Michael M Lederman

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138
    Michael M Lederman
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Infect Dis 194:1677-85. 2006
  2. ncbi request reprint Microbicides and other topical strategies to prevent vaginal transmission of HIV
    Michael M Lederman
    Case Western Reserve University, 2061 Cornell Road, Cleveland, Ohio, USA
    Nat Rev Immunol 6:371-82. 2006
  3. pmc Haemophilia, human immunodeficiency virus and human immunodeficiency virus pathogenesis
    Michael M Lederman
    Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Thromb Haemost 104:911-4. 2010
  4. pmc Determinants of protection among HIV‐exposed seronegative persons: an overview
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Infect Dis 202:S333-8. 2010
  5. pmc The lymph node in HIV pathogenesis
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44118, USA
    Semin Immunol 20:187-95. 2008
  6. pmc Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection
    Michael M Lederman
    Department of Medicine, Case Western Reserve University, 1100 Euclid Ave, Cleveland, OH 44118, USA
    Retrovirology 5:116. 2008
  7. pmc Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    Michael M Lederman
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 204:1217-26. 2011
  8. ncbi request reprint Biology of CCR5 and its role in HIV infection and treatment
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    JAMA 296:815-26. 2006
  9. ncbi request reprint TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    Nicole L Yonkers
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Veterans Affairs Medical Center, University Hospitals of Cleveland and Cleveland Clinic Foundation, Cleveland, OH 44106, USA
    J Immunol 178:4436-44. 2007
  10. ncbi request reprint Differential effect of interleukin-2 treatment on primary and secondary immunizations in HIV infected individuals
    Haydar Kuekrek
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44116, USA
    AIDS 19:1967-74. 2005

Research Grants

  1. ADULT AIDS CLINICAL TRIALS UNIT
    Michael Lederman; Fiscal Year: 2004
  2. CENTER FOR AIDS RESEARCH(CFAR)
    Michael Lederman; Fiscal Year: 2007
  3. 2007 Case CFAR Annual Spring Conference
    Michael Lederman; Fiscal Year: 2007
  4. Topical Immune modulatory strategies to prevent HIV transmission
    Michael Lederman; Fiscal Year: 2007
  5. Case CFAR Meeting: HIV Pathogenesis
    Michael Lederman; Fiscal Year: 2006
  6. Case AIDS Clinical Trials Unit
    Michael Lederman; Fiscal Year: 2007
  7. CONFERENCE ON HIV PATHOGENESIS
    Michael Lederman; Fiscal Year: 2005
  8. Immune Mechanisms and HIV Disease Pathogenesis
    Michael Lederman; Fiscal Year: 2004

Detail Information

Publications80

  1. ncbi request reprint Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138
    Michael M Lederman
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Infect Dis 194:1677-85. 2006
    ..Although the determinants of immune deficiency and immune restoration in chronic human immunodeficiency virus (HIV)-1 infection are not well understood, immune activation has been proposed as being central to the pathogenesis of HIV...
  2. ncbi request reprint Microbicides and other topical strategies to prevent vaginal transmission of HIV
    Michael M Lederman
    Case Western Reserve University, 2061 Cornell Road, Cleveland, Ohio, USA
    Nat Rev Immunol 6:371-82. 2006
    ..We discuss the targets for topical agents that have been identified by studies of the biology of HIV infection and provide an overview of the progress towards the development of a usable agent...
  3. pmc Haemophilia, human immunodeficiency virus and human immunodeficiency virus pathogenesis
    Michael M Lederman
    Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Thromb Haemost 104:911-4. 2010
    ....
  4. pmc Determinants of protection among HIV‐exposed seronegative persons: an overview
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Infect Dis 202:S333-8. 2010
    ....
  5. pmc The lymph node in HIV pathogenesis
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44118, USA
    Semin Immunol 20:187-95. 2008
    ..In this essay, we will review some of the data that have been accumulated and propose a testable model that may reconcile them...
  6. pmc Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection
    Michael M Lederman
    Department of Medicine, Case Western Reserve University, 1100 Euclid Ave, Cleveland, OH 44118, USA
    Retrovirology 5:116. 2008
    ..We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection...
