Charles H King

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint The unacknowledged impact of chronic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
    Chronic Illn 4:65-79. 2008
  2. pmc Health metrics for helminth infections
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2109 Adelbert Road, BRB Room 422, Cleveland, OH 44106, USA Electronic address
    Acta Trop 141:150-60. 2015
  3. pmc Evaluation of the health-related quality of life of children in Schistosoma haematobium-endemic communities in Kenya: a cross-sectional study
    Carolyn C Terer
    Department of Public Health, School of Health Sciences, Kenyatta University, Nairobi, Kenya
    PLoS Negl Trop Dis 7:e2106. 2013
  4. pmc Partnering parasites: evidence of synergism between heavy Schistosoma haematobium and Plasmodium species infections in Kenyan children
    Lia S Florey
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Negl Trop Dis 6:e1723. 2012
  5. ncbi request reprint Transmission control for schistosomiasis - why it matters now
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Trends Parasitol 22:575-82. 2006
  6. ncbi request reprint Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
  7. ncbi request reprint Long-term outcomes of school-based treatment for control of urinary schistosomiasis: a review of experience in Coast Province, Kenya
    Charles H King
    Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mem Inst Oswaldo Cruz 101:299-306. 2006
  8. pmc Parasites and poverty: the case of schistosomiasis
    Charles H King
    International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
    Acta Trop 113:95-104. 2010
  9. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
  10. pmc Asymmetries of poverty: why global burden of disease valuations underestimate the burden of neglected tropical diseases
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 2:e209. 2008

Research Grants

Collaborators

Detail Information

Publications56

  1. doi request reprint The unacknowledged impact of chronic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
    Chronic Illn 4:65-79. 2008
    ....
  2. pmc Health metrics for helminth infections
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2109 Adelbert Road, BRB Room 422, Cleveland, OH 44106, USA Electronic address
    Acta Trop 141:150-60. 2015
    ..Gaps in current knowledge of disease burden are identified, and interim approaches to disease burden assessment are discussed. ..
  3. pmc Evaluation of the health-related quality of life of children in Schistosoma haematobium-endemic communities in Kenya: a cross-sectional study
    Carolyn C Terer
    Department of Public Health, School of Health Sciences, Kenyatta University, Nairobi, Kenya
    PLoS Negl Trop Dis 7:e2106. 2013
    ..This makes it difficult to estimate the disease burden specific to schistosomiasis using the standard DALY metric...
  4. pmc Partnering parasites: evidence of synergism between heavy Schistosoma haematobium and Plasmodium species infections in Kenyan children
    Lia S Florey
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Negl Trop Dis 6:e1723. 2012
    ..This study was undertaken to help identify the social and environmental determinants of multiple parasite infection in one such community...
  5. ncbi request reprint Transmission control for schistosomiasis - why it matters now
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Trends Parasitol 22:575-82. 2006
    ..The next generation of schistosomiasis control can be optimized using new monitoring tools and effective transmission containment...
  6. ncbi request reprint Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
    ..To develop an evidenced-based reassessment of schistosomiasis-related disability, we did a systematic review of data on disability-associated outcomes for all forms of schistosomiasis...
  7. ncbi request reprint Long-term outcomes of school-based treatment for control of urinary schistosomiasis: a review of experience in Coast Province, Kenya
    Charles H King
    Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mem Inst Oswaldo Cruz 101:299-306. 2006
    ..We conclude that continued treatment into adulthood, as well as efforts at long-term prevention of infection (transmission control) are necessary to achieve optimal morbidity control in affected communities...
  8. pmc Parasites and poverty: the case of schistosomiasis
    Charles H King
    International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
    Acta Trop 113:95-104. 2010
    ..Their results should highlight the strong potential of integrated parasite control in efforts for poverty reduction...
  9. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
    ..In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose, in Schistosoma-endemic areas of Africa...
  10. pmc Asymmetries of poverty: why global burden of disease valuations underestimate the burden of neglected tropical diseases
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 2:e209. 2008
    ..The present DALY framework needs to be substantially revised if the GBD is to become a valid and useful system for determining health priorities...
