G A McComsey

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir
    Grace A McComsey
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Antivir Ther 17:347-53. 2012
  2. ncbi Increased carotid intima media thickness and cardiac biomarkers in HIV infected children
    Grace A McComsey
    Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 21:921-7. 2007
  3. ncbi Extensive investigations of mitochondrial DNA genome in treated HIV-infected subjects: beyond mitochondrial DNA depletion
    Grace McComsey
    Rainbow Babies and Children s Hospital and Center for AIDS Research of Case Western Reserve University, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 39:181-8. 2005
  4. ncbi Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine
    Grace A McComsey
    Rainbow Babies and Children s Hospital bCase School of Medicine Center for AIDS Research, Cleveland, Ohio, USA
    AIDS 19:15-23. 2005
  5. ncbi Fragility fractures in HIV-infected patients: need for better understanding of diagnosis and management
    Grace A McComsey
    Case Western Reserve University, Cleveland, OH, USA
    J Int Assoc Physicians AIDS Care (Chic) 3:86-91. 2004
  6. ncbi Mitochondrial dysfunction: patient monitoring and toxicity management
    Grace McComsey
    Case Western Reserve University, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 37:S30-5. 2004
  7. ncbi Uridine supplementation in HIV lipoatrophy: pilot trial on safety and effect on mitochondrial indices
    G A McComsey
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    Eur J Clin Nutr 62:1031-7. 2008
  8. ncbi Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study
    G A McComsey
    Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    Clin Infect Dis 46:1290-6. 2008
  9. ncbi Asymptomatic hyperlactataemia: predictive value, natural history and correlates
    Grace A McComsey
    Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Antivir Ther 9:205-12. 2004
  10. ncbi Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy
    Grace A McComsey
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    HIV Clin Trials 9:126-36. 2008

Research Grants

  1. Inflammation, Heart and Bone
    Grace A McComsey; Fiscal Year: 2010
  2. Metabolic Consequences of Thymidine Sparing Regimens
    Grace A McComsey; Fiscal Year: 2010
  3. Role of Mitochondria in HIV Lipoatrophy
    Grace McComsey; Fiscal Year: 2009
  4. Uridine Supplementation for HIV lipoatrophy
    Grace McComsey; Fiscal Year: 2007
  5. Metabolic Consequences of Thymidine Sparing Regimens
    Grace McComsey; Fiscal Year: 2007
  6. Training Program in Pediatric Infectious Diseases
    Grace McComsey; Fiscal Year: 2006