  7. pmc Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    Michael M Lederman
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 204:1217-26. 2011
    ..Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection...
  8. ncbi request reprint Biology of CCR5 and its role in HIV infection and treatment
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    JAMA 296:815-26. 2006
    ..In this article, we explore the effects that targeting CCR5 may have on host defenses in individuals with immunity already compromised by HIV infection...
  9. ncbi request reprint TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection
    Nicole L Yonkers
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Veterans Affairs Medical Center, University Hospitals of Cleveland and Cleveland Clinic Foundation, Cleveland, OH 44106, USA
    J Immunol 178:4436-44. 2007
    ....
  10. ncbi request reprint Differential effect of interleukin-2 treatment on primary and secondary immunizations in HIV infected individuals
    Haydar Kuekrek
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44116, USA
    AIDS 19:1967-74. 2005
    ..As interleukin (IL)-2 therapy increases CD4 cell counts in HIV infected subjects, it emerged as a candidate for the partial restoration of immune competence in this disease...
  11. pmc Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function
    Sara J Conry
    Department of Medicine, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland, OH, USA
    J Virol 83:11175-87. 2009
    ....
  12. pmc Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and production
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Virol 79:4109-19. 2005
    ..Application of CpG ODNs in HIV disease for adjuvant or immunoregulatory purposes may be particularly useful for HIV+ donors without high-level viremia...
  13. ncbi request reprint Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function
    Christoph G Lange
    Center for AIDS Research, Department of Medicine, Division of Infectious Diseases, Case Western Reserve University, University Hospitals of Cleveland, 2061 Cornell Road, Cleveland, OH 44106, USA
    AIDS 18:605-13. 2004
    ....
  14. pmc Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation
    Nicholas T Funderburg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, OH, USA
    Blood 115:161-7. 2010
    ..Thus, drivers of immune activation in HIV disease, such as HIV replication, and potentially, microbial translocation, may activate clotting cascades and contribute to thrombus formation and cardiovascular morbidities in HIV infection...
  15. ncbi request reprint Impact of suppression of viral replication by highly active antiretroviral therapy on immune function and phenotype in chronic HIV-1 infection
    Christoph G Lange
    Department of Medicine, Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA
    J Acquir Immune Defic Syndr 30:33-40. 2002
    ....
  16. ncbi request reprint Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection
    Christoph G Lange
    Center for AIDS Research, Case Western University School of Medicine, Cleveland, OH 44106, USA
    AIDS 17:2015-23. 2003
    ....
  17. pmc Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
    Nicholas Funderburg
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 3:e1915. 2008
    ..Recently, heightened systemic translocation of microbial products was found in persons with chronic HIV infection and this was linked to immune activation and CD4(+) T cell homeostasis...
  18. pmc Pretreatment levels of soluble cellular receptors and interleukin-6 are associated with HIV disease progression in subjects treated with highly active antiretroviral therapy
    Robert C Kalayjian
    MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
    J Infect Dis 201:1796-805. 2010
    ....
  19. ncbi request reprint Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement
    Scott F Sieg
    Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, Ohio 44106 4984, USA
    J Infect Dis 192:62-70. 2005
    ..Thus, in HIV infection, central memory T cells may be highly susceptible to bystander mechanisms of immune activation, leading to S-phase entry...
  20. ncbi request reprint Distinct mechanisms of T cell reconstitution can be identified by estimating thymic volume in adult HIV-1 disease
    Robert C Kalayjian
    Division of Infectious Diseases, MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    J Infect Dis 192:1577-87. 2005
    ..We have attempted to identify factors associated with T cell reconstitution in response to highly active antiretroviral therapy...
  21. ncbi request reprint Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection
    Benigno Rodriguez
    Division of Infectious Diseases, Case Western Reserve University, Center foe AIDS Research, University Hospitals of Cleveland, Cleveland, Ohio, USA
    AIDS 20:1379-89. 2006
    ..To examine the effects of interferon-alpha (IFN-alpha) on T cell survival and activation in HIV infection...
