Moses L Joloba

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Comparison of transformation frequencies among selected Streptococcus pneumoniae serotypes
    Moses L Joloba
    Department of Medical Microbiology, Makerere University College of Health Sciences, Upper Mulago hill road, PO Box 7072, Kampala, Uganda
    Int J Antimicrob Agents 36:124-8. 2010
  2. ncbi request reprint What is the most reliable solid culture medium for tuberculosis treatment trials?
    Moses L Joloba
    Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda Uganda Case Western Reserve University Research Collaboration, Kampala, Uganda Electronic address
    Tuberculosis (Edinb) 94:311-6. 2014
  3. pmc Incremental yield of serial sputum cultures for diagnosis of tuberculosis among HIV infected smear negative pulmonary TB suspects in Kampala, Uganda
    Willy Ssengooba
    School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 7:e37650. 2012
  4. pmc Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection
    Deus Lukoye
    Public Health Department, Kampala City Council, Kampala, Uganda
    PLoS ONE 6:e16130. 2011
  5. pmc Anti-tuberculosis drug resistance among new and previously treated sputum smear-positive tuberculosis patients in Uganda: results of the first national survey
    Deus Lukoye
    National Tuberculosis Leprosy Program Ministry of Health, Kampala, Uganda
    PLoS ONE 8:e70763. 2013
  6. pmc Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease
    Eddie M Wampande
    Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Infect Dis 13:484. 2013
  7. pmc Evaluation of Capilia TB assay for rapid identification of Mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
    Christopher Muchwa
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Res Notes 5:44. 2012
  8. pmc Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in South-Western Uganda
    Joel Bazira
    Department of Microbiology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
    BMC Infect Dis 11:81. 2011
  9. pmc Direct susceptibility testing for multi drug resistant tuberculosis: a meta-analysis
    Freddie Bwanga
    Department of Medical Microbiology Makerere University College of Health Sciences Kampala, Uganda
    BMC Infect Dis 9:67. 2009
  10. pmc Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    BMC Infect Dis 9:53. 2009

Research Grants

  1. ROLE OF RHOMBOID HOMOLOGUES IN MYCOBACTERIA SIGNALING
    Moses Joloba; Fiscal Year: 2006
  2. CELL TO CELL SIGNALING IN MYCOBACTERIA
    Moses Joloba; Fiscal Year: 2007
  3. CELL TO CELL SIGNALING IN MYCOBACTERIA
    Moses Joloba; Fiscal Year: 2008
  4. CELL TO CELL SIGNALING IN MYCOBACTERIA
    Moses Joloba; Fiscal Year: 2009
  5. CELL TO CELL SIGNALING IN MYCOBACTERIA
    MOSES LUTAAKOME JOLOBA; Fiscal Year: 2010

