A J McCullough

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Pathophysiology of nonalcoholic steatohepatitis
    Arthur J McCullough
    Case Western Reserve University and Schwartz Center for Metabolism and Nutrition at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    J Clin Gastroenterol 40:S17-29. 2006
  2. ncbi request reprint Update on nonalcoholic fatty liver disease
    Arthur J McCullough
    Division of Gastroenterology and the Robert Schwartz Center of Metabolism and Nutrition at MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Clin Gastroenterol 34:255-62. 2002
  3. ncbi request reprint Clinical features and natural history of nonalcoholic steatosis syndromes
    Y Falck-Ytter
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Semin Liver Dis 21:17-26. 2001
  4. ncbi request reprint Steatohepatitis in obese individuals
    Wael I Youssef
    Division of Gastroenterology, The Robert Schwartz Center for Metabolism and Nutrition at Metro Health Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA
    Best Pract Res Clin Gastroenterol 16:733-47. 2002
  5. ncbi request reprint Thiazolidinediones for nonalcoholic steatohepatitis--promising but not ready for prime time
    Arthur J McCullough
    N Engl J Med 355:2361-3. 2006
  6. ncbi request reprint Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
  7. ncbi request reprint The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    Arthur J McCullough
    Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH 44109, USA
    Clin Liver Dis 8:521-33, viii. 2004
  8. ncbi request reprint Diabetes mellitus, obesity, and hepatic steatosis
    Wael Youssef
    Division of Gastroenterology, Case Western Reserve University, Cleveland, OH, USA
    Semin Gastrointest Dis 13:17-30. 2002
  9. ncbi request reprint Nonalcoholic fatty liver disease in patients with type 2 diabetes
    Zobair M Younossi
    The Cleveland Clinic Foundation, Cleveland, USA
    Clin Gastroenterol Hepatol 2:262-5. 2004
  10. ncbi request reprint Obesity and non-alcoholic fatty liver disease in chronic hepatitis C
    Zobair M Younossi
    Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, Virginia 22042, USA
    J Clin Gastroenterol 38:705-9. 2004

