H M Lazarus

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint When, how, and what cell source for hematopoietic cell transplantation in first complete remission adult acute lymphoblastic leukemia?
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center and Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Hematology Am Soc Hematol Educ Program 2012:382-8. 2012
  2. doi request reprint Acute leukemia in adults: novel allogeneic transplant strategies
    Hillard M Lazarus
    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hematology 17:S47-51. 2012
  3. ncbi request reprint Reduced-intensity conditioning for acute myeloid leukemia: is this strategy correct
    H M Lazarus
    Department of Medicine, Comprehensive Cancer Center of Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Leukemia 20:1673-82. 2006
  4. ncbi request reprint Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
  5. pmc Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993
    Hillard M Lazarus
    Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 108:465-72. 2006
  6. ncbi request reprint Utility of single versus tandem autotransplants for advanced testes/germ cell cancer: a center for international blood and marrow transplant research (CIBMTR) analysis
    Hillard M Lazarus
    University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 13:778-89. 2007
  7. pmc Influence of age and histology on outcome in adult non-Hodgkin lymphoma patients undergoing autologous hematopoietic cell transplantation (HCT): a report from the Center For International Blood & Marrow Transplant Research (CIBMTR)
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 14:1323-33. 2008
  8. pmc A comparison of HLA-identical sibling allogeneic versus autologous transplantation for diffuse large B cell lymphoma: a report from the CIBMTR
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 16:35-45. 2010
  9. doi request reprint Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts
    Hillard M Lazarus
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 17:970-8. 2011
  10. ncbi request reprint Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001

Detail Information

Publications100

  1. doi request reprint When, how, and what cell source for hematopoietic cell transplantation in first complete remission adult acute lymphoblastic leukemia?
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center and Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Hematology Am Soc Hematol Educ Program 2012:382-8. 2012
    ..The ongoing advances in conventional therapy intensity, however, now yield improved results and ongoing reassessment of the place of HCT needs to be continued; every effort should be made to enroll eligible patients in clinical trials...
  2. doi request reprint Acute leukemia in adults: novel allogeneic transplant strategies
    Hillard M Lazarus
    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hematology 17:S47-51. 2012
    ..These and other strategies are improving the outlook of AML HCT recipients...
  3. ncbi request reprint Reduced-intensity conditioning for acute myeloid leukemia: is this strategy correct
    H M Lazarus
    Department of Medicine, Comprehensive Cancer Center of Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Leukemia 20:1673-82. 2006
    ..The transplant community now is poised to design and complete investigations to ascertain the true role of RIC in the treatment of AML...
  4. ncbi request reprint Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
    ..The optimal MSC dose and frequency of administration to prevent or treat GVHD during allogeneic HSC transplantation should be evaluated further in phase II clinical trials...
  5. pmc Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993
    Hillard M Lazarus
    Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 108:465-72. 2006
    ..03) for those without. CNS leukemia in adult ALL is uncommon at diagnosis. Adult Ph-negative ALL patients, however, can attain long-term disease-free survival using SCT as well as conventional chemotherapy...
  6. ncbi request reprint Utility of single versus tandem autotransplants for advanced testes/germ cell cancer: a center for international blood and marrow transplant research (CIBMTR) analysis
    Hillard M Lazarus
    University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 13:778-89. 2007
    ..Patient selection bias for either transplant approach, however, may affect the results of this observational study; a randomized trial is needed to determine which approach, if either, is better...
  7. pmc Influence of age and histology on outcome in adult non-Hodgkin lymphoma patients undergoing autologous hematopoietic cell transplantation (HCT): a report from the Center For International Blood & Marrow Transplant Research (CIBMTR)
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 14:1323-33. 2008
    ..Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended...
  8. pmc A comparison of HLA-identical sibling allogeneic versus autologous transplantation for diffuse large B cell lymphoma: a report from the CIBMTR
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 16:35-45. 2010
    ....
  9. doi request reprint Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts
    Hillard M Lazarus
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 17:970-8. 2011
    ..Prompt recognition of this condition and protracted treatment with nonabsorbable or systemic corticosteroids or the combination may lead to resolution...
  10. ncbi request reprint Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001
    ..We studied the use of transplantation of umbilical-cord blood to restore hematopoiesis in adults...
  11. pmc Is the International Staging System superior to the Durie-Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant
    P N Hari
    Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Leukemia 23:1528-34. 2009
    ..However, neither system was strongly predictive of outcomes, indicating the need for newer schemes incorporating other prognostic markers...
  12. ncbi request reprint Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    O N Koc
    Departments of Medicine and Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 18:307-16. 2000
    ....
