Wei Jiang

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
    Nicholas Funderburg
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 3:e1915. 2008
  2. pmc Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells
    Wei Jiang
    Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Immunol 186:2080-6. 2011
  3. ncbi request reprint Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement
    Scott F Sieg
    Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, Ohio 44106 4984, USA
    J Infect Dis 192:62-70. 2005
  4. ncbi request reprint TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 4984, USA
    Eur J Immunol 37:2205-13. 2007
  5. pmc Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population
    Lihong Wang
    Department of Immunology, Harbin Medical University, Harbin 150081, China
    BMC Cancer 7:173. 2007
  6. pmc Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    J Virol 82:7837-45. 2008
  7. pmc Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation
    Nicholas T Funderburg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, OH, USA
    Blood 115:161-7. 2010
  8. ncbi request reprint Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection
    Benigno Rodriguez
    Division of Infectious Diseases, Case Western Reserve University, Center foe AIDS Research, University Hospitals of Cleveland, Cleveland, Ohio, USA
    AIDS 20:1379-89. 2006
  9. pmc Intracellular Casp8p41 content is inversely associated with CD4 T cell count
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 202:386-91. 2010
  10. pmc Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7288, USA
    Blood 113:5497-505. 2009

Collaborators

Detail Information

Publications42

  1. pmc Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis
    Nicholas Funderburg
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 3:e1915. 2008
    ..Recently, heightened systemic translocation of microbial products was found in persons with chronic HIV infection and this was linked to immune activation and CD4(+) T cell homeostasis...
  2. pmc Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells
    Wei Jiang
    Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Immunol 186:2080-6. 2011
    ..Although resting naive B cells are poor APCs, they can be activated by TLR9 agonists to serve as potent APCs for class I MHC-restricted T cell responses. This novel activity of naive B cells could be exploited for vaccine design...
  3. ncbi request reprint Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement
    Scott F Sieg
    Case Western Reserve University and University Hospitals of Cleveland, Center for AIDS Research, Cleveland, Ohio 44106 4984, USA
    J Infect Dis 192:62-70. 2005
    ..Thus, in HIV infection, central memory T cells may be highly susceptible to bystander mechanisms of immune activation, leading to S-phase entry...
  4. ncbi request reprint TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 4984, USA
    Eur J Immunol 37:2205-13. 2007
    ..We propose that the activation and expansion of naïve B cells induced by TLR9 agonists could enhance the potential of these cells to interact with cognate antigens and facilitate cell-mediated immune responses...
  5. pmc Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population
    Lihong Wang
    Department of Immunology, Harbin Medical University, Harbin 150081, China
    BMC Cancer 7:173. 2007
    ..To evaluate the potential influences of CTLA-4 gene polymorphisms on breast cancer risk, a case-control study was conducted in Han women of Northeast China...
  6. pmc Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106, USA
    J Virol 82:7837-45. 2008
    ..Impaired responsiveness to TLR9 agonists may contribute to defects in humoral immunity in HIV infection...
  7. pmc Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation
    Nicholas T Funderburg
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University University Hospitals of Cleveland, OH, USA
    Blood 115:161-7. 2010
    ..Thus, drivers of immune activation in HIV disease, such as HIV replication, and potentially, microbial translocation, may activate clotting cascades and contribute to thrombus formation and cardiovascular morbidities in HIV infection...
  8. ncbi request reprint Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection
    Benigno Rodriguez
    Division of Infectious Diseases, Case Western Reserve University, Center foe AIDS Research, University Hospitals of Cleveland, Cleveland, Ohio, USA
    AIDS 20:1379-89. 2006
    ..To examine the effects of interferon-alpha (IFN-alpha) on T cell survival and activation in HIV infection...
  9. pmc Intracellular Casp8p41 content is inversely associated with CD4 T cell count
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 202:386-91. 2010
    ..This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection...
  10. pmc Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106 7288, USA
    Blood 113:5497-505. 2009
    ..Defective monocyte responses to IFNalpha/beta may play an important role in the pathogenesis of HIV-1 infection, and decreased IFNalpha/betaR expression may serve as a novel marker of disease progression...
  11. pmc Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    Wei Jiang
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 199:1177-85. 2009
    ..These findings are consistent with the importance of microbial translocation in immunodeficiency and T cell homeostasis in chronic HIV infection...
  12. pmc Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation
    Wei Jiang
    Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    J Virol 88:5369-80. 2014
