Wesley K Kroeze

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint G-protein-coupled receptors at a glance
    Wesley K Kroeze
    Departments of Biochemistry, Neurosciences and Psychiatry, NIMH Psychoactive Drug Screening Program, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    J Cell Sci 116:4867-9. 2003
  2. ncbi request reprint H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
    Wesley K Kroeze
    Department of Biochemistry, RM W463, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    Neuropsychopharmacology 28:519-26. 2003
  3. pmc p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling
    Douglas J Sheffler
    Departments of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:4717-22. 2006
  4. pmc Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity
    Ryan T Strachan
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio, USA
    Mol Pharmacol 77:327-38. 2010
  5. ncbi request reprint Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors
    Anushree Bhatnagar
    Department of Biochemistry, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA
    J Biol Chem 279:34614-23. 2004
  6. ncbi request reprint Screening the receptorome yields validated molecular targets for drug discovery
    Bryan L Roth
    Department of Biochemistry, Case Comprehensive Cancer Center, National Institute of Mental Health Psychoactive Drug Screening Program, Case Western Reserve University Medical School, Cleveland, OH 44106, USA
    Curr Pharm Des 12:1785-95. 2006
  7. ncbi request reprint Screening the receptorome
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH 44106, USA
    J Psychopharmacol 20:41-6. 2006
  8. ncbi request reprint Molecular biology of serotonin receptors structure and function at the molecular level
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Top Med Chem 2:507-28. 2002
  9. ncbi request reprint Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    Bryan L Roth
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nat Rev Drug Discov 3:353-9. 2004
  10. pmc Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
    Atheir I Abbas
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucleic Acids Res 38:e118. 2010

Collaborators

  • Kurt Kristiansen
  • David M Weiner
  • Bryan Roth
  • H Y Meltzer
  • Douglas J Sheffler
  • Ryan T Strachan
  • Atheir I Abbas
  • Anushree Bhatnagar
  • David A Shapiro
  • Noah Sciaky
  • Mark R Cronan
  • Niels H Jensen
  • Martilias S Farrell
  • Daniel J Urban
  • Zefeng Wang
  • Piotr Mieczkowski
  • Sandra J Hufeisen
  • Ariel Y Deutch
  • Patrick Leahy
  • Bonnie G Garcia
  • Jens C Bruning
  • BethAnn Compton-Toth

Detail Information

Publications11

  1. ncbi request reprint G-protein-coupled receptors at a glance
    Wesley K Kroeze
    Departments of Biochemistry, Neurosciences and Psychiatry, NIMH Psychoactive Drug Screening Program, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    J Cell Sci 116:4867-9. 2003
  2. ncbi request reprint H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
    Wesley K Kroeze
    Department of Biochemistry, RM W463, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    Neuropsychopharmacology 28:519-26. 2003
    ....
  3. pmc p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling
    Douglas J Sheffler
    Departments of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:4717-22. 2006
    ..Because RSK2-inactivating mutations in humans lead to Coffin-Lowry syndrome, our results imply that alterations in GPCR signaling may account for some of its clinical manifestations...
  4. pmc Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity
    Ryan T Strachan
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio, USA
    Mol Pharmacol 77:327-38. 2010
    ..This study provides the first evidence that deletion of a single kinase can elicit profound changes in patterns of agonist functional selectivity...
  5. ncbi request reprint Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors
    Anushree Bhatnagar
    Department of Biochemistry, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA
    J Biol Chem 279:34614-23. 2004
    ..These studies provide compelling evidence for a prominent role of Cav-1 in regulating the functional activity of not only 5-HT(2A) serotonin receptors but also selected Galpha(q)-coupled receptors...
  6. ncbi request reprint Screening the receptorome yields validated molecular targets for drug discovery
    Bryan L Roth
    Department of Biochemistry, Case Comprehensive Cancer Center, National Institute of Mental Health Psychoactive Drug Screening Program, Case Western Reserve University Medical School, Cleveland, OH 44106, USA
    Curr Pharm Des 12:1785-95. 2006
    ..Additionally, we will provide evidence that receptorome-based screening provides insights into novel therapeutic indications of approved medications and serves to validate targets for therapeutic drug discovery...
  7. ncbi request reprint Screening the receptorome
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH 44106, USA
    J Psychopharmacol 20:41-6. 2006
    ....
  8. ncbi request reprint Molecular biology of serotonin receptors structure and function at the molecular level
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Top Med Chem 2:507-28. 2002
    ..Finally, examples will be given to demonstrate that a detailed knowledge of the predicted structure of one receptor can be useful for structure-based drug design...
  9. ncbi request reprint Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    Bryan L Roth
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nat Rev Drug Discov 3:353-9. 2004
  10. pmc Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
    Atheir I Abbas
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucleic Acids Res 38:e118. 2010
    ....
  11. ncbi request reprint Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6
    David A Shapiro
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:11441-9. 2002
    ..L. Roth and D. A. Shapiro (2001) Expert Opin. Ther. Targets 5, 685-695) and others, that this may represent a general mechanism of activation for many, but not all, G-protein-coupled receptors...