Grace A McComsey

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229
    Grace A McComsey
    Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    AIDS 24:2507-15. 2010
  2. ncbi request reprint Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV
    Grace A McComsey
    Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio, USA
    AIDS 21:2473-82. 2007
  3. pmc Bone disease in HIV infection: a practical review and recommendations for HIV care providers
    Grace A McComsey
    Department of Pediatrics and Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Clin Infect Dis 51:937-46. 2010
  4. pmc Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202
    Grace A McComsey
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 207:604-11. 2013
  5. pmc Inflammation markers after randomization to abacavir/lamivudine or tenofovir/emtricitabine with efavirenz or atazanavir/ritonavir
    Grace A McComsey
    Case Western Reserve University and Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    AIDS 26:1371-85. 2012
  6. pmc Carotid intima media thickness, inflammatory markers, and endothelial activation markers in HIV Patients with lipoatrophy increased at 48 weeks regardless of use of rosiglitazone or placebo
    Marisa Tungsiripat
    Cleveland Clinic, Ohio, USA
    AIDS Res Hum Retroviruses 27:295-302. 2011
  7. pmc Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir
    Grace A McComsey
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Antivir Ther 17:347-53. 2012
  8. ncbi request reprint Increased carotid intima media thickness and cardiac biomarkers in HIV infected children
    Grace A McComsey
    Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 21:921-7. 2007
  9. pmc Associations of inflammatory markers with AIDS and non-AIDS clinical events after initiation of antiretroviral therapy: AIDS clinical trials group A5224s, a substudy of ACTG A5202
    Grace A McComsey
    Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH Harvard School of Public Health, Boston, MA Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Social and Scientific Systems, Inc, Silver Spring, MD Gilead Sciences, Foster City, CA GlaxoSmithKline, Research Triangle, NC Department of Medicine, Johns Hopkins University, Baltimore, MD Frontier Science and Technology Research Foundation, Amherst, NY Department of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA
    J Acquir Immune Defic Syndr 65:167-74. 2014
  10. doi request reprint Elevated D-dimer is independently associated with endothelial dysfunction: a cross-sectional study in HIV-infected adults on antiretroviral therapy
    Corrilynn O Hileman
    MetroHealth Medical Center, Cleveland, OH, USA
    Antivir Ther 17:1345-9. 2012

Detail Information

Publications54

  1. pmc Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229
    Grace A McComsey
    Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    AIDS 24:2507-15. 2010
    ..Lipoatrophy is prevalent on thymidine nucleoside reverse transcriptase inhibitors (tNRTIs). A pilot trial showed that uridine (NucleomaxX) increased limb fat...
  2. ncbi request reprint Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV
    Grace A McComsey
    Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio, USA
    AIDS 21:2473-82. 2007
    ..Bisphosphonates are currently the mainstay of treatment for postmenopausal and male osteoporosis in HIV-uninfected individuals; however, their efficacy and safety in HIV-infected patients remains unclear...
  3. pmc Bone disease in HIV infection: a practical review and recommendations for HIV care providers
    Grace A McComsey
    Department of Pediatrics and Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Clin Infect Dis 51:937-46. 2010
    ..We also discuss the importance of considering secondary causes of osteoporosis. Finally, we discuss treatment of the more severe cases of bone disease, while outlining the caveats and gaps in our knowledge...
  4. pmc Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202
    Grace A McComsey
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 207:604-11. 2013
    ..The effect of nonthymidine nucleoside reverse-transcriptase inhibitors (NRTIs) on fat mitochondrial DNA (mtDNA) content and function is unclear...
  5. pmc Inflammation markers after randomization to abacavir/lamivudine or tenofovir/emtricitabine with efavirenz or atazanavir/ritonavir
    Grace A McComsey
    Case Western Reserve University and Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    AIDS 26:1371-85. 2012
    ..The effect of specific antiretrovirals on inflammation is unclear...
  6. pmc Carotid intima media thickness, inflammatory markers, and endothelial activation markers in HIV Patients with lipoatrophy increased at 48 weeks regardless of use of rosiglitazone or placebo
    Marisa Tungsiripat
    Cleveland Clinic, Ohio, USA
    AIDS Res Hum Retroviruses 27:295-302. 2011
    ..008). In our study of virologically controlled subjects with lipoatrophy, rosiglitazone did not independently increase carotid IMT, endothelial activation, and inflammatory cytokines...
  7. pmc Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir
    Grace A McComsey
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Antivir Ther 17:347-53. 2012
    ..Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity...
