John J Mieyal

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Molecular mechanisms and clinical implications of reversible protein S-glutathionylation
    John J Mieyal
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 10:1941-88. 2008
  2. pmc Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 12:1339-53. 2010
  3. pmc Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells
    Melissa D Shelton
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4965, USA
    J Biol Chem 284:4760-6. 2009
  4. pmc Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 11:1059-81. 2009
  5. ncbi request reprint Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB
    Suparna Qanungo
    Department of Anatomy, Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:18427-36. 2007
  6. ncbi request reprint Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress
    MOLLY M GALLOGLY
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, and the Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, OH 44106 4965, United States
    Curr Opin Pharmacol 7:381-91. 2007
  7. ncbi request reprint Glutaredoxin: role in reversible protein s-glutathionylation and regulation of redox signal transduction and protein translocation
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106 4965, USA
    Antioxid Redox Signal 7:348-66. 2005
  8. pmc Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4965, USA
    Biochemistry 47:11144-57. 2008
  9. pmc Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
    Chen Yao
    Department of Pathology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Mol Genet 22:328-44. 2013
  10. pmc Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease
    Elizabeth A Sabens Liedhegner
    Department of Pharmacology, Case Western Reserve University, School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4965, United States
    Chem Res Toxicol 24:1644-52. 2011

Collaborators

  • William M Johnson
  • Edward J Lesnefsky
  • Vernon E Anderson
  • Xiongwei Zhu
  • Wen Wang
  • Melissa D Shelton
  • MOLLY M GALLOGLY
  • David W Starke
  • Harish V Pai
  • Suparna Qanungo
  • Chen Yao
  • Erin M G Allen
  • Elizabeth A Sabens Liedhegner
  • Elizabeth A Sabens
  • Anne M Distler
  • Rajan S Kombu
  • Charles L Hoppel
  • Timothy S Kern
  • Usha Srinivasan
  • P Boon Chock
  • Amy C Nulton-Persson
  • Jinwei Zhang
  • Hanno Roder
  • Maria Deak
  • Shu G Chen
  • Amy L Wilson-Delfosse
  • Yue Gao
  • Dario R Alessi
  • Kelly M Steller
  • Joanne K Kelleher
  • Rime Abbas
  • Henri Brunengraber
  • Guo Fang Zhang
  • Juan R Sanabria
  • Amanda K Leonberg
  • Susan M English Ospina
  • Anna Liisa Nieminen
  • T William Jordan
  • Aveenash Bala
  • Shu Chuan Jao
  • Luke I Szweda