  13. ncbi request reprint Time-dependent effect of non-Hodgkin's lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation
    P Fu
    Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Cleveland, Ohio 44106, United States
    Contemp Clin Trials 29:157-64. 2008
    ..65). The time-dependent effect of lymphoma grade on disease-free survival suggests the need for early (within first year) incorporation of novel therapeutic approaches in management of patients with indolent NHL undergoing autotransplant...
  14. ncbi request reprint Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF
    O N Koc
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Oncol 18:1824-30. 2000
    ....
  15. ncbi request reprint Controversy in multiple myeloma transplants: tandem autotransplants and mini-allografts
    D H Vesole
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 28:725-35. 2001
    ..At present, these strategies remain investigational and cannot be considered the standard-of-care for multiple myeloma patients...
  16. ncbi request reprint A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation
    D J Winston
    Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
    Bone Marrow Transplant 28:187-96. 2001
    ..These results should be considered when designing cost-effective strategies for the use of intravenous immunoglobulin in allogeneic marrow transplants receiving other current regimens for prophylaxis of GVHD and infection...
  17. pmc Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies
    T L Kindwall-Keller
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
    Bone Marrow Transplant 47:924-33. 2012
    ..Taken together, one-unit UCB transplantation with a threshold cell dose 2.5 × 10(7)/kg recipient weight after RIC is a viable option for adults, although infusion of two units confers a lower relapse incidence...
  18. ncbi request reprint Autotransplants for Hodgkin's disease in first relapse or second remission: a report from the autologous blood and marrow transplant registry (ABMTR)
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    Bone Marrow Transplant 27:387-96. 2001
    ..Future investigations should focus on strategies designed to decrease relapse after autotransplantation, particularly in patients at high risk for relapse...
  19. ncbi request reprint Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer
    B W Cooper
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 16:3509-17. 1998
    ..To determine whether occult tumor contamination of autologous bone marrow or peripheral-blood progenitor cells (PBPC) influences clinical outcome after high-dose chemotherapy in patients with stage IV breast cancer...
  20. ncbi request reprint Outcome of adult umbilical cord blood transplant patients admitted to a medical intensive care unit
    N Naeem
    Division of Pulmonary and Critical Care, Department of Medicine, University Hospitals of Cleveland, Cleveland 44106 5067, OH, USA
    Bone Marrow Transplant 38:733-8. 2006
    ..03), and a low platelet count (P = 0.03). We conclude that transfer of UCBT patients to an ICU may be predicted by their preparative regimen, while ICU mortality may be predicted by physiologic parameters upon admission...
  21. ncbi request reprint Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance
    J Kline
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Bone Marrow Transplant 41:505-13. 2008
    ..New strategies to exploit auto-GVHD and enhance a GVM effect such as through the depletion of regulatory T cells or through use of newer immunomodulatory agents may improve the efficacy of auto-HCT...
  22. ncbi request reprint Pre-mobilization therapy blood CD34+ cell count predicts the likelihood of successful hematopoietic stem cell mobilization
    P Fu
    Department of Epidemiology and Biostatistics, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 38:189-96. 2006
    ..Prospectively identifying individuals at risk for mobilization failure would allow for improved treatment planning, resource utilization and time saving...
  23. ncbi request reprint Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?
    A F Cashen
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Bone Marrow Transplant 39:577-88. 2007
    ..Here, we review the current state of stem cell mobilization in normal donors and discuss novel strategies for donor stem cell mobilization...
  24. ncbi request reprint Lowering the prophylactic platelet transfusion threshold: a prospective analysis
    J B Lawrence
    Institute of Pathology; Reserve University and University Hospitals of Cleveland, OH 44106, USA
    Leuk Lymphoma 41:67-76. 2001
    ..2% vs. 18.4% (p=0.014); minor hemorrhage, 63.6% vs. 70.1% (p<0.001). Thus, hemorrhage was not increased with the lower trigger level. A 10 x 10(9) /L prophylactic platelet transfusion threshold value is safe and effective...
  25. ncbi request reprint Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases
    O N Koc
    Department of Medicine, University of Hospitals of Cleveland, OH, USA
    Exp Hematol 27:1675-81. 1999
    ..Whether culture expanded normal MSCs can be successfully transplanted into patients with storage diseases and provide therapeutic benefit needs to be determined...
  26. ncbi request reprint Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter?