Collaborators

Detail Information

Publications30

  1. pmc Comparison of transformation frequencies among selected Streptococcus pneumoniae serotypes
    Moses L Joloba
    Department of Medical Microbiology, Makerere University College of Health Sciences, Upper Mulago hill road, PO Box 7072, Kampala, Uganda
    Int J Antimicrob Agents 36:124-8. 2010
    ..This is the first study to compare the transformation frequencies of pneumococcal clinical isolates using genomic DNA that carries the composite Tn916-like element...
  2. ncbi request reprint What is the most reliable solid culture medium for tuberculosis treatment trials?
    Moses L Joloba
    Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda Uganda Case Western Reserve University Research Collaboration, Kampala, Uganda Electronic address
    Tuberculosis (Edinb) 94:311-6. 2014
    ..6% specificity of 7H10S (95% CI 75.7%-87.8%) was highest (P = 0.098). Our results support 7H11S as the medium of choice. Further studies in different areas where recovery and contamination are likely to vary, are recommended. ..
  3. pmc Incremental yield of serial sputum cultures for diagnosis of tuberculosis among HIV infected smear negative pulmonary TB suspects in Kampala, Uganda
    Willy Ssengooba
    School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 7:e37650. 2012
    ..Even then, the number of sputum samples required remains unspecified. Here, we determined the Incremental Yield (IY) and number of samples required to diagnose an additional PTB case upon second and third serial sputum culture...
  4. pmc Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection
    Deus Lukoye
    Public Health Department, Kampala City Council, Kampala, Uganda
    PLoS ONE 6:e16130. 2011
    ..We studied drug resistance and HIV infection in a representative sample of 533 smear-positive tuberculosis patients diagnosed in Kampala, Uganda...
  5. pmc Anti-tuberculosis drug resistance among new and previously treated sputum smear-positive tuberculosis patients in Uganda: results of the first national survey
    Deus Lukoye
    National Tuberculosis Leprosy Program Ministry of Health, Kampala, Uganda
    PLoS ONE 8:e70763. 2013
    ..We conducted a national drug resistance survey to investigate the levels and patterns of resistance to first and second line anti-TB drugs among new and previously treated sputum smear-positive TB cases...
  6. pmc Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease
    Eddie M Wampande
    Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Infect Dis 13:484. 2013
    ..Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala...
  7. pmc Evaluation of Capilia TB assay for rapid identification of Mycobacterium tuberculosis complex in BACTEC MGIT 960 and BACTEC 9120 blood cultures
    Christopher Muchwa
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Res Notes 5:44. 2012
    ..abstract:..
  8. pmc Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in South-Western Uganda
    Joel Bazira
    Department of Microbiology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
    BMC Infect Dis 11:81. 2011
    ..tuberculosis strains is important in tuberculosis control. We determined the genetic diversity and susceptibility profiles of mycobacteria isolated from tuberculosis patients in Mbarara, South Western Uganda...
  9. pmc Direct susceptibility testing for multi drug resistant tuberculosis: a meta-analysis
    Freddie Bwanga
    Department of Medical Microbiology Makerere University College of Health Sciences Kampala, Uganda
    BMC Infect Dis 9:67. 2009
    ....
  10. pmc Sensitivity of direct versus concentrated sputum smear microscopy in HIV-infected patients suspected of having pulmonary tuberculosis
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    BMC Infect Dis 9:53. 2009
    ..Sputum concentration increases the sensitivity of smear microscopy for the diagnosis of tuberculosis (TB), but few studies have investigated this method in human immunodeficiency virus (HIV)-infected individuals...
  11. pmc Detection of multiple strains of Mycobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala, Uganda
    Katherine R Dickman
    Department of Pediatrics, Boston Medical Center, Boston University, Boston, USA
    BMC Infect Dis 10:349. 2010
    ..We aimed to determine the prevalence of MTB multiple strain infections in Kampala, and the impact of these infections on clinical presentation of tuberculosis (TB) and response to treatment...
  12. pmc Use of the GenoType(R) MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda
    Joel Bazira
    Department of Microbiology, Faculty of Medicine, Mbarara University of Science and Technology, P, O, Box 1410, Mbarara, Uganda
    BMC Clin Pathol 10:5. 2010
    ..Drug resistance levels and patterns among Mycobacterium tuberculosis isolates from newly diagnosed and previously treated tuberculosis patients in Mbarara Uganda were investigated...
  13. pmc Determination of circulating Mycobacterium tuberculosis strains and transmission patterns among pulmonary TB patients in Kawempe municipality, Uganda, using MIRU-VNTR
    Lydia Nabyonga
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Res Notes 4:280. 2011
    ..abstract:..
  14. pmc Species and genotypic diversity of non-tuberculous mycobacteria isolated from children investigated for pulmonary tuberculosis in rural Uganda
    Benon B Asiimwe
    Department of Medical Microbiology, Makerere University College of Health Sciences, P O Box 7072, Kampala, Uganda
    BMC Infect Dis 13:88. 2013
    ....
  15. pmc Comparison of rapid tests for detection of rifampicin-resistant Mycobacterium tuberculosis in Kampala, Uganda
    Sam Ogwang
    Department of Medical Microbiology, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Infect Dis 9:139. 2009
    ..The aim of the present study was to assess the feasibility of implementing technology for rapid detection of rifampicin resistance in a high disease burden setting in Africa...
  16. pmc Molecular characterization of Staphylococcus aureus from patients with surgical site infections at Mulago Hospital in Kampala, Uganda
    Jeremiah Seni
    Department of Medical Microbiology, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 8:e66153. 2013
    ..However, the S. aureus genotypes circulating among patients are not known. Here, we report S. aureus lineages circulating in patients with surgical site infections (SSI) at Mulago National hospital, Kampala, Uganda...
  17. pmc Evaluation of in-house PCR for diagnosis of smear-negative pulmonary tuberculosis in Kampala, Uganda
    Lydia Nakiyingi
