Zhenghong Lee

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Radio-deoxynucleoside Analogs used for Imaging tk Expression in a Transgenic Mouse Model of Induced Hepatocellular Carcinoma
    Haibin Tian
    1 Departments of Radiology
    Theranostics 2:597-606. 2012
  2. doi request reprint Imaging stem cell implant for cellular-based therapies
    Zhenghong Lee
    Department of Radiology, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Exp Biol Med (Maywood) 233:930-40. 2008
  3. pmc Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging
    Fangjing Wang
    Department of Biomedical Engineering, University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Physiol Genomics 37:23-34. 2009
  4. doi request reprint Imaging early stage osteogenic differentiation of mesenchymal stem cells
    David J Corn
    Department of Radiology, University Hospitals Case Medical Center, Cleveland, Ohio 44016, USA
    J Orthop Res 31:871-9. 2013
  5. doi request reprint [(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma
    Nicolas Salem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Imaging Biol 13:140-51. 2011
  6. pmc Transport and metabolism of radiolabeled choline in hepatocellular carcinoma
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Pharm 7:2077-92. 2010
  7. doi request reprint Imaging lipid synthesis in hepatocellular carcinoma with [methyl-11c]choline: correlation with in vivo metabolic studies
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, and Department of Radiology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Nucl Med 52:98-106. 2011
  8. doi request reprint PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline
    Jeffrey A Kolthammer
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Eur J Nucl Med Mol Imaging 38:1248-56. 2011
  9. doi request reprint Cross-species hybridization of woodchuck hepatitis viral infection-induced woodchuck hepatocellular carcinoma using human, rat and mouse oligonucleotide microarrays
    Fangjing Wang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    J Gastroenterol Hepatol 24:605-17. 2009
  10. pmc Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver
    Xincheng Lu
    Case Comprehensive Cancer Centre, Case Western Reserve University, Cleveland, OH 44106, USA
    J Hepatol 55:96-102. 2011

Research Grants

  1. Quantitative FDG-PET for Hepatomacellular Carcinoma
    Zhenghong Lee; Fiscal Year: 2003
  2. Quantitative FDG-PET for Imaging Woodchuck HCC
    Zhenghong Lee; Fiscal Year: 2004
  3. Quantitative FDG-PET for Imaging Woodchuck HCC
    Zhenghong Lee; Fiscal Year: 2005
  4. Quantitative FDG-PET for Imaging Woodchuck HCC
    Zhenghong Lee; Fiscal Year: 2006
  5. Effective PET Imaging in Liver Cancer
    Zhenghong Lee; Fiscal Year: 2009
  6. Effective PET Imaging in Liver Cancer
    Zhenghong Lee; Fiscal Year: 2010

