Research Topics
Species | Emma K LarkinSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Detail Information
Publications
Assessing the impact of global versus local ancestry in association studiesSun Jung Kang
Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106 USA
BMC Proc 3:S107. 2009....- Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart StudyAllison R Baker
Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University, 11400 Euclid Avenue, Suite 260, Cleveland, Ohio 44106, USA
BMC Proc 3:S42. 2009..We conclude that while both univariate and multivariate family-based association analysis can identify genes of interest, our multivariate approach is less affected by multiple testing correction and yields more significant results... - A regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and associationEmma K Larkin
Case Western Reserve University, Department of Epidemiology and Biostatistics, Cleveland, OH 44106, USA
BMC Genet 6:S95. 2005..3 cM. Power and type I error were determined by the number of replicates significant at the 0.05 level... - Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep durationEmma K Larkin
Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Triangle Building Suite 260, 10400 Euclid Ave, Cleveland, OH 44106, USA
Circulation 111:1978-84. 2005..The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk... - Linkage of serum leptin levels in families with sleep apneaE K Larkin
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
Int J Obes (Lond) 29:260-7. 2005..To identify regions on the genome linked to plasma leptin levels... - Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peakEmma K Larkin
Department of Epidemiology and Biostatistics, Case Western Reserve University, 11400 Euclid Avenue, Ste 260, Cleveland, OH 44106 6083, USA
Genet Epidemiol 30:101-10. 2006..Overall, the evidence suggests that there is a disease susceptibility locus for obstructive sleep apnea in the region of ApoE, but ApoE itself is unlikely to be the causative locus... - Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass indexE K Larkin
Center for Clinical Investigation, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 6083, USA
Ann Hum Genet 72:762-73. 2008..These analyses suggest genetic loci for sleep apnea that operate both independently of BMI and through BMI-related pathways... - Comparison of affected sibling-pair linkage methods to identify gene x gene interaction in GAW15 simulated dataEmma K Larkin
Department of Epidemiology and Biostatistics, Case Western Reserve University, Triangle Building, Suite 260, 11400 Euclid Avenue, Cleveland, Ohio 44106 USA
BMC Proc 1:S66. 2007..Additionally, the lack of data on discordant sibships may have decreased the power to identify gene x gene interactions... - Decreased quality of life associated with obesity in school-aged childrenSamuel L Friedlander
Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Arch Pediatr Adolesc Med 157:1206-11. 2003.... - Variation in childhood asthma among former preterm infantsJonathan Grischkan
Department of Pediatrics, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
J Pediatr 144:321-6. 2004..Differential susceptibility to asthma among preterm children may relate to exposures that operate in the in utero and early postnatal environment to accelerate lung development, alter innate immunity, or both... - The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertensionSanjay R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital and Case Western Reserve University, Cleveland, OH, USA
Sleep 30:531-3. 2007..To identify the role of polymorphisms in the angiotensin-converting enzyme (ACE) gene in modulating susceptibility to hypertension in sleep apnea... - Relationship between obstructive sleep apnea and diurnal leptin rhythmsSanjay R Patel
Rainbow Babies and Children s Hospital, Cleveland, OH, USA
Sleep 27:235-9. 2004..Several studies have reported an association between obstructive sleep apnea and leptin, a hormone that influences satiety and body weight. We evaluated the relationship of leptin levels and the overnight change in levels with sleep apnea... - Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurityCarol L Rosen
Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio 44106-6003, USA
J Pediatr 142:383-9. 2003..2% (95% CI, 1.2%, 3.2%). CONCLUSIONS: SDB is a relatively common condition in 8- to 11-year-old children. Potentially vulnerable subgroups, black children, and former preterm infants, are at increased risk... - Sex influences endothelial function in sleep-disordered breathingMichael D Faulx
Division of Cardiology, Case Western Reserve University, University Hospitals of Cleveland, OH, USA
Sleep 27:1113-20. 2004..CONCLUSIONS: Moderate levels of SBD are associated with impaired conduit and resistance endothelial function in women. Women with SDB may be more vulnerable to early SDB-related cardiovascular disease than are men... - Predictors of longitudinal change in sleep-disordered breathing in a nonclinic populationSusan Redline
Department of Pediatrics, Division of Clinical Epidemiology, Case Western Reserve University, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106 6003, USA
Sleep 26:703-9. 2003..To quantify and identify the determinants of the 5-year change in the respiratory disturbance index (RDI)... - Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based techniqueLamia H Ibrahim
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 6003, USA
Sleep 33:643-6. 2010..We evaluated the familial aggregation of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency cardiopulmonary coupling (e-LFC), to assess their utility in genetic studies... - Empirical evidence for "syndrome Z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measuresNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7281, USA
Sleep 32:615-22. 2009.... - Modeling the complex gene x environment interplay in the simulated rheumatoid arthritis GAW15 data using latent variable structural equation modelingNora L Nock
Division of Genetic and Molecular Epidemiology, Case Western Reserve University, Cleveland, OH 44106 7281, USA
BMC Proc 1:S118. 2007..Moreover, because some a priori biological information is needed to form an initial substantive model, our approach may be most appropriate for candidate gene SNP panel applications... - Short duration of sleep increases risk of colorectal adenomaCheryl L Thompson
Department of Family Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Cancer 117:841-7. 2011..However, few studies have investigated their associations with risk of colorectal neoplasia... - Shared genetic basis for obstructive sleep apnea and adiposity measuresS R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
Int J Obes (Lond) 32:795-800. 2008..Obesity and obstructive sleep apnea each have a substantial genetic basis and commonly coexist in individuals. The degree to which the genetic underpinnings for these disorders overlap has not been previously quantified... - Heritability of upper airway dimensions derived using acoustic pharyngometryS R Patel
Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
Eur Respir J 32:1304-8. 2008..These findings demonstrate the potential utility of acoustic pharyngometry in dissecting the genetic basis of sleep apnoea... - Development and validation of school-based asthma and allergy screening instruments for parents and studentsSusan Redline
Department of Pediatrics, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
Ann Allergy Asthma Immunol 90:516-28. 2003..The increasing morbidity attributable to asthma among school-aged children suggests the potential utility of school-based asthma screening programs... - Health-related quality of life and sleep-disordered breathing in childrenCarol L Rosen
Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106 6003, USA
Sleep 25:657-66. 2002..To assess the extent to which sleep-disordered breathing (SDB) is associated with impairment of health-related quality of life (HRQOL) in children.. - Utility of noninvasive pharyngometry in epidemiologic studies of childhood sleep-disordered breathingKenneth J Monahan
Department of Internal Medicine, Case Western Reserve University, University Hospitals of Cleveland, OH, USA
Am J Respir Crit Care Med 165:1499-503. 2002..Thus, minimum CSA is a useful measure for evaluating SDB risk factors in preadolescent children... - Discussing gene-gene interaction: warning--translating equations to English may result in jabberwockyChristopher W Bartlett
Center for Quantitative and Computational Biology and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
Genet Epidemiol 31:S61-7. 2007..The difficulty of using (primarily) affected sib pair data in a gene x gene interaction analysis is explored... - Predictors of loud snoring in persons with spinal cord injuryN T Ayas
Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, Massachusetts 02132, USA
J Spinal Cord Med 24:30-4. 2001..CONCLUSION: Because snoring is a marker for obstructive sleep apnea (OSA), the data suggest that in obese individuals with SCI, the use of antispasticity medications may be a risk factor for OSA...