- Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradationElena Kamynina
Case School of Medicine, WG 48, Case Western Reserve University, Cleveland, OH 44106, USA
Mol Cell Biol 27:1809-22. 2007..Onco-Dbl, lacking the spectrin homology domain, cannot bind these regulators and therefore accumulates in cells at high levels, leading to persistent stimulation of its downstream signaling pathways...
- Regulation of the Dbl proto-oncogene by heat shock cognate protein 70 (Hsc70)Krista P Kauppinen
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 280:21638-44. 2005..We propose that Hsc70 attenuates Dbl activity by maintaining an inactive conformation in which the amino terminus is "folded over" the catalytic DH-PH domain...
- Cell Transformation by Dbl-like onco-proteinsDanny Manor; Fiscal Year: 2006..abstract_text> ..
- Functions of Tocopherol Transfer ProteinDanny Manor; Fiscal Year: 2007..Studies proposed in this application will provide critical information that is likely to improve our understanding of vitamin E function as a mediator of human health. ..