H M Lazarus

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Hematopoietic progenitor cell transplantation in breast cancer: current status and future directions
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, University Hospital of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Cancer Invest 16:102-26. 1998
  2. ncbi request reprint Autotransplants for Hodgkin's disease in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry
    H M Lazarus
    Lymphoma Working Committee of the Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 17:534-45. 1999
  3. pmc Intravenous penciclovir for treatment of herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial. The Penciclovir Immunocompromised Study Group
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 43:1192-7. 1999
  4. ncbi request reprint Autologous transplantation for diffuse aggressive non-Hodgkin's lymphoma in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry
    J M Vose
    Lymphoma Working Committee of the Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI, USA
    J Clin Oncol 19:406-13. 2001
  5. ncbi request reprint Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001
  6. ncbi request reprint Autotransplants for Hodgkin's disease in first relapse or second remission: a report from the autologous blood and marrow transplant registry (ABMTR)
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    Bone Marrow Transplant 27:387-96. 2001
  7. pmc Is the International Staging System superior to the Durie-Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant
    P N Hari
    Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Leukemia 23:1528-34. 2009
  8. ncbi request reprint Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF
    O N Koc
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Oncol 18:1824-30. 2000
  9. ncbi request reprint Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    O N Koc
    Departments of Medicine and Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 18:307-16. 2000
  10. pmc Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies
    T L Kindwall-Keller
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
    Bone Marrow Transplant 47:924-33. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Hematopoietic progenitor cell transplantation in breast cancer: current status and future directions
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, University Hospital of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Cancer Invest 16:102-26. 1998
    ....
  2. ncbi request reprint Autotransplants for Hodgkin's disease in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry
    H M Lazarus
    Lymphoma Working Committee of the Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 17:534-45. 1999
    ..e., those with primary induction failure) have a poor prognosis. Some subjects who receive high-dose therapy with autologous hematopoietic progenitor-cell infusion experience prolonged progression-free survival...
  3. pmc Intravenous penciclovir for treatment of herpes simplex infections in immunocompromised patients: results of a multicenter, acyclovir-controlled trial. The Penciclovir Immunocompromised Study Group
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 43:1192-7. 1999
    ..In conclusion, PCV q12h is a well-tolerated and effective therapy for mucocutaneous HSV infection in IC patients and offers a reduced frequency of dosing compared with ACV q8h...
  4. ncbi request reprint Autologous transplantation for diffuse aggressive non-Hodgkin's lymphoma in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry
    J M Vose
    Lymphoma Working Committee of the Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI, USA
    J Clin Oncol 19:406-13. 2001
    ....
  5. ncbi request reprint Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001
    ..We studied the use of transplantation of umbilical-cord blood to restore hematopoiesis in adults...
  6. ncbi request reprint Autotransplants for Hodgkin's disease in first relapse or second remission: a report from the autologous blood and marrow transplant registry (ABMTR)
    H M Lazarus
    Department of Medicine, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    Bone Marrow Transplant 27:387-96. 2001
    ..Future investigations should focus on strategies designed to decrease relapse after autotransplantation, particularly in patients at high risk for relapse...
  7. pmc Is the International Staging System superior to the Durie-Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant
    P N Hari
    Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Leukemia 23:1528-34. 2009
    ..However, neither system was strongly predictive of outcomes, indicating the need for newer schemes incorporating other prognostic markers...
  8. ncbi request reprint Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF
    O N Koc
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Oncol 18:1824-30. 2000
    ....
  9. ncbi request reprint Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    O N Koc
    Departments of Medicine and Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 18:307-16. 2000
    ....
  10. pmc Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies
    T L Kindwall-Keller
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
    Bone Marrow Transplant 47:924-33. 2012
    ..Taken together, one-unit UCB transplantation with a threshold cell dose 2.5 × 10(7)/kg recipient weight after RIC is a viable option for adults, although infusion of two units confers a lower relapse incidence...
  11. ncbi request reprint A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation
    D J Winston
    Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
    Bone Marrow Transplant 28:187-96. 2001
    ..These results should be considered when designing cost-effective strategies for the use of intravenous immunoglobulin in allogeneic marrow transplants receiving other current regimens for prophylaxis of GVHD and infection...
  12. ncbi request reprint Time-dependent effect of non-Hodgkin's lymphoma grade on disease-free survival of relapsed/refractory patients treated with high-dose chemotherapy plus autotransplantation
    P Fu
    Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Cleveland, Ohio 44106, United States
    Contemp Clin Trials 29:157-64. 2008
    ..65). The time-dependent effect of lymphoma grade on disease-free survival suggests the need for early (within first year) incorporation of novel therapeutic approaches in management of patients with indolent NHL undergoing autotransplant...
