Michael E Maguire

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Magnesium chemistry and biochemistry
    Michael E Maguire
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Biometals 15:203-10. 2002
  2. ncbi request reprint The structure of CorA: a Mg(2+)-selective channel
    Michael E Maguire
    Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Curr Opin Struct Biol 16:432-8. 2006
  3. ncbi request reprint Magnesium transporters: properties, regulation and structure
    Michael E Maguire
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Front Biosci 11:3149-63. 2006
  4. pmc Regulation of CorA Mg2+ channel function affects the virulence of Salmonella enterica serovar typhimurium
    Krisztina M Papp-Wallace
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    J Bacteriol 190:6509-16. 2008
  5. pmc The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium
    Krisztina M Papp-Wallace
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    J Bacteriol 190:6517-23. 2008
  6. pmc SitABCD is the alkaline Mn(2+) transporter of Salmonella enterica serovar Typhimurium
    David G Kehres
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    J Bacteriol 184:3159-66. 2002
  7. ncbi request reprint Manganese transport and the role of manganese in virulence
    Krisztina M Papp-Wallace
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Annu Rev Microbiol 60:187-209. 2006
  8. ncbi request reprint Magnesium, manganese, and divalent cation transport assays in intact cells
    Michael E Maguire
    Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 394:289-305. 2007
  9. pmc Cation selectivity by the CorA Mg2+ channel requires a fully hydrated cation
    Andrea S Moomaw
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Biochemistry 49:5998-6008. 2010
  10. pmc The CorA Mg2+ transporter does not transport Fe2+
    Krisztina M Papp
    Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    J Bacteriol 186:7653-8. 2004

Research Grants

  1. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2003
  2. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2004
  3. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2003
  4. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2005
  5. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2006
  6. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2007
  7. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2009
  8. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2002
  9. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2002
  10. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2001

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Magnesium chemistry and biochemistry
    Michael E Maguire
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Biometals 15:203-10. 2002
  2. ncbi request reprint The structure of CorA: a Mg(2+)-selective channel
    Michael E Maguire
    Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Curr Opin Struct Biol 16:432-8. 2006
    ..Finally, there are bound Mg2+ ions in the cytosolic domain that are well placed to control the interaction of the ring of positive charge and the negatively charged helices, and thus control Mg2+ entry...
  3. ncbi request reprint Magnesium transporters: properties, regulation and structure
    Michael E Maguire
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Front Biosci 11:3149-63. 2006
    ....
  4. pmc Regulation of CorA Mg2+ channel function affects the virulence of Salmonella enterica serovar typhimurium
    Krisztina M Papp-Wallace
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    J Bacteriol 190:6509-16. 2008
    ..J. Bacteriol. 190:6517-6523, 2008). Further study of the regulation of CorA expression and function provides an opportunity to dissect the complexity of Mg(2+) homeostasis and its ties to virulence within the bacterium...
  5. pmc The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium
    Krisztina M Papp-Wallace
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    J Bacteriol 190:6517-23. 2008
    ..Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence...
  6. pmc SitABCD is the alkaline Mn(2+) transporter of Salmonella enterica serovar Typhimurium
    David G Kehres
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    J Bacteriol 184:3159-66. 2002
    ....
  7. ncbi request reprint Manganese transport and the role of manganese in virulence
    Krisztina M Papp-Wallace
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Annu Rev Microbiol 60:187-209. 2006
    ..The concluding section describes possible enzymatic roles for Mn(2+) that might help explain why Mn(2+) is necessary for virulence...
  8. ncbi request reprint Magnesium, manganese, and divalent cation transport assays in intact cells
    Michael E Maguire
    Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 394:289-305. 2007
    ..g., use of 63Ni2+ or 57Co2+ in place of 28Mg2+ to measure Mg2+ influx. Both vacuum filtration and centrifugation assays are described. In addition, the use and misuse of chelating agents is discussed...
  9. pmc Cation selectivity by the CorA Mg2+ channel requires a fully hydrated cation
    Andrea S Moomaw
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Biochemistry 49:5998-6008. 2010
    ..Instead, the loop appears to form an initial binding site for hydrated Mg(2+), not for the dehydrated cation. The loop residues may function to accelerate dehydration of the before entry of Mg(2+) into the pore of the channel...
  10. pmc The CorA Mg2+ transporter does not transport Fe2+
    Krisztina M Papp
    Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    J Bacteriol 186:7653-8. 2004
    ..We conclude that CorA does not transport Fe2+ and that the relationship, if any, between iron toxicity and corA is indirect...
  11. pmc X-ray crystallography and isothermal titration calorimetry studies of the Salmonella zinc transporter ZntB
    Qun Wan
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Structure 19:700-10. 2011
    ..Our crystal structures and isothermal titration calorimetry data indicate that there are three Zn(2+) binding sites in the full-length ZntB, two of which could be involved in Zn(2+) transport...
  12. pmc The CorA Mg2+ transporter is a homotetramer
    Mary Ann Warren
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4965, USA
    J Bacteriol 186:4605-12. 2004
    ..Thus, CorA appears to be a homotetramer with a TM segment of one monomer physically close to the same TM segment of another monomer...
  13. ncbi request reprint Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria
    David G Kehres
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    FEMS Microbiol Rev 27:263-90. 2003
    ..This suggests that Mn2+ may play an important role in central carbon metabolism. Further studies will be required, however, to determine whether these or other actions of Mn2+ within the cell are the relevant factors in pathogenesis...
  14. ncbi request reprint Bacterial homologs of eukaryotic membrane proteins: the 2-TM-GxN family of Mg(2+) transporters
    Krisztina M Papp-Wallace
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Membr Biol 24:351-6. 2007
    ..The recent crystal structure of a bacterial CorA shows that the structure of this family is unlike that of any other class of transporter or channel currently known...
  15. pmc The unique nature of mg2+ channels
    Andrea S Moomaw
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Physiology (Bethesda) 23:275-85. 2008
    ..Many questions about these channels remain, however, including the molecular basis of Mg2+ selectivity and the physiological role(s) of their eukaryotic homologs...
  16. ncbi request reprint Structure, properties and regulation of magnesium transport proteins
    David G Kehres
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Biometals 15:261-70. 2002
  17. pmc Regulation of Salmonella enterica serovar Typhimurium mntH transcription by H(2)O(2), Fe(2+), and Mn(2+)
    David G Kehres
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    J Bacteriol 184:3151-8. 2002
    ..183:4806-4813, 2001). Using Deltafur, DeltamntR, and Deltafur DeltamntR mutant strains as well as mutations in the Fur- and MntR-binding motif elements, we found that Fe(2+) can also mediate repression through the Mn(2+) repressor MntR...
  18. ncbi request reprint Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells
    Andrea M P Romani
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    Biometals 15:271-83. 2002
  19. pmc The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum
    Gregor Grass
    Institut fur Mikrobiologie, Martin Luther Universitat, Halle, Germany
    J Bacteriol 187:1604-11. 2005
    ..coli cells hypersensitive to Co2+ and sensitive to Mn2+. ZupT did not appear to be metal regulated: expression of a Phi(zupT-lacZ) operon fusion indicated that zupT is expressed constitutively at a low level...
  20. pmc Transcriptional regulation of sitABCD of Salmonella enterica serovar Typhimurium by MntR and Fur
    Jack S Ikeda
    Department of Microbiology, University of Illinois, B103 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
    J Bacteriol 187:912-22. 2005
    ....
  21. pmc The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model
    Michelle L Zaharik
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3 Canada
    Infect Immun 72:5522-5. 2004
    ....
  22. ncbi request reprint The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase
    Karsten R O Hazlett
    Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030 3710, USA
    J Biol Chem 278:20687-94. 2003
    ..Our data also indicate that Gpm expression and, therefore, glycolysis would not be abrogated when T. pallidum encounters high Zn2+ levels...
  23. pmc Crystal structure of the CorA Mg2+ transporter
    Vladimir V Lunin
    Department of Medical Biophysics, University of Toronto, 112 College Street, Toronto, Ontario M5G 1L6, Canada
    Nature 440:833-7. 2006
    ..An apparent Mg2+ ion was bound between monomers at a conserved site in the cytoplasmic domain, suggesting a mechanism to link gating of the pore to the intracellular concentration of Mg2+...
  24. pmc The MgtC virulence factor of Salmonella enterica serovar Typhimurium activates Na(+),K(+)-ATPase
    Dorothee Gunzel
    Institut für Klinische Physiologie, Charite Universitatsmedizin Berlin, D 12200 Berlin, Germany
    J Bacteriol 188:5586-94. 2006
    ..These results suggest that the serovar Typhimurium MgtC protein may be involved in regulating membrane potential but does not directly transport Mg(2+) or another ion...