  22. ncbi request reprint Interleukin-2 Increases CD4+ lymphocyte numbers but does not enhance responses to immunization: results of A5046s
    Hernan Valdez
    Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA
    J Infect Dis 187:320-5. 2003
    ..Despite dramatic increases in CD4(+) lymphocyte counts, IL-2 did not enhance immunization responses...
  23. pmc Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS ONE 8:e56527. 2013
    ..003). These studies identify IFNα derived from lymph nodes, rather than blood leukocytes, as a possible source of the IFN-I signature that contributes to immune activation in HIV-1 infection...
  24. pmc Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors
    Todd Hulgan
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    Eur J Clin Pharmacol 65:1081-8. 2009
    ..The aim of our study was to characterize the effects of the P-glycoprotein substrate cyclosporin A on T cell P-glycoprotein activity in human immunodeficiency virus-infected participants in the AIDS Clinical Trials Group study A5138...
  25. pmc Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    Wei Jiang
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 199:1177-85. 2009
    ..These findings are consistent with the importance of microbial translocation in immunodeficiency and T cell homeostasis in chronic HIV infection...
  26. pmc Neonatal T-cell maturation and homing receptor responses to Toll-like receptor ligands differ from those of adult naive T cells: relationship to prematurity
    Maricruz Crespo
    Department of Pediatrics, Case Western Reserve School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Pediatr Res 71:136-43. 2012
    ....
  27. ncbi request reprint Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection
    Jeffrey M Jacobson
    Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, New York, New York 10003, USA
    J Infect Dis 188:1804-14. 2003
    ..Studies have reported that plasma human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4+ lymphocyte counts in HIV-infected patients improved after treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF)...
  28. pmc Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7288, USA
    Blood 113:5497-505. 2009
    ..Defective monocyte responses to IFNalpha/beta may play an important role in the pathogenesis of HIV-1 infection, and decreased IFNalpha/betaR expression may serve as a novel marker of disease progression...
  29. pmc Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease
    Benigno Rodriguez
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    J Leukoc Biol 90:621-8. 2011
    ..These observations suggest that alterations in naïve T cell subset frequencies could contribute to naïve T cell dysfunction in HIV disease, but these alterations are not necessarily the result of chronic immune activation...
  30. ncbi request reprint Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    Michael M Lederman
    Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA
    Science 306:485-7. 2004
    ..These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention...
  31. ncbi request reprint T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment
    Mireya Diaz
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 17:1145-9. 2003
    ..To examine baseline predictors of T-cell receptor rearrangement excision circle (TREC) levels and their changes during treatment with combined antiretroviral therapy...
  32. pmc Older HIV-infected patients on antiretroviral therapy have B-cell expansion and attenuated CD4 cell increases with immune activation reduction
    Robert C Kalayjian
    MetroHealth Medical Center, Cleveland, OH, USA
    AIDS 27:1563-71. 2013
    ..The contribution of immune activation to accelerated HIV-disease progression in older individuals has not been delineated...
  33. ncbi request reprint HIV coinfection impairs CD28-mediated costimulation of hepatitis C virus-specific CD8 cells
    Nicole L Yonkers
    Department of Medicine, Cleveland Veterans Administration Medical Center, Center for AIDS Research and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    J Infect Dis 194:391-400. 2006
    ..However, it is unclear whether reduced CD28 expression affects immune responses to non-HIV antigens, potentially contributing to susceptibility to opportunistic infection...
  34. pmc Intracellular Casp8p41 content is inversely associated with CD4 T cell count
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 202:386-91. 2010
    ..This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection...
  35. ncbi request reprint Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection
    Donald D Anthony
    Department of Medicine, Veterans Administration Medical Center, Center for AIDS Research, and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 172:4907-16. 2004
    ..These selectively different impairments may contribute to the reduced adaptive immune response to HCV in HCV-HIV coinfection...
  36. pmc HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease
    Carey L Shive
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Acquir Immune Defic Syndr 61:145-52. 2012
    ..This study was designed to explore the relationship between HIV-1 replication and IL-6 induction...