    N Naeem
    Department of Medicine, Division of Hematology Oncology, Cleveland, OH, USA
    Bone Marrow Transplant 37:119-33. 2006
    ..SCT recipients comprise a heterogeneous group; to further advance this field, prospective multicenter trials involving larger populations from many centers are needed to reduce the biases of retrospective and single-center reports...
  27. ncbi request reprint Clinical application of hematopoietic progenitor cell expansion: current status and future prospects
    S M Devine
    Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA
    Bone Marrow Transplant 31:241-52. 2003
    ....
  28. ncbi request reprint Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults
    Nashaat S Hamza
    Department of Medicine, Case Western Reserve University University Hospitals Research Institute, Cleveland, OH 44106 5065, USA
    Br J Haematol 124:488-98. 2004
    ..25 in UCB and 0.35 in MUD recipients. UCB transplantation in adults is associated with delayed neutrophil and lymphocyte recovery compared with MUD grafting, and higher rates of bacteraemia at early time points after transplantation...
  29. ncbi request reprint Stem cell transplantation in follicular lymphoma: progress at last?
    W W Tse
    Department of Medicine, Comprehensive Cancer Center of Case Western Reserve University, Cleveland, OH 44106, USA
    Bone Marrow Transplant 34:929-38. 2004
    ..Future considerations include incorporation of novel preparative regimens, in vitro purging techniques, antilymphoma vaccines, post transplant immunotherapy and ex vivo-manipulated donor lymphocyte infusions...
  30. ncbi request reprint Mesenchymal stem cells: heading into the clinic
    O N Koc
    Department of Medicine, The Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, OH 44106, USA
    Bone Marrow Transplant 27:235-9. 2001
    ..This article will review our current understanding of bone marrow stroma and MSCs and their potential therapeutic role in the setting of hematopoietic stem cell transplantation...
  31. ncbi request reprint Hematopoietic progenitor cell transplantation in breast cancer: current status and future directions
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, University Hospital of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Cancer Invest 16:102-26. 1998
    ....
  32. doi request reprint Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm?
    D Bobak
    Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Bone Marrow Transplant 42:705-13. 2008
    ..Finally, we provide a management algorithm for the diagnosis and treatment of CDAD at our institution...
  33. ncbi request reprint Lack of isohemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation
    M Snell
    Department of Internal Medicine, Division of Hematology Oncology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Bone Marrow Transplant 38:135-40. 2006
    ..We conclude that donor IHs are not produced in patients undergoing minor ABO incompatible UCBTs suggesting fundamental immunologic differences between allogeneic PBSCT and UCBT...
  34. ncbi request reprint Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..Data regarding the outcome of cord-blood transplantation in adults are scant, despite the fact that these grafts are increasingly used in adults...
  35. pmc Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma
    Paul M Barr
    Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Br J Haematol 147:89-96. 2009
    ..Cumulative myelosuppression and neuropathy was observed. The combination of fludarabine, bortezomib, and rituximab appears to be an active regimen with manageable toxicity for relapsed NHL...
  36. doi request reprint Correlation between ZAP-70, phospho-ZAP-70, and phospho-Syk expression in leukemic cells from patients with CLL
    David Kaplan
    Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cytometry B Clin Cytom 78:115-22. 2010
    ....
  37. ncbi request reprint High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality
    Punit D Wadhwa
    Department of Medicine, Comprehensive Cancer Center of the University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biol Blood Marrow Transplant 11:13-22. 2005
    ..BEP with or without IFR is a highly effective and well-tolerated regimen in the relapsed/refractory lymphoma setting. It has low morbidity and transplant-related mortality and a low incidence (3%) of posttransplantation malignancy...
  38. doi request reprint Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant
    Paul M Barr
    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Am J Hematol 84:484-7. 2009
    ..Future investigations of agents targeting the protein kinase C pathway may benefit from early response assessment using flow cytometry to evaluate T-cell apoptosis...
  39. doi request reprint A Phase II trial of autologous stem cell transplantation followed by mini-allogeneic stem cell transplantation for the treatment of multiple myeloma: an analysis of Eastern Cooperative Oncology Group ECOG E4A98 and E1A97
    David H Vesole
    Department of Medicine, St Vincent s Comprehensive Cancer Center, New York, New York, USA
    Biol Blood Marrow Transplant 15:83-91. 2009
    ..Because a plateau in PFS or OS was not observed with this treatment approach even in patients achieving CR, we suggest that future studies use posttransplantation maintenance therapy...
  40. doi request reprint Secondary MGUS after autologous hematopoietic progenitor cell transplantation in plasma cell myeloma: a matter of undetermined significance
    G V Manson
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bone Marrow Transplant 47:1212-6. 2012
    ....
  41. ncbi request reprint Immune restoration following hematopoietic stem cell transplantation: an evolving target
    J J Auletta
    Comprehensive Cancer Center, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH, USA
    Bone Marrow Transplant 35:835-57. 2005
    ..This paper will review our current understanding for IR following HSCT and the novel ways in which to restore immune function and decrease transplant-related toxicity in the transplant recipient...
  42. ncbi request reprint Autotransplantation versus HLA-matched unrelated donor transplantation for acute myeloid leukaemia: a retrospective analysis from the Center for International Blood and Marrow Transplant Research
    Hillard M Lazarus
    University Hospitals of Cleveland, Ireland Cancer Center, Cleveland, OH, USA
    Br J Haematol 132:755-69. 2006
    ..Cytogenetics, however, were known in only two-thirds of patients and treatment bias cannot be eliminated...
  43. doi request reprint Non-Hodgkin's lymphoma in the elderly
    Paolo F Caimi
    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Drugs Aging 27:211-38. 2010
    ..Highly selected individuals up to age 70 years may attain long-term survival benefit from autoHCT, although transplant-related mortality is higher than in younger patients...
  44. ncbi request reprint Influence of human leucocyte antigen disparity and graft lymphocytes on allogeneic engraftment and survival after umbilical cord blood transplant in adults
    Willem J van Heeckeren
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Br J Haematol 139:464-74. 2007
    ....
  45. ncbi request reprint 'GVHD': graft-versus-host disease or graft-versus-Hodgkin's disease? An old acronym with new meaning
    D L Porter
    Bone Marrow and Stem Cell Transplant Program, Division of Hematology Oncology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Bone Marrow Transplant 31:739-46. 2003
    ..Nonmyeloablative conditioning and allogeneic SCT may induce a direct GVHL reaction with less conditioning regimen-related toxicity and ultimately may have the potential to improve cure rates and survival for advanced HL patients...
  46. ncbi request reprint Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting?
    E D Batts
    Department of Medicine, Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 40:709-19. 2007
    ....
  47. pmc Intravenous penciclovir for treatment of herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial. The Penciclovir Immunocompromised Study Group
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 43:1192-7. 1999
    ..In conclusion, PCV q12h is a well-tolerated and effective therapy for mucocutaneous HSV infection in IC patients and offers a reduced frequency of dosing compared with ACV q8h...
  48. ncbi request reprint Should involved-field radiation therapy be used as an adjunct to lymphoma autotransplantation?
    P Wadhwa
    Department of Medicine, Comprehensive Cancer Center of the University Hospitals of Cleveland Case Western Reserve University, Cleveland, OH 44106, USA
    Bone Marrow Transplant 29:183-9. 2002
    ....
  49. ncbi request reprint Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH)
    O N Koc
    Division of Hematology Oncology, Department of Medicine at Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 30:215-22. 2002
    ..We conclude that donor allogeneic MSC infusion is safe and may be associated with reversal of disease pathophysiology in some tissues. The role of MSCs in the management of Hurler syndrome and MLD should be further evaluated...
  50. pmc Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant
    Sonali M Smith
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Biol Blood Marrow Transplant 14:904-12. 2008
    ..HCT2 should be considered for patients with relapsed HL or NHL after HCT1 without alternative allogeneic stem cell transplant options...
  51. ncbi request reprint Peritransplant use of ultraviolet-B irradiation (UV-B) therapy is detrimental to allogeneic stem cell transplantation outcome
    Meltem Yüksel
    Department of Medicine, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 12:665-71. 2006
    ..However, although other phototherapeutic modalities may be effective against GVHD, extended UV-B therapy should not be used during early phases of decreased conditioning allogeneic transplantation...
  52. ncbi request reprint A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia
    Brenda W Cooper
    Department of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Leuk Res 27:35-44. 2003
    ..The predicted up-regulation of topoisomerase II activity by topoisomerase I inhibition was not observed at this dose and schedule and may provide insight into the modest anti-leukemia activity of the regimen...
  53. doi request reprint High-dose melphalan and the development of hematopoietic stem-cell transplantation: 25 years later
    Hillard M Lazarus
    Department of Medicine, University Hospitals Case Medical Center, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Oncol 26:2240-3. 2008
  54. ncbi request reprint Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies
    Afshin Dowlati
    Developmental Therapeutics Program and the Division of Hematology Oncology, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Clin Cancer Res 9:5929-35. 2003
    ..Preclinical in vitro and in vivo studies demonstrate synergistic activity and increased tumor apoptosis in B-cell malignancies when a prolonged infusion of bryostatin 1 is followed by vincristine...
