Robert Miller

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint Translating stem cell therapies to the clinic
    Robert H Miller
    Department of Neuroscience, Center for Translational Neuroscience, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States
    Neurosci Lett 519:87-92. 2012
  2. pmc Restoring the balance between disease and repair in multiple sclerosis: insights from mouse models
    Robert H Miller
    Department of Neurosciences, Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Dis Model Mech 3:535-9. 2010
  3. ncbi request reprint Cellular approaches for stimulating CNS remyelination
    Robert H Miller
    Center for Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Regen Med 2:817-29. 2007
  4. pmc Building bridges with astrocytes for spinal cord repair
    Robert H Miller
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4975, USA
    J Biol 5:6. 2006
  5. ncbi request reprint Dissecting demyelination
    Robert H Miller
    Center for Translational Neuroscience, Department of Neuroscience, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Neurosci 10:1351-4. 2007
  6. ncbi request reprint The potential of mesenchymal stem cells for neural repair
    Robert H Miller
    Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Discov Med 9:236-42. 2010
  7. pmc CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis
    Liping Liu
    Neuroinflammation Research Center, Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 13:319-26. 2010
  8. ncbi request reprint Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2
    Dolly A Padovani-Claudio
    Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106 6002, USA
    Glia 54:471-83. 2006
  9. pmc Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    Lianhua Bai
    Case Western Reserve University, Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106, USA
    Glia 57:1192-203. 2009
  10. pmc In vivo quantification of myelin changes in the vertebrate nervous system
    Yanming Wang
    Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:14663-9. 2009

Research Grants

  1. Gordon Conference on Myelin
    Robert Miller; Fiscal Year: 2004
  2. DEVELOPMENT OF OLIGODENDROCYTES IN THE SPINAL CORD
    Robert Miller; Fiscal Year: 2006
  3. 2006 Myelin Gordon Conference
    Robert Miller; Fiscal Year: 2006
  4. Chemokine Synergy with PDGF Oligodendrocyte Precursors
    Robert Miller; Fiscal Year: 2007
  5. Development of Oligodendrycytes in the Spinal Cord
    Robert H Miller; Fiscal Year: 2010
  6. 15th Biennial Meeting of the ISDN
    Robert Miller; Fiscal Year: 2004
  7. DEVELOPMENT OF OLIGODENDROCYTES IN THE SPINAL CORD
    Robert Miller; Fiscal Year: 2001
  8. Oligodendrocyte Loss Following Early Ischemic Injury
    Robert Miller; Fiscal Year: 2003
  9. Development of Oligodendrycytes in the Spinal Cord
    Robert Miller; Fiscal Year: 2009