  37. pmc Baseline levels of soluble CD14 and CD16+56- natural killer cells are negatively associated with response to interferon/ribavirin therapy during HCV-HIV-1 coinfection
    Donald D Anthony
    Department of Medicine, Divisions of Infectious and Rheumatic Diseases, Case Western Reserve University, Center for AIDS Research, University Hospitals of Cleveland and VA Medical Center, Cleveland, OH 44106, USA
    J Infect Dis 206:969-73. 2012
    ..IL28B genotype was associated with therapy response but not sCD14 or CD16(+)56(-) NK frequency. Markers of innate immune activation predict poor host response to IFN-α-based HCV therapy during HCV-HIV coinfection...
  38. ncbi request reprint Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease
    Hernan Valdez
    Case Western Reserve University, University Hospitals of Cleveland Center for AIDS Research, Ohio, USA
    AIDS 16:1859-66. 2002
    ..To describe the magnitude of immune restoration after long-term control of HIV-1 replication. DESIGN Prospective study of immune restoration in patients starting highly active antiretroviral therapy (HAART)...
  39. pmc Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    J Virol 82:7837-45. 2008
    ..Impaired responsiveness to TLR9 agonists may contribute to defects in humoral immunity in HIV infection...
  40. ncbi request reprint In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help
    Janelle R Salkowitz
    Center For AIDS Research and Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 189:971-83. 2004
    ....
  41. ncbi request reprint MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study
    David W Haas
    Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA
    J Acquir Immune Defic Syndr 34:295-8. 2003
    ..It is concluded with 95% confidence that phase 1 viral decay differences between exon 26 TT and CC groups are unlikely to exceed 18%...
  42. ncbi request reprint Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication
    Miguel E Quinones-Mateu
    Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    AIDS 17:F39-48. 2003
    ..Mechanisms underlying mucosal transmission of HIV-1 are incompletely understood. We describe the anti-HIV-1 activity of human beta-defensins (hBD), small cationic molecules that provide protection at mucosal surfaces...
  43. pmc Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation
    Nicholas T Funderburg
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4952, USA
    Immunology 140:87-97. 2013
    ..Local damage to the gastrointestinal tract in IBD may result in systemic inflammation and T-cell activation. ..
  44. pmc Bacterial colonization and beta defensins in the female genital tract in HIV infection
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, 2109 Adelbert Rd, CWRU BRB1048B, 4984, Cleveland, OH 44106, USA
    Curr HIV Res 10:504-12. 2012
    ..These results suggest that HIV infection is associated with impaired regulation of innate defenses at mucosal sites...
  45. pmc A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults
    LANCE T VERNON
    Case Western Reserve University School of Dental Medicine, Department of Biological Sciences, Cleveland, Ohio 44106 4905, USA
    AIDS Res Hum Retroviruses 27:1157-66. 2011
    ..In the context of HIV infection, PD may contribute to CVD risk. Intervention studies treating PD may help clarify this association...
  46. ncbi request reprint Impaired induction of CD27 and CD28 predicts naive CD4 T cell proliferation defects in HIV disease
    Angel A Luciano
    Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Department of Medicine, Division of Infectious Diseases, Cleveland, Ohio 44106, USA
    J Immunol 179:3543-9. 2007
    ..Thus, failure to increase surface expression of costimulatory molecules may contribute to the naive T cell expansion failure that characterizes HIV infection...
  47. ncbi request reprint Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes
    Robert C Kalayjian
    MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 187:1924-33. 2003
    ..Because of their common association with age and HIV disease, naive CD8(+) cell depletion, diminished CD28 expression on CD8(+) cells, and reduced thymic volumes are possible correlates of the interaction of age with HIV disease...
  48. pmc Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success
    Rajeev K Mehlotra
    Center for Global Health and Diseases and Diseases, Wolstein Research Bldg, Room 4204, 2103 Cornell Rd, Cleveland, OH 44106 7286, USA
    J Infect Dis 204:291-8. 2011
    ..In patients receiving highly active antiretroviral therapy (HAART), antiretroviral drug-metabolizing enzyme and transporter gene polymorphisms, as well as chemokine receptor gene polymorphisms, may influence response to treatment...
