Emma K Larkin

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Assessing the impact of global versus local ancestry in association studies
    Sun Jung Kang
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106 USA
    BMC Proc 3:S107. 2009
  2. pmc Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study
    Allison R Baker
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University, 11400 Euclid Avenue, Suite 260, Cleveland, Ohio 44106, USA
    BMC Proc 3:S42. 2009
  3. pmc A regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and association
    Emma K Larkin
    Case Western Reserve University, Department of Epidemiology and Biostatistics, Cleveland, OH 44106, USA
    BMC Genet 6:S95. 2005
  4. ncbi request reprint Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration
    Emma K Larkin
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Triangle Building Suite 260, 10400 Euclid Ave, Cleveland, OH 44106, USA
    Circulation 111:1978-84. 2005
  5. ncbi request reprint Linkage of serum leptin levels in families with sleep apnea
    E K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Int J Obes (Lond) 29:260-7. 2005
  6. ncbi request reprint Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak
    Emma K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 11400 Euclid Avenue, Ste 260, Cleveland, OH 44106 6083, USA
    Genet Epidemiol 30:101-10. 2006
  7. pmc Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass index
    E K Larkin
    Center for Clinical Investigation, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 6083, USA
    Ann Hum Genet 72:762-73. 2008
  8. pmc Comparison of affected sibling-pair linkage methods to identify gene x gene interaction in GAW15 simulated data
    Emma K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Triangle Building, Suite 260, 11400 Euclid Avenue, Cleveland, Ohio 44106 USA
    BMC Proc 1:S66. 2007
  9. ncbi request reprint Decreased quality of life associated with obesity in school-aged children
    Samuel L Friedlander
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Arch Pediatr Adolesc Med 157:1206-11. 2003
  10. ncbi request reprint Variation in childhood asthma among former preterm infants
    Jonathan Grischkan
    Department of Pediatrics, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    J Pediatr 144:321-6. 2004

