C J Malemud

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus
    Charles W Denko
    Department of Medicine Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5076, USA
    BMC Musculoskelet Disord 5:37. 2004
  2. ncbi request reprint Matrix metalloproteinases (MMPs) in health and disease: an overview
    Charles J Malemud
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Front Biosci 11:1696-701. 2006
  3. ncbi request reprint Cytokines as therapeutic targets for osteoarthritis
    Charles J Malemud
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    BioDrugs 18:23-35. 2004
  4. ncbi request reprint Matrix metalloproteinases: role in skeletal development and growth plate disorders
    Charles J Malemud
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
    Front Biosci 11:1702-15. 2006
  5. ncbi request reprint Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases
    C J Malemud
    Division of Rheumatic Diseases Department of Medicine and Department of Anatomy, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
    Mini Rev Med Chem 6:689-98. 2006
  6. ncbi request reprint Growth hormone, VEGF and FGF: involvement in rheumatoid arthritis
    Charles J Malemud
    Department of Medicine Division of Rheumatic Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 2061 Cornell Road, Room 207 Cleveland, OH 44106 5076, USA
    Clin Chim Acta 375:10-9. 2007
  7. ncbi request reprint Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways
    Charles J Malemud
    Medicine and Anatomy, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland OH 44106 5076, USA
    Curr Opin Pharmacol 7:339-43. 2007
  8. ncbi request reprint Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs
    Charles J Malemud
    Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Department of Medicine, Division of Rheumatic Diseases, 2061 Cornell Road, Cleveland, Ohio 44106 5076, USA
    Expert Opin Ther Targets 12:171-83. 2008
  9. ncbi request reprint Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndrome
    C J Malemud
    Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5076, USA
    Clin Exp Rheumatol 27:S86-91. 2009
  10. doi request reprint Anticytokine therapy for osteoarthritis: evidence to date
    Charles J Malemud
    Department of Medicine, Division of Rheumatic Diseases, Department of Anatomy, Case Western Reserve University, School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106 5076, USA
    Drugs Aging 27:95-115. 2010