  49. ncbi request reprint Plasma levels of B-lymphocyte stimulator increase with HIV disease progression
    Benigno Rodriguez
    University Hospitals of Cleveland, Cleveland, OH, USA
    AIDS 17:1983-5. 2003
    ..Moreover, BLyS levels increased exponentially below 100 CD4 cells/microl. BLyS and globulin levels increase as HIV dis ease progresses, suggesting a role for BLyS in the hypergammaglobulinemia of HIV infection...
  50. pmc The effect of aging on T-regulatory cell frequency in HIV infection
    Allan R Tenorio
    Section of Infectious Diseases, Department of Medicine, Rush Medical College, 600 S Paulina Street, Suite 143 AAC, Chicago, Illinois 60612, USA
    Clin Immunol 130:298-303. 2009
    ..T-reg percentages are increased in the older HIV(+) population and may play a role in the accelerated disease progression seen in older HIV-infected persons...
  51. ncbi request reprint TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 4984, USA
    Eur J Immunol 37:2205-13. 2007
    ..We propose that the activation and expansion of naïve B cells induced by TLR9 agonists could enhance the potential of these cells to interact with cognate antigens and facilitate cell-mediated immune responses...
  52. ncbi request reprint Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients
    Benigno Rodriguez
    University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, Ohio 44106, USA
    J Infect Dis 187:504-7. 2003
    ..This association was found to be independent of baseline CD4 cell count and plasma HIV RNA, which indicates that an association exists between GBV-C infection and response to HAART...
  53. pmc The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
    Peter W Hunt
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Blood 121:4635-46. 2013
    ..These results may have relevance for trials of maraviroc for HIV preexposure prophylaxis and graft-versus-host disease. This trial was registered at www.clinicaltrials.gov as #NCT00735072...
  54. pmc Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome
    Nicholas T Funderburg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Blood 120:4599-608. 2012
    ..Therefore, drivers of immune activation and inflammation in HIV-1 disease may alter monocyte subpopulations and activation phenotype, contributing to a pro-atherothrombotic state that may drive cardiovascular risk in HIV-1 infection...
  55. ncbi request reprint Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4
    Zhimin Feng
    Department of Biological Sciences, Case School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 177:782-6. 2006
    ....
  56. pmc Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
    Maura Manion
    Division of Infectious Diseases, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 7:e30306. 2012
    ..In HIV infection, type I interferons may delay disease progression by inhibiting viral replication while at the same time accelerating disease progression by contributing to chronic immune activation...
  57. ncbi request reprint Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
    Craig W Hendrix
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 37:1253-62. 2004
    ..Overall, however, the average change in viral load across all patients was +0.03 log10 HIV RNA. Given these results, AMD3100 is not being further developed for ARV therapy, but development continues for stem cell mobilization...
  58. pmc Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients
    Nicholas Funderburg
    Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 5:e13188. 2010
    ..Maraviroc treatment for HIV-1 infected patients results in larger CD4(+) T cell rises than are attributable to its antiviral activity alone. We investigated whether this is due to modulation of T cell activation and inflammation...
  59. ncbi request reprint Close link between CD4+ and CD8+ T cell proliferation defects in patients with human immunodeficiency virus disease and relationship to extended periods of CD4+ lymphopenia
    Scott F Sieg
    Center for AIDS Research, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Infect Dis 185:1401-16. 2002
    ....
  60. ncbi request reprint New entrants to HIV care are presenting only at marginally earlier stages of disease but may increasingly represent groups perceived at lower risk
    Chariclia V Loupa
    Center for AIDS Research, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Int Assoc Physicians AIDS Care (Chic) 4:47-51. 2005
    ..Treatment has improved HIV infection prognosis, but whether risk and health care seeking behavior have improved is unclear...
  61. ncbi request reprint Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection
    Benigno Rodriguez
    Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio, USA
    JAMA 296:1498-506. 2006
    ..Plasma human immunodeficiency virus (HIV) RNA level predicts HIV disease progression, but the extent to which it explains the variability in rate of CD4 cell depletion is poorly characterized...
  62. pmc Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2
    Nicholas Funderburg
    Departments of Molecular Biology and Microbiology and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:18631-5. 2007
    ..Thus, human TLR signaling is not restricted to recognition of microbial patterns but also can be initiated by host-derived peptides such as hBD-3...