  8. ncbi request reprint Increased carotid intima media thickness and cardiac biomarkers in HIV infected children
    Grace A McComsey
    Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 21:921-7. 2007
    ..To assess carotid intima media thickness (IMT) and cardiac biomarkers in HIV infected children on antiretroviral therapy (ART)...
  9. pmc Associations of inflammatory markers with AIDS and non-AIDS clinical events after initiation of antiretroviral therapy: AIDS clinical trials group A5224s, a substudy of ACTG A5202
    Grace A McComsey
    Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH Harvard School of Public Health, Boston, MA Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Social and Scientific Systems, Inc, Silver Spring, MD Gilead Sciences, Foster City, CA GlaxoSmithKline, Research Triangle, NC Department of Medicine, Johns Hopkins University, Baltimore, MD Frontier Science and Technology Research Foundation, Amherst, NY Department of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA
    J Acquir Immune Defic Syndr 65:167-74. 2014
    ..The association of inflammatory biomarkers with clinical events after antiretroviral therapy initiation is unclear...
  10. doi request reprint Elevated D-dimer is independently associated with endothelial dysfunction: a cross-sectional study in HIV-infected adults on antiretroviral therapy
    Corrilynn O Hileman
    MetroHealth Medical Center, Cleveland, OH, USA
    Antivir Ther 17:1345-9. 2012
    ..D-Dimer elevations have been associated with a striking increase in mortality in HIV-infected patients. However, D-Dimer has not been directly linked to endothelial dysfunction in HIV...
  11. pmc Rosiglitazone improves lipoatrophy in patients receiving thymidine-sparing regimens
    Marisa Tungsiripat
    Cleveland Clinic, Ohio, USA
    AIDS 24:1291-8. 2010
    ..None specifically excluded the use of tNRTIs. We report the first study in individuals treated with tNRTI-sparing regimens using a TZD for treatment of HIV lipoatrophy...
  12. pmc Weight and lean body mass change with antiretroviral initiation and impact on bone mineral density
    Kristine M Erlandson
    aUniversity of Colorado Anschutz Medical Campus Aurora, Colorado bHarvard School of Public Health, Boston cBrigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts dLos Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California eUniversity of Pennsylvania, Philadelphia, Pennsylvania fGilead Sciences, Foster City, California gViiV Healthcare, Research Triangle, North Carolina hSocial and Scientific Systems, Inc, Silver Spring, Maryland iCase Western Reserve University, Cleveland, Ohio, USA
    AIDS 27:2069-79. 2013
    ..To compare the effect that initiating different antiretroviral therapy (ART) regimens has on weight, BMI, and lean body mass (LBM) and explore how changes in body composition are associated with bone mineral density (BMD)...
  13. pmc Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to antiretroviral therapy and not to HIV infection
    Grace A McComsey
    Case Western Reserve University, Cleveland, OH, USA
    Antivir Ther 13:715-22. 2008
    ..The aim of this study was to assess the effect of antiretroviral therapy (ART) versus HIV on mitochondria in fat...
  14. pmc Subjective clinical lipoatrophy assessment correlates with DEXA-measured limb fat
    Marisa Tungsiripat
    Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    HIV Clin Trials 10:314-9. 2009
    ..We aim to assess the validity of physician- and patient-rated diagnoses of lipoatrophy by evaluating the correlation between clinical assessments of lipoatrophy and objective fat indices...
  15. doi request reprint Heightened inflammation is linked to carotid intima-media thickness and endothelial activation in HIV-infected children
    Allison C Ross
    Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH, USA
    Atherosclerosis 211:492-8. 2010
    ..We compared proinflammatory cytokines and adhesion molecules in HIV+ children versus healthy controls, and assessed their relationship to carotid intima-media thickness (IMT)...
  16. pmc Peripheral and central fat changes in subjects randomized to abacavir-lamivudine or tenofovir-emtricitabine with atazanavir-ritonavir or efavirenz: ACTG Study A5224s
    Grace A McComsey
    Department of Pediatrics and Medicine, Case Western Reserve University and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Clin Infect Dis 53:185-96. 2011
    ..We compare the effect of 4 different antiretroviral regimens on limb and visceral fat...
  17. pmc Endothelial activation markers are linked to HIV status and are independent of antiretroviral therapy and lipoatrophy
    Allison C Ross
    Department of Pediatrics, Rainbow Babies and Children s Hospital, and Department of Pediatrics and Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 49:499-506. 2008
    ....