Collaborators

Detail Information

Publications26

  1. pmc Assessing the impact of global versus local ancestry in association studies
    Sun Jung Kang
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106 USA
    BMC Proc 3:S107. 2009
    ....
  2. pmc Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study
    Allison R Baker
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University, 11400 Euclid Avenue, Suite 260, Cleveland, Ohio 44106, USA
    BMC Proc 3:S42. 2009
    ..We conclude that while both univariate and multivariate family-based association analysis can identify genes of interest, our multivariate approach is less affected by multiple testing correction and yields more significant results...
  3. pmc A regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and association
    Emma K Larkin
    Case Western Reserve University, Department of Epidemiology and Biostatistics, Cleveland, OH 44106, USA
    BMC Genet 6:S95. 2005
    ..3 cM. Power and type I error were determined by the number of replicates significant at the 0.05 level...
  4. ncbi request reprint Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration
    Emma K Larkin
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Triangle Building Suite 260, 10400 Euclid Ave, Cleveland, OH 44106, USA
    Circulation 111:1978-84. 2005
    ..The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk...
  5. ncbi request reprint Linkage of serum leptin levels in families with sleep apnea
    E K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Int J Obes (Lond) 29:260-7. 2005
    ..To identify regions on the genome linked to plasma leptin levels...
  6. ncbi request reprint Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak
    Emma K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 11400 Euclid Avenue, Ste 260, Cleveland, OH 44106 6083, USA
    Genet Epidemiol 30:101-10. 2006
    ..Overall, the evidence suggests that there is a disease susceptibility locus for obstructive sleep apnea in the region of ApoE, but ApoE itself is unlikely to be the causative locus...
  7. pmc Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass index
    E K Larkin
    Center for Clinical Investigation, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 6083, USA
    Ann Hum Genet 72:762-73. 2008
    ..These analyses suggest genetic loci for sleep apnea that operate both independently of BMI and through BMI-related pathways...
  8. pmc Comparison of affected sibling-pair linkage methods to identify gene x gene interaction in GAW15 simulated data
    Emma K Larkin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Triangle Building, Suite 260, 11400 Euclid Avenue, Cleveland, Ohio 44106 USA
    BMC Proc 1:S66. 2007
    ..Additionally, the lack of data on discordant sibships may have decreased the power to identify gene x gene interactions...
  9. ncbi request reprint Decreased quality of life associated with obesity in school-aged children
    Samuel L Friedlander
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Arch Pediatr Adolesc Med 157:1206-11. 2003
    ..Design, Setting, and..
  10. ncbi request reprint Variation in childhood asthma among former preterm infants
    Jonathan Grischkan
    Department of Pediatrics, Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    J Pediatr 144:321-6. 2004
    ..Study design Former preterm children (n=251) were identified from a birth cohort. Examinations, including lung function testing, were performed at ages 8 to 11 years. Perinatal exposures were ascertained from neonatal medical records...
  11. ncbi request reprint The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital and Case Western Reserve University, Cleveland, OH, USA
    Sleep 30:531-3. 2007
    ..To identify the role of polymorphisms in the angiotensin-converting enzyme (ACE) gene in modulating susceptibility to hypertension in sleep apnea...
  12. ncbi request reprint Relationship between obstructive sleep apnea and diurnal leptin rhythms
    Sanjay R Patel
    Rainbow Babies and Children s Hospital, Cleveland, OH, USA
    Sleep 27:235-9. 2004
    ..Several studies have reported an association between obstructive sleep apnea and leptin, a hormone that influences satiety and body weight. We evaluated the relationship of leptin levels and the overnight change in levels with sleep apnea...
  13. ncbi request reprint Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurity
    Carol L Rosen
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6003, USA
    J Pediatr 142:383-9. 2003
    ..To evaluate the extent to which sleep-disordered breathing (SDB) varies with putative demographic and medical risk factors and to estimate the prevalence of undiagnosed SDB...
  14. ncbi request reprint Sex influences endothelial function in sleep-disordered breathing
    Michael D Faulx
    Division of Cardiology, Case Western Reserve University, University Hospitals of Cleveland, OH, USA
    Sleep 27:1113-20. 2004
    ..We determined whether flow-mediated dilation (FMD) and peak blood flow (PBF) increase after cuff occlusion is altered with SDB...
  15. ncbi request reprint Predictors of longitudinal change in sleep-disordered breathing in a nonclinic population
    Susan Redline
    Department of Pediatrics, Division of Clinical Epidemiology, Case Western Reserve University, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106 6003, USA
    Sleep 26:703-9. 2003
    ..To quantify and identify the determinants of the 5-year change in the respiratory disturbance index (RDI)...
  16. pmc Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique
    Lamia H Ibrahim
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 6003, USA
    Sleep 33:643-6. 2010
    ..We evaluated the familial aggregation of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency cardiopulmonary coupling (e-LFC), to assess their utility in genetic studies...
  17. pmc Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7281, USA
    Sleep 32:615-22. 2009
    ....
  18. pmc Modeling the complex gene x environment interplay in the simulated rheumatoid arthritis GAW15 data using latent variable structural equation modeling
    Nora L Nock
    Division of Genetic and Molecular Epidemiology, Case Western Reserve University, Cleveland, OH 44106 7281, USA
    BMC Proc 1:S118. 2007
    ..Moreover, because some a priori biological information is needed to form an initial substantive model, our approach may be most appropriate for candidate gene SNP panel applications...
  19. pmc Short duration of sleep increases risk of colorectal adenoma
    Cheryl L Thompson
    Department of Family Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Cancer 117:841-7. 2011
    ..However, few studies have investigated their associations with risk of colorectal neoplasia...
  20. pmc Shared genetic basis for obstructive sleep apnea and adiposity measures
    S R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:795-800. 2008
    ..Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified...
  21. pmc Heritability of upper airway dimensions derived using acoustic pharyngometry
    S R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Eur Respir J 32:1304-8. 2008
    ..These findings demonstrate the potential utility of acoustic pharyngometry in dissecting the genetic basis of sleep apnoea...
  22. ncbi request reprint Development and validation of school-based asthma and allergy screening instruments for parents and students
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Ann Allergy Asthma Immunol 90:516-28. 2003
    ..The increasing morbidity attributable to asthma among school-aged children suggests the potential utility of school-based asthma screening programs...
  23. ncbi request reprint Health-related quality of life and sleep-disordered breathing in children
    Carol L Rosen
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106 6003, USA
    Sleep 25:657-66. 2002
    ..To assess the extent to which sleep-disordered breathing (SDB) is associated with impairment of health-related quality of life (HRQOL) in children..
  24. ncbi request reprint Utility of noninvasive pharyngometry in epidemiologic studies of childhood sleep-disordered breathing
    Kenneth J Monahan
    Department of Internal Medicine, Case Western Reserve University, University Hospitals of Cleveland, OH, USA
    Am J Respir Crit Care Med 165:1499-503. 2002
    ..Thus, minimum CSA is a useful measure for evaluating SDB risk factors in preadolescent children...
  25. ncbi request reprint Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky
    Christopher W Bartlett
    Center for Quantitative and Computational Biology and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
    Genet Epidemiol 31:S61-7. 2007
    ..The difficulty of using (primarily) affected sib pair data in a gene x gene interaction analysis is explored...
  26. ncbi request reprint Predictors of loud snoring in persons with spinal cord injury
    N T Ayas
    Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, Massachusetts 02132, USA
    J Spinal Cord Med 24:30-4. 2001
    ..CONCLUSION: Because snoring is a marker for obstructive sleep apnea (OSA), the data suggest that in obese individuals with SCI, the use of antispasticity medications may be a risk factor for OSA...