Collaborators

Detail Information

Publications46

  1. doi request reprint Translating stem cell therapies to the clinic
    Robert H Miller
    Department of Neuroscience, Center for Translational Neuroscience, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States
    Neurosci Lett 519:87-92. 2012
    ..While preclinical studies are moving extremely rapidly, the effective translation of these studies to the clinical arena remains extremely challenging...
  2. pmc Restoring the balance between disease and repair in multiple sclerosis: insights from mouse models
    Robert H Miller
    Department of Neurosciences, Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Dis Model Mech 3:535-9. 2010
    ..This Commentary will review established murine models of MS, and discuss emerging technologies that promise to provide insights into the mechanisms of myelin repair...
  3. ncbi request reprint Cellular approaches for stimulating CNS remyelination
    Robert H Miller
    Center for Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Regen Med 2:817-29. 2007
    ....
  4. pmc Building bridges with astrocytes for spinal cord repair
    Robert H Miller
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4975, USA
    J Biol 5:6. 2006
    ..Transplantation of a novel astrocyte cell type derived from glial-restricted precursors in vitro raise the eventual possibility of cellular therapy for spinal cord injury...
  5. ncbi request reprint Dissecting demyelination
    Robert H Miller
    Center for Translational Neuroscience, Department of Neuroscience, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Neurosci 10:1351-4. 2007
    ..Defining the rate-limiting steps and most vulnerable aspects at each stage of myelin repair will provide logical targets for therapeutic intervention in demyelinating diseases such as multiple sclerosis...
  6. ncbi request reprint The potential of mesenchymal stem cells for neural repair
    Robert H Miller
    Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Discov Med 9:236-42. 2010
    ..In each situation, treatment with MSCs results in substantial functional benefit and these pre-clinical studies have led to the initiation of a number of clinical trials worldwide in neural repair...
  7. pmc CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis
    Liping Liu
    Neuroinflammation Research Center, Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 13:319-26. 2010
    ..These data suggest that cuprizone-induced demyelination is useful for modeling certain aspects of multiple sclerosis pathogenesis...
  8. ncbi request reprint Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2
    Dolly A Padovani-Claudio
    Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106 6002, USA
    Glia 54:471-83. 2006
    ..Together, these findings indicate that the chemokine receptor CXCR2 is important for the development and maintenance of the oligodendrocyte lineage, myelination, and white matter in the vertebrate CNS...
  9. pmc Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    Lianhua Bai
    Case Western Reserve University, Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106, USA
    Glia 57:1192-203. 2009
    ..Together, these data suggest that the BM-hMSCs represent a viable option for therapeutic approaches...
  10. pmc In vivo quantification of myelin changes in the vertebrate nervous system
    Yanming Wang
    Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:14663-9. 2009
    ....
  11. ncbi request reprint Extracellular and intracellular regulation of oligodendrocyte development: roles of Sonic hedgehog and expression of E proteins
    Caroline R Sussman
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
    Glia 40:55-64. 2002
    ..We propose that E2A and/or HEB, possibly in combination with Olig1 and 2, are critical components of oligodendrogenesis and may regulate cell survival, proliferation, and fate decisions in the oligodendrocyte lineage...
  12. ncbi request reprint The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration
    Hui Hsin Tsai
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell 110:373-83. 2002
    ..These data suggest that population of presumptive white matter by oligodendrocyte precursors is dependent on localized expression of CXCL1...
  13. pmc Cancer in the elderly
    Nathan A Berger
    Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4971, USA
    Trans Am Clin Climatol Assoc 117:147-55; discussion 155-6. 2006
    ..Studies will be addressed in the high priority research areas of 1) Treatment Efficacy and Tolerance, 2) Effects of Comorbidities, 3) Psychosocial Issues, and 4) Biology of Aging Cancer...
  14. ncbi request reprint The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation
    Caroline R Sussman
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    J Neurosci 25:5757-62. 2005
    ....
  15. ncbi request reprint Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusion
    Nicholas C Bambakidis
    Departments of Neurological Surgery and Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Spine J 4:16-26. 2004
    ....
  16. ncbi request reprint High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord
    Cynthia A Deboy
    Department of Neurology, Johns Hopkins University, School of Medicine, USA
    Brain 130:2199-210. 2007
    ..These data suggest that high resolution DTI may be a more sensitive method than conventional imaging for detecting axonal damage at sites distant from inflammation...
  17. ncbi request reprint Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina
    Limin Gao
    Department of Neurosciences, Case School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 290:277-86. 2006
    ..These data combined with the proposed inhibition of OPC migration by molecules selectively expressed at the nerve retina junction suggest that multiple mechanisms combine to suppress retinal myelination during development...
  18. ncbi request reprint NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells
    Karen L Baracskay
    Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Glia 55:1001-10. 2007
    ..NG2(+) cells appear prior to the expression of A2B5(+) cells and generate A2B5(+) cells. We propose that during development NG2(+)/A2B5(-) cells (pre-OPCs) represent the direct ancestor to A2B5(+) O2A progenitor cells (OPCs)...
  19. pmc Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain
    Chuanshen Wu
    Department of Neurosciences, Lerner Research Institute and Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 29:7649-57. 2009
    ..We propose that betaT4 cells are an endogenous cell source that can be recruited to promote neural repair in the adult telencephalon...
  20. ncbi request reprint Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice
    Karen L Baracskay
    Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Neurosci Res 70:645-54. 2002
    ..These data provide additional evidence that oligodendrogenesis is differentially regulated in white matter and gray matter and implicate PLP/DM20 as a modulator of these differences...
  21. pmc IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production
    Jinbo Liu
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106 USA
    J Immunol 180:5882-9. 2008
    ....
  22. ncbi request reprint Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4
    Robert H Miller
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci Res 76:9-19. 2004
    ..These data suggest that BMP4 contributes to the pattern of spinal cord oligodendrogenesis by regulating both induction and maturation of spinal cord OPCs...
  23. pmc Distinct modes of migration position oligodendrocyte precursors for localized cell division in the developing spinal cord
    Hui Hsin Tsai
    Center for Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Neurosci Res 87:3320-30. 2009
    ..These studies suggest that positional cues are critical for regulating OPC behavior during spinal cord development...
