J H Nadeau

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Naturally occurring variation in cardiovascular traits among inbred mouse strains
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, MS 5038, Cleveland, Ohio 44106 5038, USA
    Genomics 79:679-85. 2002
  2. ncbi request reprint Interacting genetic loci cause airway hyperresponsiveness
    Kate G Ackerman
    Division of Genetics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiol Genomics 21:105-11. 2005
  3. pmc Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution
    J H Nadeau
    Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Genetics 147:1259-66. 1997
  4. pmc Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations
    Joseph H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genome Res 13:2082-91. 2003
  5. ncbi request reprint The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs
    J H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospitals of Cleveland, Cleveland, USA
    Nat Genet 25:381-4. 2000
  6. ncbi request reprint Analysing complex genetic traits with chromosome substitution strains
    J H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Nat Genet 24:221-5. 2000
  7. ncbi request reprint Modifier genes in mice and humans
    J H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospital of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Genet 2:165-74. 2001
  8. ncbi request reprint Modifier genes and protective alleles in humans and mice
    Joseph H Nadeau
    Department of Genetics and Center for Computational Genomics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA
    Curr Opin Genet Dev 13:290-5. 2003
  9. ncbi request reprint Counting on comparative maps
    J H Nadeau
    Genetics Department, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Trends Genet 14:495-501. 1998
  10. ncbi request reprint Genomic strategies for defining and dissecting developmental and physiological pathways
    J H Nadeau
    Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Curr Opin Genet Dev 8:311-5. 1998

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Naturally occurring variation in cardiovascular traits among inbred mouse strains
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, MS 5038, Cleveland, Ohio 44106 5038, USA
    Genomics 79:679-85. 2002
    ....
  2. ncbi request reprint Interacting genetic loci cause airway hyperresponsiveness
    Kate G Ackerman
    Division of Genetics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiol Genomics 21:105-11. 2005
    ....
  3. pmc Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution
    J H Nadeau
    Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Genetics 147:1259-66. 1997
    ....
  4. pmc Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations
    Joseph H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genome Res 13:2082-91. 2003
    ..These networks are therefore an important approach for defining and characterizing functional relations in complex biological systems in health and disease...
  5. ncbi request reprint The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs
    J H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospitals of Cleveland, Cleveland, USA
    Nat Genet 25:381-4. 2000
    ..Despite recent progress in QTLs, we expect that mutagenesis is will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target...
  6. ncbi request reprint Analysing complex genetic traits with chromosome substitution strains
    J H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Nat Genet 24:221-5. 2000
    ..We discuss the construction, applications and advantages of CSSs compared with conventional crosses for detecting and analysing QTLs, including those that have weak phenotypic effects...
  7. ncbi request reprint Modifier genes in mice and humans
    J H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospital of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Genet 2:165-74. 2001
    ....
  8. ncbi request reprint Modifier genes and protective alleles in humans and mice
    Joseph H Nadeau
    Department of Genetics and Center for Computational Genomics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA
    Curr Opin Genet Dev 13:290-5. 2003
    ..Together these modifier genes and protective alleles provide important glimpses into the molecular and cellular basis for the functional networks that provide robustness and homeostasis in complex biological systems...
  9. ncbi request reprint Counting on comparative maps
    J H Nadeau
    Genetics Department, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Trends Genet 14:495-501. 1998
    ..We review the analytical methods that have been developed for characterizing these maps and evaluate their application to existing comparative maps mainly for plants and animals...
  10. ncbi request reprint Genomic strategies for defining and dissecting developmental and physiological pathways
    J H Nadeau
    Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Curr Opin Genet Dev 8:311-5. 1998
    ..Together, these complementary approaches will test whether reductionism can account for the complex web of interactions that lead from genetic variation to morphological, physiological, and behavioral traits in health and disease...
  11. ncbi request reprint Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain
    A Matin
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Nat Genet 23:237-40. 1999
    ....
  12. ncbi request reprint 129/Sv mice--a model system for studying germ cell biology and testicular cancer
    L I Jiang
    Department of Genetics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Mamm Genome 12:89-94. 2001
    ..In this review we summarize current understanding of the biology and genetics of TGCTs in mice and discuss the relevance of this work to testicular cancer in humans...
  13. pmc Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition
    R A Keri
    Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 97:383-7. 2000
    ..In addition, these results support the rare incidence of GC tumors in the human population, and suggest that the ability of certain fertility drugs to cause ovarian tumors may depend on an individual's genetic predisposition...
  14. ncbi request reprint Pathways database system
    Z Meral Ozsoyoglu
    Center for Computational Genomics, Case Western Reserve University CWRU, Cleveland, Ohio 44106, USA
    OMICS 7:123-5. 2003
    ....
  15. ncbi request reprint L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons
    Qi Shi
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Ann N Y Acad Sci 1003:461-3. 2003
  16. pmc Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis
    Haifeng Shao
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 105:19910-4. 2008
    ..These results have implications for identification of complex trait genes, developmental and physiological studies of phenotypic variation, and opportunities to engineer phenotypic outcomes in complex biological systems...
  17. pmc Analyzing complex traits with congenic strains
    Haifeng Shao
    Department of Genetics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mamm Genome 21:276-86. 2010
    ..Sequential analysis rigorously resolved phenotypic heterogeneity among strains in the congenic panels and found QTLs that other methods failed to detect...
  18. ncbi request reprint Genetic and molecular control of folate-homocysteine metabolism in mutant mice
    Sheila Ernest
    Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mamm Genome 13:259-67. 2002
    ..These results begin to unravel the complex relations between elevation of a single amino acid in the blood and the diverse birth defects and adult diseases associated with hyperhomocysteinemia...
  19. ncbi request reprint Genetics. Modifying the message
    Joseph H Nadeau
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Science 301:927-8. 2003
  20. doi request reprint Spontaneous metastasis in mouse models of testicular germ-cell tumours
    J L Zechel
    Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Institute of Pathology, Cleveland OH, USA
    Int J Androl 34:e278-87. 2011
    ..Together, these results provide the first evidence for spontaneous TGCT metastasis in mice and show that these metastases originate from primary TGCTs rather than independently from ectopic stem cells...
  21. ncbi request reprint Phenotype-driven genetic approaches in mice: high-throughput phenotyping for discovering new models of cardiovascular disease
    B D Hoit
    Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Trends Cardiovasc Med 11:82-9. 2001
    ..Insights into the genetic control of these diseases could lead to improved diagnosis and treatment as well as a deeper understanding of basic physiological processes...
  22. pmc Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in mice
    Toshimori Kitami
    Department of Genetics, Center for Computational Genomics and Systems Biology, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Physiol Genomics 35:182-90. 2008
    ....
  23. pmc Resistance to diet-induced obesity in mice with a single substituted chromosome
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
    Physiol Genomics 35:116-22. 2008
    ..A better understanding of these genotype-phenotype relationships may enable a more individualized diagnosis and treatment of obesity and the metabolic syndrome...
  24. ncbi request reprint Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes
    L H Chadwick
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Genomics 70:66-73. 2000
    ....
  25. ncbi request reprint Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains
    Thomas D Krewson
    Division of Pediatric Endocrinology and Metabolism, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Endocrinology 145:4447-51. 2004
    ..These findings demonstrate that chromosomes 6 and 13 harbor QTLs that control the timing of VO. Identification of the responsible genes may reveal factors that regulate the maturation of the HPG axis and determine the timing of puberty...
  26. ncbi request reprint A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice
    Brandon M Nathan
    Division of Pediatric Endocrinology and Metabolism, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Endocrinology 147:5132-8. 2006
    ..These findings represent an important advancement toward identification of novel factors that regulate maturation of the hypothalamic-pituitary-gonadal axis and determine the timing of puberty...
  27. ncbi request reprint Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects
    Sheila Ernest
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Physiol Genomics 21:404-10. 2005
    ..Finally, gene-diet interactions affected heritability of mean tHcy levels. These studies showed that each of these factors contributes to tHcy levels and provided important clues to understanding homocysteine homeostasis in humans...
  28. ncbi request reprint L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists
    Qi Shi
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Pharmacol Exp Ther 305:131-42. 2003
    ..The relevance of these findings for the role of mGluRs in the pathogenesis of homocysteine-mediated phenomena is discussed...
