Research Topics
Genomes and Genes
| J H NadeauSummaryAffiliation: Case Western Reserve University Country: USA Publications
| Collaborators
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Detail Information
Publications
Naturally occurring variation in cardiovascular traits among inbred mouse strainsBrian D Hoit
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, 11100 Euclid Avenue, MS 5038, Cleveland, Ohio 44106 5038, USA
Genomics 79:679-85. 2002....- Interacting genetic loci cause airway hyperresponsivenessKate G Ackerman
Division of Genetics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Physiol Genomics 21:105-11. 2005.... 
Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolutionJ H Nadeau
Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
Genetics 147:1259-66. 1997....- Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populationsJoseph H Nadeau
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genome Res 13:2082-91. 2003..These networks are therefore an important approach for defining and characterizing functional relations in complex biological systems in health and disease... - The roads from phenotypic variation to gene discovery: mutagenesis versus QTLsJ H Nadeau
Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospitals of Cleveland, Cleveland, USA
Nat Genet 25:381-4. 2000..Despite recent progress in QTLs, we expect that mutagenesis is will ultimately prove more effective because the prospects of gene identification are high and every gene affecting a trait is potentially a target... - Analysing complex genetic traits with chromosome substitution strainsJ H Nadeau
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Nat Genet 24:221-5. 2000..We discuss the construction, applications and advantages of CSSs compared with conventional crosses for detecting and analysing QTLs, including those that have weak phenotypic effects... - Modifier genes in mice and humansJ H Nadeau
Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics, University Hospital of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Nat Rev Genet 2:165-74. 2001.... - Modifier genes and protective alleles in humans and miceJoseph H Nadeau
Department of Genetics and Center for Computational Genomics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA
Curr Opin Genet Dev 13:290-5. 2003..Together these modifier genes and protective alleles provide important glimpses into the molecular and cellular basis for the functional networks that provide robustness and homeostasis in complex biological systems... - Counting on comparative mapsJ H Nadeau
Genetics Department, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Trends Genet 14:495-501. 1998..We review the analytical methods that have been developed for characterizing these maps and evaluate their application to existing comparative maps mainly for plants and animals... - Genomic strategies for defining and dissecting developmental and physiological pathwaysJ H Nadeau
Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
Curr Opin Genet Dev 8:311-5. 1998..Together, these complementary approaches will test whether reductionism can account for the complex web of interactions that lead from genetic variation to morphological, physiological, and behavioral traits in health and disease... - Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strainA Matin
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
Nat Genet 23:237-40. 1999.... - 129/Sv mice--a model system for studying germ cell biology and testicular cancerL I Jiang
Department of Genetics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
Mamm Genome 12:89-94. 2001..In this review we summarize current understanding of the biology and genetics of TGCTs in mice and discuss the relevance of this work to testicular cancer in humans... - Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor dispositionR A Keri
Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 97:383-7. 2000..In addition, these results support the rare incidence of GC tumors in the human population, and suggest that the ability of certain fertility drugs to cause ovarian tumors may depend on an individual's genetic predisposition... - Pathways database systemZ Meral Ozsoyoglu
Center for Computational Genomics, Case Western Reserve University CWRU, Cleveland, Ohio 44106, USA
OMICS 7:123-5. 2003.... - L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neuronsQi Shi
Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
Ann N Y Acad Sci 1003:461-3. 2003 - Genetic architecture of complex traits: large phenotypic effects and pervasive epistasisHaifeng Shao
Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 105:19910-4. 2008..These results have implications for identification of complex trait genes, developmental and physiological studies of phenotypic variation, and opportunities to engineer phenotypic outcomes in complex biological systems... 