  24. ncbi request reprint Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions
    Molly L Fuller
    Department of Neurosciences and Center for Translational Neuroscience, Case School of Medicine, Cleveland, OH 44106, USA
    Ann Neurol 62:288-300. 2007
    ..To determine the role of bone morphogenetic proteins (BMPs) in stimulating glial scar formation in demyelinating lesions of the adult spinal cord...
  25. ncbi request reprint Regulation of oligodendrocyte development in the vertebrate CNS
    Robert H Miller
    Department of Neurosciences, School of Medicine, Case Western Reserve University E 721, 2109 Adelbert Road, Cleveland, OH 44106 4975, USA
    Prog Neurobiol 67:451-67. 2002
    ..Understanding the regulation of oligodendrogenesis will facilitate the use of these endogenous precursors to enhance repair in a variety of pathological conditions...
  26. ncbi request reprint Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injury
    Nicholas C Bambakidis
    Department of Neurosurgery, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurosurg 99:70-5. 2003
    ..To assess its role in the repair of demyelination following spinal cord injury (SCI), escalating doses of Shh were injected into demyelinated lesions in adult rat spinal cords...
  27. ncbi request reprint Emerging roles for bone morphogenetic proteins in central nervous system glial biology
    Alison K Hall
    Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurosci Res 76:1-8. 2004
    ..Additional functions for members of the TGFbeta superfamily in CNS injury responses are emerging suggesting these molecules represent useful targets for manipulating neural responses to CNS insults...
  28. ncbi request reprint Netrin-1 is required for the normal development of spinal cord oligodendrocytes
    Hui Hsin Tsai
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 26:1913-22. 2006
    ..These data indicate that netrin-1 is crucial for both the initial dispersal of spinal cord oligodendrocyte precursors and their subsequent development in the presumptive white matter...
  29. ncbi request reprint The promise of stem cells for neural repair
    Robert H Miller
    Department of Neurosciences, Center for Stem Cell and Regenerative Medicine, Case School of Medicine Cleveland, OH 44106, USA
    Brain Res 1091:258-64. 2006
    ..Given the commonality of processes mediating the assembly of multicellular systems, the approaches developed in the CNS will likely be applicable for selective cell replacement in the auditory system...
  30. ncbi request reprint Glial cell migration directed by axon guidance cues
    Hui Hsin Tsai
    Dept of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Trends Neurosci 25:173-5; discussion 175-6. 2002
    ..These studies suggest a novel mechanism governing glial precursor migration and provide new insights into development and the potential to direct CNS injury repair...
  31. ncbi request reprint Dorsally derived oligodendrocytes come of age
    Robert H Miller
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Neuron 45:1-3. 2005
    ..These cells share expression of the PDGFalpha receptor and Olig2 with their ventral counterparts but differ in the requirement for Nkx6 and hedgehog signaling...
  32. ncbi request reprint Identification and characterization of mouse cochlear stem cells
    Michael V Yerukhimovich
    Department of Otolaryngology, Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Dev Neurosci 29:251-60. 2007
    ..Our results show that cochleae from neonatal mice harbor cells capable of forming spheres and cells from these spheres appear to be better endowed to become hair cells...
  33. ncbi request reprint Control of astrocyte migration in the developing cerebral cortex
    Chad T Jacobsen
    Department of Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Dev Neurosci 25:207-16. 2003
    ..These data suggest the existence of distinct migrational cues in the CNS and that environmental, not cell intrinsic properties primarily regulate astrocyte migration through the developing cortex...
  34. pmc PTPmu suppresses glioma cell migration and dispersal
    Adam M Burgoyne
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neuro Oncol 11:767-78. 2009
    ..Together, these data suggest that loss of PTPmu in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPmu in glioma progression...
  35. pmc Molecular probes for imaging myelinated white matter in CNS
    Chunying Wu
    Department of Radiology and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Med Chem 51:6682-8. 2008
    ..These studies suggested that these stilbene derivatives can be used as myelin-imaging probes to monitor myelin pathology in vivo...
  36. ncbi request reprint Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal
    Hui Hsin Tsai
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Development 130:2095-105. 2003
    ..These data indicate the initial dispersal of oligodendrocyte precursors from their localized origin is guided by a chemorepellent response to netrin 1...
  37. ncbi request reprint Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons
    Limin Gao
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 26:7619-28. 2006
    ..The dependence of OPCs on retinal axonal cues appears to be a common phenomenon, because ocular retardation (or(J)) mice lacking optic nerve have dramatically reduced OPCs in the midline of the third ventricle...
  38. pmc Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury
    Marcus Mazur
    Department of Neurosurgery, Rainbow Babies and Children s Hospital, Center for Translational Neuroscience, The Neurological Institute of University Hospitals Case Medical Center, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosurg Pediatr 6:206-21. 2010
    ..Furthermore, the authors suggest that neonatal exogenous recombinant human EPO (rhEPO) administration can restore the mismatch of EPO ligand and receptor levels, and enhance neural cell survival...
  39. pmc Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury
    Sarah A Busch
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 30:255-65. 2010
    ....
  40. ncbi request reprint Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats
    Shenandoah Robinson
    Department of Neurological Surgery, Case Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Neurobiol Dis 18:568-81. 2005
    ....
  41. ncbi request reprint Human mesenchymal stem cells signals regulate neural stem cell fate
    Lianhua Bai
    Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurochem Res 32:353-62. 2007
    ..We propose that the selective promotion of neuronal and oligodendroglial fates in neural stem cell progeny is responsible for the ability of MSCs to enhance recovery after a wide range of CNS injuries...
  42. ncbi request reprint LINGO-1 negatively regulates myelination by oligodendrocytes
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 8:745-51. 2005
    ..The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination...
  43. doi request reprint LINGO-1 and its role in CNS repair
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States
    Int J Biochem Cell Biol 40:1971-8. 2008
    ..The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases...
  44. ncbi request reprint Endogenous stem cell proliferation after central nervous system injury: alternative therapeutic options
    Nicholas C Bambakidis
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
    Neurosurg Focus 19:E1. 2005
    ..In this review the authors provide a brief overview of the enhancement of endogenous stem cell proliferation following neurological insult...
  45. ncbi request reprint The expanding influence of stem cells in neural repair
    Robert H Miller
    Ann Neurol 61:187-8. 2007
  46. ncbi request reprint NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination
    Xinhua Lee
    Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:220-5. 2007
    ..The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development...