  13. ncbi request reprint Controversy in multiple myeloma transplants: tandem autotransplants and mini-allografts
    D H Vesole
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 28:725-35. 2001
    ..At present, these strategies remain investigational and cannot be considered the standard-of-care for multiple myeloma patients...
  14. ncbi request reprint High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America
    K H Antman
    Breast Cancer Working Committee of the Autologous Blood and Marrow Transplant Registry of North America, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    J Clin Oncol 15:1870-9. 1997
    ..To identify trends in high-dose therapy with autologous hematopoietic stem-cell support (autotransplants) for breast cancer (1989 to 1995)...
  15. ncbi request reprint Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer
    B W Cooper
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 16:3509-17. 1998
    ..To determine whether occult tumor contamination of autologous bone marrow or peripheral-blood progenitor cells (PBPC) influences clinical outcome after high-dose chemotherapy in patients with stage IV breast cancer...
  16. ncbi request reprint Outcome of adult umbilical cord blood transplant patients admitted to a medical intensive care unit
    N Naeem
    Division of Pulmonary and Critical Care, Department of Medicine, University Hospitals of Cleveland, Cleveland 44106 5067, OH, USA
    Bone Marrow Transplant 38:733-8. 2006
    ..03), and a low platelet count (P = 0.03). We conclude that transfer of UCBT patients to an ICU may be predicted by their preparative regimen, while ICU mortality may be predicted by physiologic parameters upon admission...
  17. ncbi request reprint Syngeneic hematopoietic stem cell transplantation for women with metastatic breast cancer
    J D Rizzo
    International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Bone Marrow Transplant 32:151-5. 2003
    ..This suggests that residual cancer in the patient is the major contributor to relapse after transplantation for breast cancer...
  18. ncbi request reprint Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?
    A F Cashen
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Bone Marrow Transplant 39:577-88. 2007
    ..Here, we review the current state of stem cell mobilization in normal donors and discuss novel strategies for donor stem cell mobilization...
  19. ncbi request reprint Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance
    J Kline
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Bone Marrow Transplant 41:505-13. 2008
    ..New strategies to exploit auto-GVHD and enhance a GVM effect such as through the depletion of regulatory T cells or through use of newer immunomodulatory agents may improve the efficacy of auto-HCT...
  20. ncbi request reprint Pre-mobilization therapy blood CD34+ cell count predicts the likelihood of successful hematopoietic stem cell mobilization
    P Fu
    Department of Epidemiology and Biostatistics, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 38:189-96. 2006
    ..Prospectively identifying individuals at risk for mobilization failure would allow for improved treatment planning, resource utilization and time saving...
  21. ncbi request reprint Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases
    O N Koc
    Department of Medicine, University of Hospitals of Cleveland, OH, USA
    Exp Hematol 27:1675-81. 1999
    ..Whether culture expanded normal MSCs can be successfully transplanted into patients with storage diseases and provide therapeutic benefit needs to be determined...
  22. ncbi request reprint Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm?
    D Bobak
    Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Bone Marrow Transplant 42:705-13. 2008
    ..Finally, we provide a management algorithm for the diagnosis and treatment of CDAD at our institution...
  23. ncbi request reprint Mesenchymal stem cells: heading into the clinic
    O N Koc
    Department of Medicine, The Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, OH 44106, USA
    Bone Marrow Transplant 27:235-9. 2001
    ..This article will review our current understanding of bone marrow stroma and MSCs and their potential therapeutic role in the setting of hematopoietic stem cell transplantation...
  24. ncbi request reprint Transfer of the hematopoietic stem cell transplant patient to the intensive care unit: does it really matter?
    N Naeem
    Department of Medicine, Division of Hematology Oncology, Cleveland, OH, USA
    Bone Marrow Transplant 37:119-33. 2006
    ..SCT recipients comprise a heterogeneous group; to further advance this field, prospective multicenter trials involving larger populations from many centers are needed to reduce the biases of retrospective and single-center reports...
  25. doi request reprint Umbilical cord blood graft enhancement strategies: has the time come to move these into the clinic?
    M Norkin
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0278, USA
    Bone Marrow Transplant 48:884-9. 2013
    ..Nevertheless, expectations remain high that eventually ex vivo enhancement will be able to improve clinical outcomes and significantly extend the applicability of UCB transplantation. ..