Research Grants

  1. NASH PROJECT
    Arthur McCullough; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Pathophysiology of nonalcoholic steatohepatitis
    Arthur J McCullough
    Case Western Reserve University and Schwartz Center for Metabolism and Nutrition at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    J Clin Gastroenterol 40:S17-29. 2006
    ..Which of the pathophysiologic factors (which are discussed in this review), either alone or in combination, will eventually provide the basis for the most effective therapy has yet to be determined...
  2. ncbi request reprint Update on nonalcoholic fatty liver disease
    Arthur J McCullough
    Division of Gastroenterology and the Robert Schwartz Center of Metabolism and Nutrition at MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Clin Gastroenterol 34:255-62. 2002
    ..Future therapies will depend on a greater understanding of the pathophysiology and should focus on diminishing fibrosis...
  3. ncbi request reprint Clinical features and natural history of nonalcoholic steatosis syndromes
    Y Falck-Ytter
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Semin Liver Dis 21:17-26. 2001
    ..However, a number of important unresolved issues must be clarified before the true natural history of this disease can be fully understood...
  4. ncbi request reprint Steatohepatitis in obese individuals
    Wael I Youssef
    Division of Gastroenterology, The Robert Schwartz Center for Metabolism and Nutrition at Metro Health Medical Center, Case Western Reserve University, Cleveland, OH 44109, USA
    Best Pract Res Clin Gastroenterol 16:733-47. 2002
    ..Bariatric surgery is indicated in selected patients.A greater understanding of the pathophysiological progression of NASH in obese patients must be obtained in order to develop more focused and improved therapy...
  5. ncbi request reprint Thiazolidinediones for nonalcoholic steatohepatitis--promising but not ready for prime time
    Arthur J McCullough
    N Engl J Med 355:2361-3. 2006
  6. ncbi request reprint Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    Anna Wieckowska
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Hepatology 46:582-9. 2007
    ..They will not only help in the diagnosis of NASH, but also be useful for assessment of treatment response and prognosis and remain a research priority in the NAFLD field...
  7. ncbi request reprint The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    Arthur J McCullough
    Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH 44109, USA
    Clin Liver Dis 8:521-33, viii. 2004
    ..The major risk factors for fibrosis include diabetes or obesity, an aspartate aminotransferase/alanine aminotransferase ratio of greater than 1, age older than 50, and hepatic histology...
  8. ncbi request reprint Diabetes mellitus, obesity, and hepatic steatosis
    Wael Youssef
    Division of Gastroenterology, Case Western Reserve University, Cleveland, OH, USA
    Semin Gastrointest Dis 13:17-30. 2002
    ..These include anti-oxidants such as vitamin E and betaine, bile acid therapy with ursodeoxycholic acid, and improved insulin sensitivity with metformin. Another potential therapeutic strategy is the reduction of inflammatory cytokines...
  9. ncbi request reprint Nonalcoholic fatty liver disease in patients with type 2 diabetes
    Zobair M Younossi
    The Cleveland Clinic Foundation, Cleveland, USA
    Clin Gastroenterol Hepatol 2:262-5. 2004
    ..The aim of this study was to assess the outcome of patients with NAFLD and DM...
  10. ncbi request reprint Obesity and non-alcoholic fatty liver disease in chronic hepatitis C
    Zobair M Younossi
    Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, Virginia 22042, USA
    J Clin Gastroenterol 38:705-9. 2004
    ..Superimposed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) may affect HCV-related fibrosis. We performed a study to determine the relationship between NAFLD and chronic hepatitis C...
  11. pmc Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans
    Satish C Kalhan
    Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
    Metabolism 57:305-12. 2008
    ..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus...
  12. ncbi request reprint Pathogenesis of non-alcoholic steatohepatitis: human data
    John Edmison
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Clin Liver Dis 11:75-104, ix. 2007
    ..Although fatty liver may be caused by other factors, this review concentrates on fatty liver associated with insulin resistance, sometimes referred to as the primary form...
  13. pmc Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    Naga Chalasani
    Indiana University School of Medicine, 1050 Wishard Boulevard, Indianapolis, IN 46202, USA
    J Hepatol 48:829-34. 2008
    ..The relationship between severity and zonal location of steatosis and the presence of steatohepatitis and various histological features that define NASH has not been formally studied...
  14. ncbi request reprint Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessment
    Claudia O Zein
    Division of Gastroenterology and Hepatology, University Hospitals of Cleveland, Cleveland, OH, USA
    Hepatology 44:1564-71. 2006
    ..In conclusion, smoking may accelerate the progression of PBC. This could be induced by exposure to chemicals in cigarette smoke...
  15. ncbi request reprint In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    Anna Wieckowska
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hepatology 44:27-33. 2006
    ..These data highlight the potential usefulness of this test as a noninvasive diagnostic means of determining histological disease severity in patients with NAFLD...
  16. ncbi request reprint Steroids or cocktails for alcoholic hepatitis
    Robert O'Shea
    J Hepatol 44:633-6. 2006
  17. ncbi request reprint Insulin resistance: a metabolic pathway to chronic liver disease
    Elisabetta Bugianesi
    Gastroenterology Department, University of Turin, Turin, Italy
    Hepatology 42:987-1000. 2005
    ..Finally, the ability of insulin-sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed...
  18. ncbi request reprint Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    ..NAS of > or =5 correlated with a diagnosis of NASH, and biopsies with scores of less than 3 were diagnosed as "not NASH."..
  19. ncbi request reprint Treatment of alcoholic hepatitis
    Robert S O'Shea
    Department of Gastroenterology and Hepatology A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Liver Dis 9:103-34. 2005
    ....
  20. ncbi request reprint Pathologic features associated with fibrosis in nonalcoholic fatty liver disease
    Terry Gramlich
    Cleveland Clinic Foundation, OH, USA
    Hum Pathol 35:196-9. 2004
    ..We conclude that the presence of hepatocyte injury in NAFLD is associated with fibrosis. These pathological features can be used to establish the pathological criteria for diagnosis of the progressive form of NAFLD or NASH...
  21. ncbi request reprint Obesity and its nurturing effect on hepatitis C
    Arthur J McCullough
    Hepatology 38:557-9. 2003
  22. doi request reprint Ascitic fluid lactoferrin for diagnosis of spontaneous bacterial peritonitis
    Mansour A Parsi
    Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Gastroenterology 135:803-7. 2008
    ..The aim of this study was to assess the utility of ascitic fluid lactoferrin (AFLAC) for the diagnosis of SBP and to identify a cut-off level that can be used for future development of a rapid bedside test...

Research Grants2

  1. NASH PROJECT
    Arthur McCullough; Fiscal Year: 2007
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