Analyzing complex traits with congenic strainsHaifeng Shao
Department of Genetics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Mamm Genome 21:276-86. 2010..Sequential analysis rigorously resolved phenotypic heterogeneity among strains in the congenic panels and found QTLs that other methods failed to detect...- Genetic and molecular control of folate-homocysteine metabolism in mutant miceSheila Ernest
Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Mamm Genome 13:259-67. 2002..These results begin to unravel the complex relations between elevation of a single amino acid in the blood and the diverse birth defects and adult diseases associated with hyperhomocysteinemia... - Genetics. Modifying the messageJoseph H Nadeau
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
Science 301:927-8. 2003 - Spontaneous metastasis in mouse models of testicular germ-cell tumoursJ L Zechel
Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Institute of Pathology, Cleveland OH, USA
Int J Androl 34:e278-87. 2011..Together, these results provide the first evidence for spontaneous TGCT metastasis in mice and show that these metastases originate from primary TGCTs rather than independently from ectopic stem cells... - Phenotype-driven genetic approaches in mice: high-throughput phenotyping for discovering new models of cardiovascular diseaseB D Hoit
Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA
Trends Cardiovasc Med 11:82-9. 2001..Insights into the genetic control of these diseases could lead to improved diagnosis and treatment as well as a deeper understanding of basic physiological processes... - Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in miceToshimori Kitami
Department of Genetics, Center for Computational Genomics and Systems Biology, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
Physiol Genomics 35:182-90. 2008.... - Resistance to diet-induced obesity in mice with a single substituted chromosomeDavid A Buchner
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4955, USA
Physiol Genomics 35:116-22. 2008..A better understanding of these genotype-phenotype relationships may enable a more individualized diagnosis and treatment of obesity and the metabolic syndrome... - Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genesL H Chadwick
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Genomics 70:66-73. 2000.... - Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strainsThomas D Krewson
Division of Pediatric Endocrinology and Metabolism, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
Endocrinology 145:4447-51. 2004..These findings demonstrate that chromosomes 6 and 13 harbor QTLs that control the timing of VO. Identification of the responsible genes may reveal factors that regulate the maturation of the HPG axis and determine the timing of puberty... - A quantitative trait locus on chromosome 6 regulates the onset of puberty in miceBrandon M Nathan
Division of Pediatric Endocrinology and Metabolism, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
Endocrinology 147:5132-8. 2006..These findings represent an important advancement toward identification of novel factors that regulate maturation of the hypothalamic-pituitary-gonadal axis and determine the timing of puberty... - Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effectsSheila Ernest
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Physiol Genomics 21:404-10. 2005..Finally, gene-diet interactions affected heritability of mean tHcy levels. These studies showed that each of these factors contributes to tHcy levels and provided important clues to understanding homocysteine homeostasis in humans... - L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonistsQi Shi
Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Pharmacol Exp Ther 305:131-42. 2003..The relevance of these findings for the role of mGluRs in the pathogenesis of homocysteine-mediated phenomena is discussed... - Genetic resistance to diet-induced obesity in chromosome substitution strains of miceLindsay C Burrage
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Mamm Genome 21:115-29. 2010.... - Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modificationsKirsten K Youngren
Department of Genetics, Case Western Reserve University School of Medicine and Center for Human Genetics and Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Hum Mol Genet 12:389-98. 2003..Finally, we propose that these TGCTs result from disrupted testicular and spermatogenic developmental programs... - Testicular teratocarcinogenesis in mice--a reviewA Matin
Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
APMIS 106:174-82. 1998..In this paper, we review the genetics and development of germ cell tumours in 129/Sv mice, summarize the status of Ter mapping, and provide evidence that different genetic pathways lead to unilateral and bilateral tumours... - Disorganization in mice and humansN H Robin
Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio, USA
Am J Med Genet 101:334-8. 2001..Ds may be the genetic basis for more usual and seemingly sporadic human birth defects as well... - Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type miceSheila Ernest
Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Hum Mol Genet 15:3387-93. 2006..These results raise the possibility of using metabolite and expression profiles to distinguish folate-responsive and resistance adult females who are at risk for bearing fetuses with an NTD... - Transgenerational genetic effects on phenotypic variation and disease riskJoseph H Nadeau
Department of Genetics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Hum Mol Genet 18:R202-10. 2009.... - Quantitative trait locus analysis for hemostasis and thrombosisQila Sa
Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland, OH 44195, USA
Mamm Genome 19:406-12. 2008..Thus, we have identified new QTLs and candidate genes not previously known to influence thrombotic risk... - Genetic and phenotypic analysis of seizure susceptibility in PL/J miceToshimori Kitami
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Mamm Genome 15:698-703. 2004..The PL/J strain serves as an interesting new model for studying the genetics, neurobiology, and pharmacology of epilepsy... - Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17Carrie A Millward
Department of Nutrition, Case Western Reserve University School of Medicine, Biomedical Research Building 925, 2109 Adelbert Road, Cleveland, OH 44106 4955, USA
Mamm Genome 20:71-82. 2009..These congenic strains provide mouse models to identify genes and metabolic pathways that are involved in the development of NAFLD and aspects of diet-induced metabolic syndrome... - Diet-induced hepatocellular carcinoma in genetically predisposed miceAnnie E Hill-Baskin
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Hum Mol Genet 18:2975-88. 2009..A similar diet modification may have important implications for prevention of HCCs in humans... - Testicular germ cell tumors in mice: new ways to study a genetically complex traitJason D Heaney
Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
Methods Mol Biol 450:211-31. 2008..We discuss the application of modifier genes in genetic interaction tests and sensitized polygenic trait analyses toward the understanding of the complex genetics and biology of TGCT susceptibility in mice... - Feature identification in circadian rhythms of mice strains using in vivo informationEvren Gurkan
Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106 7071, USA
Mamm Genome 19:366-77. 2008..This work provides the foundation for future studies directed at investigating the influence of chromosomal substitutions on the regulation of circadian rhythms in these two strains... - Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumorsMan Yee J Lam
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Hum Mol Genet 16:2233-40. 2007.... - Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumorsRui Zhu
Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 70:7264-72. 2010..Our data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis... - Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivationPhilip D Anderson
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
Cancer Res 69:9112-7. 2009.... - Nutrigenes, functional genomics and systems biologySheila Ernest
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Nutr 133:4267-8. 2003..Accordingly, a model system is needed to test systems biology. In our studies, we used the homocysteine-folate metabolism as a model system... - The role of the mouse y chromosome on susceptibility to testicular germ cell tumorsPhilip D Anderson
Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
Cancer Res 69:3614-8. 2009..Our results show that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis... - Mapping quantitative trait loci for anxiety in chromosome substitution strains of miceJonathan B Singer
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genetics 169:855-62. 2005..We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity... - Genetic dissection of complex traits with chromosome substitution strains of miceJonathan B Singer
Broad Institute, Cambridge, MA 02142, USA
Science 304:445-8. 2004..These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains... - An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouseIvona Percec
Howard Hughes Medical Institute, and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Genetics 164:1481-94. 2003.... - Implementing large-scale ENU mutagenesis screens in North AmericaAmander T Clark
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Genetica 122:51-64. 2004..The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening... - Listening to genetic background noiseJoseph H Nadeau
N Engl J Med 352:1598-9. 2005 - Finding genes that underlie complex traitsAnne M Glazier
Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, DuCane Road, London W12 0NN, UK
Science 298:2345-9. 2002..These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field... - Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strainsTracey L Petryshen
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Broad Institute of Harvard, 185 Cambridge Street, Cambridge, MA 02139, USA
Genetics 171:1895-904. 2005..The regions contain a limited number of strong biological candidate genes that are potential risk genes for psychiatric disorders in which patients have PPI impairments... 
Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragilityKarl J Jepsen
Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, USA
Mamm Genome 18:492-507. 2007..Genetic or environmental perturbations that alter these functional interactions during growth would be expected to lead to loss of function and suboptimal adult bone quality...- Chromosome substitution strains: a new way to study genetically complex traitsAnnie E Hill
Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Methods Mol Med 128:153-72. 2006..Several published studies demonstrate the considerable utility of these strains and new applications for CSSs continue to be discovered... - Hierarchical relationship between bone traits and mechanical properties in inbred miceKarl J Jepsen
Department of Orthopaedics, Box 1188, Mount Sinai School of Medicine, One Gustave Levy Place, New York, New York 10029, USA
Mamm Genome 14:97-104. 2003..Moreover, because the traits we examined are measurable with non-invasive means, this approach may also prove directly applicable to osteoporosis risk assessment... - Single nucleotide polymorphisms: tackling complexityJoseph H Nadeau
Nature 420:517-8. 2002 - RNA-RNA interaction prediction and antisense RNA target searchCan Alkan
Department of Genome Sciences, University of Washington, Seattle, 98195, USA
J Comput Biol 13:267-82. 2006..Equipped with this fast approach, we apply our method to discover targets for any given antisense RNA in the associated genome sequence... - ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalitiesIchiro Nishimura
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Box 951668, CHS B3 087, Los Angeles, CA 90095, USA
Crit Rev Oral Biol Med 14:320-30. 2003..These approaches will produce a wealth of new data on critical genes that influence the size and shape of the human face... - A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) miceChristophe Poirier
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
Genetics 168:1557-62. 2004..Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo... - The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumoursKirsten K Youngren
Department of Genetics and
Nature 435:360-4. 2005..TGCT development in the 129-Ter mouse strain models paediatric TGCT in humans. This work will have important implications for our understanding of the genetic control of TGCT pathogenesis and PGC biology... - Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival timeDaniel R Prows
Children s Hospital Medical Center, Division and Program in Human Genetics, 3333 Burnet Ave, MLC 7016, Building R, Room 1464, Cincinnati, OH 45229 3039, USA
Am J Respir Cell Mol Biol 38:68-77. 2008..Together, these findings support most of the previously identified QTLs linked to ALI survival and established lines of mice to further resolve Aliq1... - Search for testicular cancer gene hits dead-endAngabin Matin
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cell Cycle 4:1136-8. 2005..The identity of Ter as Dead end and its function in PGCs will help clarify the role of editing in PGC biology and elucidate the causes of TGCTs in mice and humans... - Autosomal dominant mutations affecting X inactivation choice in the mouseIvona Percec
Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Science 296:1136-9. 2002..We have used chemical mutagenesis in the mouse to identify specific factors involved in X inactivation and report two genetically distinct autosomal mutations with dominant effects on X chromosome choice early in embryogenesis...