Research Grants21

  1. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2003
    ..abstract_text> ..
  2. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2004
    ..abstract_text> ..
  3. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2003
    ..Preliminary data suggest that it alters cellular Ca2+ homeostasis. This renewal proposal seeks to determine the basis for its unusual expression and to investigate its possible role in Ca2+ homeostasis. ..
  4. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2005
    ..abstract_text> ..
  5. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2006
    ..In addition, it mediates Mg2+ flux into mitochondria and thus is important in control of Mg2+ homeostasis in eukaryotic cells and possibly in the mitochondrion's role in apoptosis. ..
  6. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2007
    ..In addition, it mediates Mg2+ flux into mitochondria and thus is important in control of Mg2+ homeostasis in eukaryotic cells and possibly in the mitochondrion's role in apoptosis. ..
  7. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2009
    ..In addition, it mediates Mg2+ flux into mitochondria and thus is important in control of Mg2+ homeostasis in eukaryotic cells and possibly in the mitochondrion's role in apoptosis. ..
  8. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2002
    ..Preliminary data suggest that it alters cellular Ca2+ homeostasis. This renewal proposal seeks to determine the basis for its unusual expression and to investigate its possible role in Ca2+ homeostasis. ..
  9. Manganese Homeostasis and Salmonella
    Michael Maguire; Fiscal Year: 2002
    ..abstract_text> ..
  10. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2001
    ..Preliminary data suggest that it alters cellular Ca2+ homeostasis. This renewal proposal seeks to determine the basis for its unusual expression and to investigate its possible role in Ca2+ homeostasis. ..
  11. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 1999
    ..Preliminary data suggest that it alters cellular Ca2+ homeostasis. This renewal proposal seeks to determine the basis for its unusual expression and to investigate its possible role in Ca2+ homeostasis. ..
  12. MAGNESIUM TRANSPORT IN SALMONELLA TYPHIMURIUM
    Michael Maguire; Fiscal Year: 1992
    ....
  13. MAGNESIUM TRANSPORT IN SALMONELLA TYPHIMURIUM
    Michael Maguire; Fiscal Year: 1993
    ....
  14. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2000
    ..Preliminary data suggest that it alters cellular Ca2+ homeostasis. This renewal proposal seeks to determine the basis for its unusual expression and to investigate its possible role in Ca2+ homeostasis. ..
  15. MAGNESIUM HOMEOSTASIS IN MICROORGANISMS
    Michael Maguire; Fiscal Year: 2009
    ..abstract_text> ..