Research Grants21

  1. Gordon Conference on Myelin
    Robert Miller; Fiscal Year: 2004
    ....
  2. DEVELOPMENT OF OLIGODENDROCYTES IN THE SPINAL CORD
    Robert Miller; Fiscal Year: 2006
    ..abstract_text> ..
  3. 2006 Myelin Gordon Conference
    Robert Miller; Fiscal Year: 2006
    ..In keeping with the goals of the Gordon Conference such interactions will provide impetus and direction to the field of myelin biology. ..
  4. Chemokine Synergy with PDGF Oligodendrocyte Precursors
    Robert Miller; Fiscal Year: 2007
    ..will define GRO-alpha as an important regulatory molecule in oligodendrogenesis and a potential target for therapy in diseases of myelin, such as Multiple Sclerosis, and disorders of unregulated gliogenesis such as oligodendroglioma ..
  5. Development of Oligodendrycytes in the Spinal Cord
    Robert H Miller; Fiscal Year: 2010
    ..Such information will provide new targets for the development of treatments for demyelinating diseases such as Multiple Sclerosis. ..
  6. 15th Biennial Meeting of the ISDN
    Robert Miller; Fiscal Year: 2004
    ..This is an exciting time in developmental neuroscience and the types of scientific interactions afforded by this meeting will help to advance our understanding by bringing together workers in distinct but related areas. ..
  7. DEVELOPMENT OF OLIGODENDROCYTES IN THE SPINAL CORD
    Robert Miller; Fiscal Year: 2001
    ..These studies will provide important new information on the mechanisms underlying oligodendrocyte development in the vertebrate CNS, and will lead to novel approaches to achieve remyelination after CNS injury or demyelinating diseases. ..
  8. Oligodendrocyte Loss Following Early Ischemic Injury
    Robert Miller; Fiscal Year: 2003
    ..Completion of this project will identify candidate molecules that will be useful for the development of novel therapeutic interventions for treating a common and devastating pediatric CNS problem. ..
  9. Development of Oligodendrycytes in the Spinal Cord
    Robert Miller; Fiscal Year: 2009
    ..Such information will provide new targets for the development of treatments for demyelinating diseases such as Multiple Sclerosis. ..