JAMES JACOBBERGER

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    Nhu An Pham
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Mol Cancer Ther 3:1239-48. 2004
  2. ncbi request reprint Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity
    James W Jacobberger
    Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106 4944, USA
    Cytometry A 54:75-88. 2003
  3. pmc Cell density related gene expression: SV40 large T antigen levels in immortalized astrocyte lines
    Phyllis S Frisa
    Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 4106 4944, USA
    BMC Cell Biol 3:10. 2002
  4. ncbi request reprint A new biomarker for mitotic cells
    James W Jacobberger
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cytometry A 73:5-15. 2008
  5. ncbi request reprint CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses
    Tao Yan
    Department of Radiation Oncology, LTR 6068, University Hospitals of Cleveland Ireland Cancer Center, 11100 Euclid Avenue, Cleveland, OH 44106 6068, USA
    Mol Cancer Ther 3:1147-57. 2004
  6. ncbi request reprint Inhibition of cdk1 by alsterpaullone and thioflavopiridol correlates with increased transit time from mid G2 through prophase
    Deena V Soni
    Environmental Health Sciences Department, Case Western Reserve University, Cleveland, Ohio, USA
    Cell Cycle 3:349-57. 2004
  7. pmc DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation
    Kedar Hastak
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 105:6314-9. 2008
  8. ncbi request reprint Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies
    Afshin Dowlati
    Developmental Therapeutics Program and the Division of Hematology Oncology, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Clin Cancer Res 9:5929-35. 2003
  9. pmc p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    J Clin Invest 109:1481-92. 2002
  10. ncbi request reprint Cyclin B1 is rate limiting but not essential for mitotic entry and progression in mammalian somatic cells
    Deena V Soni
    Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Cell Cycle 7:1285-300. 2008

Research Grants

  1. Multiparameter Cell Cycle Analysis
    JAMES JACOBBERGER; Fiscal Year: 2007
  2. Compucyte iCyte Imaging Cytometer
    JAMES JACOBBERGER; Fiscal Year: 2004
  3. STANDARDIZED MULTIPARAMETRIC CELL CYCLE ANALYSIS
    JAMES JACOBBERGER; Fiscal Year: 2003
  4. CWRU FLOW CYTOMETER AND CELL SORTER
    JAMES JACOBBERGER; Fiscal Year: 2001