  18. pmc Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy
    Grace A McComsey
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    HIV Clin Trials 9:126-36. 2008
    ..The effects of gestational nucleoside reverse transcriptase inhibitors (NRTIs) on mitochondrial DNA (mtDNA) are controversial. The effects of mtDNA depletion on mitochondrial function have not been assessed...
  19. pmc Vitamin D supplementation and endothelial function in vitamin D deficient HIV-infected patients: a randomized placebo-controlled trial
    Chris T Longenecker
    University Hospitals Case Medical Center, Cleveland, OH, USA
    Antivir Ther 17:613-21. 2012
    ..Vitamin D deficiency is prevalent in HIV patients but the effect of vitamin D supplementation on cardiovascular risk in this population is unknown...
  20. ncbi request reprint Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine
    Grace A McComsey
    Rainbow Babies and Children s Hospital bCase School of Medicine Center for AIDS Research, Cleveland, Ohio, USA
    AIDS 19:15-23. 2005
    ..As apoptosis and dysfunction of electron transport chain (ETC) activities may underlie mitochondrial toxicity, these parameters were also evaluated...
  21. pmc Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG
    Grace A McComsey
    Departments of Pediatrics and Medicine, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    J Infect Dis 203:1791-801. 2011
    ..Long-term effects of abacavir (ABC)-lamivudine (3TC), compared with tenofovir (TDF)-emtricitabine (FTC) with efavirenz (EFV) or atazanavir plus ritonavir (ATV/r), on bone mineral density (BMD) have not been analyzed...
  22. ncbi request reprint Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection
    Chris T Longenecker
    aUniversity Hospitals Harrington Heart and Vascular Institute bCase Western Reserve University cUniversity Hospitals Infectious Diseases Institute dDepartment of Radiology, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    AIDS 28:969-77. 2014
    ....
  23. doi request reprint Omega-3 fatty acids do not improve endothelial function in virologically suppressed HIV-infected men: a randomized placebo-controlled trial
    Corrilynn O Hileman
    Department of Medicine, Division of Infectious Diseases, MetroHealth Medical Center, Cleveland, Ohio, USA
    AIDS Res Hum Retroviruses 28:649-55. 2012
    ..This suggests that omega-3 fatty acids may not be potent enough to counteract the enhanced inflammation and endothelial dysfunction due to HIV and antiretrovirals...
  24. pmc Higher plasma myeloperoxidase levels are not associated with an increased risk for cardiovascular events in HIV-infected adults
    Dalia El-Bejjani
    Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106, USA
    HIV Clin Trials 9:207-11. 2008
    ..Elevated myeloperoxidase (MPO) levels are predictive of high cardiovascular (CV) risk in the general population. The value of MPO as a CV marker in the HIV population has not been investigated...
  25. pmc Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    Michael M Lederman
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 204:1217-26. 2011
    ..Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection...
  26. doi request reprint Rate and predictors of carotid artery intima media thickness progression in antiretroviral-naive HIV-infected and uninfected adults: a 48-week matched prospective cohort study
    Corrilynn O Hileman
    MetroHealth Medical Center, Cleveland, OH, USA
    Antivir Ther 18:921-9. 2013
    ..Carotid intima media thickness (CIMT) progresses faster in HIV-infected adults on antiretroviral therapy (ART) than the general population. It is unclear if the rate of progression is similarly faster in ART-naive, HIV-infected adults...
  27. doi request reprint Effects of HIV and antiretroviral therapy on resting energy expenditure in adult HIV-infected women-a matched, prospective, cross-sectional study
    Alison L Mittelsteadt
    Department of Infectious Diseases, Case Western Reserve University, Cleveland, OH, USA
    J Acad Nutr Diet 113:1037-43. 2013
    ..However, limited data exist on REE in HIV-infected women and the effect of antiretroviral therapy (ART) on REE in this population...
  28. pmc Short communication: initiation of an abacavir-containing regimen in HIV-infected adults is associated with a smaller decrease in inflammation and endothelial activation markers compared to non-abacavir-containing regimens
    Corrilynn O Hileman
    MetroHealth Medical Center, Cleveland, Ohio, USA
    AIDS Res Hum Retroviruses 28:1561-4. 2012
    ..When taken with an NNRTI, abacavir induced a smaller decrease in inflammation biomarkers in this cohort, suggesting a possible proinflammatory effect of this nucleoside analogue...