  11. ncbi request reprint Increased ratio of tumor necrosis factor-alpha to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity
    Alex N Wamachi
    Kenya Medical Research Institute, Nairobi, Kenya
    J Infect Dis 190:2020-30. 2004
    ..These results indicate that increased TNF-alpha production, relative to that of IL-10, is associated with developing bladder-wall morbidity with S. haematobium infection...
  12. doi request reprint Human schistosomiasis
    Daniel G Colley
    Center for Tropical and Emerging Global Disease and Department of Microbiology, University of Georgia, Athens, GA, USA Electronic address
    Lancet 383:2253-64. 2014
    ..In some locations, elimination of transmission is now the goal; however, more sensitive diagnostics are needed in both the field and clinics, and integrated environmental and health-care management will be needed to ensure elimination...
  13. pmc Monitoring malaria vector control interventions: effectiveness of five different adult mosquito sampling methods
    Shirley A Onyango
    Department of Zoological Sciences, Kenyatta University, P O Box 43844, Nairobi 00100, Kenya
    J Med Entomol 50:1140-51. 2013
    ..There are still no sufficiently efficient mosquito collection methods for sampling outdoor mosquitoes, particularly those that are bloodfed...
  14. pmc Impact of drought on the spatial pattern of transmission of Schistosoma haematobium in coastal Kenya
    Francis M Mutuku
    Department of Environmental Studies, Emory University, Atlanta, Georgia, USA
    Am J Trop Med Hyg 85:1065-70. 2011
    ..The implications of extreme weather and climate conditions on risk and transmission of S. haematobium and their relevance to control strategies are discussed...
  15. ncbi request reprint Distribution patterns and cercarial shedding of Bulinus nasutus and other snails in the Msambweni area, Coast Province, Kenya
    H Curtis Kariuki
    Division of Vector Borne Diseases, Ministry of Health, Nairobi, Kenya
    Am J Trop Med Hyg 70:449-56. 2004
    ..Water lily (Nymphaea spp.) and several aquatic grass species appeared necessary for local colonization by B. nasutus or L. purpureus...
  16. pmc Interepidemic Rift Valley fever virus seropositivity, northeastern Kenya
    A Desiree LaBeaud
    Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    Emerg Infect Dis 14:1240-6. 2008
    ..Rural Gumarey reported more mosquito and animal exposure than Sogan-Godud. Seropositive persons were more likely to have visual impairment and retinal lesions; other physical findings did not differ...
  17. pmc Projecting the long-term impact of school- or community-based mass-treatment interventions for control of Schistosoma infection
    Xiaoxia Wang
    Department of Mathematics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 6:e1903. 2012
    ..Variations in drug schedules involving increased population coverage and/or treatment frequency are now undergoing field trials. However, their relative effectiveness in long-term infection suppression is presently unknown...
  18. pmc Impact of insecticide-treated bed nets on malaria transmission indices on the south coast of Kenya
    Francis M Mutuku
    Department of Environmental Studies, Emory University, Atlanta, Georgia, USA
    Malar J 10:356. 2011
    ..arabiensis and Anopheles merus playing a secondary role. Since 2001, bed net use has increased progressively and reached high levels by 2009-2010 with corresponding decline in malaria transmission...
  19. pmc Development of a specimen-sparing multichannel bead assay to detect antiparasite IgG4 for the diagnosis of Schistosoma and Wuchereria infections on the coast of Kenya
    Adam S Duvall
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio Division of Vector Borne and Neglected Tropical Diseases, Ministry of Public Health and Sanitation, Nairobi, Kenya Department of Environmental Sciences, Emory University, Atlanta, Georgia
    Am J Trop Med Hyg 90:638-45. 2014
    ..Measuring antibody by MFI is feasible and may provide more accurate epidemiological information than current parasitological tests, especially in the setting of low-intensity infections...
  20. pmc Factors affecting infection or reinfection with Schistosoma haematobium in coastal Kenya: survival analysis during a nine-year, school-based treatment program
    Sudtida A Satayathum
    Department of Epidemiology and Biostatistics, and Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Am J Trop Med Hyg 75:83-92. 2006
    ..haematobium transmission in this setting. In large population-based control programs, treatment allocation strategies may need to be tailored to local conditions on a village-by-village basis...
