Jonathan Karn

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc A new BET on the control of HIV latency
    Jonathan Karn
    Department of Molecular Biology and Microbiology Case School of Medicine Cleveland, OH USA
    Cell Cycle 12:545-6. 2013
  2. pmc Transcriptional and posttranscriptional regulation of HIV-1 gene expression
    Jonathan Karn
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cold Spring Harb Perspect Med 2:a006916. 2012
  3. pmc The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
    Jonathan Karn
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
    Curr Opin HIV AIDS 6:4-11. 2011
  4. pmc Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes
    Uri R Mbonye
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Pathog 9:e1003338. 2013
  5. pmc Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency
    Richard Pearson
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    J Virol 82:12291-303. 2008
  6. pmc T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway
    Young Kyeung Kim
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Room W200, Cleveland, OH 44106 4960, USA
    J Mol Biol 410:896-916. 2011
  7. pmc Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure
    Uri Mbonye
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, United States
    Virology 454:328-39. 2014
  8. pmc Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat
    Julie K Jadlowsky
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 34:1911-28. 2014
  9. pmc CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency
    Mudit Tyagi
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    EMBO J 26:4985-95. 2007
  10. pmc Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    Mudit Tyagi
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4960, USA
    J Virol 84:6425-37. 2010

Collaborators

  • Mudit Tyagi
  • John C Tilton
  • Koh Fujinaga
  • Mark D Adams
  • Julie K Jadlowsky
  • Gabriele Varani
  • David M Margolis
  • John A Robinson
  • Michelle J West
  • Eric J Arts
  • Uri Mbonye
  • Young Kyeung Kim
  • Biswajit Das
  • Xiaolan Yu
  • Curtis Dobrowolski
  • Julia Friedman
  • Richard Pearson
  • Fengchun Ye
  • Abdel Malek Shahir
  • Zhimin Feng
  • Nabil F Bissada
  • Aaron Weinberg
  • Mark B Lucera
  • Uri R Mbonye
  • Matthew S Lalonde
  • Joseph Hokello
  • Julian Wong
  • Jinfeng Sha
  • Carisa A Tilton
  • Stanley Nithianantham
  • Aiman A Haqqani
  • Caroline O Tabler
  • Hongxia Mao
  • Betty Eapen
  • Jingfeng Sha
  • Giridharan Gokulrangan
  • Mark R Chance
  • Manish Datt
  • Maxwell Cooper
  • Kara S Keedy
  • Zafiria Athanassiou
  • Chung K Chu
  • Michael A Lobritz
  • Annette Ratcliff
  • Won Kyung Cho
  • Nancie M Archin
  • Mastooreh Chamanian
  • Kara Lassen
  • Cheng Ming Chiang
  • Cyril F Bourgeois
  • Shwu Yuan Wu

Detail Information

Publications17

  1. pmc A new BET on the control of HIV latency
    Jonathan Karn
    Department of Molecular Biology and Microbiology Case School of Medicine Cleveland, OH USA
    Cell Cycle 12:545-6. 2013
    ..Comment on: Boehm D, et al. Cell Cycle 2012; 12:452-62...
  2. pmc Transcriptional and posttranscriptional regulation of HIV-1 gene expression
    Jonathan Karn
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cold Spring Harb Perspect Med 2:a006916. 2012
    ..In cells that are not fully activated, limiting levels of Tat and Rev act as potent blocks to premature virus production...
  3. pmc The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
    Jonathan Karn
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
    Curr Opin HIV AIDS 6:4-11. 2011
    ..This review will focus on recent insights into the HIV transcriptional control mechanisms that provide the biochemical basis for understanding latency...
  4. pmc Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes
    Uri R Mbonye
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Pathog 9:e1003338. 2013
    ....
  5. pmc Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency
    Richard Pearson
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    J Virol 82:12291-303. 2008
    ..This decreases Tat production below the levels that are required to sustain HIV gene expression...
  6. pmc T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway
    Young Kyeung Kim
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Room W200, Cleveland, OH 44106 4960, USA
    J Mol Biol 410:896-916. 2011
    ....
  7. pmc Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure
    Uri Mbonye
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, United States
    Virology 454:328-39. 2014
    ..An in-depth comprehensive understanding of the molecular control of HIV-1 transcription should inform the development of optimal combinatorial reactivation strategies that are intended to purge the latent viral reservoir. ..
  8. pmc Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat
    Julie K Jadlowsky
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 34:1911-28. 2014
    ..In contrast to most cellular genes, HIV is highly activated by the combined effects of NELF-E depletion and activation of initiation by TNF-α, suggesting that opportunities exist to selectively activate latent HIV proviruses. ..
  9. pmc CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency
    Mudit Tyagi
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    EMBO J 26:4985-95. 2007
    ..We conclude that CBF-1 is a previously overlooked factor that induces transcriptional silencing during the establishment of HIV latency...
  10. pmc Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    Mudit Tyagi
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4960, USA
    J Virol 84:6425-37. 2010
    ..Thus, a combination of restrictive chromatin structures at the HIV long terminal repeat and limiting P-TEFb levels contribute to transcriptional silencing leading to latency in primary CD4(+) T cells...
  11. pmc Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications
    Biswajit Das
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States
    Virology 474:65-81. 2015
    ....
  12. pmc Control of HIV latency by epigenetic and non-epigenetic mechanisms
    Uri Mbonye
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr HIV Res 9:554-67. 2011
    ....
  13. pmc Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2
    Julia Friedman
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4960, USA
    J Virol 85:9078-89. 2011
    ..These findings suggest that PRC2-mediated silencing is an important feature of HIV latency and that inhibitors of histone methylation may play a useful role in induction strategies designed to eradicate latent HIV pools...
  14. pmc Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA
    Matthew S Lalonde
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 7:e1002038. 2011
    ..Our results suggest that antiviral drugs targeting TAR RNA might be highly effective due to a dual inhibitory mechanism...
  15. pmc Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication
    Xiaolan Yu
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Virol 88:4466-79. 2014
    ..These new findings provide mechanistic support that SCFAs from periodontal pathogens stimulate KSHV replication and infection in the oral cavity and are potential risk factors for development of oral Kaposi's sarcoma (KS)...
  16. pmc The histone deacetylase inhibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T cells to HIV by increasing the kinetics and efficiency of postentry viral events
    Mark B Lucera
    Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Virol 88:10803-12. 2014
    ....
  17. pmc Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency
    Young Kyeung Kim
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    EMBO J 25:3596-604. 2006
    ..We conclude that the recruitment and activation of TFIIH represents a rate-limiting step for the emergence of HIV from latency...