J P Kirwan

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle
    J P Kirwan
    Departments of Reproductive Biology and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Appl Physiol (1985) 88:797-803. 2000
  2. ncbi request reprint Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus
    J P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building, 2500 MetroHealth Dr, Cleveland, OH 44109 1998, USA
    Diabetes Care 24:1602-7. 2001
  3. ncbi request reprint Effects of a moderate glycemic meal on exercise duration and substrate utilization
    J P Kirwan
    Noll Physiological Research Center, Penn State University, University Park, PA 16802, USA
    Med Sci Sports Exerc 33:1517-23. 2001
  4. ncbi request reprint Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia
    J P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Endocrinol Metab 281:E1137-43. 2001
  5. ncbi request reprint Effects of moderate and high glycemic index meals on metabolism and exercise performance
    J P Kirwan
    Noll Physiological Research Center, Penn State University, University Park, PA, USA
    Metabolism 50:849-55. 2001
  6. pmc Age attenuates leucine oxidation after eccentric exercise
    E L Kullman
    Cleveland Clinic, Pathobiology, Cleveland, OH 44195, USA
    Int J Sports Med 34:695-9. 2013
  7. pmc Overweight, obesity and intentional weight loss in chronic kidney disease: NHANES 1999-2006
    S D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Int J Obes (Lond) 36:1585-90. 2012
  8. pmc Fasting hyperglycaemia blunts the reversal of impaired glucose tolerance after exercise training in obese older adults
    S K Malin
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Diabetes Obes Metab 14:835-41. 2012
  9. pmc Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes
    S R Kashyap
    Endocrinology and Metabolism Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Obes (Lond) 34:462-71. 2010
  10. ncbi request reprint Maternal factors that determine neonatal size and body fat
    P M Catalano
    Department of Reproductive Biology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Curr Diab Rep 1:71-7. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle
    J P Kirwan
    Departments of Reproductive Biology and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Appl Physiol (1985) 88:797-803. 2000
    ..60, P < 0.02). We conclude that regular exercise leads to greater insulin-stimulated IRS-1-associated PI3-kinase activation in human skeletal muscle, thus facilitating enhanced insulin-mediated glucose uptake...
  2. ncbi request reprint Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus
    J P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building, 2500 MetroHealth Dr, Cleveland, OH 44109 1998, USA
    Diabetes Care 24:1602-7. 2001
    ....
  3. ncbi request reprint Effects of a moderate glycemic meal on exercise duration and substrate utilization
    J P Kirwan
    Noll Physiological Research Center, Penn State University, University Park, PA 16802, USA
    Med Sci Sports Exerc 33:1517-23. 2001
    ..To determine whether eating a breakfast cereal with a moderate glycemic index could alter substrate utilization and improve exercise duration...
  4. ncbi request reprint Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia
    J P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Endocrinol Metab 281:E1137-43. 2001
    ....
  5. ncbi request reprint Effects of moderate and high glycemic index meals on metabolism and exercise performance
    J P Kirwan
    Noll Physiological Research Center, Penn State University, University Park, PA, USA
    Metabolism 50:849-55. 2001
    ..We conclude that a MOD-GI meal provides a significant performance and metabolic advantage when consumed 45 minutes before exercise...
  6. pmc Age attenuates leucine oxidation after eccentric exercise
    E L Kullman
    Cleveland Clinic, Pathobiology, Cleveland, OH 44195, USA
    Int J Sports Med 34:695-9. 2013
    ..The decreased efficiency of protein utilization in older men may contribute to impaired maintenance, growth, and repair of body tissues with advancing age. ..
  7. pmc Overweight, obesity and intentional weight loss in chronic kidney disease: NHANES 1999-2006
    S D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Int J Obes (Lond) 36:1585-90. 2012
    ..We aimed to examine: (a) lifestyle and behavioral factors, (b) factors related to pursuing weight loss and (c) weight loss modalities pursued by CKD and non-CKD individuals who are overweight and obese...
  8. pmc Fasting hyperglycaemia blunts the reversal of impaired glucose tolerance after exercise training in obese older adults
    S K Malin
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Diabetes Obes Metab 14:835-41. 2012
    ..However, no study has determined the efficacy of exercise training on glucose metabolism in the different prediabetes subtypes...
  9. pmc Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes
    S R Kashyap
    Endocrinology and Metabolism Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Obes (Lond) 34:462-71. 2010
    ..Hyperglycemia resolves quickly after bariatric surgery, but the underlying mechanism and the most effective type of surgery remains unclear...
  10. ncbi request reprint Maternal factors that determine neonatal size and body fat
    P M Catalano
    Department of Reproductive Biology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Curr Diab Rep 1:71-7. 2001
    ..Additional studies of maternal glucose and lipid metabolism are needed to better evaluate fetal growth...
  11. doi request reprint Ghrelin suppression is associated with weight loss and insulin action following gastric bypass surgery at 12 months in obese adults with type 2 diabetes
    A Samat
    Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA
    Diabetes Obes Metab 15:963-6. 2013
    ..78, p = 0.01) and peak postprandial GLP-1 (r = -0.73, p = 0.03). These data suggest that postprandial ghrelin suppression may be part of the mechanism that contributes to diabetes remission after RYGB surgery. ..
  12. ncbi request reprint In vitro evidence that hyperglycemia stimulates tumor necrosis factor-alpha release in obese women with polycystic ovary syndrome
    F Gonzalez
    Department of Reproductive Biology, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
    J Endocrinol 188:521-9. 2006
    ..MNC-derived TNFalpha release may contribute to insulin resistance and hyperandrogenism, particularly when the combination of PCOS and increased adiposity is present...
  13. ncbi request reprint Insulin signalling, exercise and cellular integrity
    J P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH 44109 1998, U S A
    Biochem Soc Trans 31:1281-5. 2003
    ..Understanding these adaptations is essential in order to establish a sound theoretical basis for recommending exercise as a therapeutic intervention for insulin resistance and type 2 diabetes...