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    Nhu An Pham
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Mol Cancer Ther 3:1239-48. 2004
    ..Our findings suggest that, in addition to the known effects on cancer prevention, sulforaphane may have activity in established pancreatic cancer...
  2. ncbi request reprint Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity
    James W Jacobberger
    Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106 4944, USA
    Cytometry A 54:75-88. 2003
    ..Here, we asked whether we could measure a phosphorylated epitope on Stat5 by cytometry, and whether that measurement would respond to Bcr/Abl inhibition...
  3. pmc Cell density related gene expression: SV40 large T antigen levels in immortalized astrocyte lines
    Phyllis S Frisa
    Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 4106 4944, USA
    BMC Cell Biol 3:10. 2002
    ..Here, we asked whether SV40 large T antigen (Tag) levels, driven by two different promoters, changed in a predictable and regular manner during exponential growth in clonal astrocyte cell lines, immortalized and dependent on Tag...
  4. ncbi request reprint A new biomarker for mitotic cells
    James W Jacobberger
    Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cytometry A 73:5-15. 2008
    ..To facilitate use without confusion about specificity, we suggest the trivial name, pS780 for this mitotic epitope...
  5. ncbi request reprint CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses
    Tao Yan
    Department of Radiation Oncology, LTR 6068, University Hospitals of Cleveland Ireland Cancer Center, 11100 Euclid Avenue, Cleveland, OH 44106 6068, USA
    Mol Cancer Ther 3:1147-57. 2004
    ..The two signaling kinases seem to work cooperatively to ensure that 6-TG damaged cells arrest at these cell cycle checkpoints...
  6. ncbi request reprint Inhibition of cdk1 by alsterpaullone and thioflavopiridol correlates with increased transit time from mid G2 through prophase
    Deena V Soni
    Environmental Health Sciences Department, Case Western Reserve University, Cleveland, Ohio, USA
    Cell Cycle 3:349-57. 2004
    ..These results suggest that cdk1-cyclin activity is rate limiting for cell cycle progression during a period from mid G2 through prophase...
  7. pmc DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation
    Kedar Hastak
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 105:6314-9. 2008
    ....
  8. ncbi request reprint Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies
    Afshin Dowlati
    Developmental Therapeutics Program and the Division of Hematology Oncology, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Clin Cancer Res 9:5929-35. 2003
    ..Preclinical in vitro and in vivo studies demonstrate synergistic activity and increased tumor apoptosis in B-cell malignancies when a prolonged infusion of bryostatin 1 is followed by vincristine...
  9. pmc p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    J Clin Invest 109:1481-92. 2002
    ..By slowing LPT cycling, p53 may act as a negative regulator of mucosal immunity, promoting immunological tolerance by preventing excessive T cell replication...
  10. ncbi request reprint Cyclin B1 is rate limiting but not essential for mitotic entry and progression in mammalian somatic cells
    Deena V Soni
    Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Cell Cycle 7:1285-300. 2008
    ..Lack of uniformity in other phenotypes suggest that these are low penetrance effects that are exacerbated or compensated in some systems by other mechanisms...
  11. pmc Monitoring Plasmodium falciparum growth and development by UV flow cytometry using an optimized Hoechst-thiazole orange staining strategy
    Brian T Grimberg
    Center for Global Health and Disease, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 7286, USA
    Cytometry A 73:546-54. 2008
    ..Investigation of the mechanisms by which anti-malarial drugs and antibodies act against different Pf lifecycle stages will be aided by this cytometric strategy...
  12. ncbi request reprint Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis
    Robert C Briggs
    Departments of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 66:4645-51. 2006
    ..We propose that MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in MDS is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death...
  13. ncbi request reprint Increasing the power of cytometry
    James W Jacobberger
    Nat Methods 3:343-4. 2006
  14. ncbi request reprint Whole blood fixation and permeabilization protocol with red blood cell lysis for flow cytometry of intracellular phosphorylated epitopes in leukocyte subpopulations
    Sue Chow
    Department of Pathology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cytometry A 67:4-17. 2005
    ..Detection of phospho-Thr 202/Tyr 204-p44/42 extracellular-regulated kinase (ERK) after phorbol ester acetate (PMA) stimulation was used as a model to measure phospho-epitopes in leukocyte populations in whole blood...
  15. ncbi request reprint Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes
    Robin E Miller
    Department of Pediatrics, University Hospitals Ireland Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Exp Hematol 30:738-44. 2002
    ..CTLA-4 mediates negative T-cell signaling and may contribute to the development of allogeneic tolerance. In this study, we compared protein and mRNA expression of CTLA-4 in stimulated UCB and adult peripheral blood T cells...
  16. ncbi request reprint Cytometry of the cell cycle: cycling through history
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10532, USA
    Cytometry A 58:21-32. 2004

Research Grants15

  1. Multiparameter Cell Cycle Analysis
    JAMES JACOBBERGER; Fiscal Year: 2007
    ..3c) test the hypothesis that the Transition State model can be generalized through GI. ..
  2. Compucyte iCyte Imaging Cytometer
    JAMES JACOBBERGER; Fiscal Year: 2004
    ..abstract_text> ..
  3. STANDARDIZED MULTIPARAMETRIC CELL CYCLE ANALYSIS
    JAMES JACOBBERGER; Fiscal Year: 2003
    ..abstract_text> ..
  4. CWRU FLOW CYTOMETER AND CELL SORTER
    JAMES JACOBBERGER; Fiscal Year: 2001
    ....