Ann M Moormann

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc A polymerase chain reaction/ligase detection reaction fluorescent microsphere assay to determine Plasmodium falciparum MSP-119 haplotypes
    Arlene E Dent
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Am J Trop Med Hyg 77:250-5. 2007
  2. pmc Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
    Amolo S Asito
    School of Pure and Applied Science, Kenyatta University, Nairobi, Kenya
    Malar J 7:238. 2008
  3. pmc Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya
    Ann M Moormann
    Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
    Am J Trop Med Hyg 81:489-95. 2009
  4. ncbi request reprint Exposure to holoendemic malaria results in suppression of Epstein-Barr virus-specific T cell immunosurveillance in Kenyan children
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, 44106, USA
    J Infect Dis 195:799-808. 2007
  5. ncbi request reprint Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Am J Trop Med Hyg 74:585-90. 2006
  6. pmc Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan adults
    Arlene E Dent
    Case Western Reserve University, Cleveland, OH, USA
    Malar J 8:162. 2009
  7. pmc Allele specificity of gamma interferon responses to the carboxyl-terminal region of Plasmodium falciparum merozoite surface protein 1 by Kenyan adults with naturally acquired immunity to malaria
    Michele D Spring
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    Infect Immun 78:4431-41. 2010
  8. pmc Humoral and cellular immunity to Plasmodium falciparum merozoite surface protein 1 and protection from infection with blood-stage parasites
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 208:149-58. 2013
  9. pmc Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH
    Int J Cancer 124:1721-6. 2009
  10. pmc Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection
    Arlene E Dent
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA
    Malar J 11:287. 2012