  29. doi request reprint Genetic resistance to diet-induced obesity in chromosome substitution strains of mice
    Lindsay C Burrage
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mamm Genome 21:115-29. 2010
    ....
  30. ncbi request reprint Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications
    Kirsten K Youngren
    Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics and Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Hum Mol Genet 12:389-98. 2003
    ..Finally, we propose that these TGCTs result from disrupted testicular and spermatogenic developmental programs...
  31. ncbi request reprint Testicular teratocarcinogenesis in mice--a review
    A Matin
    Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    APMIS 106:174-82. 1998
    ..In this paper, we review the genetics and development of germ cell tumours in 129/Sv mice, summarize the status of Ter mapping, and provide evidence that different genetic pathways lead to unilateral and bilateral tumours...
  32. ncbi request reprint Disorganization in mice and humans
    N H Robin
    Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Am J Med Genet 101:334-8. 2001
    ..Ds may be the genetic basis for more usual and seemingly sporadic human birth defects as well...
  33. ncbi request reprint Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice
    Sheila Ernest
    Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 15:3387-93. 2006
    ..These results raise the possibility of using metabolite and expression profiles to distinguish folate-responsive and resistance adult females who are at risk for bearing fetuses with an NTD...
  34. pmc Transgenerational genetic effects on phenotypic variation and disease risk
    Joseph H Nadeau
    Department of Genetics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Hum Mol Genet 18:R202-10. 2009
    ....
  35. pmc Quantitative trait locus analysis for hemostasis and thrombosis
    Qila Sa
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland, OH 44195, USA
    Mamm Genome 19:406-12. 2008
    ..Thus, we have identified new QTLs and candidate genes not previously known to influence thrombotic risk...
  36. ncbi request reprint Genetic and phenotypic analysis of seizure susceptibility in PL/J mice
    Toshimori Kitami
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Mamm Genome 15:698-703. 2004
    ..The PL/J strain serves as an interesting new model for studying the genetics, neurobiology, and pharmacology of epilepsy...
  37. doi request reprint Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17
    Carrie A Millward
    Department of Nutrition, Case Western Reserve University School of Medicine, Biomedical Research Building 925, 2109 Adelbert Road, Cleveland, OH 44106 4955, USA
    Mamm Genome 20:71-82. 2009
    ..These congenic strains provide mouse models to identify genes and metabolic pathways that are involved in the development of NAFLD and aspects of diet-induced metabolic syndrome...
  38. pmc Diet-induced hepatocellular carcinoma in genetically predisposed mice
    Annie E Hill-Baskin
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 18:2975-88. 2009
    ..A similar diet modification may have important implications for prevention of HCCs in humans...
  39. doi request reprint Testicular germ cell tumors in mice: new ways to study a genetically complex trait
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 450:211-31. 2008
    ..We discuss the application of modifier genes in genetic interaction tests and sensitized polygenic trait analyses toward the understanding of the complex genetics and biology of TGCT susceptibility in mice...
  40. pmc Feature identification in circadian rhythms of mice strains using in vivo information
    Evren Gurkan
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106 7071, USA
    Mamm Genome 19:366-77. 2008
    ..This work provides the foundation for future studies directed at investigating the influence of chromosomal substitutions on the regulation of circadian rhythms in these two strains...
  41. ncbi request reprint Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors
    Man Yee J Lam
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 16:2233-40. 2007
    ....
  42. pmc Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors
    Rui Zhu
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 70:7264-72. 2010
    ..Our data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis...
  43. pmc Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation
    Philip D Anderson
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 69:9112-7. 2009
    ....
  44. ncbi request reprint Nutrigenes, functional genomics and systems biology
    Sheila Ernest
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Nutr 133:4267-8. 2003
    ..Accordingly, a model system is needed to test systems biology. In our studies, we used the homocysteine-folate metabolism as a model system...
  45. pmc The role of the mouse y chromosome on susceptibility to testicular germ cell tumors
    Philip D Anderson
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 69:3614-8. 2009
    ..Our results show that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis...
  46. pmc Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice
    Jonathan B Singer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genetics 169:855-62. 2005
    ..We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity...
