Affiliation: Case Western Reserve University
Malm T, Mariani M, Donovan L, Neilson L, Landreth G. Activation of the nuclear receptor PPARÎ´ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation. J Neuroinflammation. 2015;12:7 pubmed publisher
..This study demonstrates that GW0742 treatment has a prominent anti-inflammatory effect in 5XFAD mice and suggests that PPARÎ´ agonists may have therapeutic utility in treating AD. ..
Savage J, Jay T, Goduni E, Quigley C, Mariani M, Malm T, et al
. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. J Neurosci. 2015;35:6532-43 pubmed publisher
..Thus, nuclear receptor agonists increase MerTK and Axl expression on plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque clearance. ..
Skerrett R, Pellegrino M, Casali B, Taraboanta L, Landreth G. Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor ? Agonist Treatment Reduces Amyloid ? Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice. J Biol Chem. 2015;290:21591-602 pubmed publisher
..These results suggest that combined LXR/PPAR? agonist treatment merits further investigation for the treatment of AD. ..
Casali B, Corona A, Mariani M, Karlo J, Ghosal K, Landreth G. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:9173-81 pubmed publisher
Corona A, Kodoma N, Casali B, Landreth G. ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice. J Neuroimmune Pharmacol. 2016;11:61-72 pubmed publisher
..These data indicate that ABCA1-induced lipidation of ApoE is necessary for the ability of bexarotene to clear hippocampal soluble A? and ameliorate cognitive deficits. ..
Landreth G, Reed Geaghan E. Toll-like receptors in Alzheimer's disease. Curr Top Microbiol Immunol. 2009;336:137-53 pubmed publisher
..The TLR-mediated microglial response has beneficial roles in stimulating phagocytosis as well as detrimental roles in the Abeta-stimulated release of neurotoxic products. ..
Pucilowska J, Vithayathil J, Tavares E, Kelly C, Karlo J, Landreth G. The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway. J Neurosci. 2015;35:3190-200 pubmed publisher
..2del mice exhibit anxiety-like behaviors and impaired memory. Our findings provide evidence of ERK dysregulation, developmental abnormalities in neurogenesis, and behavioral impairment associated with the 16p11.2 chromosomal deletion. ..
Vithayathil J, Pucilowska J, Goodnough L, ATIT R, Landreth G. Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation. J Neurosci. 2015;35:6836-48 pubmed publisher
..These findings establish that ERK signaling regulates maintenance of progenitor cells required for development of the dentate gyrus. ..
Jay T, Hirsch A, Broihier M, Miller C, Neilson L, Ransohoff R, et al
. Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease. J Neurosci. 2017;37:637-647 pubmed publisher
..In addition, we examine how TREM2 affects the function of the brain immune cell populations in which it is expressed throughout disease progression to understand possible mechanisms underlying its differential impacts on pathology. ..