    ..This cycling may be a consequence of exposure to microbial products, to plasma viremia, or, otherwise, to proinflammatory cytokines...
  13. doi request reprint Diagnostic utility of TP53 and cytokeratin 7 immunohistochemistry in idiopathic inflammatory bowel disease-associated neoplasia
    Hao Xie
    1 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA 2 Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA
    Mod Pathol 27:303-13. 2014
    ..Our results suggested that a combination of CK7 and TP53 immunohistochemistry may be helpful in diagnosing inflammatory bowel disease-associated dysplasia in difficult cases. ..
  14. doi request reprint Collagenous colitis in children and adolescents: study of 7 cases and literature review
    Xiuli Liu
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 26:881-7. 2013
    ..Treatment is less standardized in children and adolescents with CC...
  15. pmc Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
    Gareth A D Hardy
    Department of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
    PLoS ONE 8:e56527. 2013
    ..003). These studies identify IFNα derived from lymph nodes, rather than blood leukocytes, as a possible source of the IFN-I signature that contributes to immune activation in HIV-1 infection...
  16. pmc Bacterial colonization and beta defensins in the female genital tract in HIV infection
    Wei Jiang
    Division of Infectious Diseases, Department of Medicine, Center for AIDS Research, Case Western Reserve University and University Hospitals Case Medical Center, 2109 Adelbert Rd, CWRU BRB1048B, 4984, Cleveland, OH 44106, USA
    Curr HIV Res 10:504-12. 2012
    ..These results suggest that HIV infection is associated with impaired regulation of innate defenses at mucosal sites...
  17. doi request reprint Endometriosis involving the mucosa of the intestinal tract: a clinicopathologic study of 15 cases
    Wei Jiang
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 26:1270-8. 2013
    ..Vascular involvement by endometriosis was identified in one case. Endometrial hyperplasia (n=2) and cancer (n=1) were also seen in the ectopic tissue. All patients were alive at follow-up (3-216 months, mean 67 months)...
  18. pmc High expression of survivin is prognostic of shorter survival but not predictive of adjuvant gemcitabine benefit in patients with resected pancreatic adenocarcinoma
    Hao Xie
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA
    J Histochem Cytochem 61:148-55. 2013
    ..However, survivin has no predictive value of adjuvant gemcitabine benefit...
  19. pmc Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and production
    Wei Jiang
    Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Virol 79:4109-19. 2005
    ..Application of CpG ODNs in HIV disease for adjuvant or immunoregulatory purposes may be particularly useful for HIV+ donors without high-level viremia...
  20. doi request reprint Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma
    Wei Jiang
    Departments of Anatomic Pathology, Cleveland, OH 44195, USA
    Am J Surg Pathol 36:1385-94. 2012
    ....
  21. doi request reprint Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial
    Wei Jiang
    Department of Medicine, Duke University Medical Center, DUMC Box 3366, Durham, NC 27710, USA
    JAMA 309:2139-49. 2013
    ..Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied...
  22. doi request reprint Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma
    Hao Xie
    Department of Anatomic Pathology, The Cleveland Clinic, Ohio, USA
    Cancer 119:173-81. 2013
    ..The objective of this study was to evaluate the predictive roles of RRM1 in the survival of patients with resectable pancreatic adenocarcinoma who received treatment with gemcitabine or nongemcitabine adjuvant therapy...
  23. doi request reprint Increased crypt apoptosis is a feature of autoimmune-associated chronic antibiotic refractory pouchitis
    Wei Jiang
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 55:549-57. 2012
    ..Pouchitis is the most common long-term complication in patients with IPAA. While immune-mediated disorders frequently coexist with IBD, they appear to be associated with an increased risk for chronic antibiotic-refractory pouchitis...
  24. doi request reprint Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiovasc Transl Res 5:92-9. 2012
    ..1 unit) (HR 0.73, 95% CI 0.56-0.96) were significantly associated with survival of patients with HF and co-morbid MDD. The results suggest that low plasma omega-3 FA is a significant factor for reduced survival in HF patients with MDD...
  25. pmc Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma
    Hao Xie
    Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Int J Clin Exp Pathol 5:347-55. 2012
    ..This study aimed to determine if RRM2 protein expression was prognostic in patients with resectable pancreatic adenocarcinoma and predictive of adjuvant gemcitabine benefit...
  26. ncbi request reprint Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone
    Wei Jiang
    Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China
    J Hypertens 22:1953-61. 2004
    ..We examined the effect of aldosterone on ADM production and secretion and its mRNA expression in rat aortic adventitia to study the paracrine/autocrine interaction between endogenous ADM and aldosterone...
  27. pmc Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference
    Changjun Zhu
    The Burnham Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:3187-99. 2005
    ..Using immunofluorescence analysis, time-lapse microscopy, and rescue experiments, we investigate the roles of these 12 kinesins in detail...
  28. ncbi request reprint Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid
    Jing Hui Yang
    Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China
    Regul Pept 121:49-56. 2004
    ..We concluded that LPA stimulates the adventitia to produce and secrete ADM, which in turn regulates the vascular biological effects of LPA...
  29. ncbi request reprint Effects of adrenomedullin on aldosterone-induced cell proliferation in rat cardiac fibroblasts
    Wei Jiang
    Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China
    Biochim Biophys Acta 1690:265-75. 2004
    ..We reach the conclusion that aldosterone stimulates rat cardiac fibroblasts to produce and secrete ADM, which in turn regulates the proliferation-induced effects of aldosterone in these cells...
  30. ncbi request reprint Elucidation of functional groups on gram-positive and gram-negative bacterial surfaces using infrared spectroscopy
    Wei Jiang
    Department of Geosciences, Princeton University, Princeton, New Jersey 08544, USA
    Langmuir 20:11433-42. 2004
    ..The cell surface functional group chemistry is altered neither by the growth phase nor by the growth medium of bacteria. This study reveals the universality of the functional group chemistry of bacterial cell surfaces...
  31. ncbi request reprint Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
    Souad Rahmouni
    The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 8:524-31. 2006
    ..We conclude that VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner...
  32. ncbi request reprint Effect of tetramethylpyrazine on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro
    Yanhong Zou
    Department of Neuroscience and Experimental Therapeutics, Institute of Ocular Pharmacology, College of Medicine, Texas A and M University System Health Science Center College Station, Texas USA
    Curr Eye Res 32:71-5. 2007
    ..To evaluate the effect of tetramethylpyrazine (TMP) on laser-induced experimental choroidal neovascularization (CNV) in rat model in vivo and on endothelial cell proliferation in vitro...
  33. pmc High-throughput DNA methylation profiling using universal bead arrays
    Marina Bibikova
    Illumina, Inc, San Diego, California 92121, USA
    Genome Res 16:383-93. 2006
    ..The technology should prove useful for DNA methylation analyses in large populations, with potential application to the classification and diagnosis of a broad range of cancers and other diseases...
  34. ncbi request reprint DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast
    Yan Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, PR, China
    Cancer Biol Ther 6:1193-9. 2007
    ..DH334 also inhibits the kinase activity of Cdk2/CyclinA in vitro. Therefore, we speculate that the antitumor activity of beta-carboline drugs could be attributable to their inhibition of CDK...
  35. ncbi request reprint Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma
    Qiang Cui
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, China
    Hepatology 47:105-12. 2008
    ..Conclusion: This study suggests that transfer of SOCS3 by an oncolytic adenovirus represents a potent approach for cancer therapy...
  36. doi request reprint Role of uterine natural killer cells in angiogenesis of human decidua of the first-trimester pregnancy
    Guohua Li
    Department of Reproductive Endocrinology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
    Sci China C Life Sci 51:111-9. 2008
    ..Our study indicated that uNK cells, through expressing VEGF-A, may play an important role in the angiogenic response at the time of human decidualization and early placenta development...
  37. pmc The functional role of Cdc6 in S-G2/M in mammalian cells
    Eric Lau
    The Burnham Institute, La Jolla, California 92037, USA
    EMBO Rep 7:425-30. 2006
    ..These results show that Cdc6 is not only required for G1 origin licensing, but is also crucial for proper S-phase DNA replication that is essential for DNA segregation during mitosis...
  38. ncbi request reprint [Progress of study on inhibitory effects of traditional Chinese herbs on growth factor induced proliferation of vascular smooth muscle cells]
    Guang Yang
    Guangzhou University of TCM, Guangzhou 510405
    Zhongguo Zhong Xi Yi Jie He Za Zhi 25:951-4. 2005
    ....
  39. ncbi request reprint Jadomycin B, an Aurora-B kinase inhibitor discovered through virtual screening
    Da Hua Fu
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences Peking Union Medical College, Tiantan Xili 1, Beijing, P R China
    Mol Cancer Ther 7:2386-93. 2008
    ..We also present evidence suggesting that Jadomycin B induces apoptosis in tumor cells without obvious effects on cell cycle. All the results indicate that Jadomycin B is a new Aurora-B kinase inhibitor worthy of further investigation...
  40. ncbi request reprint An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis
    Hue H Luu
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Clin Exp Metastasis 22:319-29. 2005
    ..Thus, this orthotopic model should be a valuable tool to investigate factors that promote or inhibit osteosarcoma growth and/or metastasis...
  41. ncbi request reprint Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate
    Yuqiang Wang
    Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China
    Bioorg Med Chem 13:5592-9. 2005
    ..DHA-HCPT showed a greatly improved antitumor efficacy compared to HCPT...
  42. ncbi request reprint Paclitaxel nanoparticle inhibits growth of ovarian cancer xenografts and enhances lymphatic targeting
    Hongxia Lu
    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China
    Cancer Chemother Pharmacol 59:175-81. 2007
    ..The mechanism of paclitaxel nanoparticles in rats bearing ovarian cancer has been investigated in this study...