Collaborators

Detail Information

Publications27

  1. pmc Radio-deoxynucleoside Analogs used for Imaging tk Expression in a Transgenic Mouse Model of Induced Hepatocellular Carcinoma
    Haibin Tian
    1 Departments of Radiology
    Theranostics 2:597-606. 2012
    ..The purpose of this study was to use this unique animal model for initial testing with radio-labeled thymidine analogs, mainly a pair of newly emerging nucleoside analogs, D-FMAU and L-FMAU...
  2. doi request reprint Imaging stem cell implant for cellular-based therapies
    Zhenghong Lee
    Department of Radiology, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Exp Biol Med (Maywood) 233:930-40. 2008
    ..Several studies performed by our group using different imaging techniques are described, with further discussion on the issues with these current imaging approaches and potential directions for future development in stem cell imaging...
  3. pmc Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging
    Fangjing Wang
    Department of Biomedical Engineering, University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Physiol Genomics 37:23-34. 2009
    ..In conclusion, transduction of reporter genes into MSCs preserved the basic properties of stem cells while enabling noninvasive imaging in living animals to study the biodistribution and other biological activities of the cells...
  4. doi request reprint Imaging early stage osteogenic differentiation of mesenchymal stem cells
    David J Corn
    Department of Radiology, University Hospitals Case Medical Center, Cleveland, Ohio 44016, USA
    J Orthop Res 31:871-9. 2013
    ..Bioluminescence imaging (BLI) was performed to visualize the turn-on of Col1α1 upon osteogenic differentiation and followed by X-ray imaging to assess the healing process for correlation with histological analyses...
  5. doi request reprint [(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma
    Nicolas Salem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Imaging Biol 13:140-51. 2011
    ..In this study, the metabolic fate of [(11)C]Act in HCC was characterized...
  6. pmc Transport and metabolism of radiolabeled choline in hepatocellular carcinoma
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Pharm 7:2077-92. 2010
    ..Conversion of [(14)C]-PC into phosphatidylcholine occurred slowly in vitro. Basal oxidation and phosphorylation activities in surrounding hepatic tissue contribute to the background seen in [(11)C]-Cho PET images...
  7. doi request reprint Imaging lipid synthesis in hepatocellular carcinoma with [methyl-11c]choline: correlation with in vivo metabolic studies
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, and Department of Radiology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Nucl Med 52:98-106. 2011
    ..This study was designed to examine the relationship between choline metabolism and choline tracer uptake in HCC for PET with 11C-choline...
  8. doi request reprint PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline
    Jeffrey A Kolthammer
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Eur J Nucl Med Mol Imaging 38:1248-56. 2011
    ..In this study, PET with (18)F-fluoroethylcholine (FEC) and (11)C-choline (CHOL) were compared using an animal model of HCC. The effects of fasting on the performance of choline-based tracers were also investigated...
  9. doi request reprint Cross-species hybridization of woodchuck hepatitis viral infection-induced woodchuck hepatocellular carcinoma using human, rat and mouse oligonucleotide microarrays
    Fangjing Wang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    J Gastroenterol Hepatol 24:605-17. 2009
    ....
  10. pmc Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver
    Xincheng Lu
    Case Comprehensive Cancer Centre, Case Western Reserve University, Cleveland, OH 44106, USA
    J Hepatol 55:96-102. 2011
    ..We aimed to take advantage of the dramatic re-expression of the Afp gene in HCC to develop a hepatocarcinogenesis reporter (HCR) mouse model for dual-modality, longitudinal in vivo imaging of liver tumor development, and progression...
  11. doi request reprint Percutaneous image-guided delivery for the transplantation of mesenchymal stem cells in the setting of degenerated intervertebral discs
    J David Prologo
    Division of Vascular and Interventional Radiology, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106, USA
    J Vasc Interv Radiol 23:1084-1088.e6. 2012
    ....
  12. pmc A colorimetric assay method to measure acetyl-CoA synthetase activity: application to woodchuck model of hepatitis virus-induced hepatocellular carcinoma
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biochem Biophys Methods 70:649-55. 2007
    ..The developed assay is rapid, simple and accurate and is suitable for the investigation of ACAS activity under physiologic and pathophysiologic conditions...
  13. doi request reprint Metabolism of radiolabeled methionine in hepatocellular carcinoma
    Yu Kuang
    Nuclear Medicine Division, Department of Radiology, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA
    Mol Imaging Biol 16:44-52. 2014
    ..However, its metabolic routes in HCC have not yet been fully understood. In this study, the metabolic pathway(s) of radiolabeled Met in HCC were investigated...
  14. doi request reprint Imaging stem cell differentiation for cell-based tissue repair
    Zhenghong Lee
    Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Methods Enzymol 506:247-63. 2012
    ..This framework can be easily extended to other cell types and for differentiation into any other cell lineage for which a specific marker gene (promoter) can be identified...
  15. ncbi request reprint Imaging of mesenchymal stem cell transplant by bioluminescence and PET
    Zachary Love
    Department of Nuclear Medicine Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Nucl Med 48:2011-20. 2007
    ..In this study, we used a triple-fusion reporter system for multimodal imaging to monitor human mesenchymal stem cell (hMSC) transplants...
  16. pmc Ketosis proportionately spares glucose utilization in brain
    Yifan Zhang
    Department of Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4954, USA
    J Cereb Blood Flow Metab 33:1307-11. 2013
    ..3 to 6.3 mmol/L). Together with our meta-analysis, these data revealed that the degree and duration of ketosis has a major role in determining the corresponding change in CMRglc with ketosis. ..
  17. ncbi request reprint Bioluminescent imaging of reporter gene expression in the lungs of wildtype and model mice following the administration of PEG-stabilized DNA nanoparticles
    Assem G Ziady
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Microsc Res Tech 73:918-28. 2010
    ..Taken together, our results demonstrate that BLI is an effective and useful modality for measuring gene expression conferred by DNPs in the lung...
  18. doi request reprint Bioluminescence imaging of hematopoietic stem cell repopulation in murine models
    Yuan Lin
    Department of Medicine, Division of Hematology Oncology, Case Western Reserve University, Cleveland, OH
    Methods Mol Biol 430:295-306. 2008
    ..Xenogen IVIS200 imaging system is used to record the process, and other similar imaging systems can also be used for this process...
  19. ncbi request reprint Structure-activity relationships of 2',5'-oligoadenylate analogue modifications of prostate-specific membrane antigen (PSMA) antagonists
    Xinning Wang
    Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nucleosides Nucleotides Nucleic Acids 31:432-44. 2012
    ..Removal of 2-5A significantly reduced its biological activity. The results will provide a path to agents for targeted imaging and treatment of prostate cancer...
  20. pmc Emerging therapeutic approaches for multipotent mesenchymal stromal cells
    Paolo F Caimi
    Department of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Curr Opin Hematol 17:505-13. 2010
    ..Subsequent pilot studies using allogeneic MSCs showed safety but presented contradictory results regarding efficacy in treating graft-versus-host disease (GVHD)...
  21. pmc Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation
    Lindsay A Bonsignore
    Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106, USA
    Bone 52:93-101. 2013
    ..Thus, LPS may inhibit osseointegration in part through cell autonomous effects on osteoblasts. These results highlight bacterial debris as a type of surface contaminant that can impair the osseointegration of orthopedic implants...
  22. ncbi request reprint Quantitative evaluation of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography imaging on the woodchuck model of hepatocellular carcinoma with histological correlation
    Nicolas Salem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Imaging Biol 9:135-43. 2007
    ..The performance of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for imaging HCC on the woodchuck using Positron emission tomography (PET) was investigated in this study...
  23. pmc Ketones suppress brain glucose consumption
    Joseph C Lamanna
    Department of Anatomy, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Adv Exp Med Biol 645:301-6. 2009
    ..3) and in the frontal cortex (CMRGlu = -3.93*[BHB] + 42.7, r2 = 0.5). These data indicate that, under conditions of ketosis, glucose consumption is decreased in the cortex and cerebellum by about 10% per each mM of plasma ketone bodies...
  24. pmc Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays
    Paul W Anderson
    Department of Radiology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    World J Gastroenterol 12:4646-51. 2006
    ....
  25. ncbi request reprint Gene expression studies of hepatitis virus-induced woodchuck hepatocellular carcinoma in correlation with human results
    Fangjing Wang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Oncol 30:33-44. 2007
    ..In particular, some of the differentially expressed genes in the woodchuck HCC can be further explored for possible molecular imaging targets or biological markers in human HCC...
  26. ncbi request reprint Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma
    Yu Kuang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Comp Biochem Physiol C Toxicol Pharmacol 143:225-31. 2006
    ..87 +/- 30.62 mU/mg protein) in the same woodchuck model of HCC (P < 0.01). Our study demonstrated an increased HK activity and a decreased G6Pase activity in liver of the woodchuck models of HCC as compared to normal woodchuck liver...
  27. ncbi request reprint PET imaging-based evaluation of aerosol drugs and their delivery devices: nasal and pulmonary studies
    Zhenghong Lee
    Radiology Department, School of Medicine and Biomedical Engineering Department, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    IEEE Trans Med Imaging 21:1324-31. 2002
    ..The quantitative data are used as the scientific basis for evaluation although we also developed visualization techniques to enhance the results drawn from the data...