  63. pmc Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells
    Wei Jiang
    Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Immunol 186:2080-6. 2011
    ..Although resting naive B cells are poor APCs, they can be activated by TLR9 agonists to serve as potent APCs for class I MHC-restricted T cell responses. This novel activity of naive B cells could be exploited for vaccine design...
  64. pmc Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression
    Elizabeth Mayne
    National Health Laboratory Services and University of Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 59:340-6. 2012
    ..In this study, we explore the activation state of platelets in HIV disease...
  65. pmc Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5
    Heather A Pilch-Cooper
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, OH, USA
    Blood 118:1015-9. 2011
    ....
  66. doi request reprint S-phase entry leads to cell death in circulating T cells from HIV-infected persons
    Scott F Sieg
    Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, OH 44106, USA
    J Leukoc Biol 83:1382-7. 2008
    ..Intrinsic differences in the proliferation and survival of CD4+ and CD8+ S-phase T cells could influence the homeostatic maintenance of these T cell subsets in HIV disease...
  67. ncbi request reprint Role of Baseline pol Genotype in HIV-1 Fitness Evolution
    Jan Weber
    Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Acquir Immune Defic Syndr 33:448-60. 2003
    ..65, P < 0.0001). However, our results suggest that the preexistence of secondary mutations in protease genetic background may have implications in HIV-1 fitness evolution and virologic response to antiretroviral therapy...
  68. pmc CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro
    Janelle R Salkowitz
    Case Western Reserve University, Center for AIDS Research, School of Medicine WG7, Cleveland, OH 44106 4984, USA
    Clin Immunol 108:234-40. 2003
    ..These findings may provide important insight regarding the regulation of mechanisms that influence the rate of HIV-1 propagation and progression to AIDS...
  69. ncbi request reprint CD4+ T-lymphocyte nadir and the effect of highly active antiretroviral therapy on phenotypic and functional immune restoration in HIV-1 infection
    Christoph G Lange
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Immunol 102:154-61. 2002
    ..05). Delaying HAART may limit phenotypic and functional immune restoration in HIV-1 infection...
  70. ncbi request reprint Impaired TCR-mediated induction of Ki67 by naive CD4+ T cells is only occasionally corrected by exogenous IL-2 in HIV-1 infection
    Scott F Sieg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, OH 44106, USA
    J Immunol 171:5208-14. 2003
    ..Qualitative defects in naive T cells that cannot be routinely corrected by IL-2 have significant implications for disease pathogenesis and for strategies using IL-2 as a vaccine adjuvant in HIV disease...
  71. pmc Cohort profile: the Centers for AIDS Research Network of Integrated Clinical Systems
    Mari M Kitahata
    Department of Medicine, University of Washington, Seattle, 98195, USA
    Int J Epidemiol 37:948-55. 2008
  72. pmc Characterizing traditionally defined periodontal disease in HIV+ adults
    LANCE T VERNON
    Department of Biological Sciences, Case Western Reserve University CWRU, School of Dental Medicine, Cleveland, OH 44106 4905, USA
    Community Dent Oral Epidemiol 37:427-37. 2009
    ..Inconsistent methodological approaches may have resulted in the underestimation of traditionally-defined PD in HIV+ individuals...
  73. ncbi request reprint Placebo-controlled trial of cyclosporin-A in HIV-1 disease: implications for solid organ transplantation
    Leonard H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Acquir Immune Defic Syndr 29:356-62. 2002
    ..We report here the results of a randomized, double-blind, placebo-controlled trial to assess the safety and immunologic activity of CsA administration in early HIV disease...
  74. pmc The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes
    Nicholas T Funderburg
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Immunology 134:151-60. 2011
    ..Our data suggest that the lack of non-canonical nuclear factor-κB signalling by hBD-3 could contribute to the failure of this TLR agonist to induce production of the anti-inflammatory cytokine, IL-10, in human monocytes...