  21. ncbi request reprint Low heritable component of risk for infection intensity and infection-associated disease in urinary schistosomiasis among Wadigo village populations in Coast Province, Kenya
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4983, USA
    Am J Trop Med Hyg 70:57-62. 2004
    ..We conclude that among long-established populations of coastal Kenya, heritable variation in host susceptibility is low, and likely plays a minimal role in determining individual risk for infection or disease...
  22. ncbi request reprint High prevalence of ectopic kidney in Coast Province, Kenya
    Philip Magak
    Department of Radiology, Ministry of Health, Nairobi, Kenya
    Trop Med Int Health 9:595-600. 2004
    ..To establish the prevalence of congenital urinary tract abnormalities in a full population-based ultrasound survey of an area of coastal Kenya...
  23. pmc Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area
    Amaya L Bustinduy
    CTID Building, Liverpool School of Tropical Medicine, Liverpool, UK
    Am J Trop Med Hyg 88:433-40. 2013
    ..The broad overlap of infection-related causes for anemia and malnutrition and the high frequency of polyparasitic infections suggest that there will be significant advantages to integrated parasite control in this area...
  24. doi request reprint Association of symptoms and severity of rift valley fever with genetic polymorphisms in human innate immune pathways
    Amy G Hise
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 9:e0003584. 2015
    ..The aim of the present study was to identify human genes associated with RVF clinical disease in a high-risk population in Northeastern Province, Kenya...
  25. pmc Effect of antenatal parasitic infections on anti-vaccine IgG levels in children: a prospective birth cohort study in Kenya
    Indu Malhotra
    Case Western Reserve University, Center for Global Health and Diseases, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 9:e0003466. 2015
    ....
  26. pmc Rapid GIS-based profiling of West Nile virus transmission: defining environmental factors associated with an urban-suburban outbreak in Northeast Ohio, USA
    A Desiree LaBeaud
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    Geospat Health 2:215-25. 2008
    ..This timely working identification of the transmission scale effectively focused control interventions against newly invasive WNV in a complex North American habitat...
  27. pmc Cross-sectional study of the burden of vector-borne and soil-transmitted polyparasitism in rural communities of Coast Province, Kenya
    Donal Bisanzio
    Department of Environmental Sciences, Emory University, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 8:e2992. 2014
    ..Integration of novel quantitative tools and qualitative approaches is needed to analyze transmission dynamics and design effective interventions...
  28. pmc Physical condition and maintenance of mosquito bed nets in Kwale County, coastal Kenya
    Francis M Mutuku
    Department of Environmental Studies, Emory University, Atlanta, Georgia, USA
    Malar J 12:46. 2013
    ..Usefulness of nets declines primarily due to physical damage or loss of insecticidal activity...
  29. pmc Serologic evidence of arboviral infections among humans in Kenya
    Laura J Sutherland
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Trop Med Hyg 85:158-61. 2011
    ..In Kenya, transmission of arboviral infection continues between known epidemics and remains common across the country...
  30. pmc Measuring fitness of Kenyan children with polyparasitic infections using the 20-meter shuttle run test as a morbidity metric
    Amaya L Bustinduy
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 5:e1213. 2011
    ....
  31. pmc Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes
    Laurin J Kasehagen
    Center for Global Health and Disease, Case Western Reserve University, School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 2:e336. 2007
    ..Our limited knowledge of the selective advantages or disadvantages associated with this genotype constrains our understanding of the effect that interventions against Pv may have on the health of people living in malaria-endemic regions...
  32. pmc Planning for Rift Valley fever virus: use of geographical information systems to estimate the human health threat of white-tailed deer (Odocoileus virginianus)-related transmission
    Sravan Kakani
    Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Geospat Health 5:33-43. 2010
    ..Deer population losses, either by intervention for herd reduction or by RVF-related mortality, would substantially reduce these likely transmission zones to 53.1 km(2), i.e. by 89%...
  33. pmc Exposure to West Nile virus during the 2002 epidemic in Cuyahoga County, Ohio: a comparison of pediatric and adult behaviors
    Angelle Desiree LaBeaud
    Division of Pediatric Infectious Diseases, University Hospitals of Cleveland, Rainbow Babies and Children s Hospital, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Public Health Rep 122:356-61. 2007
    ..Limited data exist regarding risk determinants of childhood WNV infection. We conducted a survey to analyze the differences between pediatric and adult behavior relevant to WNV exposure...
