Affiliation: Case Western Reserve University
Chen Y, Perusek L, Maeda A. Autophagy in light-induced retinal damage. Exp Eye Res. 2016;144:64-72 pubmed publisher
Parmar T, Parmar V, Perusek L, Georges A, Takahashi M, Crabb J, et al
. Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration. J Immunol. 2018;200:3128-3141 pubmed publisher
..Overall these results suggest that LCN2 is involved in prosurvival responses during cell stress and plays an important role in regulating inflammation during retinal degeneration. ..
Sahu B, Maeda A. RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models. Methods Mol Biol. 2018;1753:89-102 pubmed publisher
..Here, we describe biochemical analyses of the visual cycle in mouse models using RPE cells. ..
Sahu B, Maeda A. Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function. Nutrients. 2016;8: pubmed
..Herein we describe the function of RDHs in the RPE and the retina, particularly in rod photoreceptor cells, their regulatory properties for retinoid homeostasis and future therapeutic strategy for treatment of retinal diseases. ..
Parmar V, Parmar T, Arai E, Perusek L, Maeda A. A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells. Stem Cell Res. 2018;27:95-104 pubmed publisher
..Collectively, these data obtained with hiPSC-RPE cells provide evidence that A2E plays an important role in pathogenesis of retinal degenerative diseases in humans. ..
Maeda A, Maeda T, Palczewski K. Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci. 2006;47:4540-6 pubmed
..Rod and cone visual function improved significantly in the mouse model of F. albipunctatus after treatment with 9-cis-retinal, suggesting a potential approach to slow the progression of cone dystrophy in affected humans. ..
Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009;50:5435-43 pubmed publisher
..The protective roles were examined of the all-trans-RDHs, Rdh8 and Rdh12, and the ATP-binding cassette transporter Abca4, retinoid cycle enzymes involved in all-trans-retinal clearance...
Sahu B, Sun W, Perusek L, Parmar V, Le Y, Griswold M, et al
. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015;290:27239-47 pubmed publisher
..These results indicate that RDH10 acts in cooperation with other RDH isoforms to produce the 11-cis-retinal chromophore needed for vision. ..
Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le Y, et al
. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015;290:29035-44 pubmed publisher
..These observations indicate that Atg7-mediated autophagy is dispensable for retinoid recycling and A2E deposition; however, autophagy plays a role in coping with stress caused by A2E accumulation. ..