Robert C Kalayjian
Affiliation: Case Western Reserve University
- Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumesRobert C Kalayjian
MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
J Infect Dis 187:1924-33. 2003..Because of their common association with age and HIV disease, naive CD8(+) cell depletion, diminished CD28 expression on CD8(+) cells, and reduced thymic volumes are possible correlates of the interaction of age with HIV disease...
- Distinct mechanisms of T cell reconstitution can be identified by estimating thymic volume in adult HIV-1 diseaseRobert C Kalayjian
Division of Infectious Diseases, MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
J Infect Dis 192:1577-87. 2005..We have attempted to identify factors associated with T cell reconstitution in response to highly active antiretroviral therapy...
- Kidney Disease in HIV-Infected PersonsRobert C Kalayjian
Division of Infectious Diseases, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH, 44109, USA
Curr Infect Dis Rep 14:83-90. 2012..Robust associations between proteinuria and cardiovascular disease imply that common mechanisms of vascular endothelial dysfunction may contribute to both processes...
- Suppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney diseaseRobert C Kalayjian
Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA
AIDS 22:481-7. 2008..To examine the association between changes in glomerular filtration rates (GFR) and antiretroviral therapy (ART)-mediated suppression of plasma HIV-1 viremia...
- Renal issues in HIV infectionRobert C Kalayjian
Division of Infectious Diseases, MetroHealth Medical Center, Cleveland, OH 44109, USA
Curr HIV/AIDS Rep 8:164-71. 2011..The emerging experience with kidney transplantation also suggests this to be a viable option in selected patients...
- Pretreatment levels of soluble cellular receptors and interleukin-6 are associated with HIV disease progression in subjects treated with highly active antiretroviral therapyRobert C Kalayjian
MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
J Infect Dis 201:1796-805. 2010....
- The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy eraSamir K Gupta
Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Antivir Ther 14:543-9. 2009..Proteinuria is associated with progressive renal disease and overall mortality in HIV-infected patients; however, the prevalence and correlates of quantitative proteinuria in the highly active antiretroviral therapy era are unknown...
- The effect of aging on T-regulatory cell frequency in HIV infectionAllan R Tenorio
Section of Infectious Diseases, Department of Medicine, Rush Medical College, 600 S Paulina Street, Suite 143 AAC, Chicago, Illinois 60612, USA
Clin Immunol 130:298-303. 2009..T-reg percentages are increased in the older HIV(+) population and may play a role in the accelerated disease progression seen in older HIV-infected persons...
- Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine careRobert C Kalayjian
Metro Health Medical Center, Cleveland, Ohio, USA
AIDS 26:1907-15. 2012....
- Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cellsMichael M Lederman
Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Infect Dis 204:1217-26. 2011..Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection...
- Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV diseaseBenigno Rodriguez
Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
J Leukoc Biol 90:621-8. 2011..These observations suggest that alterations in naïve T cell subset frequencies could contribute to naïve T cell dysfunction in HIV disease, but these alterations are not necessarily the result of chronic immune activation...
- The treatment of HIV-associated nephropathyRobert C Kalayjian
MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA
Adv Chronic Kidney Dis 17:59-71. 2010..Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy...
- Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptaseZixin Hu
Section of Retroviral Therapeutics, Brigham and Women s Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 45:494-500. 2007..These results show that Delta70 enhances resistance to certain purine and pyrimidine analogues and contributes to multinucleoside resistance in the appropriate viral genetic background...