Danny Manor

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70)
    Krista P Kauppinen
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:21638-44. 2005
  2. doi request reprint Vitamin e trafficking in neurologic health and disease
    Lynn Ulatowski
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 email
    Annu Rev Nutr 33:87-103. 2013
  3. pmc Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation
    Elena Kamynina
    Case School of Medicine, WG 48, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 27:1809-22. 2007
  4. pmc Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases
    Meghana Gupta
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 288:14522-30. 2013
  5. pmc Hepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation
    Varsha Thakur
    Department of Nutrition, School of Medicine
    Biochemistry 49:9339-44. 2010

Research Grants

  1. Cell Transformation by Dbl-like onco-proteins
    Danny Manor; Fiscal Year: 2006
  2. Functions of Tocopherol Transfer Protein
    Danny Manor; Fiscal Year: 2007

Collaborators

  • Hong Wang
  • Elena Kamynina
  • Lynn Ulatowski
  • Meghana Gupta
  • Samantha Morley
  • Varsha Thakur
  • Nora Muakkassa
  • Faping Duan
  • Krista P Kauppinen
  • Shayna Brathwaite
  • Stacey Chung
  • Gaurav Sharma
  • Krista Kauppinen
  • Jared I Wels

Detail Information

Publications5

  1. ncbi request reprint Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70)
    Krista P Kauppinen
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 280:21638-44. 2005
    ..We propose that Hsc70 attenuates Dbl activity by maintaining an inactive conformation in which the amino terminus is "folded over" the catalytic DH-PH domain...
  2. doi request reprint Vitamin e trafficking in neurologic health and disease
    Lynn Ulatowski
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 email
    Annu Rev Nutr 33:87-103. 2013
    ..The critical roles of this protein and its ligand are underscored by the debilitating pathologies that characterize human carriers of mutations in the TTPA gene. ..
  3. pmc Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation
    Elena Kamynina
    Case School of Medicine, WG 48, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Cell Biol 27:1809-22. 2007
    ..Onco-Dbl, lacking the spectrin homology domain, cannot bind these regulators and therefore accumulates in cells at high levels, leading to persistent stimulation of its downstream signaling pathways...
  4. pmc Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases
    Meghana Gupta
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 288:14522-30. 2013
    ..These findings indicate that Plekhg4 is an aggregation-prone member of the Dbl family GEFs and that regulation of GTPase signaling is critical for proper cerebellar function...
  5. pmc Hepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation
    Varsha Thakur
    Department of Nutrition, School of Medicine
    Biochemistry 49:9339-44. 2010
    ..These findings suggest that vitamin E imparts a distinct conformation on TTP that is associated with localization to a specific cellular compartment, where the protein is less susceptible to proteasomal degradation...

Research Grants4

  1. Cell Transformation by Dbl-like onco-proteins
    Danny Manor; Fiscal Year: 2006
    ..abstract_text> ..
  2. Functions of Tocopherol Transfer Protein
    Danny Manor; Fiscal Year: 2007
    ..Studies proposed in this application will provide critical information that is likely to improve our understanding of vitamin E function as a mediator of human health. ..