Detail Information

Publications38

  1. ncbi Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir
    Grace A McComsey
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Antivir Ther 17:347-53. 2012
    ..Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity...
  2. ncbi Increased carotid intima media thickness and cardiac biomarkers in HIV infected children
    Grace A McComsey
    Rainbow Babies and Childrens Hospital, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 21:921-7. 2007
    ..To assess carotid intima media thickness (IMT) and cardiac biomarkers in HIV infected children on antiretroviral therapy (ART)...
  3. ncbi Extensive investigations of mitochondrial DNA genome in treated HIV-infected subjects: beyond mitochondrial DNA depletion
    Grace McComsey
    Rainbow Babies and Children s Hospital and Center for AIDS Research of Case Western Reserve University, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 39:181-8. 2005
    ..In past investigations, studies have looked at mtDNA depletion and a few specific mutations but not at the entire mtDNA genome to correlate with clinical toxicity...
  4. ncbi Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine
    Grace A McComsey
    Rainbow Babies and Children s Hospital bCase School of Medicine Center for AIDS Research, Cleveland, Ohio, USA
    AIDS 19:15-23. 2005
    ..As apoptosis and dysfunction of electron transport chain (ETC) activities may underlie mitochondrial toxicity, these parameters were also evaluated...
  5. ncbi Fragility fractures in HIV-infected patients: need for better understanding of diagnosis and management
    Grace A McComsey
    Case Western Reserve University, Cleveland, OH, USA
    J Int Assoc Physicians AIDS Care (Chic) 3:86-91. 2004
    ..In HIV and ART, osteopenia and osteoporosis are multifactorial, and health promotion or medical health maintenance should anticipate and prevent morbidity of bone fragility fractures...
  6. ncbi Mitochondrial dysfunction: patient monitoring and toxicity management
    Grace McComsey
    Case Western Reserve University, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 37:S30-5. 2004
    ..This may allow prompt discontinuation of the causative agent(s) and initiation of appropriate therapeutic measures, thereby increasing the chances of reversibility of the syndrome...
  7. ncbi Uridine supplementation in HIV lipoatrophy: pilot trial on safety and effect on mitochondrial indices
    G A McComsey
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    Eur J Clin Nutr 62:1031-7. 2008
    ..We aim to study the effect of uridine supplementation on human adipocyte mitochondrial DNA (mtDNA) levels in subjects with human immunodeficiency (HIV) lipoatrophy...
  8. ncbi Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study
    G A McComsey
    Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    Clin Infect Dis 46:1290-6. 2008
    ..Lipoatrophy and mitochondrial toxicity have been linked to stavudine use, but it is unclear whether switching to a lower dose can reduce these toxicities while maintaining human immunodeficiency virus (HIV) suppression...
  9. ncbi Asymptomatic hyperlactataemia: predictive value, natural history and correlates
    Grace A McComsey
    Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Antivir Ther 9:205-12. 2004
    ..The significance of asymptomatic hyperlactataemia is unknown...
  10. ncbi Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy
    Grace A McComsey
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    HIV Clin Trials 9:126-36. 2008
    ..The effects of gestational nucleoside reverse transcriptase inhibitors (NRTIs) on mitochondrial DNA (mtDNA) are controversial. The effects of mtDNA depletion on mitochondrial function have not been assessed...
  11. ncbi Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus-infected patients switched from stavudine to abacavir or zidovudine: the results of the TARHEEL study
    Grace A McComsey
    Case Western Reserve, Cleveland, Ohio, USA
    Clin Infect Dis 38:263-70. 2004
    ..HIV suppression was maintained over the study period. In conclusion, replacing stavudine with abacavir or zidovudine resulted in improvement in stavudine-induced lipoatrophy...
  12. ncbi Lipid oxidative markers are significantly increased in lipoatrophy but not in sustained asymptomatic hyperlactatemia
    Grace A McComsey
    Rainbow Babies and Children s Hospital, and Center for AIDS Research of Case Western Reserve University, and University Hospitals of Cleveland, Ohio, USA
    J Acquir Immune Defic Syndr 34:45-9. 2003
    ..082 +/- 0.021 vs. 0.053 +/- 0.021, respectively; P < 0.05)...
  13. ncbi Effect of antioxidants on glucose metabolism and plasma lipids in HIV-infected subjects with lipoatrophy
    Grace McComsey
    Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    J Acquir Immune Defic Syndr 33:605-7. 2003
    ..Controlled trials are required to evaluate directly the effects of these agents on lipid and glucose metabolism...
  14. ncbi Impact of protease inhibitor substitution with efavirenz in HIV-infected children: results of the First Pediatric Switch Study
    Grace McComsey
    Rainbow Babies and Children s Hospital, Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA
    Pediatrics 111:e275-81. 2003
    ..We report here the results of the first open-label PI-switch study in HIV-infected children...
  15. ncbi Update on mitochondrial toxicity of antiretrovirals and its link to lipodystrophy
    Grace McComsey
    Rainbow Babies and Children s Hospital, Case Western Reserve University Center for AIDS Research, Cleveland, Ohio, USA
    AIDS Rev 4:140-7. 2002
    ..This review will focus on the pathogenesis of mitochondrion damage caused by nucleoside analogs and its clinical consequences, particularly in respect to body-shape changes...
  16. ncbi Analysis of the mitochondrial DNA genome in the peripheral blood leukocytes of HIV-infected patients with or without lipoatrophy
    Grace McComsey
    Department of Pediatrics, Division of Infectious Diseases, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    AIDS 16:513-8. 2002
    ..To investigate the molecular mechanisms of nucleoside analogue reverse transcriptase inhibitor (NRTI)-associated mitochondrial dysfunction...
  17. ncbi Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy
    Allison C Ross
    Rainbow Babies and Children s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Clin Infect Dis 49:1119-27. 2009
    ....
  18. ncbi Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to antiretroviral therapy and not to HIV infection
    Grace A McComsey
    Case Western Reserve University, Cleveland, OH, USA
    Antivir Ther 13:715-22. 2008
    ..The aim of this study was to assess the effect of antiretroviral therapy (ART) versus HIV on mitochondria in fat...
  19. ncbi Placebo-controlled trial of prednisone in advanced HIV-1 infection
    G A McComsey
    Case Western Reserve University and University Hospitals of Cleveland, Ohio, USA
    AIDS 15:321-7. 2001
    ..These results suggest that, in stable HIV-1 disease, these immune activation markers are more likely consequences of but not inducers of HIV-1 replication...
  20. ncbi Metabolic complications of antiretroviral therapy in children
    Ethan G Leonard
    Division of Pediatric Infectious Diseases, Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA
    Pediatr Infect Dis J 22:77-84. 2003
    ..This review summarizes the epidemiology and management of lipodystrophy, dyslipidemia, insulin resistance, hyperlactatemia, osteopenia and growth failure in HIV-infected children...
  21. ncbi Antiretroviral therapy in HIV-infected children: the metabolic cost of improved survival
    Ethan G Leonard
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 4410, USA
    Infect Dis Clin North Am 19:713-29. 2005
    ..The benefits of HAART in HIV infection are indisputable, but the impetus to find a cure or design more tolerable therapy is clear. Infarction may replace infection as the major cause of morbidity and mortality from HIV...
  22. ncbi Rosiglitazone improves lipoatrophy in patients receiving thymidine-sparing regimens
    Marisa Tungsiripat
    Cleveland Clinic, Ohio, USA
    AIDS 24:1291-8. 2010
    ..None specifically excluded the use of tNRTIs. We report the first study in individuals treated with tNRTI-sparing regimens using a TZD for treatment of HIV lipoatrophy...
  23. ncbi Statins Blunt HAART-Induced CD4 T-Cell Gains but Have No Long-Term Effect on Virologic Response to HAART
    Benigno Rodriguez
    University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, OH
    J Int Assoc Physicians AIDS Care (Chic) 6:198-202. 2007
    ..Studies with longer follow-up and detailed metabolic and immunologic monitoring are needed to confirm these findings and assess their significance and mechanisms...
  24. ncbi Endothelial activation markers are linked to HIV status and are independent of antiretroviral therapy and lipoatrophy
    Allison C Ross
    Department of Pediatrics, Rainbow Babies and Children s Hospital, and Department of Pediatrics and Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 49:499-506. 2008
    ....
  25. ncbi Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV
    Grace A McComsey
    Rainbow Babies and Children s Hospital and Case Western Reserve University, Cleveland, Ohio, USA
    AIDS 21:2473-82. 2007
    ..Bisphosphonates are currently the mainstay of treatment for postmenopausal and male osteoporosis in HIV-uninfected individuals; however, their efficacy and safety in HIV-infected patients remains unclear...