  34. pmc Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya
    Ann M Moormann
    Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
    Am J Trop Med Hyg 81:489-95. 2009
    ....
  35. pmc A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni
    Daniel G Colley
    Schistosomiasis Consortium for Operational Research and Evaluation, University of Georgia, Athens, GA 30602, USA
    Am J Trop Med Hyg 88:426-32. 2013
    ..We conclude that one urine POC-CCA test can replace Kato-Katz testing for community-level S. mansoni prevalence mapping...
  36. pmc Birthweight in offspring of mothers with high prevalence of helminth and malaria infection in coastal Kenya
    Jessica K Fairley
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30308, USA
    Am J Trop Med Hyg 88:48-53. 2013
    ..The high prevalence of maternal infection coupled with a higher than expected percentage of LBW highlight a need for further investigation of the association of maternal co-infection with LBW...
  37. ncbi request reprint Randomized comparison of low-dose versus standard-dose praziquantel therapy in treatment of urinary tract morbidity due to Schistosoma haema tobium infection
    Charles H King
    Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106 4983, USA
    Am J Trop Med Hyg 66:725-30. 2002
    ..We conclude that in certain settings, a 20 mg/kg dose of praziquantel may be sufficient in providing control of morbidity due to urinary schistosomiasis in population-based treatment programs...
  38. ncbi request reprint Will genetic testing alter the management of disease caused by infectious agents? A cost-effectiveness analysis of gene-testing strategies for prevention of rheumatic Fever
    Charles H King
    School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Clin Infect Dis 34:1491-9. 2002
    ..When used with available antibiotic prophylaxis, genetic testing has the potential to provide a cost-effective strategy for the primary prevention of RF and its sequelae...
  39. ncbi request reprint Measuring morbidity in schistosomiasis mansoni: relationship between image pattern, portal vein diameter and portal branch thickness in large-scale surveys using new WHO coding guidelines for ultrasound in schistosomiasis
    Charles H King
    Division of Geographic Medicine, Case Western Reserve University and University Hospitals of Cleveland, OH 44103 4983, USA
    Trop Med Int Health 8:109-17. 2003
    ..We evaluated the performance of the qualitative and quantitative components of the new Niamey criteria...
  40. pmc Modeling the effect of chronic schistosomiasis on childhood development and the potential for catch-up growth with different drug treatment strategies promoted for control of endemic schistosomiasis
    David Gurarie
    Department of Mathematics, Department of Pediatrics, and Center for Global Health and Diseases, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA
    Am J Trop Med Hyg 84:773-81. 2011
    ....
  41. doi request reprint Cross-sectional survey of Rift Valley fever virus exposure in Bodhei village located in a transitional coastal forest habitat in Lamu county, Kenya
    Samuel Muiruri
    Department of Pathology, Kenyatta University, Nairobi, Kenya Vector Borne Diseases Control Unit, Ministry of Health, Nairobi, Kenya Office of Director of Health, Garissa County, Kenya Department of Ophthalmology, Thika Level 5 Hospital, Ministry of Health, Thika, Kenya Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio
    Am J Trop Med Hyg 92:394-400. 2015
    ..The results confirm that significant RVFV transmission occurs outside of recognized high-risk areas and independent of known epidemic periods. ..
  42. pmc Meta-analysis of urine heme dipstick diagnosis of Schistosoma haematobium infection, including low-prevalence and previously-treated populations
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America Schistosomiasis Consortium for Operational Research and Evaluation, University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 7:e2431. 2013
    ..The objective of the present study was to perform meta-analysis of dipstick accuracy for S. haematobium infection in endemic regions, with special attention to performance where infection intensity or prevalence was low...
  43. pmc Potential for autoimmune pathogenesis of Rift Valley Fever virus retinitis
    Shoshana Newman-Gerhardt
    National Institutes of Health, Building 29B, Room 2C17, 29 Lincoln Way, Bethesda, MD 20892, USA
    Am J Trop Med Hyg 89:495-7. 2013
    ..Further investigation into the possible immune pathogenesis of RVFV retinitis could lead to improved therapies to prevent or treat this severe complication...
