M J Laughlin

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001
  2. pmc Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies
    T L Kindwall-Keller
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
    Bone Marrow Transplant 47:924-33. 2012
  3. ncbi request reprint Umbilical cord blood for allogeneic transplantation in children and adults
    M J Laughlin
    Department of Medicine, Case Western Reserve University, University Hospitals Ireland Cancer Center, Cleveland, Ohio, USA
    Bone Marrow Transplant 27:1-6. 2001
  4. doi request reprint Umbilical cord blood transplantation in adult myeloid leukemia
    W W Tse
    Division of Hematology Oncology, Department of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Abraham J and Phyllis Katz Cord Blood Foundation, Center for Stem Cell and Regenerative Medicine, Cleveland, OH 44106 7284, USA
    Bone Marrow Transplant 41:465-72. 2008
  5. pmc The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation
    W Wu
    Department of Medicine, Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 26:736-45. 2012
  6. ncbi request reprint Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation
    Beth A Kaminski
    Case Western Reserve University, 11100 Euclid Ave, Wearn 433, Cleveland, OH 44106 5065, USA
    Blood 102:4608-17. 2003
  7. ncbi request reprint Deficient IFN-gamma expression in umbilical cord blood (UCB) T cells can be rescued by IFN-gamma-mediated increase in NFATc2 expression
    Suzanne Kadereit
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 5061, USA
    J Clin Immunol 23:485-97. 2003
  8. ncbi request reprint Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes
    Robin E Miller
    Department of Pediatrics, University Hospitals Ireland Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Exp Hematol 30:738-44. 2002
  9. ncbi request reprint Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/CD38(-) early progenitors cultured over human MSCs as a feeder layer
    Suzanne Kadereit
    Department of Medicine, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106 5061, USA
    Stem Cells 20:573-82. 2002
  10. ncbi request reprint Influence of human leucocyte antigen disparity and graft lymphocytes on allogeneic engraftment and survival after umbilical cord blood transplant in adults
    Willem J van Heeckeren
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Br J Haematol 139:464-74. 2007

Research Grants

Collaborators

  • H M Lazarus
  • D A Rizzieri
  • P Rubinstein
  • Juliet N Barker
  • JAMES JACOBBERGER
  • Phyllis S Frisa
  • K D Bunting
  • Suzanne Kadereit
  • Pingfu Fu
  • W W Tse
  • W Wu
  • T L Kindwall-Keller
  • Beth A Kaminski
  • Robin E Miller
  • Willem J van Heeckeren
  • Jonathan L Goldberg
  • Laura R Fanning
  • Jennifer Jaroscak
  • Howard J Meyerson
  • Thomas O Kleen
  • Nashaat S Hamza
  • Magdalena Tary-Lehmann
  • Omer N Koc
  • Salem Akel
  • Margaret M Kozik
  • Kathleen Daum-Woods
  • R Liu
  • M Kucia
  • B W Cooper
  • J M Carlson-Barko
  • Y Hegerfeldt
  • C Curtis
  • W Marlicz
  • N Greco
  • C H Kim
  • P Fu
  • P Barr
  • J Ratajczak
  • R J Creger
  • M Z Ratajczak
  • W van Heeckeren
  • H J Meyerson
  • L R Fanning
  • S Margevicius
  • S L Gerson
  • S L Zang
  • Richard J Creger
  • Luis Solchaga
  • Brenda W Cooper
  • Margaret Forster
  • William W Tse
  • Robert M Fox
  • Vincent J Pompili
  • Tamila L Kindwall-Keller
  • Marcie R Finney
  • Laura F Slivka
  • Margaret Kozik
  • Lara Kulchycki
  • Gopala Yadavalli
  • Michelle Lisgaris
  • Robert Fox
  • Laura Nadeau
  • Robert A Salata
  • Martina L Veigl
  • Gwendolyn R Junge
  • Kevin R Stein
  • Cari Petrow-Sadowski
  • Thomas Kleen
  • Patrick Leahy
  • David A Topa
  • Tomas Radivoyevitch
  • Francis W Ruscetti
  • Emese Szekely
  • William J Murphy
  • Lisbeth A Welniak
  • Stephen E Haynesworth
  • Dennis Templeton
  • John D Fayen
  • Linda S Deeds
  • Shaden F Mohammad
  • R Michael Sramkoski
  • Kevin Stein
  • Kathleen Daum Woods
  • Glenn W Goetchius
  • Susan B Shurin