Detail Information

Publications22

  1. pmc Molecular mechanisms and clinical implications of reversible protein S-glutathionylation
    John J Mieyal
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 10:1941-88. 2008
    ..Examples involving changes in S-glutathionylation of specific proteins are discussed in the context of diabetes, cardiovascular and lung diseases, cancer, and neurodegenerative diseases...
  2. pmc Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 12:1339-53. 2010
    ..Taken together, these data indicate diminution of Grx1 in elderly animals contributes to increased apoptotic susceptibility via regulation of NFkappaB function...
  3. pmc Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells
    Melissa D Shelton
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4965, USA
    J Biol Chem 284:4760-6. 2009
    ..Hence Grx-mediated activation of IKK via deglutathionylation may play a central role in diabetic complications in vivo where Grx1 is increased...
  4. pmc Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 11:1059-81. 2009
    ..Part II presents potential mechanisms for in vivo regulation of Grx activity, providing avenues for future studies...
  5. ncbi request reprint Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB
    Suparna Qanungo
    Department of Anatomy, Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:18427-36. 2007
    ..The results indicate that GRx-dependent S-glutathionylation of p65-NFkappaB is most likely responsible for NAC-mediated NFkappaB inactivation and enhanced hypoxic apoptosis...
  6. ncbi request reprint Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress
    MOLLY M GALLOGLY
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, and the Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, OH 44106 4965, United States
    Curr Opin Pharmacol 7:381-91. 2007
    ..Accordingly, this review focuses primarily on mechanisms of catalysis in mammalian systems...
  7. ncbi request reprint Glutaredoxin: role in reversible protein s-glutathionylation and regulation of redox signal transduction and protein translocation
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106 4965, USA
    Antioxid Redox Signal 7:348-66. 2005
    ..Among many proteins under consideration, actin, protein tyrosine phosphatase-1B, and Ras stand out as the best current examples for establishing this regulatory mechanism...
  8. pmc Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4965, USA
    Biochemistry 47:11144-57. 2008
    ..Estimation of Grx1 and Grx2 concentrations within mitochondria predicts comparable deglutathionylation activities within the mitochondrial subcompartments, suggesting localized regulatory functions for both isozymes...
  9. pmc Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
    Chen Yao
    Department of Pathology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Mol Genet 22:328-44. 2013
    ..Our findings indicate that the LRRK2 kinase activity is critical for neurodegeneration caused by R1441C and G2019S mutations, suggesting that kinase inhibition of LRRK2 may represent a promising therapeutic strategy for PD...
  10. pmc Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease
    Elizabeth A Sabens Liedhegner
    Department of Pharmacology, Case Western Reserve University, School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4965, United States
    Chem Res Toxicol 24:1644-52. 2011
    ..These results identify ASK1 as the main pro-apoptotic pathway activated in response to L-DOPA treatment, implicating it as a potential target for adjunct therapy in PD...
  11. pmc Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, and Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, Ohio 44106 4965, USA
    Mol Cells 25:332-46. 2008
    ....
  12. pmc Dysregulation of glutathione homeostasis in neurodegenerative diseases
    William M Johnson
    Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Nutrients 4:1399-440. 2012
    ..The pros and cons of administration of N-acetylcysteine or glutathione as therapeutic agents for neurodegenerative diseases, as well as the potential utility of serum glutathione as a biomarker, are critically evaluated...
  13. ncbi request reprint What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria?
    Harish V Pai
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio
    Antioxid Redox Signal 9:2027-33. 2007
    ..We hypothesize that GRx1 and GRx2 in their unique locations regulate different functions of the mitochondria via reversible S-glutathionylation...
  14. pmc Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans
    Rajan S Kombu
    Department of Nutrition, Case Western Reserve University, School of Medicine, 10900 Euclid Ave, W G48, Cleveland, OH 44106 4954, USA
    Am J Physiol Endocrinol Metab 297:E260-9. 2009
    ....
  15. pmc Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal
    Xiaochun Zhu
    Departments of Chemistry, Pharmacology, and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Chem Res Toxicol 22:1050-9. 2009
    ..Stable antielectrophile-ONE-protein cross-links may serve as biomarkers of oxidative stress and may represent a novel mechanism of irreversible protein glutathionylation...
  16. ncbi request reprint Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:12467-74. 2007
    ..Thus, GRx may represent a novel therapeutic target to inhibit diabetic retinopathy...
  17. pmc Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease
    Elizabeth A Sabens
    Department of Pharmacology, Case Western Reserve University, School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4965, USA
    Biochemistry 49:2715-24. 2010
    ..Overall l-DOPA is shown to impair the collaborative contributions of the Grx and Trx systems to neuron survival...
  18. ncbi request reprint Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status
    Amy C Nulton-Persson
    Department of Physiology and Biophysics and Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 42:4235-42. 2003
    ..These studies demonstrate a novel mechanism by which KGDH activity and mitochondrial function can be modulated by redox status...
  19. pmc Selective inactivation of glutaredoxin by sporidesmin and other epidithiopiperazinediones
    Usha Srinivasan
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Biochemistry 45:8978-87. 2006
    ..This study implicates selective modification of sulfhydryls of target proteins in some of the cytotoxic effects of the ETP fungal toxins and their synthetic analogues...
  20. pmc Protein-thiol oxidation and cell death: regulatory role of glutaredoxins
    Erin M G Allen
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Antioxid Redox Signal 17:1748-63. 2012
    ..Aberrant regulation of protein glutathionylation/deglutathionylation reactions due to changes in Grx activity can disrupt both apoptotic and survival signaling pathways...
  21. pmc Posttranslational modification of cysteine in redox signaling and oxidative stress: focus on s-glutathionylation
    John J Mieyal
    1 Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio
    Antioxid Redox Signal 16:471-5. 2012
    ..Antioxid. Redox Signal. 16, 471-475...
  22. ncbi request reprint Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction
    David W Starke
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    J Biol Chem 278:14607-13. 2003
    ..These studies characterize GRx as a versatile catalyst, facilitating GS-radical scavenging and S-glutathionylation of redox signal mediators, consistent with a critical role in cellular regulation...