Montano M, Doughman Y, Deng H, Chaplin L, Yang J, Wang N, et al. Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008;102:415-22 pubmed
..The basis for this role of HEXIM1 is that VEGF is a direct transcriptional target of HEXIM1, and involves attenuation a repressive effects of C/EBPalpha on VEGF gene transcription. ..
Montano M, Desjardins C, Doughman Y, Hsieh Y, Hu Y, Bensinger H, et al. Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse. Cardiovasc Res. 2013;99:74-82 pubmed publisher
..HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy. ..