Detail Information

Publications16

  1. ncbi request reprint Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors
    M J Laughlin
    Department of Medicine, Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, OH 44106 5065, USA
    N Engl J Med 344:1815-22. 2001
    ..We studied the use of transplantation of umbilical-cord blood to restore hematopoiesis in adults...
  2. pmc Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies
    T L Kindwall-Keller
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
    Bone Marrow Transplant 47:924-33. 2012
    ..Taken together, one-unit UCB transplantation with a threshold cell dose 2.5 × 10(7)/kg recipient weight after RIC is a viable option for adults, although infusion of two units confers a lower relapse incidence...
  3. ncbi request reprint Umbilical cord blood for allogeneic transplantation in children and adults
    M J Laughlin
    Department of Medicine, Case Western Reserve University, University Hospitals Ireland Cancer Center, Cleveland, Ohio, USA
    Bone Marrow Transplant 27:1-6. 2001
    ..Intensive clinical and laboratory research is ongoing focused on strategies to foster UCB allogeneic donor engraftment, thereby allowing wider application of this stem cell source for patients requiring allogeneic transplantation...
  4. doi request reprint Umbilical cord blood transplantation in adult myeloid leukemia
    W W Tse
    Division of Hematology Oncology, Department of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Abraham J and Phyllis Katz Cord Blood Foundation, Center for Stem Cell and Regenerative Medicine, Cleveland, OH 44106 7284, USA
    Bone Marrow Transplant 41:465-72. 2008
    ..Clinical studies are needed with focus on disease-specific UCB transplantation outcomes, including AML, acute lymphoblastic leukemia, and lymphoma...
  5. pmc The bone marrow-expressed antimicrobial cationic peptide LL-37 enhances the responsiveness of hematopoietic stem progenitor cells to an SDF-1 gradient and accelerates their engraftment after transplantation
    W Wu
    Department of Medicine, Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 26:736-45. 2012
    ..This novel approach would be particularly important in cord blood transplantations, where the number of HSCs available is usually limited...
  6. ncbi request reprint Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation
    Beth A Kaminski
    Case Western Reserve University, 11100 Euclid Ave, Wearn 433, Cleveland, OH 44106 5065, USA
    Blood 102:4608-17. 2003
    ..Reduced global expression of NFAT-associated genes, as well as cytokines and chemokines, in UCB CD4+ T cells may contribute to the decreased graft-versus-host disease (GVHD) observed after UCB transplantation...
  7. ncbi request reprint Deficient IFN-gamma expression in umbilical cord blood (UCB) T cells can be rescued by IFN-gamma-mediated increase in NFATc2 expression
    Suzanne Kadereit
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 5061, USA
    J Clin Immunol 23:485-97. 2003
    ..Our results point to impaired function in the antigen-presenting cell population of cord blood, playing a role in the hyporesponsiveness of T cells...
  8. ncbi request reprint Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes
    Robin E Miller
    Department of Pediatrics, University Hospitals Ireland Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Exp Hematol 30:738-44. 2002
    ..CTLA-4 mediates negative T-cell signaling and may contribute to the development of allogeneic tolerance. In this study, we compared protein and mRNA expression of CTLA-4 in stimulated UCB and adult peripheral blood T cells...
  9. ncbi request reprint Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/CD38(-) early progenitors cultured over human MSCs as a feeder layer
    Suzanne Kadereit
    Department of Medicine, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio 44106 5061, USA
    Stem Cells 20:573-82. 2002
    ....
  10. ncbi request reprint Influence of human leucocyte antigen disparity and graft lymphocytes on allogeneic engraftment and survival after umbilical cord blood transplant in adults
    Willem J van Heeckeren
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Br J Haematol 139:464-74. 2007
    ....
  11. ncbi request reprint Umbilical cord blood stem cells: implications for cardiovascular regenerative medicine
    Jonathan L Goldberg
    Department of Medicine, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 7284, USA
    J Mol Cell Cardiol 42:912-20. 2007
    ..Although studies suggest efficacy with no obvious safety concerns the mechanism for this therapeutic effect is unknown...
  12. ncbi request reprint Unrelated cord blood allogeneic stem cell transplantation for MDS
    Mary J Laughlin
    Case Western Reserve University, Cleveland, OH 44106 7284, USA
    Leuk Lymphoma 47:569-70. 2006
  13. ncbi request reprint Recipient-specific tolerance after HLA-mismatched umbilical cord blood stem cell transplantation
    Thomas O Kleen
    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 7284, USA
    Transplantation 80:1316-22. 2005
    ..However, despite the increased use of UCB in stem cell transplantation, the mechanisms underlying these favorable outcomes are not well delineated...
  14. ncbi request reprint Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults
    Nashaat S Hamza
    Department of Medicine, Case Western Reserve University University Hospitals Research Institute, Cleveland, OH 44106 5065, USA
    Br J Haematol 124:488-98. 2004
    ..25 in UCB and 0.35 in MUD recipients. UCB transplantation in adults is associated with delayed neutrophil and lymphocyte recovery compared with MUD grafting, and higher rates of bacteraemia at early time points after transplantation...
  15. ncbi request reprint Neutralization of autocrine transforming growth factor-beta in human cord blood CD34(+)CD38(-)Lin(-) cells promotes stem-cell-factor-mediated erythropoietin-independent early erythroid progenitor development and reduces terminal differentiation
    Salem Akel
    Leukocyte Biology Section, Basic Research Laboratory, Center for Cancer Research, NCI Frederick, Frederick, Maryland 21702 1201, USA
    Stem Cells 21:557-67. 2003
    ..Serum addition stimulated enucleation (54% +/- 18%), which was lower (26% +/- 14%) with anti-TGF-beta, suggesting that optimal erythroid enucleation is Epo dependent, requiring serum factors including TGF-beta1...
  16. ncbi request reprint Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..Data regarding the outcome of cord-blood transplantation in adults are scant, despite the fact that these grafts are increasingly used in adults...

Research Grants6

  1. MECHANISMS UNDERLYING GRAFT-VERSUS-HOST DISEASE
    Mary Laughlin; Fiscal Year: 2004
    ..Moreover, since NFAT1 regulates the gene expression of cytokines and immunomodulatory molecules known to mediate GVHD, their studies may reveal new therapeutic approaches to the treatment and/or prophylaxis of GVHD. ..
  2. Marrow-Derived Stem Cells for Coronary Artery Ischemia
    Mary Laughlin; Fiscal Year: 2007
    ..abstract_text> ..