  26. ncbi request reprint Secondary MGUS after autologous hematopoietic progenitor cell transplantation in plasma cell myeloma: a matter of undetermined significance
    G V Manson
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bone Marrow Transplant 47:1212-6. 2012
    ....
  27. doi request reprint Are there roles for observational database studies and structured quantification of expert opinion to answer therapy controversies in transplants?
    R P Gale
    Center for International Blood and Marrow Research CIBMTR, Medical College of Wisconsin, Milwaukee, WI, USA
    Bone Marrow Transplant 43:435-46. 2009
    ..We suggest increased use of ODBs and expert opinion as reliable and effective ways to determine relative efficacies of new therapies in transplant settings...
  28. doi request reprint Renal allografts in plasma cell myeloma hematopoietic cell graft recipients: on the verge of an explosion?
    L Nayak
    Division of Hematology Oncology, Department of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bone Marrow Transplant 48:338-45. 2013
    ..More research is necessary to further delineate the subset of PCM patients most likely to benefit from renal transplant. A special registry for data collection for long-term follow-up may be useful to improve future patient survival...
  29. ncbi request reprint Lack of isohemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation
    M Snell
    Department of Internal Medicine, Division of Hematology Oncology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Bone Marrow Transplant 38:135-40. 2006
    ..We conclude that donor IHs are not produced in patients undergoing minor ABO incompatible UCBTs suggesting fundamental immunologic differences between allogeneic PBSCT and UCBT...
  30. ncbi request reprint Should involved-field radiation therapy be used as an adjunct to lymphoma autotransplantation?
    P Wadhwa
    Department of Medicine, Comprehensive Cancer Center of the University Hospitals of Cleveland Case Western Reserve University, Cleveland, OH 44106, USA
    Bone Marrow Transplant 29:183-9. 2002
    ....
  31. ncbi request reprint Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH)
    O N Koc
    Division of Hematology Oncology, Department of Medicine at Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 30:215-22. 2002
    ..We conclude that donor allogeneic MSC infusion is safe and may be associated with reversal of disease pathophysiology in some tissues. The role of MSCs in the management of Hurler syndrome and MLD should be further evaluated...
  32. ncbi request reprint Stem cell transplantation in follicular lymphoma: progress at last?
    W W Tse
    Department of Medicine, Comprehensive Cancer Center of Case Western Reserve University, Cleveland, OH 44106, USA
    Bone Marrow Transplant 34:929-38. 2004
    ..Future considerations include incorporation of novel preparative regimens, in vitro purging techniques, antilymphoma vaccines, post transplant immunotherapy and ex vivo-manipulated donor lymphocyte infusions...
  33. ncbi request reprint Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting?
    E D Batts
    Department of Medicine, Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 40:709-19. 2007
    ....
  34. ncbi request reprint Immune restoration following hematopoietic stem cell transplantation: an evolving target
    J J Auletta
    Comprehensive Cancer Center, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH, USA
    Bone Marrow Transplant 35:835-57. 2005
    ..This paper will review our current understanding for IR following HSCT and the novel ways in which to restore immune function and decrease transplant-related toxicity in the transplant recipient...
  35. ncbi request reprint Choices aplenty: antifungal prophylaxis in hematopoietic stem cell transplant recipients
    N S Hamza
    Department of Medicine, University Hospitals of Cleveland, 11100 Euclid Ave, Wearn 341, Cleveland, OH 44106 5065, USA
    Bone Marrow Transplant 34:377-89. 2004
    ..Such approaches may alter the current treatment strategy from prophylaxis to pre-emptive therapy, thereby potentially decreasing cost and toxicity in high-risk patients...
  36. ncbi request reprint Total parenteral nutrition and hematopoietic stem cell transplantation: an expensive placebo?
    L M Arfons
    Deparment of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bone Marrow Transplant 36:281-8. 2005
    ..Novel therapies such as recombinant human keratinocyte growth factor and glucagon-like peptide show future promise in modulating the severity and duration of mucositis, minimizing further the need for TPN...
  37. ncbi request reprint Reduced-intensity conditioning for acute myeloid leukemia: is this strategy correct
    H M Lazarus
    Department of Medicine, Comprehensive Cancer Center of Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Leukemia 20:1673-82. 2006
    ..The transplant community now is poised to design and complete investigations to ascertain the true role of RIC in the treatment of AML...
  38. ncbi request reprint Clinical application of hematopoietic progenitor cell expansion: current status and future prospects
    S M Devine
    Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA
    Bone Marrow Transplant 31:241-52. 2003
    ....