Collaborators

Detail Information

Publications29

  1. pmc Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus
    Charles W Denko
    Department of Medicine Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5076, USA
    BMC Musculoskelet Disord 5:37. 2004
    ..This study was designed to compare basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels in female systemic lupus erythematosus patients to a group of normal female subjects...
  2. ncbi request reprint Matrix metalloproteinases (MMPs) in health and disease: an overview
    Charles J Malemud
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Front Biosci 11:1696-701. 2006
    ....
  3. ncbi request reprint Cytokines as therapeutic targets for osteoarthritis
    Charles J Malemud
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    BioDrugs 18:23-35. 2004
    ....
  4. ncbi request reprint Matrix metalloproteinases: role in skeletal development and growth plate disorders
    Charles J Malemud
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
    Front Biosci 11:1702-15. 2006
    ..Genetic manipulation to correct defective or dysfunctional MMP genes or MMP activity found in certain human chondrodysplasias may provide a novel strategy for treating medical disorders characterized by skeletal anomalies...
  5. ncbi request reprint Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases
    C J Malemud
    Division of Rheumatic Diseases Department of Medicine and Department of Anatomy, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
    Mini Rev Med Chem 6:689-98. 2006
    ..The efficacy of SAPK/MAPK inhibitors in animal models of inflammation, arthritis, heart failure, cancer and neurological degeneration has provided the impetus for using them in human studies of inflammation and in clinical trials...
  6. ncbi request reprint Growth hormone, VEGF and FGF: involvement in rheumatoid arthritis
    Charles J Malemud
    Department of Medicine Division of Rheumatic Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 2061 Cornell Road, Room 207 Cleveland, OH 44106 5076, USA
    Clin Chim Acta 375:10-9. 2007
    ..Acidic FGF (FGF-1) and basic FGF (FGF-2) have also been implicated in aberrant synoviocyte proliferation (i.e. synovial hyperplasia) and apoptosis resistance in adult RA...
  7. ncbi request reprint Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways
    Charles J Malemud
    Medicine and Anatomy, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland OH 44106 5076, USA
    Curr Opin Pharmacol 7:339-43. 2007
    ..Several of these compounds are already being tested in human subjects to assess their oral bioavailability, pharmacokinetics and toxicity...
  8. ncbi request reprint Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs
    Charles J Malemud
    Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Department of Medicine, Division of Rheumatic Diseases, 2061 Cornell Road, Cleveland, Ohio 44106 5076, USA
    Expert Opin Ther Targets 12:171-83. 2008
    ..Peripheral inflammation in RA may influence neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, as well as growth factor production, which can modify neural circuitry and contribute to depression...
  9. ncbi request reprint Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndrome
    C J Malemud
    Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5076, USA
    Clin Exp Rheumatol 27:S86-91. 2009
    ..To critically evaluate the role of several notable 'pain pathways' in the fibromyalgia syndrome (FMS)...
  10. doi request reprint Anticytokine therapy for osteoarthritis: evidence to date
    Charles J Malemud
    Department of Medicine, Division of Rheumatic Diseases, Department of Anatomy, Case Western Reserve University, School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106 5076, USA
    Drugs Aging 27:95-115. 2010
    ..Since the prevalence of OA is high in the elderly population, future development of DMOADs must also take into account potential differences in the way DMOADs would be metabolized in the older individual compared with younger people...
  11. ncbi request reprint Cardiovascular disease complications in systemic lupus erythematosus
    Alexander Torres
    Department of Medicine, Division of Rheumatic Diseases, University Hospitals Case Medical Center, 2061 Cornell Road, Cleveland, OH 44106 5076, USA
    Biomark Med 3:239-52. 2009
    ....
  12. ncbi request reprint Future directions for research and treatment of osteoarthritis
    C J Malemud
    Departments of Medicine and Anatomy, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 4946, USA
    Front Biosci 4:D762-71. 1999
    ....
  13. ncbi request reprint Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes
    S Islam
    Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Osteoarthritis Cartilage 9:684-93. 2001
    ....
  14. ncbi request reprint Proteoglycans synthesized by chondrocytes of human nonarthritic and osteoarthritic cartilage
    R Shuckett
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    Proc Soc Exp Biol Med 190:275-81. 1989
    ..The findings are noteworthy in that these differences were not previously apparent when organ-cultured cartilage was used to assess putative alterations in proteoglycans between the two groups...
  15. ncbi request reprint Suppression of proteoglycan synthesis in chondrocyte cultures derived from canine intervertebral disc
    J U Yoo
    Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio
    Spine (Phila Pa 1976) 17:221-4. 1992
    ....
  16. ncbi request reprint Human cartilage from late stage familial osteoarthritis transcribes type II collagen mRNA encoding a cysteine in position 519
    D Holderbaum