    Infectious Diseases Institute, Makerere University College of Health Sciences, Mulago Hospital Complex, Kampala, Uganda
    BMC Res Notes 5:487. 2012
    ..Two smear-negative sputum samples were obtained from each PTB suspect and processed simultaneously for identification of MTBC using in-house PCR and LJ culture...
  18. pmc The T2 Mycobacterium tuberculosis Genotype, Predominant in Kampala, Uganda, Shows Negative Correlation with Antituberculosis Drug Resistance
    Deus Lukoye
    National Tuberculosis and Leprosy Program, Kampala, Uganda
    Antimicrob Agents Chemother 58:3853-9. 2014
    ..Patients' HIV status plays no role with respect to the MTC lineage distribution. ..
  19. pmc Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Uganda
    Jeremiah Seni
    Department of Medical Microbiology, Makerere University College of Health Sciences, PO Box 7072, Kampala, Uganda
    BMC Res Notes 6:298. 2013
    ..To address the limited data in Uganda on SSIs, we present the spectrum of bacteria isolated from hospitalized patients, the magnitude and impact of MDR bacterial isolates among patients with SSIs...
  20. ncbi request reprint Prevalence of virulence determinants in Staphylococcus epidermidis from ICU patients in Kampala, Uganda
    Moses S Okee
    Makerere University College of Health Sciences, Kampala, Uganda
    J Infect Dev Ctries 6:242-50. 2012
    ..To distinguish invasive strains, comparative studies of patient and community isolates may offer some clues. We investigated the distribution of virulence determinants in patient isolates from Uganda...
  21. pmc Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Microbiol 10:272. 2010
    ..We report detailed phylogenetic and genomic analyses devoted to prokaryotic rhomboids of an important genus, Mycobacterium...
  22. pmc High prevalence of methicillin resistant Staphylococcus aureus in the surgical units of Mulago hospital in Kampala, Uganda
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Res Notes 4:326. 2011
    ..abstract:..
  23. pmc Evaluation of Cepheid's Xpert MTB/RIF Test on Pleural Fluid in the Diagnosis of Pleural Tuberculosis in a High Prevalence HIV/TB Setting
    John K Lusiba
    Makerere University College of Heath Sciences, Kampala, Uganda
    PLoS ONE 9:e102702. 2014
    ..Xpert MTB/Rif test has been widely evaluated in sputum specimens but data on its performance in pleural TB is scarce. We evaluated the accuracy of Cepheid's Xpert MTB/Rif test on pleural fluid in the diagnosis of pleural TB in Uganda...
  24. pmc Evaluation of the Xpert MTB/RIF test for the diagnosis of childhood pulmonary tuberculosis in Uganda: a cross-sectional diagnostic study
    Moorine Penninah Sekadde
    Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Infect Dis 13:133. 2013
    ..The sputum culture on both Lowenstein-Jensen (LJ) and Mycobacteria Growth Indicator Tube (MGIT) was the gold standard...
  25. pmc Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in peri-urban Kampala, Uganda
    Benon B Asiimwe
    Department of Medical Microbiology, Makerere University Medical School, Kampala, Republic of Uganda
    BMC Infect Dis 8:101. 2008
    ..This study determined the predominant strain lineages that cause TB in Rubaga division, Kampala, Uganda, and the prevalence of resistance to key anti-tuberculosis drugs in this community...
  26. pmc Aetiology of pulmonary symptoms in HIV-infected smear negative recurrent PTB suspects in Kampala, Uganda: a cross-sectional study
    Alphonse Okwera
    Department of Internal Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 8:e82257. 2013
    ..Category II anti-TB drugs may be inappropriate and may expose patients to pill burden, drug toxicities and drug-drug interactions...
  27. pmc Isolation of Mycobacterium avium subspecies paratuberculosis from Ugandan cattle and strain differentiation using optimised DNA typing techniques
    Julius Boniface Okuni
    College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P O Box 7062, Kampala, Uganda
    BMC Vet Res 8:99. 2012
    ..The aim of this study was to isolate and characterise MAP from seropositive cattle and paratuberculosis lesions in tissues obtained from slaughtered cattle in Uganda...
  28. pmc An Early Morning Sputum Sample Is Necessary for the Diagnosis of Pulmonary Tuberculosis, Even with More Sensitive Techniques: A Prospective Cohort Study among Adolescent TB-Suspects in Uganda
    Willy Ssengooba
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda Iganga Mayuge Demographic Surveillance Sites, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda
    Tuberc Res Treat 2012:970203. 2012
    ..Among TB-suspected adolescents in rural Uganda, the EM sputum culture has a high incremental diagnostic yield. Therefore, EM sputum in addition to spot sample culture is necessary for improved TB case detection...
  29. pmc Identification of Staphylococcus aureus: DNase and Mannitol salt agar improve the efficiency of the tube coagulase test
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Upper Mulago hill road, Kampala, Uganda
    Ann Clin Microbiol Antimicrob 9:23. 2010
    ..The efficiency of human and sheep plasma with tube coagulase tests was also evaluated...
  30. pmc Direct nitrate reductase assay versus microscopic observation drug susceptibility test for rapid detection of MDR-TB in Uganda
    Freddie Bwanga
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    PLoS ONE 6:e19565. 2011
    ..In the study settings, the direct NRA was highly sensitive and specific. We consider it to have a strong potential for timely detection of MDR-TB in RLS...

Research Grants5

  1. ROLE OF RHOMBOID HOMOLOGUES IN MYCOBACTERIA SIGNALING
    Moses Joloba; Fiscal Year: 2006
    ..This will expand our understanding of mycobacterial biology and may provide novel candidate vaccines and drug targets. ..
  2. CELL TO CELL SIGNALING IN MYCOBACTERIA
    Moses Joloba; Fiscal Year: 2007
    ..This will enrich our knowledge on mycobacterial biology and may reveal novel drug and vaccine targets. ..
  3. CELL TO CELL SIGNALING IN MYCOBACTERIA
    Moses Joloba; Fiscal Year: 2008
    ..This will enrich our knowledge on mycobacterial biology and may reveal novel drug and vaccine targets. ..
  4. CELL TO CELL SIGNALING IN MYCOBACTERIA
    Moses Joloba; Fiscal Year: 2009
    ..This will enrich our knowledge on mycobacterial biology and may reveal novel drug and vaccine targets. ..
  5. CELL TO CELL SIGNALING IN MYCOBACTERIA
    MOSES LUTAAKOME JOLOBA; Fiscal Year: 2010
    ..This will enrich our knowledge on mycobacterial biology and may reveal novel drug and vaccine targets. ..