  55. ncbi request reprint A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia
    Brenda W Cooper
    Department of Medicine, University Hospitals of Cleveland, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Clin Cancer Res 10:6830-9. 2004
    ..A novel regimen designed to maximize antileukemia activity of carboplatin through inhibiting repair of platinum-DNA adducts was conducted in poor prognosis, acute leukemia patients...
  56. ncbi request reprint D cyclins in CD5+ B-cell lymphoproliferative disorders: cyclin D1 and cyclin D2 identify diagnostic groups and cyclin D1 correlates with ZAP-70 expression in chronic lymphocytic leukemia
    Howard J Meyerson
    Department of Pathology, Case Western Reserve University and the Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Am J Clin Pathol 125:241-50. 2006
    ..The results indicate that flow cytometric analysis of D cyclins may help in classification of CD5+ B-cell lymphoproliferative disorders...
  57. ncbi request reprint Hematopoietic recovery after unrelated umbilical cord-blood allogeneic transplantation in adults treated with in vivo stem cell factor (R-MetHuSCF) and filgrastim administration
    Punit D Wadhwa
    Allogeneic Transplant Program, Case Western Reserve University, Department of Medicine, Ireland Comprehensive Cancer Center, University Hospitals of Cleveland, 11100 Euclid Avenue, Wearn 433, Cleveland, OH 44106 5065, USA
    Leuk Res 27:215-20. 2003
    ..Both patients remain in cytogenetic remission at 28 months follow-up. 'In vivo UCB expansion' with administration of concomitant R-MetHuSCF and filgrastim may facilitate prompt hematologic engraftment...
  58. pmc Second hematopoietic stem cell transplantation in myeloid malignancies
    Lisa M Arfons
    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Curr Opin Hematol 16:112-23. 2009
    ..Herein, we review and examine the data of second allogeneic stem cell transplant after autologous, allogeneic and umbilical cord blood transplantation...
  59. ncbi request reprint Choices aplenty: antifungal prophylaxis in hematopoietic stem cell transplant recipients
    N S Hamza
    Department of Medicine, University Hospitals of Cleveland, 11100 Euclid Ave, Wearn 341, Cleveland, OH 44106 5065, USA
    Bone Marrow Transplant 34:377-89. 2004
    ..Such approaches may alter the current treatment strategy from prophylaxis to pre-emptive therapy, thereby potentially decreasing cost and toxicity in high-risk patients...
  60. ncbi request reprint Total parenteral nutrition and hematopoietic stem cell transplantation: an expensive placebo?
    L M Arfons
    Deparment of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 36:281-8. 2005
    ..Novel therapies such as recombinant human keratinocyte growth factor and glucagon-like peptide show future promise in modulating the severity and duration of mucositis, minimizing further the need for TPN...
  61. ncbi request reprint Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34 cell enrichment device
    Willem J van Heeckeren
    Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, OH, USA
    Br J Haematol 132:42-55. 2006
    ..Further studies are needed to determine whether rituximab purging is more effective than the use of unpurged autografts...
  62. doi request reprint Azotemia associated with use of lenalidomide in plasma cell dyscrasias
    Eric D Batts
    University Hospitals Case Medical Center and Ireland Cancer Center and Case Comprehensive Cancer Center, Cleveland, OH, USA
    Leuk Lymphoma 49:1108-15. 2008
    ..We advise careful monitoring of renal function after initiation of lenalidomide in this setting...
  63. ncbi request reprint Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. A multicenter, randomized trial
    Drew J Winston
    Department of Medicine, UCLA Medical Center, Room 42 121 CHS, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Ann Intern Med 138:705-13. 2003
    ..Because of concerns about fungal resistance with fluconazole and toxicity with amphotericin B, alternative prophylactic regimens have become necessary...
  64. doi request reprint Follicular non-Hodgkin lymphoma: long-term results of stem-cell transplantation
    Paul M Barr
    Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Curr Opin Oncol 20:502-8. 2008
    ..Hematopoietic stem-cell transplantation is an effective treatment option for follicular lymphoma. This review summarizes recent updates of the literature focusing on the available long-term follow-up of high-dose therapeutic approaches...
  65. ncbi request reprint Intravenous immunoglobulin: appropriate indications and uses in hematopoietic stem cell transplantation
    Denise R Sokos
    Department of Pharmacy, Comprehensive Cancer Center of University Hospitals of Cleveland, Case Western Reserve University, Ohio, USA
    Biol Blood Marrow Transplant 8:117-30. 2002
    ..Hospital monitoring programs may be a valuable way to detect areas of high use and allow for streamlining of prescribing...
