Liem Nguyen

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint Mycobacterial subversion of chemotherapeutic reagents and host defense tactics: challenges in tuberculosis drug development
    Liem Nguyen
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Annu Rev Pharmacol Toxicol 49:427-53. 2009
  2. doi request reprint Molecular Biology of Drug Resistance in Mycobacterium tuberculosis
    Tasha Smith
    Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA
    Curr Top Microbiol Immunol 374:53-80. 2013
  3. pmc Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of β-lactam-β-lactamase inhibitor combinations
    Sebastian G Kurz
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 57:6085-96. 2013
  4. doi request reprint Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis
    Kerstin A Wolff
    Case Western Reserve University School of Medicine, Department of Molecular Biology and Microbiology, Cleveland, OH 44106, USA
    Expert Rev Anti Infect Ther 10:971-81. 2012
  5. pmc Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria
    Kerstin A Wolff
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Wood Building, 10900 Euclid Avenue, Cleveland, OH 44106 4960, USA
    Antimicrob Agents Chemother 53:3515-9. 2009
  6. doi request reprint A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium
    Hoa T Nguyen
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Microbiol 76:348-64. 2010

Collaborators

  • Jean Pieters
  • Kerstin A Wolff
  • Hoa T Nguyen
  • Tasha Smith
  • Sebastian G Kurz
  • Richard H Cartabuke
  • Sam Ogwang
  • Andrea M Hujer
  • John S Blanchard
  • Lee W Tremblay
  • Christopher R Bethel
  • Saugata Hazra
  • Kerri M Smith
  • Robert A Bonomo
  • Yan Xu
  • Ajay Singh

Detail Information

Publications6

  1. doi request reprint Mycobacterial subversion of chemotherapeutic reagents and host defense tactics: challenges in tuberculosis drug development
    Liem Nguyen
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Annu Rev Pharmacol Toxicol 49:427-53. 2009
    ..tuberculosis. This knowledge may help to reveal current targets for the development of novel antituberculosis drugs...
  2. doi request reprint Molecular Biology of Drug Resistance in Mycobacterium tuberculosis
    Tasha Smith
    Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA
    Curr Top Microbiol Immunol 374:53-80. 2013
    ..tuberculosis strains but also help shorten the current treatment courses required for drug susceptible TB. ..
  3. pmc Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of β-lactam-β-lactamase inhibitor combinations
    Sebastian G Kurz
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 57:6085-96. 2013
    ..tuberculosis. ..
  4. doi request reprint Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis
    Kerstin A Wolff
    Case Western Reserve University School of Medicine, Department of Molecular Biology and Microbiology, Cleveland, OH 44106, USA
    Expert Rev Anti Infect Ther 10:971-81. 2012
    ..These approaches might help broaden the currently limited chemotherapeutic options of not only drug-resistant but also drug-susceptible tuberculosis, which still remains one of the most common infectious diseases in the developing world...
  5. pmc Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria
    Kerstin A Wolff
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Wood Building, 10900 Euclid Avenue, Cleveland, OH 44106 4960, USA
    Antimicrob Agents Chemother 53:3515-9. 2009
    ..Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics...
  6. doi request reprint A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium
    Hoa T Nguyen
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Microbiol 76:348-64. 2010
    ..These results support a model in which LpqB, MtrB and MtrA form a three-component system that co-ordinates cytokinetic and cell wall homeostatic processes...