Collaborators

Detail Information

Publications25

  1. pmc A polymerase chain reaction/ligase detection reaction fluorescent microsphere assay to determine Plasmodium falciparum MSP-119 haplotypes
    Arlene E Dent
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Am J Trop Med Hyg 77:250-5. 2007
    ..Application of this method is an inexpensive, accurate, and high-throughput alternative to distinguish the predominant MSP-1(19) haplotypes in epidemiologic studies...
  2. pmc Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children
    Amolo S Asito
    School of Pure and Applied Science, Kenyatta University, Nairobi, Kenya
    Malar J 7:238. 2008
    ..The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype...
  3. pmc Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya
    Ann M Moormann
    Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
    Am J Trop Med Hyg 81:489-95. 2009
    ....
  4. ncbi request reprint Exposure to holoendemic malaria results in suppression of Epstein-Barr virus-specific T cell immunosurveillance in Kenyan children
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, 44106, USA
    J Infect Dis 195:799-808. 2007
    ..Malaria and Epstein-Barr virus (EBV) infection are cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). The mechanisms by which these pathogens predispose to eBL are not known...
  5. ncbi request reprint Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Am J Trop Med Hyg 74:585-90. 2006
    ..This suggests that cytokine responses to LSA-1 and TRAP are transient under natural exposure conditions...
  6. pmc Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan adults
    Arlene E Dent
    Case Western Reserve University, Cleveland, OH, USA
    Malar J 8:162. 2009
    ....
  7. pmc Allele specificity of gamma interferon responses to the carboxyl-terminal region of Plasmodium falciparum merozoite surface protein 1 by Kenyan adults with naturally acquired immunity to malaria
    Michele D Spring
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    Infect Immun 78:4431-41. 2010
    ..Although immunity against MSP1 alone will not confer protection against malaria, demonstrating a relative and sustained increase in T-cell immunity to MSP1 after vaccination would be a reasonable measurement of vaccine responsiveness...
  8. pmc Humoral and cellular immunity to Plasmodium falciparum merozoite surface protein 1 and protection from infection with blood-stage parasites
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 208:149-58. 2013
    ..Understanding immune correlates of protection from malaria would facilitate vaccine development and identification of biomarkers that reflect changes in susceptibility resulting from ongoing malaria control efforts...
  9. pmc Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH
    Int J Cancer 124:1721-6. 2009
    ..This study demonstrates a selective loss of EBNA1-specific T cell responses in children with eBL and suggests a potential immunotherapeutic target for this EBV-associated lymphoma...
  10. pmc Broadly reactive antibodies specific for Plasmodium falciparum MSP-1(19) are associated with the protection of naturally exposed children against infection
    Arlene E Dent
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA
    Malar J 11:287. 2012
    ..IgG antibodies directed against all four variants have been detected, but it is not known if these variant specific antibodies are associated with haplotype-specific protection from infection...
  11. ncbi request reprint Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infection
    Chandy C John
    Center for Global Health and Diseases, Rainbow Center for International Child Health, Division of Pediatric Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Trop Med Hyg 73:222-8. 2005
    ..High levels of IgG antibodies to CSP, LSA-1, and TRAP may be useful immune correlates of protection against P. falciparum infection in malaria-endemic populations...
  12. pmc Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria
    Chandy C John
    Center for Global Health and Diseases, Case Western Researve University, Cleveland, OH, USA
    Infect Immun 72:5135-42. 2004
    ..IFN-gamma responses to LSA-1 appear to require repeated P. falciparum exposure and/or increased age and, as measured by ELISA, are associated with protection against clinical malaria and anemia...
  13. pmc Antibody-mediated growth inhibition of Plasmodium falciparum: relationship to age and protection from parasitemia in Kenyan children and adults
    Arlene E Dent
    Case Western Reserve University, Cleveland, Ohio, USA
    PLoS ONE 3:e3557. 2008
    ..Growth inhibition assays (GIA) offer a convenient method to quantify functional antibody activity against blood stage malaria...
  14. ncbi request reprint Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of Kenya
    Chandy C John
    Rainbow Babies and Children s Hospital, RCICH, RBC 487, MS6008, Cleveland, OH 44106, USA
    Trans R Soc Trop Med Hyg 99:780-6. 2005
    ..3%. In this epidemic-prone highland area, inter-epidemic periods are characterized by low frequencies of asymptomatically infected individuals. Increases in gametocyte prevalence may be an early indicator of impending outbreaks...
  15. pmc Toll-like receptor polymorphisms in malaria-endemic populations
    Jennifer A Greene
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland OH, USA
    Malar J 8:50. 2009
    ..Because of their potential role in malaria pathogenesis, polymorphisms in these genes may be under selective pressure in populations where this infectious disease is endemic...
  16. ncbi request reprint Fine specificity of neonatal lymphocytes to an abundant malaria blood-stage antigen: epitope mapping of Plasmodium falciparum MSP1(33)
    Indu Malhotra
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 180:3383-90. 2008
    ..We conclude that the fetal malaria response functions in a fully adaptive manner and that this response may serve to help protect the infant from severe malaria during infancy...
  17. ncbi request reprint Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa
    Chandy C John
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    J Immunol 173:666-72. 2004
    ..falciparum infection, and suggest that the measurement of MSP-1(19) specific inhibitory Abs may serve as an accurate correlate of protection in clinical trials of MSP-1-based vaccines...
  18. pmc Antibodies to Plasmodium falciparum erythrocyte-binding antigen-175 are associated with protection from clinical malaria
    Matthew B McCarra
    Division of Global Pediatrics, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    Pediatr Infect Dis J 30:1037-42. 2011
    ..Many of these studies have not assessed whether high-titer antibodies are associated with protection and have not adjusted for differences in malaria exposure...
  19. pmc Serologic evidence of arboviral infections among humans in Kenya
    Laura J Sutherland
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Trop Med Hyg 85:158-61. 2011
    ..In Kenya, transmission of arboviral infection continues between known epidemics and remains common across the country...
  20. ncbi request reprint Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 191:1233-8. 2005
    ..Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL...
  21. ncbi request reprint Spatial clustering of endemic Burkitt's lymphoma in high-risk regions of Kenya
    Jeanette J Rainey
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Int J Cancer 120:121-7. 2007
    ....
  22. ncbi request reprint Spatial distribution of Burkitt's lymphoma in Kenya and association with malaria risk
    Jeanette J Rainey
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Trop Med Int Health 12:936-43. 2007
    ..Although crude tribe-specific incidence rates ranged between 0.0 and 3.26, tribe was not associated with BL after controlling for malaria. These findings support the aetiologic role of intense malaria transmission intensity in BL...
  23. ncbi request reprint Family environment is associated with endemic Burkitt lymphoma: a population-based case-control study
    Jeanette J Rainey
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Trop Med Hyg 78:338-43. 2008
    ..12, 90% CI:1.19, 8.17) and to have at least one deceased parent (OR=3.38, 90% CI: 1.18, 9.64). Household characteristics, especially sibship relationships, may contribute to endemic Burkitt's lymphoma and therefore warrant further study...
  24. ncbi request reprint Endemic Burkitt's lymphoma: a polymicrobial disease?
    Rosemary Rochford
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA
    Nat Rev Microbiol 3:182-7. 2005
    ..New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis...
  25. pmc Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children
    Chandy C John
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Infect Dis 197:519-26. 2008
    ..IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria...