S C Kalhan

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Glucose turnover and gluconeogenesis in human pregnancy
    S Kalhan
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Clin Invest 100:1775-81. 1997
  2. ncbi request reprint Estimation of gluconeogenesis in newborn infants
    S C Kalhan
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
    Am J Physiol Endocrinol Metab 281:E991-7. 2001
  3. ncbi request reprint Serine metabolism in human pregnancy
    Satish C Kalhan
    Departments of Pediatrics and Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Endocrinol Metab 284:E733-40. 2003
  4. ncbi request reprint Glyceroneogenesis and the source of glycerol for hepatic triacylglycerol synthesis in humans
    S C Kalhan
    Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Biol Chem 276:12928-31. 2001
  5. ncbi request reprint Gluconeogenesis in the fetus and neonate
    S Kalhan
    Department of Pediatrics, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Semin Perinatol 24:94-106. 2000
  6. ncbi request reprint Protein metabolism in pregnancy
    S C Kalhan
    Robert Schwartz MD Center for Metabolism and Nutrition and the Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109 1998, USA
    Am J Clin Nutr 71:1249S-55S. 2000
  7. ncbi request reprint Protein metabolism in the extremely low-birth weight infant
    S C Kalhan
    Robert Schwartz, MD, Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Clin Perinatol 27:23-56. 2000
  8. ncbi request reprint Pregnancy, insulin resistance and nitrogen accretion
    S C Kalhan
    Center for Metabolism and Nutrition, Cleveland, OH 44109 1998, USA
    Curr Opin Clin Nutr Metab Care 2:359-63. 1999
  9. ncbi request reprint Protein and nitrogen metabolism in gestational diabetes
    S C Kalhan
    Department of Pediatrics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 6010, USA
    Diabetes Care 21:B75-8. 1998
  10. ncbi request reprint Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants
    Prabhu S Parimi
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Am J Clin Nutr 79:402-9. 2004

Collaborators

Detail Information

Publications36

  1. pmc Glucose turnover and gluconeogenesis in human pregnancy
    S Kalhan
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Clin Invest 100:1775-81. 1997
    ..003). These data demonstrate the ability of the mother to adapt to the increasing fetal demands for glucose with advancing gestation. The mechanism for this unique quantitative adjustment to the fetal demands remains undefined...
  2. ncbi request reprint Estimation of gluconeogenesis in newborn infants
    S C Kalhan
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
    Am J Physiol Endocrinol Metab 281:E991-7. 2001
    ..These data may have important implications for the nutritional support of the healthy and sick newborn infant...
  3. ncbi request reprint Serine metabolism in human pregnancy
    Satish C Kalhan
    Departments of Pediatrics and Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Endocrinol Metab 284:E733-40. 2003
    ....
  4. ncbi request reprint Glyceroneogenesis and the source of glycerol for hepatic triacylglycerol synthesis in humans
    S C Kalhan
    Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Biol Chem 276:12928-31. 2001
    ..Alternatively, there may be two distinct pools of 3-glycerol phosphate in the liver, one involved in generating triosephosphate from glycerol and the other involved in glyceride-glycerol synthesis...
  5. ncbi request reprint Gluconeogenesis in the fetus and neonate
    S Kalhan
    Department of Pediatrics, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Semin Perinatol 24:94-106. 2000
    ..Application of new molecular biology techniques, in combination with sensitive tracer isotopic methods, will allow us to identify and examine metabolic disorders that impact GNG and help develop intervention strategies...
  6. ncbi request reprint Protein metabolism in pregnancy
    S C Kalhan
    Robert Schwartz MD Center for Metabolism and Nutrition and the Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109 1998, USA
    Am J Clin Nutr 71:1249S-55S. 2000
    ..These data suggest an integral regulation of whole-body protein and nitrogen metabolism starting early in gestation and aimed at conservation and accretion of nitrogen by the mother and the fetus...
  7. ncbi request reprint Protein metabolism in the extremely low-birth weight infant
    S C Kalhan
    Robert Schwartz, MD, Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Clin Perinatol 27:23-56. 2000
    ..This may be, in part, due to limitations in delivery of adequate calorie and nitrogen...
  8. ncbi request reprint Pregnancy, insulin resistance and nitrogen accretion
    S C Kalhan
    Center for Metabolism and Nutrition, Cleveland, OH 44109 1998, USA
    Curr Opin Clin Nutr Metab Care 2:359-63. 1999
    ....
  9. ncbi request reprint Protein and nitrogen metabolism in gestational diabetes
    S C Kalhan
    Department of Pediatrics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 6010, USA
    Diabetes Care 21:B75-8. 1998
    ..Whether the decompensation in protein turnover contributes to the persistent fetal macrosomia, even in rigorously managed GDM, remains speculative...
  10. ncbi request reprint Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants
    Prabhu S Parimi
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Am J Clin Nutr 79:402-9. 2004
    ..Although supplementation with glutamine has been suggested for growing infants, its effect on protein metabolism has not been examined...
  11. ncbi request reprint Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus
    J P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building, 2500 MetroHealth Dr, Cleveland, OH 44109 1998, USA
    Diabetes Care 24:1602-7. 2001
    ....
  12. ncbi request reprint Role of O2 in regulation of lactate dynamics during hypoxia: mathematical model and analysis
    M E Cabrera
    Department of Biomedical Engineering, Case Western Reserve University, and Rainbow Babies and Childrens Hospital, Cleveland, OH 44106 6011, USA
    Ann Biomed Eng 26:1-27. 1998
    ..Nevertheless, changes in Ca,LA, due to Cm,LA, are unlikely to be detected experimentally because changes in Cm,LA are small relative to the total LA concentrations in other tissues...
  13. ncbi request reprint Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States
    R Kalhan
    Robert Schwartz MD Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Metabolism 50:1197-202. 2001
    ..South Asians born in the United States show evidence for an altered metabolic profile in young adulthood. The relative contributions of inheritance and nutritional practices early in life to this alteration remain unclear...
  14. pmc Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period
    Mark M Kadrofske
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Endocrinol Metab 290:E622-30. 2006
    ..The mechanisms of this transient effect on whole body protein/nitrogen metabolism remain unknown...
  15. ncbi request reprint Metabolism of threonine in newborn infants
    Prabhu S Parimi
    Schwartz Center for Metabolism and Nutrition, Bell Greve Bldg, Room G 735, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Am J Physiol Endocrinol Metab 289:E981-5. 2005
    ..These data suggest that threonine is exclusively degraded by the glycine-independent serine/threonine dehydratase pathway. A higher flux of threonine relative to phenylalanine indicates higher turnover of threonine enriched proteins...
  16. ncbi request reprint Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants
    Satish C Kalhan
    Schwartz Center for Metabolism and Nutrition, MetroHealth Medical Center, Department of Pedatrics and Biochemistry, CaseWestern Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    J Pediatr 146:642-7. 2005
    ..To examine the effect of supplemental glutamine (0.6 g.kg -1 .d -1 ) on whole body protein/nitrogen and glutamine kinetics in low birth weight (LBW) infants receiving parenteral nutrition in the immediate neonatal period...
  17. ncbi request reprint Amino acids, glutamine, and protein metabolism in very low birth weight infants
    Prabhu S Parimi
    Department of Pediatrics, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Pediatr Res 58:1259-64. 2005
    ..These data show an acute increase in parenteral amino acid-suppressed proteolysis, however, such an effect was not seen when amino acids were infused for 20 h and resulted in an increase in glutamine synthesis...
  18. ncbi request reprint Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
    David E Kelley
    Department of Medicine, University of Pittsburgh, 810N Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 285:E906-16. 2003
    ..34; P < 0.01). In summary, fatty liver is relatively common in overweight and obese volunteers with type 2 DM and is an aspect of body composition related to severity of insulin resistance, dyslipidemia, and inflammatory markers...
  19. ncbi request reprint Gender differences in the regulation of amino acid metabolism
    Linda S Lamont
    Exercise Science Program, University of Rhode Island, Kingston, RI 02881, USA
    J Appl Physiol 95:1259-65. 2003
    ..Gender-specific fuel preferences during exercise are regulated by beta-adrenergic-receptor activity. Substrate availability during exercise appears to modulate the amino acid oxidation differences between genders...
  20. ncbi request reprint TNF-alpha is a predictor of insulin resistance in human pregnancy
    John P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building Rm G 232E, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Diabetes 51:2207-13. 2002
    ....
  21. ncbi request reprint Transamination of leucine and nitrogen accretion in human pregnancy and the newborn infant
    Satish C Kalhan
    Schwartz Center for Metabolism and Nutrition, Department of Pediatrics, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, USA
    J Nutr 136:281S-7S. 2006
    ..The regulatory mechanism involved in this redirection of nitrogen from irreversible loss to accretion remains under investigation...
  22. ncbi request reprint Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infants
    Prabhu S Parimi
    Department of Pediatrics, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
    Am J Physiol Endocrinol Metab 282:E618-25. 2002
    ..The negative relationship between glutamine turnover and the irreversible oxidation of protein (urea synthesis) suggests an important role of glutamine as a nitrogen source for other synthetic processes and accretion of body proteins...
  23. pmc Effect of intravenous amino acids on protein kinetics in preterm infants
    Satish C Kalhan
    Department of Gastroenterology, Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Curr Opin Clin Nutr Metab Care 10:69-74. 2007
    ..To summarize recent findings of the effects of intravenous amino acids on protein kinetics in low-birth-weight infants and to describe the potential cellular mechanism for these observations...
  24. ncbi request reprint Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat
    Srinivasan Dasarathy
    Department of Gastroenterology, Cleveland Clinic, Lerner Research Institute and the Cleveland Clinic Lerner College of Medicine, NE40, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1105-13. 2007
    ....
  25. pmc Parenteral amino acid and metabolic acidosis in premature infants
    Pushkaraj Jadhav
    Schwartz Center for Metabolism and Nutrition and Department of Pediatrics, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA
    JPEN J Parenter Enteral Nutr 31:278-83. 2007
    ..Aggressive parenteral nutrition (PN) including amino acids is recommended for low-birth-weight infants to prevent energy and protein deficit. Their impact on acid-base homeostasis has not been examined...
  26. pmc Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans
    Satish C Kalhan
    Schwartz Center for Nutrition and Metabolism, MetroHealth Center, Cleveland, OH 44109, USA
    Metabolism 57:305-12. 2008
    ..The contribution of glyceroneogenesis to triglyceride-glycerol is not affected by short (4 hours) infusion of insulin in type 2 diabetes mellitus...
  27. pmc Re: "alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins" by Ramakrishnan (Metabolism 2007;56:1550-60)
    Satish C Kalhan
    Metabolism 57:871; author reply 871-2. 2008
  28. pmc A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases
    Jaeyeon Kim
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Theor Biol 251:523-40. 2008
    ..3) Glyceroneogenesis contributes more to glycerol-3-phosphate synthesis during epinephrine infusion when pyruvate oxidation is inhibited by a high acetyl-CoA/free-CoA ratio...
  29. ncbi request reprint Glutamine supplementation in the newborn infant
    Prabhu S Parimi
    Department of Pediatrics, Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Semin Fetal Neonatal Med 12:19-25. 2007
    ..The reasons for these differences are discussed...
  30. ncbi request reprint Gluconeogenesis in humans with induced hyperlactatemia during low-intensity exercise
    Mark J Roef
    Department of Pediatric Gastroenterology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Endocrinol Metab 284:E1162-71. 2003
    ....
  31. ncbi request reprint Effect of reduced maternal inspired oxygen on hepatic glucose metabolism in the rat fetus
    Prabhu S Parimi
    Robert Schwartz MD Center for Metabolism and Nutrition, Departments of Pediatrics and Biochemistry, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Pediatr Res 53:325-32. 2003
    ..IUGR, as a result of decreased fractional inspired oxygen concentration may also be the consequence of pH-mediated changes in uterine blood flow. However, these remain to be examined in this experimental model...
  32. ncbi request reprint The key role of anaplerosis and cataplerosis for citric acid cycle function
    Oliver E Owen
    Department of Pediatrics, Case Western Reserve University School of Medicine, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, OH 44109, USA
    J Biol Chem 277:30409-12. 2002
  33. ncbi request reprint Lactate disposal via gluconeogenesis is increased during exercise in patients with mitochondrial myopathy due to complex I deficiency
    Mark J Roef
    Department of Pediatric Gastroenterology, University Children s Hospital, Utrecht, The Netherlands
    Pediatr Res 51:592-7. 2002
    ..GNG(PYR) is a significant mechanism of lactate disposal in exercising CID patients, but triglyceride infusion does not enhance their lactate disposal through this mechanism...
  34. ncbi request reprint Triacylglycerol infusion improves exercise endurance in patients with mitochondrial myopathy due to complex I deficiency
    Mark J Roef
    Department of Pediatric Gastroenterology, The University Children s Hospital, Utrecht, Netherlands
    Am J Clin Nutr 75:237-44. 2002
    ..A high-fat diet has been recommended for the treatment of patients with mitochondrial myopathy due to complex I (NADH dehydrogenase) deficiency (CID)...
  35. ncbi request reprint Triacylglycerol infusion does not improve hyperlactemia in resting patients with mitochondrial myopathy due to complex I deficiency
    Mark J Roef
    Department of Pediatric Gastroenterology, The University Children s Hospital, Utrecht, Netherlands
    Am J Clin Nutr 75:228-36. 2002
    ..A high-fat diet has been recommended for correction of biochemical abnormalities and muscle energy state in patients with complex I (NADH dehydrogenase) deficiency (CID)...
  36. pmc Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat
    Colleen K Nye
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 283:27565-74. 2008
    ..Thus, glyceroneogenesis, in contrast to glucose, via glycolysis, is quantitatively the predominant source of triglyceride glycerol in adipose tissue, skeletal muscle, and liver of the rat during fasting and high sucrose feeding...