  75. ncbi request reprint HIV long-term non-progressors maintain brisk CD8 T cell responses to other viral antigens
    Hernan Valdez
    Department of Medicine, The Veterans Administration Medical Center, and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS 16:1113-8. 2002
    ..To examine the specificity of heightened CD8 cell responses in HIV-1-infected long-term non-progressors...
  76. ncbi request reprint [Manifestation of hyper-IgE syndrome in advanced HIV-1 infection]
    Christoph G Lange
    Department of Medicine, Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University and University Hospitals of Cleveland, OH, USA
    Med Klin (Munich) 97:34-9. 2002
    ..The classical triad of Job's syndrome (Hyper-IgE syndrome), a congenital immunodeficiency disorder, includes recurrent "cold" abscesses, pneumonias and extreme elevations of the serum IgE concentration...
  77. ncbi request reprint Effect of etanercept (Enbrel) on interleukin 6, tumor necrosis factor alpha, and markers of immune activation in HIV-infected subjects receiving interleukin 2
    Beverly E Sha
    Section of Infectious Diseases, Department of Medicine, Rush Medical College, Chicago, Illinois 60612 3833, USA
    AIDS Res Hum Retroviruses 18:661-5. 2002
    ..Pretreatment with etanercept may blunt activation of IL-6 and CRP expression induced by rhIL-2. The safety and utility of etanercept in HIV-infected persons should be explored further...
  78. ncbi request reprint A new approach for 'deep salvage' trials in advanced HIV infection
    Michael M Lederman
    Center for AIDS Research, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    AIDS 21:1503-6. 2007
    ..We propose here a different approach to the evaluation of drug efficacy in individuals harbouring multidrug-resistant HIV...
  79. doi request reprint Pulmonary arterial hypertension and its association with HIV infection: an overview
    Michael M Lederman
    Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA
    AIDS 22:S1-6. 2008
    ..We will also discuss the occurrence of PAH in HIV infection and propose some hypotheses regarding pathogenesis that will be covered in more detail in the accompanying articles in this supplement...
  80. ncbi request reprint High doses of riboflavin and thiamine may help in secondary prevention of hyperlactatemia
    Grace A McComsey
    Pediatric Infectious Diseases Division, Rainbow Babies and Children s Hospital, Western Reserve University, Cleveland, USA
    AIDS Read 12:222-4. 2002
    ..Therefore, there is a need to investigate ways to prevent the recurrence of hyperlactatemia in patients who require NRTI-based therapy...

Research Grants11

  1. ADULT AIDS CLINICAL TRIALS UNIT
    Michael Lederman; Fiscal Year: 2004
    ..The CWRU ACTU will also bring to the ACTG the expertise of its faculty in the laboratory monitoring of HIV disease through its Immunology Service Laboratory and other research laboratories within the institution. ..
  2. CENTER FOR AIDS RESEARCH(CFAR)
    Michael Lederman; Fiscal Year: 2007
    ..abstract_text> ..
  3. 2007 Case CFAR Annual Spring Conference
    Michael Lederman; Fiscal Year: 2007
    ..The Case CFAR is proactive in its efforts to ensure inclusion of minority and female researchers in all aspects of Conference planning and attendance. ..
  4. Topical Immune modulatory strategies to prevent HIV transmission
    Michael Lederman; Fiscal Year: 2007
    ..We expect that the results of these studies will provide insights into mechanisms of HIV acquisition across mucosal surfaces that will guide the further development of topical strategies to prevent HIV transmission. ..
  5. Case CFAR Meeting: HIV Pathogenesis
    Michael Lederman; Fiscal Year: 2006
    ..Presentation sessions will be Cellular Restrictions Factors; Latency; Protection from HIV Infection; Immune Pathogenesis; and Vaccines. ..
  6. Case AIDS Clinical Trials Unit
    Michael Lederman; Fiscal Year: 2007
    ..administrative component: ..
  7. CONFERENCE ON HIV PATHOGENESIS
    Michael Lederman; Fiscal Year: 2005
    ....
  8. Immune Mechanisms and HIV Disease Pathogenesis
    Michael Lederman; Fiscal Year: 2004
    ..The proposal's specific request is for support to increase participation in the Conference by female and/or minority researchers and students. ..