  66. doi request reprint Thrombotic microangiopathy in haematopoietic stem cell transplantation: diagnosis and treatment
    Cecilia M Choi
    Department of Medicine, Division of Hematology Oncology, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Drugs 69:183-98. 2009
    ..One candidate may be daclizumab, especially in those with mild to moderate TMA. Rituximab therapy or the addition of defibrotide may also be beneficial. In general, plasma exchange is not recommended...
  67. pmc Rapid transport and infusion of hematopoietic cells is associated with improved outcome after myeloablative therapy and unrelated donor transplant
    Hillard M Lazarus
    University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 15:589-96. 2009
    ..These data support a general review of current transport procedures, especially for BM grafts requiring longer transport time and every effort made to minimize time from collection to infusion...
  68. ncbi request reprint Safety and pharmacokinetics of oral voriconazole in patients at risk of fungal infection: a dose escalation study
    Hillard M Lazarus
    Cleveland Cancer Center, University Hospitals of Cleveland, Ohio, USA
    J Clin Pharmacol 42:395-402. 2002
    ..No patient developed a breakthrough fungal infection. It was concluded that in this group of patients at risk of fungal infection, voriconazole pharmacokinetics was consistent with that reported in healthy volunteers...
  69. pmc Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission
    David I Marks
    Adult Blood and Marrow Transplantation BMT Unit, United Bristol Healthcare Trust, Bristol, United Kingdom
    Blood 112:426-34. 2008
    ..Nearly 40% of adults with ALL in CR1 survive 5 years after URD transplantation. Relapse risks were modest; TRM is the major cause of treatment failure. Selecting closely HLA-matched URD and reducing TRM should improve results...
  70. pmc Comparison of twin and autologous transplants for multiple myeloma
    Asad Bashey
    BMT Group of Georgia, Atlanta, GA, USA
    Biol Blood Marrow Transplant 14:1118-24. 2008
    ..49, 95% confidence interval [CI] 0.28-0.86, P = .011). Twin transplants have a significantly lower relapse risk than autotransplants in MM, suggesting that graft composition may impact outcomes following high-dose chemotherapy...
  71. ncbi request reprint Outcome of autologous transplantation for mantle cell lymphoma: a study by the European Blood and Bone Marrow Transplant and Autologous Blood and Marrow Transplant Registries
    Elisabeth Vandenberghe
    Department of Haematology, St James Hospital, Dublin, Ireland
    Br J Haematol 120:793-800. 2003
    ..99 times (95% CI: 1.66-5.38, P < 0.001) more likely to die than patients transplanted in CR1. Autologous transplantation probably improves survival in patients with MCL especially if performed in first CR...
  72. ncbi request reprint Myeloablative allogeneic hematopoietic stem cell transplantation in patients who experience relapse after autologous stem cell transplantation for lymphoma: a report of the International Bone Marrow Transplant Registry
    Cesar O Freytes
    University of Texas Health Science Center, Mail Code 7880, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Blood 104:3797-803. 2004
    ..Most likely to benefit are patients who have HLA-matched sibling donors, are in remission, and have good performance status...
  73. pmc Allogeneic transplants in follicular lymphoma: higher risk of disease progression after reduced-intensity compared to myeloablative conditioning
    Parameswaran Hari
    Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Blood Marrow Transplant 14:236-45. 2008
    ..Although disease-free survival (DPS) is similar compared to myeloablative conditioning, an increased risk of late disease progression after RIC is concerning...
  74. pmc HLA-identical sibling allogeneic transplants versus chemotherapy in acute myelogenous leukemia with t(8;21) in first complete remission: collaborative study between the German AML Intergroup and CIBMTR
    Richard F Schlenk
    University of Ulm, Ulm, Germany
    Biol Blood Marrow Transplant 14:187-96. 2008
    ..These results suggest that patients with t(8;21) AML without poor prognostic factors have higher rates of survival after chemotherapy as a post remission therapy compared to HCT...
  75. ncbi request reprint In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/
    Anthony H Goldstone
    North London Cancer Network, University College London Hospitals, London, United Kingdom
    Blood 111:1827-33. 2008
    ..There is no evidence that a single autologous transplantation can replace consolidation/maintenance in any risk group. This study is registered at http://clinicaltrials.gov as NCT00002514...