  29. ncbi request reprint Antiretroviral therapy in HIV-infected children: the metabolic cost of improved survival
    Ethan G Leonard
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 4410, USA
    Infect Dis Clin North Am 19:713-29. 2005
    ..The benefits of HAART in HIV infection are indisputable, but the impetus to find a cure or design more tolerable therapy is clear. Infarction may replace infection as the major cause of morbidity and mortality from HIV...
  30. ncbi request reprint Asymptomatic hyperlactataemia: predictive value, natural history and correlates
    Grace A McComsey
    Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Antivir Ther 9:205-12. 2004
    ..The significance of asymptomatic hyperlactataemia is unknown...
  31. pmc Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success
    Rajeev K Mehlotra
    Center for Global Health and Diseases and Diseases, Wolstein Research Bldg, Room 4204, 2103 Cornell Rd, Cleveland, OH 44106 7286, USA
    J Infect Dis 204:291-8. 2011
    ..In patients receiving highly active antiretroviral therapy (HAART), antiretroviral drug-metabolizing enzyme and transporter gene polymorphisms, as well as chemokine receptor gene polymorphisms, may influence response to treatment...
  32. pmc Relationships Between Inflammation, Immune Activation, and Bone Health Among HIV-Infected Adults on Stable Antiretroviral Therapy
    Kristine M Erlandson
    Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO and the Departments of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH
    J Acquir Immune Defic Syndr 65:290-8. 2014
    ..The aim was to determine the association between bone health and inflammation, T-cell activation, and monocyte activation among HIV-infected persons on stable antiretroviral therapy...
  33. ncbi request reprint Impact of randomized antiretroviral therapy initiation on glucose metabolism
    Kristine Mace Erlandson
    aUniversity of Colorado Anschutz Medical Campus, Aurora, Colorado bHarvard School of Public Health cBrigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts dLos Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance eGilead Sciences, Foster City, California fViiV Healthcare, Research Triangle, North Carolina gCase Western Reserve University, Cleveland, Ohio, USA
    AIDS 28:1451-61. 2014
    ..Prior studies have found that early HIV protease inhibitors contribute to glucose dysregulation. Few randomized trials have evaluated glucose indices in antiretroviral-naive individuals on newer antiretroviral therapy (ART)...
  34. doi request reprint C-reactive protein predicts 96-week carotid intima media thickness progression in HIV-infected adults naive to antiretroviral therapy
    Corrilynn O Hileman
    Case Western Reserve University School of Medicine, Cleveland, OH Department of Medicine, Division of Infectious Disease, MetroHealth Medical Center, Cleveland, OH Department of Medicine, Division of Cardiovascular Medicine, University Hospitals Harrington Heart and Vascular Institute, Cleveland, OH and Department of Pediatrics, Division of Infectious Disease, University Hospitals Case Medical Center, Cleveland, OH
    J Acquir Immune Defic Syndr 65:340-4. 2014
    ..Independent predictors of bulb CIMT progression were higher non-high-density lipoprotein cholesterol and high sensitivity C-reactive protein. Other inflammation markers were not associated with CIMT progression. ..
  35. pmc Perivascular fat, inflammation, and cardiovascular risk in HIV-infected patients on antiretroviral therapy
    Chris T Longenecker
    University Hospitals Harrington Heart and Vascular Institute, Division of Cardiology, Case Western Reserve University, Cleveland, OH, USA Electronic address
    Int J Cardiol 168:4039-45. 2013
    ..Whether specific perivascular fat depots are associated with inflammation in HIV is unknown...
  36. pmc HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease
    Carey L Shive
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 61:145-52. 2012
    ..This study was designed to explore the relationship between HIV-1 replication and IL-6 induction...
  37. ncbi request reprint Fragility fractures in HIV-infected patients: need for better understanding of diagnosis and management
    Grace A McComsey
    Case Western Reserve University, Cleveland, OH, USA
    J Int Assoc Physicians AIDS Care (Chic) 3:86-91. 2004
    ..In HIV and ART, osteopenia and osteoporosis are multifactorial, and health promotion or medical health maintenance should anticipate and prevent morbidity of bone fragility fractures...
  38. ncbi request reprint Is bone loss linked to chronic inflammation in antiretroviral-naive HIV-infected adults? A 48-week matched cohort study
    Corrilynn O Hileman
    aCase Western Reserve University School of Medicine bMetroHealth Medical Center cUniversity Hospitals Case Medical Center, Cleveland, Ohio dEmory University School of Medicine, Atlanta, Georgia, USA
    AIDS 28:1759-67. 2014
    ..Antiretroviral therapy (ART) has been implicated in bone loss in HIV. The role of inflammation and vitamin D is unclear and better investigated in ART-naive individuals...
  39. ncbi request reprint Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus-infected patients switched from stavudine to abacavir or zidovudine: the results of the TARHEEL study
    Grace A McComsey
    Case Western Reserve, Cleveland, Ohio, USA
    Clin Infect Dis 38:263-70. 2004
    ..HIV suppression was maintained over the study period. In conclusion, replacing stavudine with abacavir or zidovudine resulted in improvement in stavudine-induced lipoatrophy...
  40. ncbi request reprint New entrants to HIV care are presenting only at marginally earlier stages of disease but may increasingly represent groups perceived at lower risk
    Chariclia V Loupa
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Int Assoc Physicians AIDS Care (Chic) 4:47-51. 2005
    ..Treatment has improved HIV infection prognosis, but whether risk and health care seeking behavior have improved is unclear...
  41. pmc Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy
    Allison C Ross
    Rainbow Babies and Children s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Clin Infect Dis 49:1119-27. 2009
    ....
  42. doi request reprint Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults
    Corrilynn O Hileman
    University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 24:1958-61. 2010
    ..Tinnitus and transaminitis occurred frequently in the salsalate group. Dose reduction due to toxicities encountered and low level of inflammation may explain these results...
  43. ncbi request reprint Metabolic complications of antiretroviral therapy in children
    Ethan G Leonard
    Division of Pediatric Infectious Diseases, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    Pediatr Infect Dis J 22:77-84. 2003
    ..This review summarizes the epidemiology and management of lipodystrophy, dyslipidemia, insulin resistance, hyperlactatemia, osteopenia and growth failure in HIV-infected children...
  44. ncbi request reprint Lipid oxidative markers are significantly increased in lipoatrophy but not in sustained asymptomatic hyperlactatemia
    Grace A McComsey
    Rainbow Babies and Children s Hospital, and Center for AIDS Research of Case Western Reserve University, and University Hospitals of Cleveland, Ohio, USA
    J Acquir Immune Defic Syndr 34:45-9. 2003
    ..082 +/- 0.021 vs. 0.053 +/- 0.021, respectively; P < 0.05)...
  45. ncbi request reprint First reported case of Neisseria meningitidis periorbital cellulitis associated with meningitis
    David V Chand
    Division of Pediatric Infectious Diseases and Rheumatology, Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Pediatrics 116:e874-5. 2005
    ..Cellulitis is a rare manifestation of meningococcal disease. We describe the case of a previously healthy 4-month-old female infant who developed periorbital cellulitis associated with meningococcal meningitis...
  46. ncbi request reprint High doses of riboflavin and thiamine may help in secondary prevention of hyperlactatemia
    Grace A McComsey
    Pediatric Infectious Diseases Division, Rainbow Babies and Children s Hospital, Western Reserve University, Cleveland, USA
    AIDS Read 12:222-4. 2002
    ..Therefore, there is a need to investigate ways to prevent the recurrence of hyperlactatemia in patients who require NRTI-based therapy...
  47. ncbi request reprint Buffalo hump: what the experts suggest
    Peter J Piliero
    AIDS Clin Care 16:22-3. 2004
  48. ncbi request reprint Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy
    Ann J Melvin
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Antivir Ther 13:349-55. 2008
    ....
  49. ncbi request reprint Metabolic complications of HIV therapy in children
    Grace A McComsey
    AIDS 18:1753-68. 2004
  50. ncbi request reprint Lack of recurrence of hyperlactatemia in HIV-infected patients switched from stavudine to abacavir or zidovudine
    J Tyler Lonergan
    Department of Medicine, Owen Clinic University of California at San Diego Medical Center, 92103, USA
    J Acquir Immune Defic Syndr 36:935-42. 2004
    ....
  51. ncbi request reprint Fatty liver in HIV infection: metabolic syndrome, medicines, mitochondria, and more?
    Pierre M Gholam
    AIDS Read 17:516-7. 2007
  52. ncbi request reprint Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
    ..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
  53. ncbi request reprint Index of suspicion
    Ihuoma Eneli
    Michigan State University, East Lansing, Mich, USA
    Pediatr Rev 27:389-94. 2006
  54. ncbi request reprint Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy
    Elizabeth G Livingston
    Duke University, Durham, NC 27710, USA
    Obstet Gynecol 110:391-7. 2007
    ..To evaluate the effect of protease inhibitors on lipid and lactate levels and gastrointestinal symptoms in pregnancy...