  47. ncbi request reprint Genetic dissection of complex traits with chromosome substitution strains of mice
    Jonathan B Singer
    Broad Institute, Cambridge, MA 02142, USA
    Science 304:445-8. 2004
    ..These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains...
  48. pmc An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse
    Ivona Percec
    Howard Hughes Medical Institute, and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Genetics 164:1481-94. 2003
    ....
  49. pmc Implementing large-scale ENU mutagenesis screens in North America
    Amander T Clark
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genetica 122:51-64. 2004
    ..The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening...
  50. ncbi request reprint Listening to genetic background noise
    Joseph H Nadeau
    N Engl J Med 352:1598-9. 2005
  51. ncbi request reprint Finding genes that underlie complex traits
    Anne M Glazier
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, DuCane Road, London W12 0NN, UK
    Science 298:2345-9. 2002
    ..These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field...
  52. pmc Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains
    Tracey L Petryshen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Broad Institute of Harvard, 185 Cambridge Street, Cambridge, MA 02139, USA
    Genetics 171:1895-904. 2005
    ..The regions contain a limited number of strong biological candidate genes that are potential risk genes for psychiatric disorders in which patients have PPI impairments...
  53. pmc Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
    Karl J Jepsen
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, USA
    Mamm Genome 18:492-507. 2007
    ..Genetic or environmental perturbations that alter these functional interactions during growth would be expected to lead to loss of function and suboptimal adult bone quality...
  54. ncbi request reprint Chromosome substitution strains: a new way to study genetically complex traits
    Annie E Hill
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Methods Mol Med 128:153-72. 2006
    ..Several published studies demonstrate the considerable utility of these strains and new applications for CSSs continue to be discovered...
  55. ncbi request reprint Hierarchical relationship between bone traits and mechanical properties in inbred mice
    Karl J Jepsen
    Department of Orthopaedics, Box 1188, Mount Sinai School of Medicine, One Gustave Levy Place, New York, New York 10029, USA
    Mamm Genome 14:97-104. 2003
    ..Moreover, because the traits we examined are measurable with non-invasive means, this approach may also prove directly applicable to osteoporosis risk assessment...
  56. ncbi request reprint Single nucleotide polymorphisms: tackling complexity
    Joseph H Nadeau
    Nature 420:517-8. 2002
  57. ncbi request reprint RNA-RNA interaction prediction and antisense RNA target search
    Can Alkan
    Department of Genome Sciences, University of Washington, Seattle, 98195, USA
    J Comput Biol 13:267-82. 2006
    ..Equipped with this fast approach, we apply our method to discover targets for any given antisense RNA in the associated genome sequence...
  58. ncbi request reprint ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities
    Ichiro Nishimura
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Box 951668, CHS B3 087, Los Angeles, CA 90095, USA
    Crit Rev Oral Biol Med 14:320-30. 2003
    ..These approaches will produce a wealth of new data on critical genes that influence the size and shape of the human face...
  59. pmc A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice
    Christophe Poirier
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 168:1557-62. 2004
    ..Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo...
  60. pmc The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
    Kirsten K Youngren
    Department of Genetics and
    Nature 435:360-4. 2005
    ..TGCT development in the 129-Ter mouse strain models paediatric TGCT in humans. This work will have important implications for our understanding of the genetic control of TGCT pathogenesis and PGC biology...
  61. pmc Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time
    Daniel R Prows
    Children s Hospital Medical Center, Division and Program in Human Genetics, 3333 Burnet Ave, MLC 7016, Building R, Room 1464, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 38:68-77. 2008
    ..Together, these findings support most of the previously identified QTLs linked to ALI survival and established lines of mice to further resolve Aliq1...
  62. ncbi request reprint Search for testicular cancer gene hits dead-end
    Angabin Matin
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Cycle 4:1136-8. 2005
    ..The identity of Ter as Dead end and its function in PGCs will help clarify the role of editing in PGC biology and elucidate the causes of TGCTs in mice and humans...
  63. ncbi request reprint Autosomal dominant mutations affecting X inactivation choice in the mouse
    Ivona Percec
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 296:1136-9. 2002
    ..We have used chemical mutagenesis in the mouse to identify specific factors involved in X inactivation and report two genetically distinct autosomal mutations with dominant effects on X chromosome choice early in embryogenesis...