  76. ncbi request reprint A comparison of cyclophosphamide and total body irradiation with etoposide and total body irradiation as conditioning regimens for patients undergoing sibling allografting for acute lymphoblastic leukemia in first or second complete remission
    David I Marks
    Adult BMT Unit, Bristol Children s Hospital, Bristol, UK
    Biol Blood Marrow Transplant 12:438-53. 2006
    ..We conclude that for HLA-identical sibling allografts for acute lymphoblastic leukemia in CR2, there is an advantage in substituting etoposide for Cy or, when Cy is used, in increasing the TBI dose to > or =13 Gy...
  77. ncbi request reprint Pretransplantation consolidation chemotherapy decreases leukemia relapse after autologous blood and bone marrow transplants for acute myelogenous leukemia in first remission
    Martin S Tallman
    Northwestern University Medical School, Chicago, Illinois, USA
    Biol Blood Marrow Transplant 12:204-16. 2006
    ..Outcomes with standard-dose and high-dose cytarabine were similar. Based on our findings, we recommend that patients with AML in first remission receive consolidation before undergoing autotransplantation...
  78. ncbi request reprint Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321
    Bart Barlogie
    University of Arkansas for Medical Science, Little Rock, AR, USA
    J Clin Oncol 24:929-36. 2006
    ....
  79. ncbi request reprint Therapeutic options for patients with Hodgkin's disease and non-Hodgkin's lymphoma who relapse after autologous transplant
    Koen Van Besien
    University of Chicago, Section of Hematology Oncology, Rm I 209, 5841 South Maryland Ave, Chicago, Illinois 60637, USA
    Curr Treat Options Oncol 6:279-87. 2005
    ..New strategies designed to prevent relapse after autograft include cytokine therapy such as interleukin-2 in combination with monoclonal antibodies and the use of autologous antilymphoma vaccines...
  80. ncbi request reprint Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma
    Koen Van Besien
    Lymphoma Working Committee, International Bone Marrow Transplant Registry Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    Blood 102:3521-9. 2003
    ..We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade...
  81. ncbi request reprint Intensified induction chemotherapy in adult acute myeloid leukemia followed by high-dose chemotherapy and autologous peripheral blood stem cell transplantation: an Eastern Cooperative Oncology Group trial (E4995)
    Peter A Cassileth
    University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Leuk Lymphoma 46:55-61. 2005
    ..Nevertheless, intensive post-remission therapy was well tolerated, no treatment-related mortality occurred with autologous PBSCT, and disease-free survival and overall survival were lengthy...
  82. ncbi request reprint Conventional adjuvant chemotherapy with or without high-dose chemotherapy and autologous stem-cell transplantation in high-risk breast cancer
    Martin S Tallman
    Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago 60611, USA
    N Engl J Med 349:17-26. 2003
    ..High-dose chemotherapy with autologous hematopoietic stem-cell transplantation has been reported to be effective in the adjuvant setting for patients at high risk for relapse...
  83. ncbi request reprint Autologous transplantation for diffuse aggressive non-Hodgkin lymphoma in first relapse or second remission
    Julie M Vose
    University of Nebraska Medical Center, Omaha 68198 7680, USA
    Biol Blood Marrow Transplant 10:116-27. 2004
    ..Exposure to myeloid growth factors to accelerate recovery for recipients of bone marrow grafts may increase the risk of disease progression or death...
  84. ncbi request reprint Effect of body mass index on mortality of patients with lymphoma undergoing autologous hematopoietic cell transplantation
    Willis H Navarro
    University of California, San Francisco, San Francisco, California 94080 4990, and University Hospitals of Cleveland, OH, USA
    Biol Blood Marrow Transplant 12:541-51. 2006
    ....
  85. ncbi request reprint Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remission
    Mark R Litzow
    Mayo Clinic and Foundation, Rochester, MN, USA
    Br J Haematol 119:1115-24. 2002
    ..016). There were no differences in TRM, LFS and OS. CyTBI conditioning may lower relapse risk but produces comparable TRM, LFS and OS to BuCy for HLA-matched sibling transplantation in first remission AML...
  86. ncbi request reprint Autologous or allogeneic stem cell transplantation in patients with Waldenstrom's macroglobulinemia
    Athanasios Anagnostopoulos
    Medical Oncology, Alexandra Hospital, Athens, Greece
    Biol Blood Marrow Transplant 12:845-54. 2006
    ..Allogeneic SCT carries a much higher (40%) risk of NRM and should not be considered outside the context of a clinical trial...
  87. ncbi request reprint Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasia
    Jorge Sierra
    International Bone Marrow Transplant Registry IBMTR, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Blood 100:1997-2004. 2002
    ..Best candidates are younger patients with a low percentage of blasts and preserved platelet counts...
