    Pulmonary, Critical Care and Sleep Medicine Division, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Chest 136:617-20. 2009
    ..This case reminds pulmonary clinicians, who are frequently called on to assess the cause of hypoxemia, that specifying a contrast injection into the left arm is required in the pursuit of this specific shunt-producing anomaly...
  30. ncbi request reprint Shared genetic risk factors for obstructive sleep apnea and obesity
    Sanjay R Patel
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Appl Physiol (1985) 99:1600-6. 2005
    ..Conversely, environmental stressors such as intermittent hypoxia and sleep fragmentation produced by OSA may interact with obesity susceptibility genes to modulate the importance that these loci have on defining obesity-related traits...
  31. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
    ..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data...
  32. ncbi request reprint Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes
    Catherine J Williams
    Department of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02115, USA
    Diabetes Care 30:1233-40. 2007
    ..We aim to determine whether sleep duration and/or snoring are associated with biomarkers of CVD in women with type 2 diabetes...
  33. pmc Lack of reproducibility of linkage results in serially measured blood pressure data
    Sanjay R Patel
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusettes, USA
    BMC Genet 4:S37. 2003
    ....
  34. ncbi request reprint Whole genome scan for obstructive sleep apnea and obesity in African-American families
    Lyle J Palmer
    Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 169:1314-21. 2004
    ..Our results suggest that there are both shared and unshared genetic factors underlying susceptibility to OSA and obesity, and that the genetic determinants of obesity in this population may be modulated by apnea severity...
  35. ncbi request reprint Is siesta more beneficial than nocturnal sleep?
    Sanjay R Patel
    Arch Intern Med 167:2143-4; author reply 2144. 2007
  36. pmc Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea
    Amy S Jordan
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Research Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 99:2020-7. 2005
    ..38 +/- 0.02 vs. 0.33 +/- 0.03; P = 0.14). These results suggest that women may be protected from developing OSA by having a less collapsible upper airway for any given degree of obesity...
  37. ncbi request reprint Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis
    Sanjay R Patel
    Division of Pulmonary Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Arch Intern Med 163:565-71. 2003
    ..Since the publication of these reviews, several randomized controlled trials have been reported. We, therefore, performed a meta-analysis to assess the effect of CPAP on subjective and objective sleepiness...
  38. ncbi request reprint Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis
    Najib T Ayas
    Department of Medicine, University of British Colombia
    Sleep 27:249-53. 2004
    ....
  39. ncbi request reprint Two epidemics: are we getting fatter as we sleep less?
    Sanjay R Patel
    Sleep 27:602-3. 2004
  40. pmc Postural effects on pharyngeal protective reflex mechanisms
    Atul Malhotra
    Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:1105-12. 2004
    ..We hypothesized that tongue protruder muscles are maximally responsive to negative pressure pulses during supine sleep, when posterior tongue displacement yields pharyngeal occlusion...
  41. pmc Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea
    Raphael C Heinzer
    Division of Sleep Medicine, Sleep Disorders Program BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:114-7. 2005
    ..These results demonstrate that relatively small changes in lung volume have an important effect on the upper airway in subjects with sleep apnea during non-REM sleep...

Research Grants4

  1. The Genetics of Metabolic Dysfunction in Sleep Apnea
    Sanjay Patel; Fiscal Year: 2007
    ..These association studies will be repeated in an independent OSA population recruited from a clinical trial to ensure generalizability of findings. ..
  2. Sleep Patterns as a risk factor for disease in the Hispanic Community Health Stud
    Sanjay R Patel; Fiscal Year: 2010
    ....
  3. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2010
    ..In this study, we will conduct a trial comparing the ability of CPAP and bariatric surgery to treat sleep apnea in patients who have severe sleep apnea and morbid obesity. ..