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    Biochem Biophys Res Commun 192:1169-74. 1993
    ..The presence of both mutant and normal alleles of Col2A1 in cDNA derived from cartilage obtained from this patient suggests that Cys519-containing type II collagen may continue to be produced even in advanced stages of osteoarthritis...
  17. ncbi request reprint Fundamental pathways in osteoarthritis: an overview
    C J Malemud
    Departments of Medicine and Anatomy, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 4946, USA
    Front Biosci 4:D659-61. 1999
    ....
  18. ncbi request reprint Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases
    Charles W Denko
    Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Semin Arthritis Rheum 35:24-34. 2005
    ....
  19. ncbi request reprint Hydrostatic pressure increases apoptosis in cartilage-constructs produced from human osteoarthritic chondrocytes
    Reid Wenger
    Department of Orthodontics, Case Western Reserve University School of Dentistry, Cleveland, Ohio 44106 4946, USA
    Front Biosci 11:1690-5. 2006
    ..02) the proportion of apoptotic cells in the cartilage-constructs (41% +/- 4.2%; mean +/- SD) compared to control cartilage-constructs (28.5 +/- 8.4%)...
  20. ncbi request reprint The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients
    Charles W Denko
    Department of Medicine, Case Western Reserve University School of Medicine and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 44106 5076, USA
    Front Biosci 9:1660-4. 2004
    ..We conclude that the serum growth hormone to somatostatin ratio may be a useful surrogate marker of disease activity in symptomatic RA...
  21. ncbi request reprint Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies
    Charles J Malemud
    Department of Medicine, Case Western Reserve University School of Medicine, and Research Institute of University Hospitals of Cleveland, Ohio 44106 5076, USA
    Cells Tissues Organs 174:34-48. 2003
    ..MAPK activity appears critical for regulating chondrocyte and synoviocyte apoptosis and MMP genes...
  22. ncbi request reprint Serum growth hormone and insulin but not insulin-like growth factor-1 levels are elevated in patients with fibromyalgia syndrome
    Charles W Denko
    Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Rheumatol Int 25:146-51. 2005
    ..e., 27 microU/ml(-1)). Based on these results, basal serum GH and fasting serum insulin levels appear to be valuable surrogate markers in clinically active, normoglycemic fibromyalgia patients...
  23. ncbi request reprint Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH)
    Charles W Denko
    Department of Medicine, Case Western Reserve University School of Medicine, and the Research Institute of University Hospitals of Cleveland, Cleveland, Ohio 41106 4946, USA
    Front Biosci 7:a37-43. 2002
    ..Clinical improvement did not alter serum IGF-I concentration. We conclude that serum GH concentration could be employed to monitor clinical remission in DISH...
  24. ncbi request reprint Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9
    Kalpana Gupta
    Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Arthritis Rheum 56:3326-35. 2007
    ..Among these bands is an approximately 125-130-kd band for high molecular weight (HMW) gelatinase, which has not been characterized. This study was undertaken to characterize the HMW MMP activity in OA SF...
  25. ncbi request reprint Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-alpha, inducible nitric oxide synthase, p53, c-myc, and bax-alpha, and suppression of bcl-2
    Najmul Islam
    Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4946, USA
    J Cell Biochem 87:266-78. 2002
    ..These results indicated that HP is a strong inducer of apoptosis in osteoarthritic human chondrocytes in vitro...
  26. ncbi request reprint Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes
    Rashmi Singh
    Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106 4946, USA
    J Orthop Res 21:102-9. 2003
    ..These are novel findings and indicate that EGCG may be of potential benefit in inhibiting IL-1beta-induced catabolic effects in OA chondrocytes that are dependent on JNK activity...
  27. ncbi request reprint Intra-erythrocyte deposition of growth hormone in rheumatic diseases
    Charles W Denko
    Department of Medicine, Case Western Reserve University School of Medicine, Division of Rheumatic Diseases, Foley Building, Room 207, 2061 Cornell Road, Cleveland, OH 44106 5076, USA
    Rheumatol Int 23:11-4. 2003
    ..While intra-erythrocyte GH levels exceeded serum GH levels in osteoarthritis and DISH, intra-erythrocyte GH was not a strong predictor of serum GH levels in osteoarthritis, DISH, or in the control group...
  28. ncbi request reprint Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fractures
    Alicia L Bertone
    Comparative Orthopedic Research Laboratories, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
    Am J Vet Res 66:1881-90. 2005
    ..To compare articular cartilage from horses with naturally developing osteochondrosis (OC) with normal articular cartilage and healing cartilage obtained from horses with experimentally induced osteochondral fractures...
  29. ncbi request reprint Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH)
    Charles W Denko
    Department of Medicine, Division of Rheumatic Diseases, University Hospitals of Cleveland, 2061 Cornell Road, Cleveland, OH 44106 5076, USA
    Rheumatol Int 26:292-7. 2006
    ..However, BMI did not correlate with either basal serum GH (adjusted r2 = -0.013) or IGF-1 levels (adjusted r2 = -0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH...