Research Topics
Species | Robert MillerSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Translating stem cell therapies to the clinicRobert H Miller
Department of Neuroscience, Center for Translational Neuroscience, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States
Neurosci Lett 519:87-92. 2012..While preclinical studies are moving extremely rapidly, the effective translation of these studies to the clinical arena remains extremely challenging...
Restoring the balance between disease and repair in multiple sclerosis: insights from mouse modelsRobert H Miller
Department of Neurosciences, Center for Translational Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
Dis Model Mech 3:535-9. 2010..This Commentary will review established murine models of MS, and discuss emerging technologies that promise to provide insights into the mechanisms of myelin repair...
Cellular approaches for stimulating CNS remyelinationRobert H Miller
Center for Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Regen Med 2:817-29. 2007....- Building bridges with astrocytes for spinal cord repairRobert H Miller
Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4975, USA
J Biol 5:6. 2006..Transplantation of a novel astrocyte cell type derived from glial-restricted precursors in vitro raise the eventual possibility of cellular therapy for spinal cord injury... - Dissecting demyelinationRobert H Miller
Center for Translational Neuroscience, Department of Neuroscience, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, Ohio 44106, USA
Nat Neurosci 10:1351-4. 2007..Defining the rate-limiting steps and most vulnerable aspects at each stage of myelin repair will provide logical targets for therapeutic intervention in demyelinating diseases such as multiple sclerosis... - The potential of mesenchymal stem cells for neural repairRobert H Miller
Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Discov Med 9:236-42. 2010..In each situation, treatment with MSCs results in substantial functional benefit and these pre-clinical studies have led to the initiation of a number of clinical trials worldwide in neural repair... - CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosisLiping Liu
Neuroinflammation Research Center, Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Nat Neurosci 13:319-26. 2010..These data suggest that cuprizone-induced demyelination is useful for modeling certain aspects of multiple sclerosis pathogenesis... - Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2Dolly A Padovani-Claudio
Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106 6002, USA
Glia 54:471-83. 2006..Together, these findings indicate that the chemokine receptor CXCR2 is important for the development and maintenance of the oligodendrocyte lineage, myelination, and white matter in the vertebrate CNS... - Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosisLianhua Bai
Case Western Reserve University, Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106, USA
Glia 57:1192-203. 2009..Together, these data suggest that the BM-hMSCs represent a viable option for therapeutic approaches... - In vivo quantification of myelin changes in the vertebrate nervous systemYanming Wang
Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, and Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 29:14663-9. 2009.... - Extracellular and intracellular regulation of oligodendrocyte development: roles of Sonic hedgehog and expression of E proteinsCaroline R Sussman
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
Glia 40:55-64. 2002..We propose that E2A and/or HEB, possibly in combination with Olig1 and 2, are critical components of oligodendrogenesis and may regulate cell survival, proliferation, and fate decisions in the oligodendrocyte lineage... - The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migrationHui Hsin Tsai
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Cell 110:373-83. 2002..These data suggest that population of presumptive white matter by oligodendrocyte precursors is dependent on localized expression of CXCL1... - Cancer in the elderlyNathan A Berger
Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4971, USA
Trans Am Clin Climatol Assoc 117:147-55; discussion 155-6. 2006..Studies will be addressed in the high priority research areas of 1) Treatment Efficacy and Tolerance, 2) Effects of Comorbidities, 3) Psychosocial Issues, and 4) Biology of Aging Cancer... - The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturationCaroline R Sussman
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
J Neurosci 25:5757-62. 2005.... - Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusionNicholas C Bambakidis
Departments of Neurological Surgery and Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
Spine J 4:16-26. 2004.... - High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cordCynthia A Deboy
Department of Neurology, Johns Hopkins University, School of Medicine, USA
Brain 130:2199-210. 2007..These data suggest that high resolution DTI may be a more sensitive method than conventional imaging for detecting axonal damage at sites distant from inflammation... - Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retinaLimin Gao
Department of Neurosciences, Case School of Medicine, Cleveland, OH 44106, USA
Dev Biol 290:277-86. 2006..These data combined with the proposed inhibition of OPC migration by molecules selectively expressed at the nerve retina junction suggest that multiple mechanisms combine to suppress retinal myelination during development... - NG2-positive cells generate A2B5-positive oligodendrocyte precursor cellsKaren L Baracskay
Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Glia 55:1001-10. 2007..NG2(+) cells appear prior to the expression of A2B5(+) cells and generate A2B5(+) cells. We propose that during development NG2(+)/A2B5(-) cells (pre-OPCs) represent the direct ancestor to A2B5(+) O2A progenitor cells (OPCs)... - Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brainChuanshen Wu
Department of Neurosciences, Lerner Research Institute and Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Neurosci 29:7649-57. 2009..We propose that betaT4 cells are an endogenous cell source that can be recruited to promote neural repair in the adult telencephalon... - Oligodendrogenesis is differentially regulated in gray and white matter of jimpy miceKaren L Baracskay
Department of Neuroscience, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Neurosci Res 70:645-54. 2002..These data provide additional evidence that oligodendrogenesis is differentially regulated in white matter and gray matter and implicate PLP/DM20 as a modulator of these differences... - IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement productionJinbo Liu
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106 USA
J Immunol 180:5882-9. 2008.... - Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4Robert H Miller
Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci Res 76:9-19. 2004..These data suggest that BMP4 contributes to the pattern of spinal cord oligodendrogenesis by regulating both induction and maturation of spinal cord OPCs... - Distinct modes of migration position oligodendrocyte precursors for localized cell division in the developing spinal cordHui Hsin Tsai
Center for Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Neurosci Res 87:3320-30. 2009..These studies suggest that positional cues are critical for regulating OPC behavior during spinal cord development... - Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesionsMolly L Fuller
Department of Neurosciences and Center for Translational Neuroscience, Case School of Medicine, Cleveland, OH 44106, USA
Ann Neurol 62:288-300. 2007..To determine the role of bone morphogenetic proteins (BMPs) in stimulating glial scar formation in demyelinating lesions of the adult spinal cord... - Regulation of oligodendrocyte development in the vertebrate CNSRobert H Miller
Department of Neurosciences, School of Medicine, Case Western Reserve University E 721, 2109 Adelbert Road, Cleveland, OH 44106 4975, USA
Prog Neurobiol 67:451-67. 2002..Understanding the regulation of oligodendrogenesis will facilitate the use of these endogenous precursors to enhance repair in a variety of pathological conditions... - Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injuryNicholas C Bambakidis
Department of Neurosurgery, Case Western Reserve University, Cleveland, Ohio, USA
J Neurosurg 99:70-5. 2003..To assess its role in the repair of demyelination following spinal cord injury (SCI), escalating doses of Shh were injected into demyelinated lesions in adult rat spinal cords... - Emerging roles for bone morphogenetic proteins in central nervous system glial biologyAlison K Hall
Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106-4975, USA
J Neurosci Res 76:1-8. 2004..Additional functions for members of the TGFbeta superfamily in CNS injury responses are emerging suggesting these molecules represent useful targets for manipulating neural responses to CNS insults... - Netrin-1 is required for the normal development of spinal cord oligodendrocytesHui Hsin Tsai
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 26:1913-22. 2006..These data indicate that netrin-1 is crucial for both the initial dispersal of spinal cord oligodendrocyte precursors and their subsequent development in the presumptive white matter... - The promise of stem cells for neural repairRobert H Miller
Department of Neurosciences, Center for Stem Cell and Regenerative Medicine, Case School of Medicine Cleveland, OH 44106, USA
Brain Res 1091:258-64. 2006..Given the commonality of processes mediating the assembly of multicellular systems, the approaches developed in the CNS will likely be applicable for selective cell replacement in the auditory system... - Glial cell migration directed by axon guidance cuesHui-Hsin Tsai
Dept of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
Trends Neurosci 25:173-5; discussion 175-6. 2002..These studies suggest a novel mechanism governing glial precursor migration and provide new insights into development and the potential to direct CNS injury repair... - Dorsally derived oligodendrocytes come of ageRobert H Miller
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
Neuron 45:1-3. 2005..These cells share expression of the PDGFalpha receptor and Olig2 with their ventral counterparts but differ in the requirement for Nkx6 and hedgehog signaling... - Identification and characterization of mouse cochlear stem cellsMichael V Yerukhimovich
Department of Otolaryngology, Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
Dev Neurosci 29:251-60. 2007..Our results show that cochleae from neonatal mice harbor cells capable of forming spheres and cells from these spheres appear to be better endowed to become hair cells... - Control of astrocyte migration in the developing cerebral cortexChad T Jacobsen
Department of Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
Dev Neurosci 25:207-16. 2003..These data suggest the existence of distinct migrational cues in the CNS and that environmental, not cell intrinsic properties primarily regulate astrocyte migration through the developing cortex... - PTPmu suppresses glioma cell migration and dispersalAdam M Burgoyne
Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Neuro Oncol 11:767-78. 2009..Together, these data suggest that loss of PTPmu in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPmu in glioma progression... - Molecular probes for imaging myelinated white matter in CNSChunying Wu
Department of Radiology and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Med Chem 51:6682-8. 2008..These studies suggested that these stilbene derivatives can be used as myelin-imaging probes to monitor myelin pathology in vivo... - Netrin 1 mediates spinal cord oligodendrocyte precursor dispersalHui-Hsin Tsai
Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
Development 130:2095-105. 2003..These data indicate the initial dispersal of oligodendrocyte precursors from their localized origin is guided by a chemorepellent response to netrin 1... - Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axonsLimin Gao
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 26:7619-28. 2006..The dependence of OPCs on retinal axonal cues appears to be a common phenomenon, because ocular retardation (or(J)) mice lacking optic nerve have dramatically reduced OPCs in the midline of the third ventricle... - Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injuryMarcus Mazur
Department of Neurosurgery, Rainbow Babies and Children s Hospital, Center for Translational Neuroscience, The Neurological Institute of University Hospitals Case Medical Center, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
J Neurosurg Pediatr 6:206-21. 2010..Furthermore, the authors suggest that neonatal exogenous recombinant human EPO (rhEPO) administration can restore the mismatch of EPO ligand and receptor levels, and enhance neural cell survival... - Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injurySarah A Busch
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurosci 30:255-65. 2010.... - Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in ratsShenandoah Robinson
Department of Neurological Surgery, Case Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Neurobiol Dis 18:568-81. 2005.... - Human mesenchymal stem cells signals regulate neural stem cell fateLianhua Bai
Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Neurochem Res 32:353-62. 2007..We propose that the selective promotion of neuronal and oligodendroglial fates in neural stem cell progeny is responsible for the ability of MSCs to enhance recovery after a wide range of CNS injuries... - LINGO-1 negatively regulates myelination by oligodendrocytesSha Mi
Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Neurosci 8:745-51. 2005..The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination... - LINGO-1 and its role in CNS repairSha Mi
Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States
Int J Biochem Cell Biol 40:1971-8. 2008..The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases... - Endogenous stem cell proliferation after central nervous system injury: alternative therapeutic optionsNicholas C Bambakidis
Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona, USA
Neurosurg Focus 19:E1. 2005..In this review the authors provide a brief overview of the enhancement of endogenous stem cell proliferation following neurological insult... - The expanding influence of stem cells in neural repairRobert H Miller
Ann Neurol 61:187-8. 2007 - NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelinationXinhua Lee
Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
J Neurosci 27:220-5. 2007..The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development...
Research Grants
- Gordon Conference on MyelinRobert Miller; Fiscal Year: 2004....
- DEVELOPMENT OF OLIGODENDROCYTES IN THE SPINAL CORDRobert Miller; Fiscal Year: 2006..abstract_text> ..
- 2006 Myelin Gordon ConferenceRobert Miller; Fiscal Year: 2006..In keeping with the goals of the Gordon Conference such interactions will provide impetus and direction to the field of myelin biology. ..
- Chemokine Synergy with PDGF Oligodendrocyte PrecursorsRobert Miller; Fiscal Year: 2007..will define GRO-alpha as an important regulatory molecule in oligodendrogenesis and a potential target for therapy in diseases of myelin, such as Multiple Sclerosis, and disorders of unregulated gliogenesis such as oligodendroglioma ..
- Development of Oligodendrycytes in the Spinal CordRobert H Miller; Fiscal Year: 2010..Such information will provide new targets for the development of treatments for demyelinating diseases such as Multiple Sclerosis. ..
- 15th Biennial Meeting of the ISDNRobert Miller; Fiscal Year: 2004..This is an exciting time in developmental neuroscience and the types of scientific interactions afforded by this meeting will help to advance our understanding by bringing together workers in distinct but related areas. ..
- DEVELOPMENT OF OLIGODENDROCYTES IN THE SPINAL CORDRobert Miller; Fiscal Year: 2001..These studies will provide important new information on the mechanisms underlying oligodendrocyte development in the vertebrate CNS, and will lead to novel approaches to achieve remyelination after CNS injury or demyelinating diseases. ..
- Oligodendrocyte Loss Following Early Ischemic InjuryRobert Miller; Fiscal Year: 2003..Completion of this project will identify candidate molecules that will be useful for the development of novel therapeutic interventions for treating a common and devastating pediatric CNS problem. ..
- Development of Oligodendrycytes in the Spinal CordRobert Miller; Fiscal Year: 2009..Such information will provide new targets for the development of treatments for demyelinating diseases such as Multiple Sclerosis. ..