  88. pmc Impact of cytogenetics on outcome of matched unrelated donor hematopoietic stem cell transplantation for acute myeloid leukemia in first or second complete remission
    Martin S Tallman
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 110:409-17. 2007
    ..However, treatment-related mortality was high. Matched unrelated donor HSCT should be considered for all patients with unfavorable cytogenetics who lack a suitable HLA-matched sibling donor...
  89. ncbi request reprint Syngeneic hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma: a comparison with allogeneic and autologous transplantation--The Lymphoma Working Committee of the International Bone Marrow Transplant Registry and the European Group for Blood
    Philip J Bierman
    University of Nebraska Medical Center, Omaha, NE 68198 7680, USA
    J Clin Oncol 21:3744-53. 2003
    ..To compare results of syngeneic, allogeneic, and autologous hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma (NHL)...
  90. ncbi request reprint Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study
    Adele K Fielding
    Royal Free and University College London Medical School, and Christie Hospital National Health Service Trust, Manchester, UK
    Blood 109:944-50. 2007
    ..Prevention of recurrence is the best strategy for long-term survival in this disease...
  91. ncbi request reprint A comparison of allogeneic and autologous bone marrow transplantation for lymphoblastic lymphoma
    John E Levine
    University of Michigan Medical Center, Ann Arbor, USA
    Blood 101:2476-82. 2003
    ..In summary, alloSC transplantation for LBL is associated with fewer relapses than with autoSC transplantation, but higher TRM offsets any potential survival benefit...
  92. ncbi request reprint Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397)
    Rafael Manon
    University of Wisconsin, Madison, USA
    J Clin Oncol 23:8870-6. 2005
    ..Retrospective radiosurgery (RS) reports found no survival difference when compared with WBRT. Before RS alone was evaluated with delayed WBRT in a phase III trial, the feasibility of RS alone was tested prospectively...
  93. ncbi request reprint The role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of diffuse large cell B-cell non-Hodgkin's lymphoma
    Theresa Hahn
    Roswell Park Cancer Institute, Buffalo, NY, USA
    Biol Blood Marrow Transplant 9:667. 2003
  94. ncbi request reprint Autologous stem cell transplantation for small cell lung cancer
    J Douglas Rizzo
    Statistical Center, Health Policy Institute, Medical College of Wisconsin, Milwaukee 53226, USA
    Biol Blood Marrow Transplant 8:273-80. 2002
    ..Transplantation for patients with extensive disease does not appear to produce substantial benefit...
  95. ncbi request reprint A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy
    Francis J Giles
    M D Anderson Cancer Center, Department of Leukemia, The University of Texas, 1515 Holcombe Boulevard, Box 428, Houston, TX 77030, USA
    Leuk Res 28:559-65. 2004
    ..A major impact of Iseganan on reducing stomatitis, UOM, or its clinical sequelae in patients receiving stomatotoxic therapy was not detected on this study...
  96. pmc Comparable outcomes in nonsecretory and secretory multiple myeloma after autologous stem cell transplantation
    Shaji Kumar
    Mayo Clinic, Rochester, MN, USA
    Biol Blood Marrow Transplant 14:1134-40. 2008
    ..In this large cohort of patients undergoing ASCT, we found no difference in outcomes of patients with NSM compared to those with SM...
  97. doi request reprint High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors
    Navneet S Majhail
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:790-4. 2008
    ..More studies are needed to determine the impact of iron overload on long-term morbidity and mortality in allogeneic transplant survivors...
  98. ncbi request reprint Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
    Jacob M Rowe
    Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center and Technion, Israel Institute of Technology, Haifa 31096, Israel
    Blood 106:3760-7. 2005
    ..However, the achievement of CR within 4 weeks does not appear to be an independent prognostic factor...
  99. ncbi request reprint High-dose versus standard chemotherapy in metastatic breast cancer: comparison of Cancer and Leukemia Group B trials with data from the Autologous Blood and Marrow Transplant Registry
    Donald A Berry
    University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Clin Oncol 20:743-50. 2002
    ..To assess survival of patients with metastatic breast cancer treated with high-dose chemotherapy (HDC) versus standard-dose chemotherapy (SDC)...
  100. ncbi request reprint Breast cancer cell contamination of blood stem cell products in patients with metastatic breast cancer: predictors and clinical relevance
    Andrew L Pecora
    Cancer Center, Hackensack University Medical Center, New Jersey 07601, USA
    Biol Blood Marrow Transplant 8:536-43. 2002
    ....