  44. pmc Differentiating Schistosoma haematobium from related animal schistosomes by PCR amplifying inter-repeat sequences flanking newly selected repeated sequences
    Ibrahim Abbasi
    Kuvin Center, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Am J Trop Med Hyg 87:1059-64. 2012
    ..The Sh73/DraI assay detected snails infected with S. haematobium, S. bovis, or both, and should prove useful for screening snails where discrimination of S. haematobium from related schistosomes is required...
  45. pmc Spectrum of Rift Valley fever virus transmission in Kenya: insights from three distinct regions
    A Desiree LaBeaud
    Division of Pediatric Infectious Diseases, Case Western Reserve University, Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Am J Trop Med Hyg 76:795-800. 2007
    ..The extent of both epidemic and inter-epidemic RVFV transmission in Kenya is greater than previously documented...
  46. pmc High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya
    A Desiree LaBeaud
    Children s Hospital Oakland Research Institute, Oakland, California, United States of America Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 9:e0003436. 2015
    ..The objectives of this study were to measure the seroprevalence of CHIKV and ONNV in coastal Kenya and link it to demographics and other risk factors...
  47. pmc Do antenatal parasite infections devalue childhood vaccination?
    A Desiree LaBeaud
    Division of Pediatric Infectious Diseases, University Hospitals of Cleveland, Rainbow Babies and Children s Hospital, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 3:e442. 2009
    ..To optimize vaccine effectiveness in developing countries, better control of chronic NTDs may prove imperative...
  48. pmc Mathematical modeling of malaria infection with innate and adaptive immunity in individuals and agent-based communities
    David Gurarie
    Department of Mathematics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e34040. 2012
    ....
  49. pmc RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge
    Megan E Ermler
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    J Virol 87:4846-60. 2013
    ..In addition, we demonstrate that Toll-like-receptor-mediated signaling is not involved in IFN production, further emphasizing the importance of the RNA cellular helicases in type I IFN responses to RVFV...
  50. ncbi request reprint Ultrasound monitoring of structural urinary tract disease in Schistosoma haematobium infection
    Charles H King
    Division of Geographic Medicine, Case Western Reserve University SOM, Cleveland, Ohio 44106, USA
    Mem Inst Oswaldo Cruz 97:149-52. 2002
    ..In summary, the painless, quick, and reproducible ultrasound examination has become an essential tool in the study of urinary schistosomiasis...
  51. ncbi request reprint Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers
    Ronald E Blanton
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein Research Building, Room 4133, 2103 Cornell Road, Cleveland, OH 44106 7286, USA
    Eur J Hum Genet 13:660-8. 2005
    ..Model-free modified Haseman-Elston analysis identified linkage to a SNP in the interferon gamma receptor locus (P=0.000001). There was also weak evidence for linkage to the interleukin 13-4 region and tissue growth factor beta 1...
  52. doi request reprint Health metrics for helminthic infections
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Adv Parasitol 73:51-69. 2010
    ..This improved, more valid assessment is expected to provide evidence favouring preventive over curative intervention for control of these highly prevalent diseases...
  53. pmc Population biology of Schistosoma mating, aggregation, and transmission breakpoints: more reliable model analysis for the end-game in communities at risk
    David Gurarie
    Department of Mathematics, Case Western Reserve University, Cleveland, Ohio, United States of America Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 9:e115875. 2014
    ..We show the classic MWB has inherent inconsistencies, and propose SWB as a reliable alternative for projection of long-term control outcomes. ..
  54. ncbi request reprint Pediatric West Nile virus infection: neurologic disease presentations during the 2002 epidemic in Cuyahoga County, Ohio
    Angelle Desiree LaBeaud
    Department of Pediatrics, Division of Infectious Diseases, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    Pediatr Infect Dis J 25:751-3. 2006
    ..When compared with adults, children had significantly lower rates of WNND. Children are at a decreased risk for severe WNV and less likely to present with neurologic signs or suffer neurologic sequelae...

Research Grants2

  1. URINARY SCHISTOSOMIASIS: INFECTION AND DISEASE
    Charles King; Fiscal Year: 2004
    ..This information, combined with epidemiological modeling of control strategies, will allow accelerated synthesis of the next generation of control programs. ..
  2. HUMAN POPULATION GROWTH IMPACT ON S. HAEMATOBIUM
    Charles King; Fiscal Year: 2005
    ....