Research Grants6

  1. Quantitative FDG-PET for Hepatomacellular Carcinoma
    Zhenghong Lee; Fiscal Year: 2003
    ..The methodology developed in this research can be applied to other tracers and used for other problem-specific research. ..
  2. Quantitative FDG-PET for Imaging Woodchuck HCC
    Zhenghong Lee; Fiscal Year: 2004
    ..The methodology developed in this research can be applied to other tracers and used for other problem-specific research. ..
  3. Quantitative FDG-PET for Imaging Woodchuck HCC
    Zhenghong Lee; Fiscal Year: 2005
    ..The methodology developed in this research can be applied to other tracers and used for other problem-specific research. ..
  4. Quantitative FDG-PET for Imaging Woodchuck HCC
    Zhenghong Lee; Fiscal Year: 2006
    ..The methodology developed in this research can be applied to other tracers and used for other problem-specific research. ..
  5. Effective PET Imaging in Liver Cancer
    Zhenghong Lee; Fiscal Year: 2009
    ..Upon successful development and evaluation as proposed, the use of this new tracer will meet the urgent need for effective PET imaging for HCC, which is increasing rapidly in frequency and mortality in United States. ..
  6. Effective PET Imaging in Liver Cancer
    Zhenghong Lee; Fiscal Year: 2010
    ..Upon successful development and evaluation as proposed, the use of this new tracer will meet the urgent need for effective PET imaging for HCC, which is increasing rapidly in frequency and mortality in United States. ..