  26. ncbi Higher plasma myeloperoxidase levels are not associated with an increased risk for cardiovascular events in HIV-infected adults
    Dalia El-Bejjani
    Case Medical Center and Case Western Reserve University, Cleveland, Ohio 44106, USA
    HIV Clin Trials 9:207-11. 2008
    ..Elevated myeloperoxidase (MPO) levels are predictive of high cardiovascular (CV) risk in the general population. The value of MPO as a CV marker in the HIV population has not been investigated...
  27. ncbi Subjective clinical lipoatrophy assessment correlates with DEXA-measured limb fat
    Marisa Tungsiripat
    Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    HIV Clin Trials 10:314-9. 2009
    ..We aim to assess the validity of physician- and patient-rated diagnoses of lipoatrophy by evaluating the correlation between clinical assessments of lipoatrophy and objective fat indices...
  28. ncbi Heightened inflammation is linked to carotid intima-media thickness and endothelial activation in HIV-infected children
    Allison C Ross
    Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH, USA
    Atherosclerosis 211:492-8. 2010
    ..We compared proinflammatory cytokines and adhesion molecules in HIV+ children versus healthy controls, and assessed their relationship to carotid intima-media thickness (IMT)...
  29. ncbi Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy
    Ann J Melvin
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Antivir Ther 13:349-55. 2008
    ....
  30. ncbi High doses of riboflavin and thiamine may help in secondary prevention of hyperlactatemia
    Grace A McComsey
    Pediatric Infectious Diseases Division, Rainbow Babies and Children's Hospital, Western Reserve University, Cleveland, USA
    AIDS Read 12:222-4. 2002
    ..Therefore, there is a need to investigate ways to prevent the recurrence of hyperlactatemia in patients who require NRTI-based therapy...
  31. ncbi New entrants to HIV care are presenting only at marginally earlier stages of disease but may increasingly represent groups perceived at lower risk
    Chariclia V Loupa
    Center for AIDS Research, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Int Assoc Physicians AIDS Care (Chic Ill) 4:47-51. 2005
    ..Decreasing sexually transmitted diseases and hepatitis coinfections suggest that HIV infection is increasingly seen in populations previously perceived at lower risk...
  32. ncbi Buffalo hump: what the experts suggest
    Peter J Piliero
    AIDS Clin Care 16:22-3. 2004
  33. ncbi Lack of recurrence of hyperlactatemia in HIV-infected patients switched from stavudine to abacavir or zidovudine
    J Tyler Lonergan
    Department of Medicine, Owen Clinic University of California at San Diego Medical Center, 92103, USA
    J Acquir Immune Defic Syndr 36:935-42. 2004
    ....
  34. ncbi Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy
    Elizabeth G Livingston
    Duke University, Durham, NC 27710, USA
    Obstet Gynecol 110:391-7. 2007
    ..To evaluate the effect of protease inhibitors on lipid and lactate levels and gastrointestinal symptoms in pregnancy...
  35. ncbi Metabolic complications of HIV therapy in children
    Grace A McComsey
    AIDS 18:1753-68. 2004
  36. ncbi Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
    ..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
  37. ncbi Fatty liver in HIV infection: metabolic syndrome, medicines, mitochondria, and more?
    Pierre M Gholam
    AIDS Read 17:516-7. 2007
  38. ncbi Index of suspicion
    Ihuoma Eneli
    Michigan State University, East Lansing, Mich, USA
    Pediatr Rev 27:389-94. 2006

Research Grants14

  1. Inflammation, Heart and Bone
    Grace A McComsey; Fiscal Year: 2010
    ..In addition, we will be able to better understand the role played by chronic inflammation and oxidant stress on these complications. ..
  2. Metabolic Consequences of Thymidine Sparing Regimens
    Grace A McComsey; Fiscal Year: 2010
    ..at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  3. Role of Mitochondria in HIV Lipoatrophy
    Grace McComsey; Fiscal Year: 2009
    ..abstract_text> ..
  4. Uridine Supplementation for HIV lipoatrophy
    Grace McComsey; Fiscal Year: 2007
    ..On-study subjects will continue to be followed per study protocol for a total of 12 months. The last 6 months of the grant will be dedicated to processing of samples and analysis of all data. ..
  5. Metabolic Consequences of Thymidine Sparing Regimens
    Grace McComsey; Fiscal Year: 2007
    ..In addition, we will evaluate metabolic parameters using the clinical/imaging data obtained as part of the parent ACTG study. ..
  6. Training Program in Pediatric Infectious Diseases
    Grace McComsey; Fiscal Year: 2006
    ..abstract_text> ..